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The map label for this gene is galM [H]

Identifier: 157369533

GI number: 157369533

Start: 1418949

End: 1419992

Strand: Reverse

Name: galM [H]

Synonym: Spro_1290

Alternate gene names: 157369533

Gene position: 1419992-1418949 (Counterclockwise)

Preceding gene: 157369534

Following gene: 157369532

Centisome position: 26.06

GC content: 61.02

Gene sequence:

>1044_bases
ATGCTAAGCGACAGCCAGACGCTGGCTCCGGACGGCCAGCCTTATCAGTTAACCCAGTTGAAAAACGCCGGCGGTATGAC
CGTCACGCTGATGGATTGGGGCGCTACCTGGCTTTCCGCCGTACTGCCGCTGAAGTCAGGCAAAACGCGTGAACTGCTGC
TGGGTTGCCAAACACCGGCGGATTACCTGCAGCAGGCAGCCTATCTGGGGGCTACCGTCGGCCGCTATGCCAACCGCATC
GCTAACGCCAGCCTGTTGATTGATGGCAAGCCGCATCCACTGGTGGCCAATCAGGGGGCGCACCAGTTACACGGTGGGCC
GGAAGGCTTCAACACCCGTCGCTGGCGGATTGTTCAGCAGGATGAACAGCAGGTGAGTTACGCGCTGCATTCGCCAGACG
GCGACCAGGGGTTTCCCGGTAACCTCGACGTGCAGGTCAACTACCGCCTCACCGCCGATAATCGCCTGGAAATCAGCTAT
CAGGCGCGGACCGACAGCGCCTGCCCGGTCAACCTGACCAATCACGCCTACTTCAACCTGGACGGGGCCGGCACCGATGC
CCGTCACCAGCGGCTGCAACTGTTTGCCGACCGCTATCTGCCGGTCGACAGCGAGGGAATCCCCAGCGCCTCCCTAACCC
CGGTAGAAGGCAGTGGCATGGACTTCCGCCAGCCGAAAACCCTGCTGCAGGATTTTTTGAGCGATCGCGACCAGCAACGG
GTAAAAGGTTACGACCACGCCTATCTGCTGCACCGTACCTGCGGCGCACTGGATTGCCCGGCGGCTCACCTGTGGTCGGC
CGATGGCCAGGTGCAAATGAGCGTGTTCACCAGCGCACCGGCGTTGCAACTCTACAGCGGCAATTATCTGGGCGGCACCC
CGGCACGTGATGGCGGCAGCTATGCCAATTACGCCGGGGTAGCGCTGGAAAGCGAGTTTTTGCCAGACAGCCCTAACCAT
CCGGAATGGCCACAGCCCGACTGTTGGTTGCAGCCGGGGCAGCAATATCTCAGCGCCACCCATTATCAGTTTTATCCTAT
TTGA

Upstream 100 bases:

>100_bases
TAGAACCGGTTCGCGCAGCCGTGGCACGCGAATATCCGTTGCAGACCAACGGGTTGAAAGAAACCTTTTATGTCTGCAAA
GCGTCAGAGGGGGCAGGAAC

Downstream 100 bases:

>100_bases
CCCGCTACGCCCCTTGCCAAGCGGCAGGGGGCCGTTTGTTATAAATGCTTACCTTTTTACCCCTCCGCGCCGCAGGCCGC
TGCCTTTCCTTATTCCAAAG

Product: galactose mutarotase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLSDSQTLAPDGQPYQLTQLKNAGGMTVTLMDWGATWLSAVLPLKSGKTRELLLGCQTPADYLQQAAYLGATVGRYANRI
ANASLLIDGKPHPLVANQGAHQLHGGPEGFNTRRWRIVQQDEQQVSYALHSPDGDQGFPGNLDVQVNYRLTADNRLEISY
QARTDSACPVNLTNHAYFNLDGAGTDARHQRLQLFADRYLPVDSEGIPSASLTPVEGSGMDFRQPKTLLQDFLSDRDQQR
VKGYDHAYLLHRTCGALDCPAAHLWSADGQVQMSVFTSAPALQLYSGNYLGGTPARDGGSYANYAGVALESEFLPDSPNH
PEWPQPDCWLQPGQQYLSATHYQFYPI

Sequences:

>Translated_347_residues
MLSDSQTLAPDGQPYQLTQLKNAGGMTVTLMDWGATWLSAVLPLKSGKTRELLLGCQTPADYLQQAAYLGATVGRYANRI
ANASLLIDGKPHPLVANQGAHQLHGGPEGFNTRRWRIVQQDEQQVSYALHSPDGDQGFPGNLDVQVNYRLTADNRLEISY
QARTDSACPVNLTNHAYFNLDGAGTDARHQRLQLFADRYLPVDSEGIPSASLTPVEGSGMDFRQPKTLLQDFLSDRDQQR
VKGYDHAYLLHRTCGALDCPAAHLWSADGQVQMSVFTSAPALQLYSGNYLGGTPARDGGSYANYAGVALESEFLPDSPNH
PEWPQPDCWLQPGQQYLSATHYQFYPI
>Mature_347_residues
MLSDSQTLAPDGQPYQLTQLKNAGGMTVTLMDWGATWLSAVLPLKSGKTRELLLGCQTPADYLQQAAYLGATVGRYANRI
ANASLLIDGKPHPLVANQGAHQLHGGPEGFNTRRWRIVQQDEQQVSYALHSPDGDQGFPGNLDVQVNYRLTADNRLEISY
QARTDSACPVNLTNHAYFNLDGAGTDARHQRLQLFADRYLPVDSEGIPSASLTPVEGSGMDFRQPKTLLQDFLSDRDQQR
VKGYDHAYLLHRTCGALDCPAAHLWSADGQVQMSVFTSAPALQLYSGNYLGGTPARDGGSYANYAGVALESEFLPDSPNH
PEWPQPDCWLQPGQQYLSATHYQFYPI

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=326, Percent_Identity=36.1963190184049, Blast_Score=204, Evalue=9e-53,
Organism=Escherichia coli, GI1786971, Length=344, Percent_Identity=60.1744186046512, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17557428, Length=330, Percent_Identity=33.9393939393939, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI115533334, Length=330, Percent_Identity=33.9393939393939, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324399, Length=318, Percent_Identity=27.9874213836478, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322004, Length=366, Percent_Identity=28.6885245901639, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319493, Length=315, Percent_Identity=27.3015873015873, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24668278, Length=332, Percent_Identity=33.433734939759, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=32.7536231884058, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24583720, Length=333, Percent_Identity=32.1321321321321, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24668282, Length=332, Percent_Identity=30.1204819277108, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24641876, Length=339, Percent_Identity=26.8436578171091, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38141; Mature: 38141

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDSQTLAPDGQPYQLTQLKNAGGMTVTLMDWGATWLSAVLPLKSGKTRELLLGCQTPA
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEEECCCCH
DYLQQAAYLGATVGRYANRIANASLLIDGKPHPLVANQGAHQLHGGPEGFNTRRWRIVQQ
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCCCHHCCCCCCCCCCCEEEEEEC
DEQQVSYALHSPDGDQGFPGNLDVQVNYRLTADNRLEISYQARTDSACPVNLTNHAYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCEEEECCCEEEEE
DGAGTDARHQRLQLFADRYLPVDSEGIPSASLTPVEGSGMDFRQPKTLLQDFLSDRDQQR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
VKGYDHAYLLHRTCGALDCPAAHLWSADGQVQMSVFTSAPALQLYSGNYLGGTPARDGGS
HCCCCCEEEEEHHCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
YANYAGVALESEFLPDSPNHPEWPQPDCWLQPGQQYLSATHYQFYPI
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECC
>Mature Secondary Structure
MLSDSQTLAPDGQPYQLTQLKNAGGMTVTLMDWGATWLSAVLPLKSGKTRELLLGCQTPA
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEEECCCCH
DYLQQAAYLGATVGRYANRIANASLLIDGKPHPLVANQGAHQLHGGPEGFNTRRWRIVQQ
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCCCHHCCCCCCCCCCCEEEEEEC
DEQQVSYALHSPDGDQGFPGNLDVQVNYRLTADNRLEISYQARTDSACPVNLTNHAYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCEEEECCCEEEEE
DGAGTDARHQRLQLFADRYLPVDSEGIPSASLTPVEGSGMDFRQPKTLLQDFLSDRDQQR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
VKGYDHAYLLHRTCGALDCPAAHLWSADGQVQMSVFTSAPALQLYSGNYLGGTPARDGGS
HCCCCCEEEEEHHCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
YANYAGVALESEFLPDSPNHPEWPQPDCWLQPGQQYLSATHYQFYPI
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]