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The map label for this gene is frdA [H]

Identifier: 157368666

GI number: 157368666

Start: 464985

End: 466781

Strand: Reverse

Name: frdA [H]

Synonym: Spro_0419

Alternate gene names: 157368666

Gene position: 466781-464985 (Counterclockwise)

Preceding gene: 157368668

Following gene: 157368665

Centisome position: 8.57

GC content: 59.04

Gene sequence:

>1797_bases
GTGCAAACCTTTAACGCCGATCTTGCCATTATTGGGGCCGGGGGTGCTGGTTTACGTGCAGCAATAGCCGCAGCGGAAGC
CAACCCCCAACTGAAAATCGCGCTAATCTCAAAAGTCTACCCGATGCGCAGCCATACGGTGGCCGCTGAAGGAGGCTCCG
CCGCCGTCACTCAGGATCACGATAGCTTCGACTACCACTTCAACGACACCGTTGCCGGTGGCGATTGGCTGTGTGAACAG
GACGTGGTCGACCATTTCGTCCACAACTGCCCGCGCGAAATGACCCAGCTTGAGCAATGGGGTTGTCCATGGAGCCGTAA
AGAGGACGGTTCAGTCAACGTACGTCGCTTCGGCGGCATGAAGATTGAGCGCACCTGGTTCGCCGCCGACAAGACCGGCT
TCCACATGCTGCACACCCTGTTCCAGACCTCGCTCAAATATCCGCAAATCCAGCGTTTCGACGAGCACTTCGTGCTGGAT
ATTCTGGTGGATGACGGCCAGGCCCGCGGCCTGGTGGCGATGAACATGATGGAAGGCACCCGCGTGCAGATCCGTGCCAA
TGCAGTAGTCATGGCTACCGGCGGTGCCGGCCGCGTGTACCGCTATAACACCAACGGCGGTATCGTCACCGGTGATGGCA
TGGGCATGGCGTTCCACCACGGCATACCGCTGCGTGATATGGAGTTCGTCCAATATCACCCTACCGGCCTGCCGGGCTCC
GGTATCCTGATGACCGAAGGTTGCCGTGGCGAAGGCGGCATTCTGGTAAACAAAGACGGCTACCGCTACCTGCAGGACTA
CGGCATGGGGCCGGAAACCCCGCTGGGTGAGCCAAAGAACAAATACATGGAACTGGGCCCGCGCGACAAGGTTTCGCAGG
CTTTCTGGCATGAATGGCGTGCCGGCCGTACCGTTGCTACCCCGCGCGGAGACGTGGTTTATCTCGACCTGCGCCACCTG
GGTGAAAAGAAACTGCTGGAACGTCTGCCGTTCATCTGTGAACTGGCCAAGGCCTATGTCGGCGTCGACCCGGTGAAAGA
GCCGATCCCGGTACGTCCGACCGCGCACTACACCATGGGCGGCATTGAAACCGATCAAAACTGCGAAACCCGTATCAAAG
GGCTGTTTGCCGTCGGTGAATGTTCCTCCGTCGGCCTGCACGGCGCCAACCGCCTGGGTTCCAATTCGCTGGCGGAACTG
GTGGTGTTCGGCCGGGTAGCCGGTGAACAAGCCGCTCGCCGCGCGCTGGAAACCGGCCCGGCGAACGGTAGTGCTCTGGA
TGCACAGGGGCGCGACGTCGAAACCCGCTTGAGCAACCTGATGAAACAGGAAGGCAACGAGAACTGGGCCAAAATCCGCG
ACGAGATGGGCATGTCGATGGAAGAAGGCTGCGGTATTTACCGCACGCCGGAACTGATGCAGAAAACCGTCGATAAACTG
GCCGAGCTGAAAGAACGCTTCAAGCGCGTCAAAATTACCGACAGCTCCAGCGTGTTCAATACCGATCTGCTGTACACCAT
CGAGCTGGGTTACGGGCTGGACGTGGCCGAATGCATGGCGCATTCCGCCTTCAACCGTAAAGAATCCCGCGGTGCCCACC
AGCGTCTGGACGAAGGCTGTACCGAACGTGACGACGTGAATTTCCTCAAGCATACGCTGGCGTTCCATAACCCGAACGGC
GCACCACGCCTGGAATACAGCGACGTGAAGATCACCAAACTGCCACCGGCCAAACGTGTTTACGGCGCTGAAGCCGAAGC
GCAGGATAAAAAGGATAAGGAGCAGGCAAATGGCTGA

Upstream 100 bases:

>100_bases
AACGACAATAAACTCAGTTAGTTAGCACCCGAAGTTTTTTATAAATATTAAGCATAGATATTTAATTTGCCGTTCTTAAC
AAGAATATTGGAGGAATGCA

Downstream 100 bases:

>100_bases
GATGAACACCCTGAAAATCGAGGTCATGCGCTATAACCCGGAACGCGACTCTGAGCCGCATTTCGAGACCTTCGCGGTGC
CTTATGATGAACAAACCTCG

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDHDSFDYHFNDTVAGGDWLCEQ
DVVDHFVHNCPREMTQLEQWGCPWSRKEDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLD
ILVDDGQARGLVAMNMMEGTRVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGIPLRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRAGRTVATPRGDVVYLDLRHL
GEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRVAGEQAARRALETGPANGSALDAQGRDVETRLSNLMKQEGNENWAKIRDEMGMSMEEGCGIYRTPELMQKTVDKL
AELKERFKRVKITDSSSVFNTDLLYTIELGYGLDVAECMAHSAFNRKESRGAHQRLDEGCTERDDVNFLKHTLAFHNPNG
APRLEYSDVKITKLPPAKRVYGAEAEAQDKKDKEQANG

Sequences:

>Translated_598_residues
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDHDSFDYHFNDTVAGGDWLCEQ
DVVDHFVHNCPREMTQLEQWGCPWSRKEDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLD
ILVDDGQARGLVAMNMMEGTRVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGIPLRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRAGRTVATPRGDVVYLDLRHL
GEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRVAGEQAARRALETGPANGSALDAQGRDVETRLSNLMKQEGNENWAKIRDEMGMSMEEGCGIYRTPELMQKTVDKL
AELKERFKRVKITDSSSVFNTDLLYTIELGYGLDVAECMAHSAFNRKESRGAHQRLDEGCTERDDVNFLKHTLAFHNPNG
APRLEYSDVKITKLPPAKRVYGAEAEAQDKKDKEQANG
>Mature_598_residues
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDHDSFDYHFNDTVAGGDWLCEQ
DVVDHFVHNCPREMTQLEQWGCPWSRKEDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLD
ILVDDGQARGLVAMNMMEGTRVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGIPLRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRAGRTVATPRGDVVYLDLRHL
GEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRVAGEQAARRALETGPANGSALDAQGRDVETRLSNLMKQEGNENWAKIRDEMGMSMEEGCGIYRTPELMQKTVDKL
AELKERFKRVKITDSSSVFNTDLLYTIELGYGLDVAECMAHSAFNRKESRGAHQRLDEGCTERDDVNFLKHTLAFHNPNG
APRLEYSDVKITKLPPAKRVYGAEAEAQDKKDKEQANG

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=597, Percent_Identity=37.85594639866, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=88.4879725085911, Blast_Score=1049, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=573, Percent_Identity=40.6631762652705, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1788928, Length=553, Percent_Identity=32.7305605786618, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17505833, Length=533, Percent_Identity=39.3996247654784, Blast_Score=355, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17550100, Length=600, Percent_Identity=37, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI71986328, Length=437, Percent_Identity=27.0022883295195, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322701, Length=580, Percent_Identity=41.0344827586207, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322416, Length=580, Percent_Identity=40.3448275862069, Blast_Score=385, Evalue=1e-108,
Organism=Drosophila melanogaster, GI17137288, Length=594, Percent_Identity=38.5521885521886, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655642, Length=594, Percent_Identity=38.5521885521886, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655647, Length=594, Percent_Identity=38.5521885521886, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24663005, Length=603, Percent_Identity=36.81592039801, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66093; Mature: 66093

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDH
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEEHHCCCCCCCEEEECCCCEEEECCC
DSFDYHFNDTVAGGDWLCEQDVVDHFVHNCPREMTQLEQWGCPWSRKEDGSVNVRRFGGM
CCCCEEECCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLDILVDDGQARGLVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEECCCCCCCEEEEEECCCC
RVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGIPLRDMEFVQYHPTGLPGS
EEEEEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCEECCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWR
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
AGRTVATPRGDVVYLDLRHLGEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMG
CCCEEECCCCCEEEEEHHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
GIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRVAGEQAARRALETGP
CCCCCCCHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ANGSALDAQGRDVETRLSNLMKQEGNENWAKIRDEMGMSMEEGCGIYRTPELMQKTVDKL
CCCCEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHH
AELKERFKRVKITDSSSVFNTDLLYTIELGYGLDVAECMAHSAFNRKESRGAHQRLDEGC
HHHHHHHHEEEECCCCCEECCCEEEEEEECCCCCHHHHHHHHHHCCHHHCCHHHHHHHCC
TERDDVNFLKHTLAFHNPNGAPRLEYSDVKITKLPPAKRVYGAEAEAQDKKDKEQANG
CCCCHHHHHHHHHHEECCCCCCCEEECCEEEEECCCHHHHCCCCCHHHCHHHHHHCCC
>Mature Secondary Structure
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDH
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEEHHCCCCCCCEEEECCCCEEEECCC
DSFDYHFNDTVAGGDWLCEQDVVDHFVHNCPREMTQLEQWGCPWSRKEDGSVNVRRFGGM
CCCCEEECCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLDILVDDGQARGLVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEECCCCCCCEEEEEECCCC
RVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGIPLRDMEFVQYHPTGLPGS
EEEEEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCEECCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWR
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
AGRTVATPRGDVVYLDLRHLGEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMG
CCCEEECCCCCEEEEEHHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
GIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRVAGEQAARRALETGP
CCCCCCCHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ANGSALDAQGRDVETRLSNLMKQEGNENWAKIRDEMGMSMEEGCGIYRTPELMQKTVDKL
CCCCEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHH
AELKERFKRVKITDSSSVFNTDLLYTIELGYGLDVAECMAHSAFNRKESRGAHQRLDEGC
HHHHHHHHEEEECCCCCEECCCEEEEEEECCCCCHHHHHHHHHHCCHHHCCHHHHHHHCC
TERDDVNFLKHTLAFHNPNGAPRLEYSDVKITKLPPAKRVYGAEAEAQDKKDKEQANG
CCCCHHHHHHHHHHEECCCCCCCEEECCEEEEECCCHHHHCCCCCHHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]