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The map label for this gene is deoA

Identifier: 157368906

GI number: 157368906

Start: 726423

End: 727745

Strand: Direct

Name: deoA

Synonym: Spro_0661

Alternate gene names: 157368906

Gene position: 726423-727745 (Clockwise)

Preceding gene: 157368905

Following gene: 157368907

Centisome position: 13.33

GC content: 59.64

Gene sequence:

>1323_bases
TTGTTCCTGGCACAAGAAATTATTCGTAAAAAACGTGACGGTCAGCCGTTGAGCGAAGCGGAAATCCGCTTTTTCATCAA
TGGGATCCGTGACAATGTGGTTTCTGAAGGGCAGATCGCGGCGCTGGCGATGACCATTTACTTCCACGATATGACCATGC
CGGAGCGCGTGGCGCTCACCATGGCGATGCGTGATTCCGGCACCGTGCTGGACTGGAAAAGCCTGTCGCTGAACGGCCCG
CTGGTCGACAAGCATTCTACCGGTGGCGTGGGCGACGTGACTTCGCTGATGCTCGGCCCAATGGTGGCGGCCTGTGGCGG
CTACGTGCCGATGATCTCCGGCCGTGGCCTGGGGCATACCGGCGGTACGCTGGACAAGCTGGAAGCGATCCCGGGTTTTA
ATATTTTCCCGGACGACAATGCCTTCCGTAAGATTATTCAGGACGTGGGCGTGGCGATTATCGGCCAGACCAGCTCGCTG
GCACCGGCGGACAAGCGCTTCTACGCGACCCGTGATATTACCGCCACGGTGGATTCTATCCCGCTGATCACCGCCTCAAT
TCTGGCGAAGAAGCTGGCGGAAGGGCTGGATGCGTTGGTGATGGACGTTAAAGTCGGTTCCGGTGCCTTTATGCCAACCT
ACGCATTGTCGGCCGATCTGGCACAGGCGATTGTGGGCGTGGCTAACGGCGCAGGCTGCAAAACCACCGCGTTGCTGACT
GACATGAACCAGGTGCTGGCTTCCAGCGCCGGTAATGCGGTTGAAGTTCGCGAAGCGGTACGCTTCCTGACCGGTGAATA
CCGTAACCCGCGCCTGCTGGAAGTGACCATGGCACTGTGCGTGGAAATGCTGCTTTCCGGTGGCCTGGCGAAAGATGACG
CCGATGCGCGTGCCAAACTGCAGGCGGTGCTGGACAATGGTAAAGCGGCGGAAGTGTTTGGTCGCATGGTGGCGGCGCAA
CAGGGCCCGACCGATTTCGTCGAGCGCTACGACAGCTACCTGCCGGCGGCCACCCTGAGTAAACCGGTTTACGCCGAAAA
ACAGGGTATCATCAGTGCGATGGATACCCGTGCGCTGGGCATGGCGGTGGTATCGCTGGGCGGCGGCCGTCGTCGCGCGA
CCGACAATATCGACTACAGCGTGGGCCTGACCGGCATGGCCCGTCTGGGCGATAAAGTCGATACCCAGCAGCCGCTGGCG
GTGATCCACGCTAACGACGAAGAAAGCTGGCAGCAGGCGGCCGAAGAGGTGCGCAGTGCGATGGTGCTGAGTGACAAAGC
GCCGGAAGTGACACCAGTCGTTTATAAGCGTATCACTGAATAA

Upstream 100 bases:

>100_bases
CGGTGCCGAGCCGTCTGGCAGCGGTTACTGATCGATTCCGTCGGCAAGGCGCGATATGGCGTCTGCCTGCACTCTACATT
AGCTAAAACAGGGGGATGCC

Downstream 100 bases:

>100_bases
TTAACGAATCAGGAGTGGCAGCGGCGTTTTCGCTGTCGCCCACAGCGTGAGAACACGCAGGAGAGCATGATGAAACGCAC
ATTTATTATGGTATTAGACT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MFLAQEIIRKKRDGQPLSEAEIRFFINGIRDNVVSEGQIAALAMTIYFHDMTMPERVALTMAMRDSGTVLDWKSLSLNGP
LVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFNIFPDDNAFRKIIQDVGVAIIGQTSSL
APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYALSADLAQAIVGVANGAGCKTTALLT
DMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAKDDADARAKLQAVLDNGKAAEVFGRMVAAQ
QGPTDFVERYDSYLPAATLSKPVYAEKQGIISAMDTRALGMAVVSLGGGRRRATDNIDYSVGLTGMARLGDKVDTQQPLA
VIHANDEESWQQAAEEVRSAMVLSDKAPEVTPVVYKRITE

Sequences:

>Translated_440_residues
MFLAQEIIRKKRDGQPLSEAEIRFFINGIRDNVVSEGQIAALAMTIYFHDMTMPERVALTMAMRDSGTVLDWKSLSLNGP
LVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFNIFPDDNAFRKIIQDVGVAIIGQTSSL
APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYALSADLAQAIVGVANGAGCKTTALLT
DMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAKDDADARAKLQAVLDNGKAAEVFGRMVAAQ
QGPTDFVERYDSYLPAATLSKPVYAEKQGIISAMDTRALGMAVVSLGGGRRRATDNIDYSVGLTGMARLGDKVDTQQPLA
VIHANDEESWQQAAEEVRSAMVLSDKAPEVTPVVYKRITE
>Mature_440_residues
MFLAQEIIRKKRDGQPLSEAEIRFFINGIRDNVVSEGQIAALAMTIYFHDMTMPERVALTMAMRDSGTVLDWKSLSLNGP
LVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFNIFPDDNAFRKIIQDVGVAIIGQTSSL
APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYALSADLAQAIVGVANGAGCKTTALLT
DMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAKDDADARAKLQAVLDNGKAAEVFGRMVAAQ
QGPTDFVERYDSYLPAATLSKPVYAEKQGIISAMDTRALGMAVVSLGGGRRRATDNIDYSVGLTGMARLGDKVDTQQPLA
VIHANDEESWQQAAEEVRSAMVLSDKAPEVTPVVYKRITE

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=441, Percent_Identity=41.0430839002268, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI4503445, Length=441, Percent_Identity=41.0430839002268, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI166158922, Length=441, Percent_Identity=41.0430839002268, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1790842, Length=440, Percent_Identity=84.7727272727273, Blast_Score=762, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_SERP5 (A8G9H7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476895.1
- ProteinModelPortal:   A8G9H7
- SMR:   A8G9H7
- STRING:   A8G9H7
- GeneID:   5605714
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0661
- eggNOG:   COG0213
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BioCyc:   SPRO399741:SPRO_0661-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 46836; Mature: 46836

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRDGQPLSEAEIRFFINGIRDNVVSEGQIAALAMTIYFHDMTMPERVALT
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEHEECCCCCHHHEEE
MAMRDSGTVLDWKSLSLNGPLVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
GGTLDKLEAIPGFNIFPDDNAFRKIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHEEEECCCHHHHHHH
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYALSADLAQAIVGVANGAGCKTTALLT
HHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAKDDADARAKL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QAVLDNGKAAEVFGRMVAAQQGPTDFVERYDSYLPAATLSKPVYAEKQGIISAMDTRALG
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCHHHHHCHHHHHHHHHHH
MAVVSLGGGRRRATDNIDYSVGLTGMARLGDKVDTQQPLAVIHANDEESWQQAAEEVRSA
HHHHHCCCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
MVLSDKAPEVTPVVYKRITE
HHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MFLAQEIIRKKRDGQPLSEAEIRFFINGIRDNVVSEGQIAALAMTIYFHDMTMPERVALT
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEHEECCCCCHHHEEE
MAMRDSGTVLDWKSLSLNGPLVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
GGTLDKLEAIPGFNIFPDDNAFRKIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHEEEECCCHHHHHHH
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYALSADLAQAIVGVANGAGCKTTALLT
HHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAKDDADARAKL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QAVLDNGKAAEVFGRMVAAQQGPTDFVERYDSYLPAATLSKPVYAEKQGIISAMDTRALG
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCHHHHHCHHHHHHHHHHH
MAVVSLGGGRRRATDNIDYSVGLTGMARLGDKVDTQQPLAVIHANDEESWQQAAEEVRSA
HHHHHCCCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
MVLSDKAPEVTPVVYKRITE
HHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA