Click here to switch to the map view.

The map label for this gene is hbd [H]

Identifier: 157368838

GI number: 157368838

Start: 657409

End: 658332

Strand: Direct

Name: hbd [H]

Synonym: Spro_0593

Alternate gene names: 157368838

Gene position: 657409-658332 (Clockwise)

Preceding gene: 157368837

Following gene: 157368839

Centisome position: 12.07

GC content: 63.64

Gene sequence:

>924_bases
ATGCGTTCATCTGAGACTGTGGTGCTGGGCGCCGGGCTGATGGGGGTTGGCATCGCCACCCACTTTGCCCGCCACGGCCA
CGACGTCCTGCTGTATGACCCGGACTCGCAGCGGCTGGCAGAGGTTGCGGCGGTCGCGGGCAGTATTCTGGCGGAGCTAA
TCGAGGTTGGGCAGTTTGCGGCGGCAGAGCAGGCGACGGTGCTGGCACGTCTGAGCGTGACCGACGATCTGAACGATGTG
GCCCGCGCCCGGCTGTTGATCGAGGCGATCCCCGAGCGCCTGGCGCTCAAACACGCCTTGTACGAACAGCTGGAAGGGCT
GATTGCCGACGATGCGGTGATCGCCAGCAACACCAGCGGTCTGCCGCCGGATGAGTTGGCGGTCAGAATGATCCATCCGC
AGCGCCTGTTGATCGCCCATTTTTGGAATCCACCGCACCTGATCCCGCTGGTGGAGATCGTACCCGGCAGTGCCACCGAT
CCCCGTTATCTGACCGCGGTGCAGGAATTACTCAGTGGTATGGCACTGGAGGCGGTGCTGCTGGATCGTGCCGCACCGGG
GTTCGTTGGCAACCGGCTGCAGTTTGCGCTGCTGCGCGAGGCGCTACACATCGTACAAAGCGGCATTGCCAGTCCGCAGG
TGGTGGATCAGGTGATTCGCGCTTCGCTTGGGCGGCGTTACGCGATGGTCGGGCCGTTGGAGGCCGCCGATATGACCGGT
CTGGAGACGGTGGCGGATATCGCCCGCCACTTGCTACCGGAGCTGGCGACCGATGACAGCATGATGGCGCTGGTGGAAAG
CCGGCTCCGCCAGGGCAACACTGGCCAACGCAGCGGCCAGGGATTTTATCACTGGGATGAAGCACGCAGGGAACGCATTC
AACAGCGGCGGGCGCACCAGCTGCGTTTTGCTCTGAAACCTTAA

Upstream 100 bases:

>100_bases
CAGCGCCGTGAGGTCAACAAGGGGCTGGCGATGCTGTGCATCGGCGGCGGACAGGGCGTGGCGCTGGCGGTTGAGCGCGA
CTGATACCCAGGAGGAAACT

Downstream 100 bases:

>100_bases
CCGCACCCAACAACAATAATGAGTTGCTCAATATGGCTGGCGTGGTTCAGACATCAAGGGCAATAGGGAGTGATGATGAG
CGTTCTGATTGCCCTGGCAG

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRSSETVVLGAGLMGVGIATHFARHGHDVLLYDPDSQRLAEVAAVAGSILAELIEVGQFAAAEQATVLARLSVTDDLNDV
ARARLLIEAIPERLALKHALYEQLEGLIADDAVIASNTSGLPPDELAVRMIHPQRLLIAHFWNPPHLIPLVEIVPGSATD
PRYLTAVQELLSGMALEAVLLDRAAPGFVGNRLQFALLREALHIVQSGIASPQVVDQVIRASLGRRYAMVGPLEAADMTG
LETVADIARHLLPELATDDSMMALVESRLRQGNTGQRSGQGFYHWDEARRERIQQRRAHQLRFALKP

Sequences:

>Translated_307_residues
MRSSETVVLGAGLMGVGIATHFARHGHDVLLYDPDSQRLAEVAAVAGSILAELIEVGQFAAAEQATVLARLSVTDDLNDV
ARARLLIEAIPERLALKHALYEQLEGLIADDAVIASNTSGLPPDELAVRMIHPQRLLIAHFWNPPHLIPLVEIVPGSATD
PRYLTAVQELLSGMALEAVLLDRAAPGFVGNRLQFALLREALHIVQSGIASPQVVDQVIRASLGRRYAMVGPLEAADMTG
LETVADIARHLLPELATDDSMMALVESRLRQGNTGQRSGQGFYHWDEARRERIQQRRAHQLRFALKP
>Mature_307_residues
MRSSETVVLGAGLMGVGIATHFARHGHDVLLYDPDSQRLAEVAAVAGSILAELIEVGQFAAAEQATVLARLSVTDDLNDV
ARARLLIEAIPERLALKHALYEQLEGLIADDAVIASNTSGLPPDELAVRMIHPQRLLIAHFWNPPHLIPLVEIVPGSATD
PRYLTAVQELLSGMALEAVLLDRAAPGFVGNRLQFALLREALHIVQSGIASPQVVDQVIRASLGRRYAMVGPLEAADMTG
LETVADIARHLLPELATDDSMMALVESRLRQGNTGQRSGQGFYHWDEARRERIQQRRAHQLRFALKP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=254, Percent_Identity=32.2834645669291, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=26.6891891891892, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=26.6891891891892, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=30.0341296928328, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI20127408, Length=292, Percent_Identity=26.3698630136986, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI296179427, Length=310, Percent_Identity=28.3870967741935, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787661, Length=304, Percent_Identity=31.5789473684211, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790281, Length=279, Percent_Identity=26.8817204301075, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788682, Length=238, Percent_Identity=29.8319327731092, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=303, Percent_Identity=25.0825082508251, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=27.7397260273973, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71985930, Length=295, Percent_Identity=25.0847457627119, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=29.1095890410959, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193203623, Length=186, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115533614, Length=186, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=311, Percent_Identity=27.0096463022508, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=26.8041237113402, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508951, Length=291, Percent_Identity=26.8041237113402, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508953, Length=291, Percent_Identity=26.8041237113402, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17563036, Length=299, Percent_Identity=28.4280936454849, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45549573, Length=243, Percent_Identity=32.9218106995885, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI20129993, Length=271, Percent_Identity=35.7933579335793, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI19921000, Length=300, Percent_Identity=28.3333333333333, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24583077, Length=300, Percent_Identity=28.3333333333333, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24583079, Length=300, Percent_Identity=28.3333333333333, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33457; Mature: 33457

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSSETVVLGAGLMGVGIATHFARHGHDVLLYDPDSQRLAEVAAVAGSILAELIEVGQFA
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAEQATVLARLSVTDDLNDVARARLLIEAIPERLALKHALYEQLEGLIADDAVIASNTSG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
LPPDELAVRMIHPQRLLIAHFWNPPHLIPLVEIVPGSATDPRYLTAVQELLSGMALEAVL
CCHHHHHHHHCCCHHEEHEECCCCCCCEEHHEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LDRAAPGFVGNRLQFALLREALHIVQSGIASPQVVDQVIRASLGRRYAMVGPLEAADMTG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCHHHCCH
LETVADIARHLLPELATDDSMMALVESRLRQGNTGQRSGQGFYHWDEARRERIQQRRAHQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LRFALKP
HHHCCCC
>Mature Secondary Structure
MRSSETVVLGAGLMGVGIATHFARHGHDVLLYDPDSQRLAEVAAVAGSILAELIEVGQFA
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAEQATVLARLSVTDDLNDVARARLLIEAIPERLALKHALYEQLEGLIADDAVIASNTSG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
LPPDELAVRMIHPQRLLIAHFWNPPHLIPLVEIVPGSATDPRYLTAVQELLSGMALEAVL
CCHHHHHHHHCCCHHEEHEECCCCCCCEEHHEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LDRAAPGFVGNRLQFALLREALHIVQSGIASPQVVDQVIRASLGRRYAMVGPLEAADMTG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCHHHCCH
LETVADIARHLLPELATDDSMMALVESRLRQGNTGQRSGQGFYHWDEARRERIQQRRAHQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LRFALKP
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]