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The map label for this gene is purE [H]

Identifier: 157369406

GI number: 157369406

Start: 1280938

End: 1281462

Strand: Reverse

Name: purE [H]

Synonym: Spro_1163

Alternate gene names: 157369406

Gene position: 1281462-1280938 (Counterclockwise)

Preceding gene: 157369407

Following gene: 157369405

Centisome position: 23.52

GC content: 60.95

Gene sequence:

>525_bases
ATGGGAGCCAACGCCGCTTCAGCCACCCACGCTGGGGTTAAAATCGCAATTGTAATGGGATCAAAAAGTGACTGGGCCAC
CATGCAGTTTGCCGCCGAAGTCCTGACCTCGCTCGATGTCCCGTTCCATGCCGAAGTCGTTTCCGCTCATCGCACGCCAG
ACAAGCTGTTCAGCTTTGCCGAGCAGGCAACTGATAATGGCTTTGACGTGATCATTGCCGGTGCAGGCGGTGCTGCGCAT
CTGCCGGGCATGCTGGCGGCAAAAACGCTGGTTCCGGTGCTGGGTGTTCCGGTGCAAAGCGCCGCACTGAGCGGTGTAGA
CAGCCTGTATTCAATCGTGCAAATGCCGCGCGGTATTCCAGTGGGTACGCTGGCCATCGGCAAAGCCGGTGCCGCCAATG
CAGCCCTGCTGGCGGCACAAATTCTGGCGCTGCACGACGCCGCGCTGGCACAACGCCTCGCCGACTGGCGGCAGGCACAA
ACTGACGAGGTGCTGAACCACCCGGATCCGCGGGAGGAAGCATGA

Upstream 100 bases:

>100_bases
GTTTTCCTCGCCGTGCGCTCATGGTATGCTCTGTGCCCTCATTCGGCCTCCCGCCGCAGGCAACCGGCCGTCGTTTGTAC
AATACAGGAGCCTTACACCC

Downstream 100 bases:

>100_bases
AGCCGGTTTGCGTACTGGGCAACGGTCAGTTAGGGCGCATGCTGCGCCAGGCCGGTGAACCGCTGGGCATCGCCGTGTAC
CCGGTAGGCCTCGACGCCGA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MGANAASATHAGVKIAIVMGSKSDWATMQFAAEVLTSLDVPFHAEVVSAHRTPDKLFSFAEQATDNGFDVIIAGAGGAAH
LPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDAALAQRLADWRQAQ
TDEVLNHPDPREEA

Sequences:

>Translated_174_residues
MGANAASATHAGVKIAIVMGSKSDWATMQFAAEVLTSLDVPFHAEVVSAHRTPDKLFSFAEQATDNGFDVIIAGAGGAAH
LPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDAALAQRLADWRQAQ
TDEVLNHPDPREEA
>Mature_173_residues
GANAASATHAGVKIAIVMGSKSDWATMQFAAEVLTSLDVPFHAEVVSAHRTPDKLFSFAEQATDNGFDVIIAGAGGAAHL
PGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDAALAQRLADWRQAQT
DEVLNHPDPREEA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=165, Percent_Identity=82.4242424242424, Blast_Score=238, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=50.9933774834437, Blast_Score=151, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17825; Mature: 17693

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGANAASATHAGVKIAIVMGSKSDWATMQFAAEVLTSLDVPFHAEVVSAHRTPDKLFSFA
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
EQATDNGFDVIIAGAGGAAHLPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIP
HHHCCCCCEEEEECCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
VGTLAIGKAGAANAALLAAQILALHDAALAQRLADWRQAQTDEVLNHPDPREEA
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GANAASATHAGVKIAIVMGSKSDWATMQFAAEVLTSLDVPFHAEVVSAHRTPDKLFSFA
CCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
EQATDNGFDVIIAGAGGAAHLPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIP
HHHCCCCCEEEEECCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
VGTLAIGKAGAANAALLAAQILALHDAALAQRLADWRQAQTDEVLNHPDPREEA
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]