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The map label for this gene is galK

Identifier: 157369534

GI number: 157369534

Start: 1419986

End: 1421137

Strand: Reverse

Name: galK

Synonym: Spro_1291

Alternate gene names: 157369534

Gene position: 1421137-1419986 (Counterclockwise)

Preceding gene: 157369535

Following gene: 157369533

Centisome position: 26.08

GC content: 57.64

Gene sequence:

>1152_bases
ATGAGTTTGAAGAACCTTACCCACGCCCTGTTTACCGAACGTTTTGGCTACGCGCCCACGCTGACTATTCAGGCCCCTGG
CCGGGTGAATTTGATCGGCGAACACACCGACTATAACGACGGTTTTGTGCTGCCGTGCGCCATTGACTATCAGACGGTGA
TCGCCTGCGCCAAACGCGACGACCGTCAGATCCGGGTGATCGCCGCCGATTACGAAGGTCAGCAGGATCAATTCTCTCTC
GACAGCCCGATCGTCAGCCATCCGGATCAACGTTGGTCCGATTATGTACGCGGAGTGATCAAGCACCTGCAGCAGCGTAA
TGCCGATTTTGGCGGCGCGGATCTGGTGATTTCCGGTAATGTGCCGCAGGGCGCCGGTCTCAGTTCTTCTGCCTCGCTGG
AAGTTGCCGTTGGCCAGGCCATGCAGGCGCTGTATGCCCTGCCGCTGGATGGCGTAGCACTGGCGCTCAATGGTCAGGAA
GCGGAAAACCAGTTCGTCGGCTGCAACTGCGGGATTATGGATCAGTTGATTTCCGCACTCGGTGAAAAAGACCATGCGTT
GCTGATCGATTGCCGCACATTGGAGACCCGGGCGGTATCGGTGCCGGAAGATATTGCCGTGGTGATCATCAATTCCAATG
TGAAGCGCGGGTTGGTGGACAGCGAATACAACACTCGTCGCGAGCAGTGTGAAGAGGCCGCACGCTTCTTCGGCGTCAAG
GCGCTGCGCGACGTCAGCCCGGATCTGTTTTTCCCGATCCAGCATGAACTGGATCCGATCGTCGCCAAACGAGCGCGCCA
CGTGATCAGCGAAAACGATCGAACCCTGGCCGCAGCCGATGCGCTGGCCGCCGGTGATATGAAACTGATGGGTAAATTGA
TGGCAGAGTCACACGTCTCAATGCGCGATGACTTTGAAATTACCGTGCCGCCGATTGACCGGCTGGTTGAGATCGTTAAA
TCGGTTATCGGCGATCGCGGCGGTGTGCGCATGACCGGTGGCGGCTTTGGCGGCTGCATTGTGGCCTTGATGCCGCTGGC
GCTGGTAGAACCGGTTCGCGCAGCCGTGGCACGCGAATATCCGTTGCAGACCAACGGGTTGAAAGAAACCTTTTATGTCT
GCAAAGCGTCAGAGGGGGCAGGAACATGCTAA

Upstream 100 bases:

>100_bases
AGTTGCTGGCGGAAACCCAGCGTGATTTGACCGCAGAACAGGCCGCAGAACGTCTGCGTGCCGTTAGCGATATTCATTAC
CGTGAAGCCGGAGCCAAAAA

Downstream 100 bases:

>100_bases
GCGACAGCCAGACGCTGGCTCCGGACGGCCAGCCTTATCAGTTAACCCAGTTGAAAAACGCCGGCGGTATGACCGTCACG
CTGATGGATTGGGGCGCTAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSLKNLTHALFTERFGYAPTLTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVIACAKRDDRQIRVIAADYEGQQDQFSL
DSPIVSHPDQRWSDYVRGVIKHLQQRNADFGGADLVISGNVPQGAGLSSSASLEVAVGQAMQALYALPLDGVALALNGQE
AENQFVGCNCGIMDQLISALGEKDHALLIDCRTLETRAVSVPEDIAVVIINSNVKRGLVDSEYNTRREQCEEAARFFGVK
ALRDVSPDLFFPIQHELDPIVAKRARHVISENDRTLAAADALAAGDMKLMGKLMAESHVSMRDDFEITVPPIDRLVEIVK
SVIGDRGGVRMTGGGFGGCIVALMPLALVEPVRAAVAREYPLQTNGLKETFYVCKASEGAGTC

Sequences:

>Translated_383_residues
MSLKNLTHALFTERFGYAPTLTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVIACAKRDDRQIRVIAADYEGQQDQFSL
DSPIVSHPDQRWSDYVRGVIKHLQQRNADFGGADLVISGNVPQGAGLSSSASLEVAVGQAMQALYALPLDGVALALNGQE
AENQFVGCNCGIMDQLISALGEKDHALLIDCRTLETRAVSVPEDIAVVIINSNVKRGLVDSEYNTRREQCEEAARFFGVK
ALRDVSPDLFFPIQHELDPIVAKRARHVISENDRTLAAADALAAGDMKLMGKLMAESHVSMRDDFEITVPPIDRLVEIVK
SVIGDRGGVRMTGGGFGGCIVALMPLALVEPVRAAVAREYPLQTNGLKETFYVCKASEGAGTC
>Mature_382_residues
SLKNLTHALFTERFGYAPTLTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVIACAKRDDRQIRVIAADYEGQQDQFSLD
SPIVSHPDQRWSDYVRGVIKHLQQRNADFGGADLVISGNVPQGAGLSSSASLEVAVGQAMQALYALPLDGVALALNGQEA
ENQFVGCNCGIMDQLISALGEKDHALLIDCRTLETRAVSVPEDIAVVIINSNVKRGLVDSEYNTRREQCEEAARFFGVKA
LRDVSPDLFFPIQHELDPIVAKRARHVISENDRTLAAADALAAGDMKLMGKLMAESHVSMRDDFEITVPPIDRLVEIVKS
VIGDRGGVRMTGGGFGGCIVALMPLALVEPVRAAVAREYPLQTNGLKETFYVCKASEGAGTC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=378, Percent_Identity=45.5026455026455, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI48527957, Length=436, Percent_Identity=27.5229357798165, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4503897, Length=436, Percent_Identity=27.5229357798165, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1786972, Length=383, Percent_Identity=74.1514360313316, Blast_Score=589, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71989053, Length=392, Percent_Identity=29.0816326530612, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319494, Length=253, Percent_Identity=31.6205533596838, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=31.1203319502075, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24661292, Length=405, Percent_Identity=26.9135802469136, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI21355577, Length=405, Percent_Identity=26.9135802469136, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24661285, Length=405, Percent_Identity=26.9135802469136, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_SERP5 (A8GBA5)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477523.1
- ProteinModelPortal:   A8GBA5
- SMR:   A8GBA5
- STRING:   A8GBA5
- GeneID:   5605000
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1291
- eggNOG:   COG0153
- HOGENOM:   HBG725121
- OMA:   YNDGFVM
- ProtClustDB:   PRK05101
- BioCyc:   SPRO399741:SPRO_1291-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 41489; Mature: 41358

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKNLTHALFTERFGYAPTLTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVIACAKRD
CCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHCCC
DRQIRVIAADYEGQQDQFSLDSPIVSHPDQRWSDYVRGVIKHLQQRNADFGGADLVISGN
CCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
VPQGAGLSSSASLEVAVGQAMQALYALPLDGVALALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GEKDHALLIDCRTLETRAVSVPEDIAVVIINSNVKRGLVDSEYNTRREQCEEAARFFGVK
CCCCCEEEEEEEECCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ALRDVSPDLFFPIQHELDPIVAKRARHVISENDRTLAAADALAAGDMKLMGKLMAESHVS
HHHHCCCCEEECHHHHCCHHHHHHHHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHHCCC
MRDDFEITVPPIDRLVEIVKSVIGDRGGVRMTGGGFGGCIVALMPLALVEPVRAAVAREY
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PLQTNGLKETFYVCKASEGAGTC
CCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
SLKNLTHALFTERFGYAPTLTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVIACAKRD
CHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHCCC
DRQIRVIAADYEGQQDQFSLDSPIVSHPDQRWSDYVRGVIKHLQQRNADFGGADLVISGN
CCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
VPQGAGLSSSASLEVAVGQAMQALYALPLDGVALALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GEKDHALLIDCRTLETRAVSVPEDIAVVIINSNVKRGLVDSEYNTRREQCEEAARFFGVK
CCCCCEEEEEEEECCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ALRDVSPDLFFPIQHELDPIVAKRARHVISENDRTLAAADALAAGDMKLMGKLMAESHVS
HHHHCCCCEEECHHHHCCHHHHHHHHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHHCCC
MRDDFEITVPPIDRLVEIVKSVIGDRGGVRMTGGGFGGCIVALMPLALVEPVRAAVAREY
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PLQTNGLKETFYVCKASEGAGTC
CCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA