Click here to switch to the map view.

The map label for this gene is frdB [H]

Identifier: 157368665

GI number: 157368665

Start: 464258

End: 464992

Strand: Reverse

Name: frdB [H]

Synonym: Spro_0418

Alternate gene names: 157368665

Gene position: 464992-464258 (Counterclockwise)

Preceding gene: 157368666

Following gene: 157368664

Centisome position: 8.53

GC content: 57.28

Gene sequence:

>735_bases
ATGGCTGAGATGAACACCCTGAAAATCGAGGTCATGCGCTATAACCCGGAACGCGACTCTGAGCCGCATTTCGAGACCTT
CGCGGTGCCTTATGATGAACAAACCTCGTTGCTCGACGCCCTGGGCTACATCAAGGATAACCTGGCCCCCGACCTTTCCT
ACCGCTGGTCATGCCGTATGGCGATCTGCGGCTCGTGCGGCATGATGGTCAACCGGGTACCAAAGCTGGCCTGTAAAACT
TTCCTGCGCGAGTACACTGGCGGCATGAAGGTCGAAGCGCTGGGCAACTTCCCGATTGAGCGCGATCTGGTGGTCGACAT
GACCCACTTTATCGAAAGTCTGGAGGCGATTAAGCCTTACATCATCGGCAATAACCGCAAACCGGAAGATGGCCCTAACG
TGCAGACTCCGGCGCAGATGGCCAAGTATCACCAGTTCTCCGGCTGCATCAACTGCGGCCTGTGTTATGCCGCTTGCCCG
CAGTTCGGCCTGAACCCTGAGTTTATCGGCCCGGCGGCGATCACCCTGGCGCACCGCTACAATCTGGATAACCGCGACCA
CGGCCAGAAACAGCGTATGGCGCAGCTCAACGGTGACAATGGCGTCTGGAGCTGTACCTTTGTCGGTTACTGCTCTGAAG
TATGTCCGAAGCACGTCGACCCGGCCGCTGCCATCCAGCAGGGCAAGGTGGAAAGTGCCAAAGACTTCATGATCGCCATG
CTGAAGCCGCAATAA

Upstream 100 bases:

>100_bases
CTGGAATACAGCGACGTGAAGATCACCAAACTGCCACCGGCCAAACGTGTTTACGGCGCTGAAGCCGAAGCGCAGGATAA
AAAGGATAAGGAGCAGGCAA

Downstream 100 bases:

>100_bases
GGGAGATAAACAGCAATGACAACACAACGTAAGCCCTATGTGCGCACCATGACGCCGACCTGGTGGCAAAAGCTCGGCTT
CTACCGTTTCTATATGCTGC

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAEMNTLKIEVMRYNPERDSEPHFETFAVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNRVPKLACKT
FLREYTGGMKVEALGNFPIERDLVVDMTHFIESLEAIKPYIIGNNRKPEDGPNVQTPAQMAKYHQFSGCINCGLCYAACP
QFGLNPEFIGPAAITLAHRYNLDNRDHGQKQRMAQLNGDNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESAKDFMIAM
LKPQ

Sequences:

>Translated_244_residues
MAEMNTLKIEVMRYNPERDSEPHFETFAVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNRVPKLACKT
FLREYTGGMKVEALGNFPIERDLVVDMTHFIESLEAIKPYIIGNNRKPEDGPNVQTPAQMAKYHQFSGCINCGLCYAACP
QFGLNPEFIGPAAITLAHRYNLDNRDHGQKQRMAQLNGDNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESAKDFMIAM
LKPQ
>Mature_243_residues
AEMNTLKIEVMRYNPERDSEPHFETFAVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNRVPKLACKTF
LREYTGGMKVEALGNFPIERDLVVDMTHFIESLEAIKPYIIGNNRKPEDGPNVQTPAQMAKYHQFSGCINCGLCYAACPQ
FGLNPEFIGPAAITLAHRYNLDNRDHGQKQRMAQLNGDNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESAKDFMIAML
KPQ

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=227, Percent_Identity=29.9559471365639, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1790596, Length=244, Percent_Identity=86.0655737704918, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=37.0689655172414, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17533915, Length=231, Percent_Identity=32.4675324675325, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=33.9130434782609, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137106, Length=229, Percent_Identity=33.6244541484716, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24643156, Length=226, Percent_Identity=31.858407079646, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27331; Mature: 27199

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
9.4 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
9.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMNTLKIEVMRYNPERDSEPHFETFAVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRM
CCCCCEEEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHH
AICGSCGMMVNRVPKLACKTFLREYTGGMKVEALGNFPIERDLVVDMTHFIESLEAIKPY
HHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNNRKPEDGPNVQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCHHHHHCCCCCCCCCCCCHHHEEEHHHC
NLDNRDHGQKQRMAQLNGDNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESAKDFMIAM
CCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEE
LKPQ
ECCC
>Mature Secondary Structure 
AEMNTLKIEVMRYNPERDSEPHFETFAVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRM
CCCCEEEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHH
AICGSCGMMVNRVPKLACKTFLREYTGGMKVEALGNFPIERDLVVDMTHFIESLEAIKPY
HHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNNRKPEDGPNVQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCHHHHHCCCCCCCCCCCCHHHEEEHHHC
NLDNRDHGQKQRMAQLNGDNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESAKDFMIAM
CCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEE
LKPQ
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]