Click here to switch to the map view.

The map label for this gene is fsr [H]

Identifier: 157369389

GI number: 157369389

Start: 1262985

End: 1264205

Strand: Reverse

Name: fsr [H]

Synonym: Spro_1146

Alternate gene names: 157369389

Gene position: 1264205-1262985 (Counterclockwise)

Preceding gene: 157369391

Following gene: 157369388

Centisome position: 23.2

GC content: 53.56

Gene sequence:

>1221_bases
ATGACCGACCGTAGCGAAACCGCCCTGCCACAGGCCAAGGGCAGTGCGGTTAAAGGGACTGCTTTCTCGATTCTAGGTGC
CATCAGCGTCTCTCACCTGCTCAACGACATGATTCAATCGCTGATCCTGGCGATTTACCCGATCCTGCAGGCTGACTTCA
GCCTCAGCTTCGTGCAGATCGGCATGATTACTCTGACCTACCAGCTCACGGCGTCCTTATTGCAGCCGCTGATTGGTTAC
TACACGGATAAACATCCACAGCCGTATTCGCTGCCCATCGGCATGGGTTTTACCCTGTGCGGGCTGCTGCTGCTGTCCGT
GGCCAACACCTTCCCGCTGGTGCTGTTGGCGGCGGCATTGGTCGGTACCGGCTCTTCGGTATTCCATCCGGAATCCTCCC
GTGTAGCGCGGATGGCTTCCGGTGGCCGACATGGCCTGGCACAGTCACTGTTCCAGGTGGGCGGTAACTTTGGCAGCTCC
CTCGGGCCACTGCTGGCGGCGCTGATTATCGCGCCTTACGGCAAGGGTAACGTCGCCTGGTTCTCCCTGGCTGCGCTGCT
GGCGATTGTGGTGCTATTGCAGGTCAGTAAATGGTATCAACAACAGCATCGGGCAACAAAAGGCCAGCCTAAAACGGCCT
CTTTGGTGAAACCGCTGCCGAAACGTACGGTTACCTATGCCATTGGCATCCTGCTGGTGCTGATTTTCTCCAAATACTTC
TATCTGGCCAGCATTAGCAGTTATTACACCTTTTATCTGATGCACAAGTTCGGCGTTTCAGTGCAAAACGCCCAATTTCA
TCTGTTCGCCTTCCTGTTCGCCGTAGCCGCAGGCACCATTATCGGCGGGCCTCTTGGCGACAAGATAGGTCGAAAACGTG
TTATTTGGGGCTCCATCCTTGGTGCAGCGCCATTTACGCTTATTTTACCCTATGCATCTCTGTATTGGACCGGCATTTTA
ACGGTGTTTATTGGGGTAATACTCGCTTCGGCGTTTTCTGCCATTCTGGTTTACGCTCAGGAACTGATCCCAGGCAAAGT
GGGCATGGTTTCCGGTTTATTCTTCGGTTTTGCTTTTGGCATGGGCGGATTAGGTGCGGCAGTTCTTGGTTATGTCGCAG
ATTTGACCAGTATCGAGCTGGTCTATCAAATCTGTGCTTTCCTGCCACTGATCGGCATTATTACCGCATTGCTGCCCAAT
ATGGAGCATAACTCACAATAA

Upstream 100 bases:

>100_bases
TTTTGCGATGTGCGTCAAATTATGTCGGATATGGTAAATATTGAACAACTTGCCTAAGATATCTGCTCTGTCCTCTAAAA
CTTACCAGGCTAATAATAAA

Downstream 100 bases:

>100_bases
CCCTGCTACAGGCCCGGTTTGAATTCATCGCCAAACCGGGTCATCCCCCACACAAATCCATATTATTTGGCTTATTAAGT
GTTAAATCTCCTCATTGGCA

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTDRSETALPQAKGSAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFSLSFVQIGMITLTYQLTASLLQPLIGY
YTDKHPQPYSLPIGMGFTLCGLLLLSVANTFPLVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSS
LGPLLAALIIAPYGKGNVAWFSLAALLAIVVLLQVSKWYQQQHRATKGQPKTASLVKPLPKRTVTYAIGILLVLIFSKYF
YLASISSYYTFYLMHKFGVSVQNAQFHLFAFLFAVAAGTIIGGPLGDKIGRKRVIWGSILGAAPFTLILPYASLYWTGIL
TVFIGVILASAFSAILVYAQELIPGKVGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALLPN
MEHNSQ

Sequences:

>Translated_406_residues
MTDRSETALPQAKGSAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFSLSFVQIGMITLTYQLTASLLQPLIGY
YTDKHPQPYSLPIGMGFTLCGLLLLSVANTFPLVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSS
LGPLLAALIIAPYGKGNVAWFSLAALLAIVVLLQVSKWYQQQHRATKGQPKTASLVKPLPKRTVTYAIGILLVLIFSKYF
YLASISSYYTFYLMHKFGVSVQNAQFHLFAFLFAVAAGTIIGGPLGDKIGRKRVIWGSILGAAPFTLILPYASLYWTGIL
TVFIGVILASAFSAILVYAQELIPGKVGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALLPN
MEHNSQ
>Mature_405_residues
TDRSETALPQAKGSAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFSLSFVQIGMITLTYQLTASLLQPLIGYY
TDKHPQPYSLPIGMGFTLCGLLLLSVANTFPLVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSL
GPLLAALIIAPYGKGNVAWFSLAALLAIVVLLQVSKWYQQQHRATKGQPKTASLVKPLPKRTVTYAIGILLVLIFSKYFY
LASISSYYTFYLMHKFGVSVQNAQFHLFAFLFAVAAGTIIGGPLGDKIGRKRVIWGSILGAAPFTLILPYASLYWTGILT
VFIGVILASAFSAILVYAQELIPGKVGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALLPNM
EHNSQ

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=405, Percent_Identity=76.0493827160494, Blast_Score=589, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43286; Mature: 43155

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRSETALPQAKGSAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFSLSFVQI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLCGLLLLSVANTFPLVLLAAAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAW
HCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHH
FSLAALLAIVVLLQVSKWYQQQHRATKGQPKTASLVKPLPKRTVTYAIGILLVLIFSKYF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YLASISSYYTFYLMHKFGVSVQNAQFHLFAFLFAVAAGTIIGGPLGDKIGRKRVIWGSIL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHH
GAAPFTLILPYASLYWTGILTVFIGVILASAFSAILVYAQELIPGKVGMVSGLFFGFAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
MGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALLPNMEHNSQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDRSETALPQAKGSAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFSLSFVQI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLCGLLLLSVANTFPLVLLAAAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAW
HCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHH
FSLAALLAIVVLLQVSKWYQQQHRATKGQPKTASLVKPLPKRTVTYAIGILLVLIFSKYF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YLASISSYYTFYLMHKFGVSVQNAQFHLFAFLFAVAAGTIIGGPLGDKIGRKRVIWGSIL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHH
GAAPFTLILPYASLYWTGILTVFIGVILASAFSAILVYAQELIPGKVGMVSGLFFGFAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
MGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALLPNMEHNSQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]