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The map label for this gene is nhaA [H]

Identifier: 157368939

GI number: 157368939

Start: 765849

End: 767045

Strand: Direct

Name: nhaA [H]

Synonym: Spro_0694

Alternate gene names: 157368939

Gene position: 765849-767045 (Clockwise)

Preceding gene: 157368938

Following gene: 157368940

Centisome position: 14.06

GC content: 56.22

Gene sequence:

>1197_bases
GTGCCTTGCGCTGCTCTGGAGAGACGTATTGTGACCAACATCATTCGTCAATTTTTACGTCAGGAAGCCGCGGGCGGCAT
TATCCTGATCGTAGCCGCGATTATCGCGTTGATCATGGCCAATACCCCAGCCCAGGGGATTTATCACGCCTTCCTCAATT
TGCCTGTGATGGTGAAAGTGTCCTCACTGGAGATTGCCAAGCCACTGCTGTTGTGGATTAACGACGGCCTGATGGCGATC
TTTTTCCTGGTGGTCGGGCTGGAGGTCAAGCGCGAGCTGATGCAAGGTTCATTGGCCGGGCGTGACAAGGCCGTGTTCCC
GGCGATCGCCGCACTGGGCGGCATGCTGGCACCGGCATTGATTTACCTGATGTTCAACGGGGCGGACGAGGTTACTCGTC
AGGGATGGGCGATCCCGGCGGCAACCGATATTGCCTTTGCCCTCGGAGTGATGGCGCTATTGGGTAACCGCGTGCCGACC
AGCCTGAAGGTGTTCCTGTTGGCGCTGGCGATCATCGATGACCTGGGTGTCATCGTGATTATCGCATTGTTCTATACCCA
CGAAGTCTCGATGGCGGCATTGGGCGTGGCAGCAGCCTCTATTGCCGTGCTGGCGTTTATGAACTGGCGCGGTGTGGGCA
AAACCTCGCTTTATATGATTGTCGGTCTGGTACTGTGGGTGGCTATCCTCAAGTCCGGGGTACATGCGACGCTGGCCGGG
GTTATTATCGGCTTTATGATCCCGCTGAACGTGAAGAAAGGGCCGTCGCCGTCAGAGACGCTGGAGCATGAACTGCATCC
GTGGGTGGCATTCCTGATACTGCCGCTGTTTGCCTTTGCCAACGCCGGGGTTTCATTACAAGGCGTGTCACTGAGCGGGC
TGACCTCCCTGTTGCCGGTGGGCATTGCGGCAGGCCTGTTTATCGGTAAGCCGTTGGGCATCTTCACCTTTAGCCTGTTG
GCAGTGAAGCTGGGCATTGCGAGGCTACCTGAAGGAATTGGTTTCAAACAGGTGTTTGCCGTTTCCGTGCTCTGTGGTAT
TGGTTTCACCATGTCGATATTTATCGCTTCGCTGGCCTTTGGCGATGCGGATGTTGTACTGAGCACCTATTCGCGACTGG
GGATCCTGATTGGGTCAACCACGGCGGCGGTGGTCGGGTATGGTCTGTTACGCATGTCGTTACCACGAGTTAGATAA

Upstream 100 bases:

>100_bases
ATAGATCGGTTTTTACGATGTTTTAAGCATTTATAAACGTATTTTATCGAAGTGATTCGGCGTCTATACTCATTCCATTA
CTTTGTCTGCAGGGCCGTCT

Downstream 100 bases:

>100_bases
CTCTTTTAGGGGATCCCCTGTTCGTGGGGACTCACTACAATACAATAGCTGGTCGGAGCTGCGCAGGATAAAATATGCGC
AGCTTCGGCCATTCTGTTTG

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MPCAALERRIVTNIIRQFLRQEAAGGIILIVAAIIALIMANTPAQGIYHAFLNLPVMVKVSSLEIAKPLLLWINDGLMAI
FFLVVGLEVKRELMQGSLAGRDKAVFPAIAALGGMLAPALIYLMFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPT
SLKVFLLALAIIDDLGVIVIIALFYTHEVSMAALGVAAASIAVLAFMNWRGVGKTSLYMIVGLVLWVAILKSGVHATLAG
VIIGFMIPLNVKKGPSPSETLEHELHPWVAFLILPLFAFANAGVSLQGVSLSGLTSLLPVGIAAGLFIGKPLGIFTFSLL
AVKLGIARLPEGIGFKQVFAVSVLCGIGFTMSIFIASLAFGDADVVLSTYSRLGILIGSTTAAVVGYGLLRMSLPRVR

Sequences:

>Translated_398_residues
MPCAALERRIVTNIIRQFLRQEAAGGIILIVAAIIALIMANTPAQGIYHAFLNLPVMVKVSSLEIAKPLLLWINDGLMAI
FFLVVGLEVKRELMQGSLAGRDKAVFPAIAALGGMLAPALIYLMFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPT
SLKVFLLALAIIDDLGVIVIIALFYTHEVSMAALGVAAASIAVLAFMNWRGVGKTSLYMIVGLVLWVAILKSGVHATLAG
VIIGFMIPLNVKKGPSPSETLEHELHPWVAFLILPLFAFANAGVSLQGVSLSGLTSLLPVGIAAGLFIGKPLGIFTFSLL
AVKLGIARLPEGIGFKQVFAVSVLCGIGFTMSIFIASLAFGDADVVLSTYSRLGILIGSTTAAVVGYGLLRMSLPRVR
>Mature_397_residues
PCAALERRIVTNIIRQFLRQEAAGGIILIVAAIIALIMANTPAQGIYHAFLNLPVMVKVSSLEIAKPLLLWINDGLMAIF
FLVVGLEVKRELMQGSLAGRDKAVFPAIAALGGMLAPALIYLMFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTS
LKVFLLALAIIDDLGVIVIIALFYTHEVSMAALGVAAASIAVLAFMNWRGVGKTSLYMIVGLVLWVAILKSGVHATLAGV
IIGFMIPLNVKKGPSPSETLEHELHPWVAFLILPLFAFANAGVSLQGVSLSGLTSLLPVGIAAGLFIGKPLGIFTFSLLA
VKLGIARLPEGIGFKQVFAVSVLCGIGFTMSIFIASLAFGDADVVLSTYSRLGILIGSTTAAVVGYGLLRMSLPRVR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=381, Percent_Identity=67.1916010498688, Blast_Score=465, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 41930; Mature: 41799

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCAALERRIVTNIIRQFLRQEAAGGIILIVAAIIALIMANTPAQGIYHAFLNLPVMVKV
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEE
SSLEIAKPLLLWINDGLMAIFFLVVGLEVKRELMQGSLAGRDKAVFPAIAALGGMLAPAL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IYLMFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTSLKVFLLALAIIDDLGVIVI
HHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IALFYTHEVSMAALGVAAASIAVLAFMNWRGVGKTSLYMIVGLVLWVAILKSGVHATLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
VIIGFMIPLNVKKGPSPSETLEHELHPWVAFLILPLFAFANAGVSLQGVSLSGLTSLLPV
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHH
GIAAGLFIGKPLGIFTFSLLAVKLGIARLPEGIGFKQVFAVSVLCGIGFTMSIFIASLAF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GDADVVLSTYSRLGILIGSTTAAVVGYGLLRMSLPRVR
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PCAALERRIVTNIIRQFLRQEAAGGIILIVAAIIALIMANTPAQGIYHAFLNLPVMVKV
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEE
SSLEIAKPLLLWINDGLMAIFFLVVGLEVKRELMQGSLAGRDKAVFPAIAALGGMLAPAL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IYLMFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTSLKVFLLALAIIDDLGVIVI
HHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IALFYTHEVSMAALGVAAASIAVLAFMNWRGVGKTSLYMIVGLVLWVAILKSGVHATLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
VIIGFMIPLNVKKGPSPSETLEHELHPWVAFLILPLFAFANAGVSLQGVSLSGLTSLLPV
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHH
GIAAGLFIGKPLGIFTFSLLAVKLGIARLPEGIGFKQVFAVSVLCGIGFTMSIFIASLAF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GDADVVLSTYSRLGILIGSTTAAVVGYGLLRMSLPRVR
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA