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The map label for this gene is dppA [H]

Identifier: 157368387

GI number: 157368387

Start: 148465

End: 150072

Strand: Direct

Name: dppA [H]

Synonym: Spro_0138

Alternate gene names: 157368387

Gene position: 148465-150072 (Clockwise)

Preceding gene: 157368386

Following gene: 157368388

Centisome position: 2.72

GC content: 54.73

Gene sequence:

>1608_bases
ATGACAAGTTCCTTGGGAAAAACAGGGATTCTGAAATTCGGTATTGGGCTGATTGCGCTGACCGTTGCGGCCAGCGTGCA
AGCCAAGACTCTGGTTTACTGTTCTGAAGGTTCCCCGGAAGGGTTCAACCCGCAGCTGTTCACCTCGGGTACTACCTATG
ACGCCAGCTCGGTGCCTATTTACAACCGTCTGGTCGAATTCAAAATCGGCACCACCGAACTGCAGCCGGGCCTGGCTGAA
AAATGGGATGTCAGCGAAGACGGCAAAATCTACACCTTCCACCTGCGTAAAGGCGTGAAGTGGCAGAGCAGCAAAGACTT
CAAACCGACCCGTGATTTCAACGCCGACGACGTGGTGTTCTCCTTCGAACGTCAGCTGGACGCGAAAAATGCTTATCACA
AAGTCTCCGGCGGCAGCTATGAGTACTTTGAAGGCATGGACATGCCGAAGCTGATCGCCAAAATCGAGAAAGTGGACGAC
TACACCGTTCGCTTTGTGCTGACCCGTCCTGAGGCGCCATTTGTGGCTGACCTGGGCATGGACTTCGCTTCTATTCTGTC
TGCCGAATACGCCGACGTAATGATGAAGGCCGGCACCCCGGAGAAAATTGACCTGAACCCAATCGGTACCGGTCCGTTCC
AACTGCTGCAATACCAGAAAGACTCCAAGATTCTCTACAAGGCGTTTGACGGTTTCTGGGGCACCAAGCCGAAGATTGAC
CGTTTAGTGTTCTCCATCACGCCAGACGCTTCCGTGCGTTACGCCAAACTGCAGAAAAACGAATGCCAGGTGATGCCGTA
CCCGAACCCGGCTGACATCGCGCGCATGAAGCAGGACAAAACCATCAACCTGATGGAACAACCGGGGCTGAACGTCGGTT
ACCTGTCGTTCAACGTTGAGAAAAAACCGCTGGATAACCTGAAGGTGCGTCAGGCGTTGACCCTGGCGGTCAACAAGCAG
GCGATCATCGACGCGGTGTACCAGGGTGCAGGCCAGGCGGCCAAGAACCTGATCCCACCGACCATGTGGGGCTATAACGA
CGCGGTGAAAGACTACACCTACGATCCGGTCAAGGCTAAAGAACTGCTGAAAGAAGCGGGCATGGCAGACGGTTTCTCCA
TCGATCTGTGGGCAATGCCGGTACAGCGTCCGTACAACCCGAACGCGCGCCGCATGGCGGAAATGATCCAGTCTGACTGG
GCGAAAATCGGCGTGAAAGCCAAAATCGTAACCTATGAGTGGGGCGAATACCTCAAGCGCGCCAAAGCGGGCGAACATCA
GACGGTGATGATGGGCTGGACCGGCGACAATGGGGATCCGGATAACTTCTTCGCCACGCTGTTTAGCTGCGCCGCGGCTA
AAGATGGCTCCAACTACTCTCGCTGGTGCTACAAGCCGTTTGAAGATCTTATTCAACCGGCGCGCGCCGAATCGAACCAC
GACAAACGCATCGAACTGTACAAACAGGCTCAGGTAGTGATGCACGATCAGGCTCCGGCGCTGATTGTTGCCCACTCCAC
CGTTTACGAGCCAGTGCGTAAGGAAGTGAAGGGCTACGTCGTGGATCCGCTTGGTAAGCATCACTTTGAGAATGTCTCTC
TGGATTAA

Upstream 100 bases:

>100_bases
ATCCCTCCCAGCCTTCGGGCACGACTGCACAGGCCGCGCAATAAAAAATACAGGCTCTGGCGGTAATACACACATCACAT
CACATAATGGAGCACAAACG

Downstream 100 bases:

>100_bases
TTTCACTACCGGTTAATACCACGCCCCTCTCTTTAAGGGAGGGGTGGGGTTGCCCGTAGGCAGAGAAGCACCAGAGGTGT
GTGAGCTTTAATAAGCCTGG

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTSSLGKTGILKFGIGLIALTVAASVQAKTLVYCSEGSPEGFNPQLFTSGTTYDASSVPIYNRLVEFKIGTTELQPGLAE
KWDVSEDGKIYTFHLRKGVKWQSSKDFKPTRDFNADDVVFSFERQLDAKNAYHKVSGGSYEYFEGMDMPKLIAKIEKVDD
YTVRFVLTRPEAPFVADLGMDFASILSAEYADVMMKAGTPEKIDLNPIGTGPFQLLQYQKDSKILYKAFDGFWGTKPKID
RLVFSITPDASVRYAKLQKNECQVMPYPNPADIARMKQDKTINLMEQPGLNVGYLSFNVEKKPLDNLKVRQALTLAVNKQ
AIIDAVYQGAGQAAKNLIPPTMWGYNDAVKDYTYDPVKAKELLKEAGMADGFSIDLWAMPVQRPYNPNARRMAEMIQSDW
AKIGVKAKIVTYEWGEYLKRAKAGEHQTVMMGWTGDNGDPDNFFATLFSCAAAKDGSNYSRWCYKPFEDLIQPARAESNH
DKRIELYKQAQVVMHDQAPALIVAHSTVYEPVRKEVKGYVVDPLGKHHFENVSLD

Sequences:

>Translated_535_residues
MTSSLGKTGILKFGIGLIALTVAASVQAKTLVYCSEGSPEGFNPQLFTSGTTYDASSVPIYNRLVEFKIGTTELQPGLAE
KWDVSEDGKIYTFHLRKGVKWQSSKDFKPTRDFNADDVVFSFERQLDAKNAYHKVSGGSYEYFEGMDMPKLIAKIEKVDD
YTVRFVLTRPEAPFVADLGMDFASILSAEYADVMMKAGTPEKIDLNPIGTGPFQLLQYQKDSKILYKAFDGFWGTKPKID
RLVFSITPDASVRYAKLQKNECQVMPYPNPADIARMKQDKTINLMEQPGLNVGYLSFNVEKKPLDNLKVRQALTLAVNKQ
AIIDAVYQGAGQAAKNLIPPTMWGYNDAVKDYTYDPVKAKELLKEAGMADGFSIDLWAMPVQRPYNPNARRMAEMIQSDW
AKIGVKAKIVTYEWGEYLKRAKAGEHQTVMMGWTGDNGDPDNFFATLFSCAAAKDGSNYSRWCYKPFEDLIQPARAESNH
DKRIELYKQAQVVMHDQAPALIVAHSTVYEPVRKEVKGYVVDPLGKHHFENVSLD
>Mature_534_residues
TSSLGKTGILKFGIGLIALTVAASVQAKTLVYCSEGSPEGFNPQLFTSGTTYDASSVPIYNRLVEFKIGTTELQPGLAEK
WDVSEDGKIYTFHLRKGVKWQSSKDFKPTRDFNADDVVFSFERQLDAKNAYHKVSGGSYEYFEGMDMPKLIAKIEKVDDY
TVRFVLTRPEAPFVADLGMDFASILSAEYADVMMKAGTPEKIDLNPIGTGPFQLLQYQKDSKILYKAFDGFWGTKPKIDR
LVFSITPDASVRYAKLQKNECQVMPYPNPADIARMKQDKTINLMEQPGLNVGYLSFNVEKKPLDNLKVRQALTLAVNKQA
IIDAVYQGAGQAAKNLIPPTMWGYNDAVKDYTYDPVKAKELLKEAGMADGFSIDLWAMPVQRPYNPNARRMAEMIQSDWA
KIGVKAKIVTYEWGEYLKRAKAGEHQTVMMGWTGDNGDPDNFFATLFSCAAAKDGSNYSRWCYKPFEDLIQPARAESNHD
KRIELYKQAQVVMHDQAPALIVAHSTVYEPVRKEVKGYVVDPLGKHHFENVSLD

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=535, Percent_Identity=84.8598130841121, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1787551, Length=509, Percent_Identity=35.7563850687623, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1787052, Length=548, Percent_Identity=28.6496350364964, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787762, Length=531, Percent_Identity=26.5536723163842, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789887, Length=561, Percent_Identity=23.8859180035651, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789397, Length=505, Percent_Identity=26.1386138613861, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787495, Length=478, Percent_Identity=23.8493723849372, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081878, Length=473, Percent_Identity=23.2558139534884, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 60016; Mature: 59885

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSLGKTGILKFGIGLIALTVAASVQAKTLVYCSEGSPEGFNPQLFTSGTTYDASSVPI
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCH
YNRLVEFKIGTTELQPGLAEKWDVSEDGKIYTFHLRKGVKWQSSKDFKPTRDFNADDVVF
HHHEEEEEECCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEE
SFERQLDAKNAYHKVSGGSYEYFEGMDMPKLIAKIEKVDDYTVRFVLTRPEAPFVADLGM
EHHHHHCHHHHHEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEHHHCC
DFASILSAEYADVMMKAGTPEKIDLNPIGTGPFQLLQYQKDSKILYKAFDGFWGTKPKID
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHCCCCCEEHHHHCCCCCCCCCCC
RLVFSITPDASVRYAKLQKNECQVMPYPNPADIARMKQDKTINLMEQPGLNVGYLSFNVE
EEEEEECCCCCEEEEEECCCCCEEECCCCHHHHHHHCCCCCEEHHHCCCCEEEEEEEECC
KKPLDNLKVRQALTLAVNKQAIIDAVYQGAGQAAKNLIPPTMWGYNDAVKDYTYDPVKAK
CCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHCCCCCCHHHH
ELLKEAGMADGFSIDLWAMPVQRPYNPNARRMAEMIQSDWAKIGVKAKIVTYEWGEYLKR
HHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHH
AKAGEHQTVMMGWTGDNGDPDNFFATLFSCAAAKDGSNYSRWCYKPFEDLIQPARAESNH
HCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHCCCCCC
DKRIELYKQAQVVMHDQAPALIVAHSTVYEPVRKEVKGYVVDPLGKHHFENVSLD
CHHHHHHHHHHEEEECCCCEEEEECHHHHHHHHHHHCCEEECCCCCHHCCCCCCC
>Mature Secondary Structure 
TSSLGKTGILKFGIGLIALTVAASVQAKTLVYCSEGSPEGFNPQLFTSGTTYDASSVPI
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCH
YNRLVEFKIGTTELQPGLAEKWDVSEDGKIYTFHLRKGVKWQSSKDFKPTRDFNADDVVF
HHHEEEEEECCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEE
SFERQLDAKNAYHKVSGGSYEYFEGMDMPKLIAKIEKVDDYTVRFVLTRPEAPFVADLGM
EHHHHHCHHHHHEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEHHHCC
DFASILSAEYADVMMKAGTPEKIDLNPIGTGPFQLLQYQKDSKILYKAFDGFWGTKPKID
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHCCCCCEEHHHHCCCCCCCCCCC
RLVFSITPDASVRYAKLQKNECQVMPYPNPADIARMKQDKTINLMEQPGLNVGYLSFNVE
EEEEEECCCCCEEEEEECCCCCEEECCCCHHHHHHHCCCCCEEHHHCCCCEEEEEEEECC
KKPLDNLKVRQALTLAVNKQAIIDAVYQGAGQAAKNLIPPTMWGYNDAVKDYTYDPVKAK
CCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHCCCCCCHHHH
ELLKEAGMADGFSIDLWAMPVQRPYNPNARRMAEMIQSDWAKIGVKAKIVTYEWGEYLKR
HHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHH
AKAGEHQTVMMGWTGDNGDPDNFFATLFSCAAAKDGSNYSRWCYKPFEDLIQPARAESNH
HCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHCCCCCC
DKRIELYKQAQVVMHDQAPALIVAHSTVYEPVRKEVKGYVVDPLGKHHFENVSLD
CHHHHHHHHHHEEEECCCCEEEEECHHHHHHHHHHHCCEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]