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The map label for this gene is lpxH

Identifier: 157369407

GI number: 157369407

Start: 1281628

End: 1282350

Strand: Reverse

Name: lpxH

Synonym: Spro_1164

Alternate gene names: 157369407

Gene position: 1282350-1281628 (Counterclockwise)

Preceding gene: 157369408

Following gene: 157369406

Centisome position: 23.53

GC content: 56.71

Gene sequence:

>723_bases
ATGAACACGCTGTTCATCGCAGATCTGCATTTAAGCGCACAGGAACCGGCAATCACTGCCGGTTTTCTGCGTTTTTTGCG
GCAAGATGCCATTCACGCCGACGCCCTGTACATTCTTGGCGACCTGTTTGAAGCCTGGATCGGCGATGACGATCCCGAGC
CATTGCACGGCGAAATCGCTGCGGCACTGAAGGCGCTGCAACAGGCTGGCGTACCCTGCTACTTTATCCACGGCAACCGT
GATTTTCTGGTCGGCAAACGCTTTGCCCGTACCAGCGGTATGCAACTGCTGCCGGAAGAGCAGGTGCTGGATCTGTATGG
CCGAAAAATCCTGATCCTGCATGGCGACACGCTGTGTACCGACGATCAGGCCTACCAACAGTTTCGCCGCAAGGTACACA
ATCCGCTGATCCAAAAACTGTTTTTGGCCATGCCGCTGCGCTGGCGTCTTAAGATCGCGGCCAAAATGCGTGCCCGCAGC
CAGCAGAGTAACCAGTACAAGTCGGACTCTATTATGGACGTCAACCCACAGGCGGTTGAGCAGGCGATGCTGCGCCACAA
GGTTCACTGGATGATCCACGGTCACACTCACCGTCCGGCGGTGCATGAATTGGCATTGAGCAACGGCAAGGCCCACCGCG
TGGTGCTGGGAGCCTGGCACGTTGAAGGCTCCATGATCAAAGTCAGTGCCGACGCCGTCGAGCTGATCCAATTCCCGTTC
TAA

Upstream 100 bases:

>100_bases
ATCAAAGCGGTGAAAACCGGCCGTAGCGGCATGCACCAGGACGTACCGGTAGAAGACGTCATCGTCACTAGCGTTACCGT
CAGCGAGTAATCGCGGCTGC

Downstream 100 bases:

>100_bases
GTTCCTGACTTGTCGCACAGGTAAAAAAATTCACGCTTTTGGCAATGAAAACCGGCGACGCAACCGTTTTCCTCGCCGTG
CGCTCATGGTATGCTCTGTG

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MNTLFIADLHLSAQEPAITAGFLRFLRQDAIHADALYILGDLFEAWIGDDDPEPLHGEIAAALKALQQAGVPCYFIHGNR
DFLVGKRFARTSGMQLLPEEQVLDLYGRKILILHGDTLCTDDQAYQQFRRKVHNPLIQKLFLAMPLRWRLKIAAKMRARS
QQSNQYKSDSIMDVNPQAVEQAMLRHKVHWMIHGHTHRPAVHELALSNGKAHRVVLGAWHVEGSMIKVSADAVELIQFPF

Sequences:

>Translated_240_residues
MNTLFIADLHLSAQEPAITAGFLRFLRQDAIHADALYILGDLFEAWIGDDDPEPLHGEIAAALKALQQAGVPCYFIHGNR
DFLVGKRFARTSGMQLLPEEQVLDLYGRKILILHGDTLCTDDQAYQQFRRKVHNPLIQKLFLAMPLRWRLKIAAKMRARS
QQSNQYKSDSIMDVNPQAVEQAMLRHKVHWMIHGHTHRPAVHELALSNGKAHRVVLGAWHVEGSMIKVSADAVELIQFPF
>Mature_240_residues
MNTLFIADLHLSAQEPAITAGFLRFLRQDAIHADALYILGDLFEAWIGDDDPEPLHGEIAAALKALQQAGVPCYFIHGNR
DFLVGKRFARTSGMQLLPEEQVLDLYGRKILILHGDTLCTDDQAYQQFRRKVHNPLIQKLFLAMPLRWRLKIAAKMRARS
QQSNQYKSDSIMDVNPQAVEQAMLRHKVHWMIHGHTHRPAVHELALSNGKAHRVVLGAWHVEGSMIKVSADAVELIQFPF

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=71.25, Blast_Score=360, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_SERP5 (A8GAX8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477396.1
- ProteinModelPortal:   A8GAX8
- STRING:   A8GAX8
- GeneID:   5602557
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1164
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   SPRO399741:SPRO_1164-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 27226; Mature: 27226

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLFIADLHLSAQEPAITAGFLRFLRQDAIHADALYILGDLFEAWIGDDDPEPLHGEIA
CCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AALKALQQAGVPCYFIHGNRDFLVGKRFARTSGMQLLPEEQVLDLYGRKILILHGDTLCT
HHHHHHHHCCCCEEEEECCCEEEHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEECCCCCC
DDQAYQQFRRKVHNPLIQKLFLAMPLRWRLKIAAKMRARSQQSNQYKSDSIMDVNPQAVE
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHH
QAMLRHKVHWMIHGHTHRPAVHELALSNGKAHRVVLGAWHVEGSMIKVSADAVELIQFPF
HHHHHHHHEEEEECCCCCCHHHHHHHCCCCEEEEEEEEEEECCCEEEEEHHHHHHHCCCC
>Mature Secondary Structure
MNTLFIADLHLSAQEPAITAGFLRFLRQDAIHADALYILGDLFEAWIGDDDPEPLHGEIA
CCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AALKALQQAGVPCYFIHGNRDFLVGKRFARTSGMQLLPEEQVLDLYGRKILILHGDTLCT
HHHHHHHHCCCCEEEEECCCEEEHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEECCCCCC
DDQAYQQFRRKVHNPLIQKLFLAMPLRWRLKIAAKMRARSQQSNQYKSDSIMDVNPQAVE
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHH
QAMLRHKVHWMIHGHTHRPAVHELALSNGKAHRVVLGAWHVEGSMIKVSADAVELIQFPF
HHHHHHHHEEEEECCCCCCHHHHHHHCCCCEEEEEEEEEEECCCEEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA