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The map label for this gene is atoB [H]

Identifier: 157368837

GI number: 157368837

Start: 656187

End: 657392

Strand: Direct

Name: atoB [H]

Synonym: Spro_0592

Alternate gene names: 157368837

Gene position: 656187-657392 (Clockwise)

Preceding gene: 157368836

Following gene: 157368838

Centisome position: 12.04

GC content: 63.52

Gene sequence:

>1206_bases
ATGATGTTATCCAGGGAGAAAACCATGCAACAGGTAGTGATTGTAGCGGCGACTCGCACGCCGATTGGCAGTTTTCAGGG
CGCGCTGGCCTCATTGTCGGCGGTGGATCTGGGCACGGTGGTGGTGAAAGCCCTGCTGGCACGCAGCGGGGTTGCAGCGG
AGCAGGTGGATGAGGTGATCCTCGGGCAGGTGCTGACGGCCGGTTGTGGGCAGAACCCGGCACGCCAGACCGCATTGAAC
GCCGGGCTGCCCCATAGCGTGCCGGCGTTGACCATCAACAAAGTCTGTGGCTCCGGTCTGAAGGCGATTCATCTGGCGGT
GCAGGCGATCCGCTGTGGTGACGCCGAGGTGATTATCGCCGGGGGGCAGGAAAGCATGAGTCAGTCGCCGTATCTGATGA
ACGGCGCGCGTGCCGGACTGCGGCTGGGTCACGCTCAGTTGACTGACAGCGTGATCCAGGACGGCCTGTGGGATGCCTTC
AACGATTATCACATGGGTATCACCGCCGAAAATTTGGCGGAGAAATACGCCATTAGTCACAGCGAGCAGGATGAGTTTGC
GCTGCGTTCGCAACAGAAAACCCAGGCCGCCCAACAGGCCGGGCGTTTTGTGGCGGAAATCACTCCGGTCGAGGTCGCCA
AACCCAAAGGGGAAGTGCTGCGGGTGGCCTGTGACGAGCAACCCCGCGGCGACGCCACGCTGGAAAGTCTGGCCCGGCTG
CGTCCGGCGTTCCGCAAAGACGGTACGGTGACCGCCGGTAACGCTTCCTCAATTAACGACGGTGCGGCGGCGGTGCTGTT
GATGAGCGCGGCGAAGGCGGCCGAGCTGAAGCTGCCGGTGCTGGCGCGCATTGCCGGCTATGCGGCATCGGGTGTTGATC
CGGCGATCATGGGGATTGGTCCGGTACCGGCGGCGCGTCGCTGTCTGGCCAACGCCGGTTGGTCGCTGAGCGAAGTCGAT
TTGATCGAGGCCAATGAGGCCTTTGCCGCACAGGCGCTGGCCGTCGGCCGCGAACTGGAGTGGGACAGCGCCAGGGTCAA
TGTTAACGGCGGGGCGATAGCGCTCGGGCATCCGATCGGGGCTTCCGGTTGCCGTATTTTGGTCACGCTGTTGTATGAGA
TGCAGCGCCGTGAGGTCAACAAGGGGCTGGCGATGCTGTGCATCGGCGGCGGACAGGGCGTGGCGCTGGCGGTTGAGCGC
GACTGA

Upstream 100 bases:

>100_bases
TGCTGCGCGAACGTGCGCCCGGCGTCAGCGTGGAGGAGATTGTCGCCAAAACCGCCGGTCGGCTGATAGTGCCGACTCAG
GTGCCGGAGATGCGCTTCTG

Downstream 100 bases:

>100_bases
TACCCAGGAGGAAACTATGCGTTCATCTGAGACTGTGGTGCTGGGCGCCGGGCTGATGGGGGTTGGCATCGCCACCCACT
TTGCCCGCCACGGCCACGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MMLSREKTMQQVVIVAATRTPIGSFQGALASLSAVDLGTVVVKALLARSGVAAEQVDEVILGQVLTAGCGQNPARQTALN
AGLPHSVPALTINKVCGSGLKAIHLAVQAIRCGDAEVIIAGGQESMSQSPYLMNGARAGLRLGHAQLTDSVIQDGLWDAF
NDYHMGITAENLAEKYAISHSEQDEFALRSQQKTQAAQQAGRFVAEITPVEVAKPKGEVLRVACDEQPRGDATLESLARL
RPAFRKDGTVTAGNASSINDGAAAVLLMSAAKAAELKLPVLARIAGYAASGVDPAIMGIGPVPAARRCLANAGWSLSEVD
LIEANEAFAAQALAVGRELEWDSARVNVNGGAIALGHPIGASGCRILVTLLYEMQRREVNKGLAMLCIGGGQGVALAVER
D

Sequences:

>Translated_401_residues
MMLSREKTMQQVVIVAATRTPIGSFQGALASLSAVDLGTVVVKALLARSGVAAEQVDEVILGQVLTAGCGQNPARQTALN
AGLPHSVPALTINKVCGSGLKAIHLAVQAIRCGDAEVIIAGGQESMSQSPYLMNGARAGLRLGHAQLTDSVIQDGLWDAF
NDYHMGITAENLAEKYAISHSEQDEFALRSQQKTQAAQQAGRFVAEITPVEVAKPKGEVLRVACDEQPRGDATLESLARL
RPAFRKDGTVTAGNASSINDGAAAVLLMSAAKAAELKLPVLARIAGYAASGVDPAIMGIGPVPAARRCLANAGWSLSEVD
LIEANEAFAAQALAVGRELEWDSARVNVNGGAIALGHPIGASGCRILVTLLYEMQRREVNKGLAMLCIGGGQGVALAVER
D
>Mature_401_residues
MMLSREKTMQQVVIVAATRTPIGSFQGALASLSAVDLGTVVVKALLARSGVAAEQVDEVILGQVLTAGCGQNPARQTALN
AGLPHSVPALTINKVCGSGLKAIHLAVQAIRCGDAEVIIAGGQESMSQSPYLMNGARAGLRLGHAQLTDSVIQDGLWDAF
NDYHMGITAENLAEKYAISHSEQDEFALRSQQKTQAAQQAGRFVAEITPVEVAKPKGEVLRVACDEQPRGDATLESLARL
RPAFRKDGTVTAGNASSINDGAAAVLLMSAAKAAELKLPVLARIAGYAASGVDPAIMGIGPVPAARRCLANAGWSLSEVD
LIEANEAFAAQALAVGRELEWDSARVNVNGGAIALGHPIGASGCRILVTLLYEMQRREVNKGLAMLCIGGGQGVALAVER
D

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=53.3163265306122, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=47.4747474747475, Blast_Score=347, Evalue=9e-96,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=43.9393939393939, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=40.8629441624365, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.6279069767442, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=30, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=67.9389312977099, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=58.0152671755725, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=46.6334164588529, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44.5, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1788683, Length=402, Percent_Identity=33.5820895522388, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.8974358974359, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=40.920716112532, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=39.8477157360406, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=34.8717948717949, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=30.7692307692308, Blast_Score=177, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=45.4545454545455, Blast_Score=315, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=38.8888888888889, Blast_Score=242, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=55.6122448979592, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.6410256410256, Blast_Score=324, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=42.7109974424552, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=31.5668202764977, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41686; Mature: 41686

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLSREKTMQQVVIVAATRTPIGSFQGALASLSAVDLGTVVVKALLARSGVAAEQVDEVI
CCCCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGQVLTAGCGQNPARQTALNAGLPHSVPALTINKVCGSGLKAIHLAVQAIRCGDAEVIIA
HHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEE
GGQESMSQSPYLMNGARAGLRLGHAQLTDSVIQDGLWDAFNDYHMGITAENLAEKYAISH
CCHHHHCCCCCEECCCHHHHCCCHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCC
SEQDEFALRSQQKTQAAQQAGRFVAEITPVEVAKPKGEVLRVACDEQPRGDATLESLARL
CCCHHHHHHHHHHHHHHHHHCCEEEECCCCEECCCCCCEEEEEECCCCCCCHHHHHHHHH
RPAFRKDGTVTAGNASSINDGAAAVLLMSAAKAAELKLPVLARIAGYAASGVDPAIMGIG
HHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHEECC
PVPAARRCLANAGWSLSEVDLIEANEAFAAQALAVGRELEWDSARVNVNGGAIALGHPIG
CCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCC
ASGCRILVTLLYEMQRREVNKGLAMLCIGGGQGVALAVERD
CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECC
>Mature Secondary Structure
MMLSREKTMQQVVIVAATRTPIGSFQGALASLSAVDLGTVVVKALLARSGVAAEQVDEVI
CCCCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGQVLTAGCGQNPARQTALNAGLPHSVPALTINKVCGSGLKAIHLAVQAIRCGDAEVIIA
HHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEE
GGQESMSQSPYLMNGARAGLRLGHAQLTDSVIQDGLWDAFNDYHMGITAENLAEKYAISH
CCHHHHCCCCCEECCCHHHHCCCHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCC
SEQDEFALRSQQKTQAAQQAGRFVAEITPVEVAKPKGEVLRVACDEQPRGDATLESLARL
CCCHHHHHHHHHHHHHHHHHCCEEEECCCCEECCCCCCEEEEEECCCCCCCHHHHHHHHH
RPAFRKDGTVTAGNASSINDGAAAVLLMSAAKAAELKLPVLARIAGYAASGVDPAIMGIG
HHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHEECC
PVPAARRCLANAGWSLSEVDLIEANEAFAAQALAVGRELEWDSARVNVNGGAIALGHPIG
CCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCC
ASGCRILVTLLYEMQRREVNKGLAMLCIGGGQGVALAVERD
CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]