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The map label for this gene is mtnA

Identifier: 157369190

GI number: 157369190

Start: 1042451

End: 1043479

Strand: Reverse

Name: mtnA

Synonym: Spro_0945

Alternate gene names: 157369190

Gene position: 1043479-1042451 (Counterclockwise)

Preceding gene: 157369192

Following gene: 157369186

Centisome position: 19.15

GC content: 60.25

Gene sequence:

>1029_bases
ATGCAAGCGCTTAACACCACCAGTTTGACCTTGAGTGACAACCGACTTTTGATCCTCGATCAGCAGGCTTTACCGCAGGA
AAAACAGTGGCGCAGCTGCGACAGCGTGGAAGAACTGGTCGATCATATCCTTACCCTGCGAGTTCGGGGGGCACCGCTTA
TCGGCCTGTCCGCCAGTCTGTTGTTGGCCTTGCTGGCAGAGCGCGGCGTGCCGCGCAAAGAACTGGAGCAGGCATTGATT
ACCCTGCGTGCCTCACGGCCGACGGCAGTCAACCTGATGAATAATCTGGATCGCATGAAGCTGGCATTGGCACAGCCGCA
ATGGGTGCCTGCGATGGTGGAAGAAGCGCAGCGGTTGGTGGAGGAAGACCGAAAATTGTGCGATCGCATTGCCGATCACG
GTGCCGGGCTGGTGAAACCCGGCAGCCGCCTGCTGACCCACTGCAATACCGGGGGCCTGGCTACCGCCGGTATCGGTACC
GCTATCGGCGTACTGTTGCGTGCTCATCAGCAGGGCAAGGTACAGCAGGTGTGGGTCGATGAAACGCGTCCGCTATTGCA
GGGCGGCCGGCTGACCGCCTGGGAGCTGGGTGAACTGGGTATCCCCTACCGATTGATTTGTGACTCCATGGCGGCCAGTC
TGATGGCGCAGGGCCAGGTAGACGCCGTATGGGTGGGGGCCGATCGCATCGCTGCCAACGGTGACGTCGCCAACAAGATT
GGCACCTATAGCCTGGCGGTACTGGCGCACTATCACCGCATTCCATTCTACGTCGCCGCACCGCACACCACTCACGATCC
GCATTGCCCGAACGGGGCTGCGATCGCGATTGAACAACGGGCCGCAGTTGAAGTGACCGGTGTCACCGGCAGCTTTGGCT
CATGTCAGTGGGCACCTGTCGATGCCCCGGTTTATAACCCGGCGTTCGACGTGACACCGGCGGCATTGATTAGCGGTTGG
GTCTTCGACAGCGGCGTGATCACGCCACAGCAGGTCAGTGAAGGGATTTTTCAGCGGGCGTTGGGTTAA

Upstream 100 bases:

>100_bases
TTTTAGACGTAAAAGCATTTGGACGTCTATACATCCGGAAGTCATGTTGGCAGAATAGCTTTCCAGATGCAATAACTACG
CAACAAGGAATTAACCGCCG

Downstream 100 bases:

>100_bases
AGCCCGCGTTATAGCGCTCAGTCGAGACGCGGGTAGGCATCGGCGATGTTATCGCCGGTGAAATGCGCCACCCAGCCTTC
CGGGTTATCAAACACGCGGA

Product: eIF-2B alpha/beta/delta-like protein

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MQALNTTSLTLSDNRLLILDQQALPQEKQWRSCDSVEELVDHILTLRVRGAPLIGLSASLLLALLAERGVPRKELEQALI
TLRASRPTAVNLMNNLDRMKLALAQPQWVPAMVEEAQRLVEEDRKLCDRIADHGAGLVKPGSRLLTHCNTGGLATAGIGT
AIGVLLRAHQQGKVQQVWVDETRPLLQGGRLTAWELGELGIPYRLICDSMAASLMAQGQVDAVWVGADRIAANGDVANKI
GTYSLAVLAHYHRIPFYVAAPHTTHDPHCPNGAAIAIEQRAAVEVTGVTGSFGSCQWAPVDAPVYNPAFDVTPAALISGW
VFDSGVITPQQVSEGIFQRALG

Sequences:

>Translated_342_residues
MQALNTTSLTLSDNRLLILDQQALPQEKQWRSCDSVEELVDHILTLRVRGAPLIGLSASLLLALLAERGVPRKELEQALI
TLRASRPTAVNLMNNLDRMKLALAQPQWVPAMVEEAQRLVEEDRKLCDRIADHGAGLVKPGSRLLTHCNTGGLATAGIGT
AIGVLLRAHQQGKVQQVWVDETRPLLQGGRLTAWELGELGIPYRLICDSMAASLMAQGQVDAVWVGADRIAANGDVANKI
GTYSLAVLAHYHRIPFYVAAPHTTHDPHCPNGAAIAIEQRAAVEVTGVTGSFGSCQWAPVDAPVYNPAFDVTPAALISGW
VFDSGVITPQQVSEGIFQRALG
>Mature_342_residues
MQALNTTSLTLSDNRLLILDQQALPQEKQWRSCDSVEELVDHILTLRVRGAPLIGLSASLLLALLAERGVPRKELEQALI
TLRASRPTAVNLMNNLDRMKLALAQPQWVPAMVEEAQRLVEEDRKLCDRIADHGAGLVKPGSRLLTHCNTGGLATAGIGT
AIGVLLRAHQQGKVQQVWVDETRPLLQGGRLTAWELGELGIPYRLICDSMAASLMAQGQVDAVWVGADRIAANGDVANKI
GTYSLAVLAHYHRIPFYVAAPHTTHDPHCPNGAAIAIEQRAAVEVTGVTGSFGSCQWAPVDAPVYNPAFDVTPAALISGW
VFDSGVITPQQVSEGIFQRALG

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=354, Percent_Identity=39.2655367231638, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI23943880, Length=337, Percent_Identity=36.2017804154303, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17557462, Length=343, Percent_Identity=39.6501457725948, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6325375, Length=389, Percent_Identity=34.1902313624679, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322878, Length=229, Percent_Identity=29.2576419213974, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357667, Length=365, Percent_Identity=39.4520547945205, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24651647, Length=365, Percent_Identity=39.4520547945205, Blast_Score=221, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_SERP5 (A8GAB1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477179.1
- ProteinModelPortal:   A8GAB1
- SMR:   A8GAB1
- STRING:   A8GAB1
- GeneID:   5605064
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0945
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   VELVCTD
- ProtClustDB:   CLSK928047
- BioCyc:   SPRO399741:SPRO_0945-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 36827; Mature: 36827

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 228-228 BINDING 86-86 BINDING 187-187

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALNTTSLTLSDNRLLILDQQALPQEKQWRSCDSVEELVDHILTLRVRGAPLIGLSASL
CCCCCCCEEEECCCEEEEEECHHCCCHHHHCCHHHHHHHHHHHHHEEECCCCEECHHHHH
LLALLAERGVPRKELEQALITLRASRPTAVNLMNNLDRMKLALAQPQWVPAMVEEAQRLV
HHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EEDRKLCDRIADHGAGLVKPGSRLLTHCNTGGLATAGIGTAIGVLLRAHQQGKVQQVWVD
HHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
ETRPLLQGGRLTAWELGELGIPYRLICDSMAASLMAQGQVDAVWVGADRIAANGDVANKI
CCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEECCCCHHHHH
GTYSLAVLAHYHRIPFYVAAPHTTHDPHCPNGAAIAIEQRAAVEVTGVTGSFGSCQWAPV
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCEECCC
DAPVYNPAFDVTPAALISGWVFDSGVITPQQVSEGIFQRALG
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQALNTTSLTLSDNRLLILDQQALPQEKQWRSCDSVEELVDHILTLRVRGAPLIGLSASL
CCCCCCCEEEECCCEEEEEECHHCCCHHHHCCHHHHHHHHHHHHHEEECCCCEECHHHHH
LLALLAERGVPRKELEQALITLRASRPTAVNLMNNLDRMKLALAQPQWVPAMVEEAQRLV
HHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EEDRKLCDRIADHGAGLVKPGSRLLTHCNTGGLATAGIGTAIGVLLRAHQQGKVQQVWVD
HHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
ETRPLLQGGRLTAWELGELGIPYRLICDSMAASLMAQGQVDAVWVGADRIAANGDVANKI
CCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEECCCCHHHHH
GTYSLAVLAHYHRIPFYVAAPHTTHDPHCPNGAAIAIEQRAAVEVTGVTGSFGSCQWAPV
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCEECCC
DAPVYNPAFDVTPAALISGWVFDSGVITPQQVSEGIFQRALG
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA