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The map label for this gene is degP [H]

Identifier: 157369034

GI number: 157369034

Start: 878203

End: 879633

Strand: Direct

Name: degP [H]

Synonym: Spro_0789

Alternate gene names: 157369034

Gene position: 878203-879633 (Clockwise)

Preceding gene: 157369033

Following gene: 157369036

Centisome position: 16.12

GC content: 55.77

Gene sequence:

>1431_bases
ATGAAAAAAACCGCATTAGTTCTGAGCGCATTGGCATTCAGTATTGGTATGGCGATGGGTCCGATGACGGCCAGCGCCGC
AGAAACCGCTTCTTCCAGCACTCAACAATTGCCAAGCCTGGCACCGATGCTGGAAAAAGTGATGCCTTCCGTGGTGAGCA
TTAATGTTGAAGGCAGCACCACGGTCAATACGGCGAAGATGCCGCCGCAGTTCCAACAGTTCTTCGGTGAAGATTCACCG
TTCTGCCAGGACGGTTCGCCGTTCCAGGCCTCGCCGATGTGTCAGGGTGGCGAGCCGGGTGCACCGGGTCAGGGGACCCA
GCAGAAATTCCAGGCGCTGGGCGCCGGGGTGGTGATTGATGCCGCTAAAGGCTACGTGGTGACCAACAATCACGTGGTGG
ATAACGCCAATAAAATTCAGGTCCAATTGAACGACGGCCGTAAATTTGACGCCAAGGTGATCGGTAAGGATCCACGCTCC
GATATCGCGCTGATCCAACTGAAAGACTTTAAAAATCTGACGGCGATCAAAATGGCGGACTCCGAACAACTGCGCGTAGG
TGATTACACCGTCGCGATCGGCAACCCGTATGGGCTGGGTGAAACCGCCACCTCTGGTATTGTTTCTGCACTGGGCCGCA
GCGGCTTGAATATCGAAAACTACGAGAACTTCATCCAGACCGATGCGGCGATTAACCGCGGTAACTCCGGTGGTGCGTTG
GTTAACCTGAACGGTGAACTGATCGGCATTAACACCGCCATTTTGGCACCGGACGGCGGCAACATCGGCATCGGCTTTGC
CATCCCGAGCAACATGGTGAAAAACCTGACGGCGCAGATGGTCGAATATGGCCAGGTGAAACGCGGCGAATTGGGCATTA
TGGGTACCGAACTGAACTCTGAGCTGGCGAAAGCGATGAAAGTGGACGCGCAGCGCGGGGCCTTTGTCAGCCAGGTGATG
CCGAAATCCTCTGCCGCCAAGGCGGGTATCAAGGCCGGTGATGTGATTGTTACCATGAACGGTAAAGCCATCTCCAGCTT
CGCCTCGTTCCGTGCGGAAATCGGTACTTTGCCGGTCGGCAGCAAAATGTCGCTGGGCATTATCCGCGACGGCAAACCGG
TGACCGTGGACGTCACGCTGGAGCAAAGCGCCCAGACTCAGGTTGAATCCGGCAATATCTACACCGGTATTGAAGGCGCC
GAACTGAGCAATGGTCAGGCTGGCGCTCAGAAAGGCGTGAAGGTCGATAACGTCAAGGCCGGCAGCGCTGCCGCACGTAT
CGGTCTGAAAAAAGGCGACTTTATCCTTGGGGTTAACCAGCAGCCGATCCAGAACCTGGGCGAACTGCGTAAAATCCTCG
ACAGCAAACCGTCGGTACTGGCGCTGAATATCCTGCGCGGTGATACCACGCTGTATCTGCTGATGCAATAA

Upstream 100 bases:

>100_bases
TATTACCAATAACCTGCGCCGGAACTTAGCGGTATTAATAGGTTCTGATTATGCACAAAGACCGTAATACTTTCTGAACG
ACTTTATAAGAGACACACAG

Downstream 100 bases:

>100_bases
GGTTAACCAGCCAATCCTTGTGAACAAGGCACTCCACGACGGAGTGCCTTTTTGTTGCCTGTCGTATCAGGCCAGATGAG
CGCGAGCCGCCTGGCTGACC

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKKTALVLSALAFSIGMAMGPMTASAAETASSSTQQLPSLAPMLEKVMPSVVSINVEGSTTVNTAKMPPQFQQFFGEDSP
FCQDGSPFQASPMCQGGEPGAPGQGTQQKFQALGAGVVIDAAKGYVVTNNHVVDNANKIQVQLNDGRKFDAKVIGKDPRS
DIALIQLKDFKNLTAIKMADSEQLRVGDYTVAIGNPYGLGETATSGIVSALGRSGLNIENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTAQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVM
PKSSAAKAGIKAGDVIVTMNGKAISSFASFRAEIGTLPVGSKMSLGIIRDGKPVTVDVTLEQSAQTQVESGNIYTGIEGA
ELSNGQAGAQKGVKVDNVKAGSAAARIGLKKGDFILGVNQQPIQNLGELRKILDSKPSVLALNILRGDTTLYLLMQ

Sequences:

>Translated_476_residues
MKKTALVLSALAFSIGMAMGPMTASAAETASSSTQQLPSLAPMLEKVMPSVVSINVEGSTTVNTAKMPPQFQQFFGEDSP
FCQDGSPFQASPMCQGGEPGAPGQGTQQKFQALGAGVVIDAAKGYVVTNNHVVDNANKIQVQLNDGRKFDAKVIGKDPRS
DIALIQLKDFKNLTAIKMADSEQLRVGDYTVAIGNPYGLGETATSGIVSALGRSGLNIENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTAQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVM
PKSSAAKAGIKAGDVIVTMNGKAISSFASFRAEIGTLPVGSKMSLGIIRDGKPVTVDVTLEQSAQTQVESGNIYTGIEGA
ELSNGQAGAQKGVKVDNVKAGSAAARIGLKKGDFILGVNQQPIQNLGELRKILDSKPSVLALNILRGDTTLYLLMQ
>Mature_476_residues
MKKTALVLSALAFSIGMAMGPMTASAAETASSSTQQLPSLAPMLEKVMPSVVSINVEGSTTVNTAKMPPQFQQFFGEDSP
FCQDGSPFQASPMCQGGEPGAPGQGTQQKFQALGAGVVIDAAKGYVVTNNHVVDNANKIQVQLNDGRKFDAKVIGKDPRS
DIALIQLKDFKNLTAIKMADSEQLRVGDYTVAIGNPYGLGETATSGIVSALGRSGLNIENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTAQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVM
PKSSAAKAGIKAGDVIVTMNGKAISSFASFRAEIGTLPVGSKMSLGIIRDGKPVTVDVTLEQSAQTQVESGNIYTGIEGA
ELSNGQAGAQKGVKVDNVKAGSAAARIGLKKGDFILGVNQQPIQNLGELRKILDSKPSVLALNILRGDTTLYLLMQ

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=250, Percent_Identity=38.8, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=35.0806451612903, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI22129776, Length=248, Percent_Identity=35.4838709677419, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI7019477, Length=288, Percent_Identity=34.0277777777778, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1786356, Length=477, Percent_Identity=78.6163522012579, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI1789629, Length=479, Percent_Identity=53.8622129436326, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1789630, Length=286, Percent_Identity=40.5594405594406, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24646839, Length=253, Percent_Identity=35.1778656126482, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49583; Mature: 49583

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTALVLSALAFSIGMAMGPMTASAAETASSSTQQLPSLAPMLEKVMPSVVSINVEGST
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCC
TVNTAKMPPQFQQFFGEDSPFCQDGSPFQASPMCQGGEPGAPGQGTQQKFQALGAGVVID
EEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEE
AAKGYVVTNNHVVDNANKIQVQLNDGRKFDAKVIGKDPRSDIALIQLKDFKNLTAIKMAD
CCCCEEEECCEEECCCCEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECC
SEQLRVGDYTVAIGNPYGLGETATSGIVSALGRSGLNIENYENFIQTDAAINRGNSGGAL
CCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTAQMVEYGQVKRGELGIMGTELNS
EEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
ELAKAMKVDAQRGAFVSQVMPKSSAAKAGIKAGDVIVTMNGKAISSFASFRAEIGTLPVG
HHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCC
SKMSLGIIRDGKPVTVDVTLEQSAQTQVESGNIYTGIEGAELSNGQAGAQKGVKVDNVKA
CCCEEEEEECCCEEEEEEEECCCCCCEECCCCEEECCCCCCCCCCCCHHHCCCEECCCCC
GSAAARIGLKKGDFILGVNQQPIQNLGELRKILDSKPSVLALNILRGDTTLYLLMQ
CCHHHEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEEC
>Mature Secondary Structure
MKKTALVLSALAFSIGMAMGPMTASAAETASSSTQQLPSLAPMLEKVMPSVVSINVEGST
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCC
TVNTAKMPPQFQQFFGEDSPFCQDGSPFQASPMCQGGEPGAPGQGTQQKFQALGAGVVID
EEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEE
AAKGYVVTNNHVVDNANKIQVQLNDGRKFDAKVIGKDPRSDIALIQLKDFKNLTAIKMAD
CCCCEEEECCEEECCCCEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECC
SEQLRVGDYTVAIGNPYGLGETATSGIVSALGRSGLNIENYENFIQTDAAINRGNSGGAL
CCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTAQMVEYGQVKRGELGIMGTELNS
EEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
ELAKAMKVDAQRGAFVSQVMPKSSAAKAGIKAGDVIVTMNGKAISSFASFRAEIGTLPVG
HHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCC
SKMSLGIIRDGKPVTVDVTLEQSAQTQVESGNIYTGIEGAELSNGQAGAQKGVKVDNVKA
CCCEEEEEECCCEEEEEEEECCCCCCEECCCCEEECCCCCCCCCCCCHHHCCCEECCCCC
GSAAARIGLKKGDFILGVNQQPIQNLGELRKILDSKPSVLALNILRGDTTLYLLMQ
CCHHHEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]