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The map label for this gene is gltA [H]

Identifier: 157369505

GI number: 157369505

Start: 1386931

End: 1388223

Strand: Reverse

Name: gltA [H]

Synonym: Spro_1262

Alternate gene names: 157369505

Gene position: 1388223-1386931 (Counterclockwise)

Preceding gene: 157369527

Following gene: 157369492

Centisome position: 25.48

GC content: 54.6

Gene sequence:

>1293_bases
ATGACTGATAAGAAAGCGACGCTAACCATTAACGATGGTGAAGCTCCAATCGAACTGGGCGTATTAACCCCGACACTGGG
CCCCGATGTCCTTGATGTCCGCGCCCTGGGCTCCAAAGGTTATTTCACGTTTGATCCCGGCTTTACCTCTACCGCTTCCT
GCGAATCCAAAATCACTTTTATCGACGGTGACAAAGGCGTATTGCTGCACCGCGGCTTCCCGATCGAACAGCTGGCGAAA
GAGTCTTCCTATCTGGAAGTGTGCTACATCCTGCTGTACGGCGAAACGCCGACCGCAGAAGAGTTCGAGACCTTCAAAAC
CACCGTGACCCGTCACACCATGATCCACGATCAGATCACCCATCTGTTCCGTGGCTTCCGTCGTGACTCACACCCAATGG
CGGTGCTGTGCGGTGTGACCGGCGCCCTGGCAGCGTTCTACCACGATGCACTGGACGTCAACAACGAGCGTCACCGCGAG
ATCACCGCGTTCCGCCTGCTGTCCAAAATGCCTACCGTGGCGGCCATGTGTTACAAATATTCTCTGGGTCAGCCGTTCGT
TTATCCACGCAACGATCTGTCCTATGCCGGTAACTTCCTGCATATGATGTTTGCCACCCCGTGCGAAGAATACGTGGTGA
ACCCAGTGCTGGAACGCGCAATGGATCGCATCCTGATCCTGCACGCCGATCACGAGCAAAATGCTTCCACTTCTACCGTA
CGTACCGCAGGTTCTTCAGGCGCTAACCCGTTTGCCTGTATCGCTGCCGGTATCGCTTCACTGTGGGGCCCGGCACACGG
CGGCGCCAACGAAGCCGCACTGAAGATGCTGGAAGAGATCAAAACCGTTGAGCACATTCCTGAGTTCATCAAGCGTGCCA
AGGACAAGAACGACTCGTTCCGTCTGATGGGCTTCGGCCACCGCGTGTACAAGAACTACGACCCACGCGCCACCGTGATG
CGCGAAACCTGTCACGAAGTGCTGAAAGAACTGAACAAGAAGGACGACAACCTGTTGCAAGTGGCGATGGAGCTGGAACA
CATCGCGCTGAACGACCCGTACTTCATCGAGAAGAAACTGTATCCGAACGTCGACTTCTATTCAGGCATCATCCTGAAGG
CGATGGGGATCCCTTCTTCCATGTTCACCGTTATCTTTGCCATCGCCCGTACCATTGGCTGGATTGCACACTGGAACGAA
ATGCATGACGAAGGCATCAAGATTGCCCGTCCGCGTCAGTTGTACACCGGCTATGCCGAGCGTGACTTCAAGTCCCAAGT
GAAAAACAAATAA

Upstream 100 bases:

>100_bases
CAGAGTTAGCGTCCGCTCCATTTTTTGCGGGCAACCTGAGGAGAATTAAGGTATTTCAGTTGTTAGAGGTTTTTAAAATA
AGGCGCAAAGGAGACTGTAA

Downstream 100 bases:

>100_bases
CGCCGCTTTACCCTACGTATTGCAGCAAGACGCCGCCCCGATGGGCGGCGTTTTTTTTTGCCCTCTCCCTGGGGAGAGGG
TCGGGGTGAGGGGAAACATT

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTDKKATLTINDGEAPIELGVLTPTLGPDVLDVRALGSKGYFTFDPGFTSTASCESKITFIDGDKGVLLHRGFPIEQLAK
ESSYLEVCYILLYGETPTAEEFETFKTTVTRHTMIHDQITHLFRGFRRDSHPMAVLCGVTGALAAFYHDALDVNNERHRE
ITAFRLLSKMPTVAAMCYKYSLGQPFVYPRNDLSYAGNFLHMMFATPCEEYVVNPVLERAMDRILILHADHEQNASTSTV
RTAGSSGANPFACIAAGIASLWGPAHGGANEAALKMLEEIKTVEHIPEFIKRAKDKNDSFRLMGFGHRVYKNYDPRATVM
RETCHEVLKELNKKDDNLLQVAMELEHIALNDPYFIEKKLYPNVDFYSGIILKAMGIPSSMFTVIFAIARTIGWIAHWNE
MHDEGIKIARPRQLYTGYAERDFKSQVKNK

Sequences:

>Translated_430_residues
MTDKKATLTINDGEAPIELGVLTPTLGPDVLDVRALGSKGYFTFDPGFTSTASCESKITFIDGDKGVLLHRGFPIEQLAK
ESSYLEVCYILLYGETPTAEEFETFKTTVTRHTMIHDQITHLFRGFRRDSHPMAVLCGVTGALAAFYHDALDVNNERHRE
ITAFRLLSKMPTVAAMCYKYSLGQPFVYPRNDLSYAGNFLHMMFATPCEEYVVNPVLERAMDRILILHADHEQNASTSTV
RTAGSSGANPFACIAAGIASLWGPAHGGANEAALKMLEEIKTVEHIPEFIKRAKDKNDSFRLMGFGHRVYKNYDPRATVM
RETCHEVLKELNKKDDNLLQVAMELEHIALNDPYFIEKKLYPNVDFYSGIILKAMGIPSSMFTVIFAIARTIGWIAHWNE
MHDEGIKIARPRQLYTGYAERDFKSQVKNK
>Mature_429_residues
TDKKATLTINDGEAPIELGVLTPTLGPDVLDVRALGSKGYFTFDPGFTSTASCESKITFIDGDKGVLLHRGFPIEQLAKE
SSYLEVCYILLYGETPTAEEFETFKTTVTRHTMIHDQITHLFRGFRRDSHPMAVLCGVTGALAAFYHDALDVNNERHREI
TAFRLLSKMPTVAAMCYKYSLGQPFVYPRNDLSYAGNFLHMMFATPCEEYVVNPVLERAMDRILILHADHEQNASTSTVR
TAGSSGANPFACIAAGIASLWGPAHGGANEAALKMLEEIKTVEHIPEFIKRAKDKNDSFRLMGFGHRVYKNYDPRATVMR
ETCHEVLKELNKKDDNLLQVAMELEHIALNDPYFIEKKLYPNVDFYSGIILKAMGIPSSMFTVIFAIARTIGWIAHWNEM
HDEGIKIARPRQLYTGYAERDFKSQVKNK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=391, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI1786939, Length=428, Percent_Identity=84.5794392523365, Blast_Score=773, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=366, Percent_Identity=31.9672131147541, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=401, Percent_Identity=24.9376558603491, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=368, Percent_Identity=28.804347826087, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=401, Percent_Identity=27.1820448877805, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325257, Length=365, Percent_Identity=25.4794520547945, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24640124, Length=403, Percent_Identity=26.0545905707196, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24640126, Length=403, Percent_Identity=26.0545905707196, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21356863, Length=394, Percent_Identity=25.1269035532995, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48364; Mature: 48233

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKKATLTINDGEAPIELGVLTPTLGPDVLDVRALGSKGYFTFDPGFTSTASCESKITF
CCCCEEEEEECCCCCCEEEEEECCCCCCCCEEHEECCCCCEEEECCCCCCCCCCCCEEEE
IDGDKGVLLHRGFPIEQLAKESSYLEVCYILLYGETPTAEEFETFKTTVTRHTMIHDQIT
EECCCCEEEECCCCHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
HLFRGFRRDSHPMAVLCGVTGALAAFYHDALDVNNERHREITAFRLLSKMPTVAAMCYKY
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
SLGQPFVYPRNDLSYAGNFLHMMFATPCEEYVVNPVLERAMDRILILHADHEQNASTSTV
HCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHH
RTAGSSGANPFACIAAGIASLWGPAHGGANEAALKMLEEIKTVEHIPEFIKRAKDKNDSF
EECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
RLMGFGHRVYKNYDPRATVMRETCHEVLKELNKKDDNLLQVAMELEHIALNDPYFIEKKL
EEEECCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEHCC
YPNVDFYSGIILKAMGIPSSMFTVIFAIARTIGWIAHWNEMHDEGIKIARPRQLYTGYAE
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCHHH
RDFKSQVKNK
HHHHHHHCCC
>Mature Secondary Structure 
TDKKATLTINDGEAPIELGVLTPTLGPDVLDVRALGSKGYFTFDPGFTSTASCESKITF
CCCEEEEEECCCCCCEEEEEECCCCCCCCEEHEECCCCCEEEECCCCCCCCCCCCEEEE
IDGDKGVLLHRGFPIEQLAKESSYLEVCYILLYGETPTAEEFETFKTTVTRHTMIHDQIT
EECCCCEEEECCCCHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
HLFRGFRRDSHPMAVLCGVTGALAAFYHDALDVNNERHREITAFRLLSKMPTVAAMCYKY
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
SLGQPFVYPRNDLSYAGNFLHMMFATPCEEYVVNPVLERAMDRILILHADHEQNASTSTV
HCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHH
RTAGSSGANPFACIAAGIASLWGPAHGGANEAALKMLEEIKTVEHIPEFIKRAKDKNDSF
EECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
RLMGFGHRVYKNYDPRATVMRETCHEVLKELNKKDDNLLQVAMELEHIALNDPYFIEKKL
EEEECCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEHCC
YPNVDFYSGIILKAMGIPSSMFTVIFAIARTIGWIAHWNEMHDEGIKIARPRQLYTGYAE
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCHHH
RDFKSQVKNK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]