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The map label for this gene is uhpA [H]

Identifier: 157368381

GI number: 157368381

Start: 141077

End: 141667

Strand: Direct

Name: uhpA [H]

Synonym: Spro_0132

Alternate gene names: 157368381

Gene position: 141077-141667 (Clockwise)

Preceding gene: 157368380

Following gene: 157368382

Centisome position: 2.59

GC content: 60.41

Gene sequence:

>591_bases
ATGACCTTGCGCGTGGCGTTTATTGACGATCATGACATTGTGCGATCGGGCTTTGTGCAACTGCTGTCGCTGGAGCCGGA
TATTCAGGTGGTCGGCGAGTTCAGCAGCGCGGCTCAGGCACGCGCCGGCCTGCCCGGTCTGGAGGCGGAAATCTGTATCT
GTGATATTTCGATGCCGGACGGCAGCGGGCTGGATCTGCTGGCGGACATTCCCTCCGGTATTCGGGTGGTGATGCTGTCG
ATGCATGACAACCCGGCGCTGGTGGAGCTGGCACTGGAACGCGGTGCCTGCGGGTTCTTGTCCAAACGCTGCAAGCCGGA
AGATTTGATCACCGCGGTACGCACCGTCGCCAGCGGTGGCGTGTATCTGATGCCTGAAATCGCCCAGCAACTGGCGCGAG
TGAAGGTAGACCCACTGACCCGTCGTGAACGCGAAATCGCACTGTTGCTGGCGCAAGGACAGGAGGTGCGGGAGATTGCT
GTCGCGCTGGGGCTGTCACCCAAAACGGTACACGTGCATCGCGCCAATCTGTTCGCCAAGCTGGGTATCAACAACAACGT
CGAGCTGGCGAAGCGGATGCTGAACCTGTGA

Upstream 100 bases:

>100_bases
CTGCGCCCGGTAAAATCTGCTTATACCTTCCTTTCATCAACTAATCTGGCTCAGGCTTGCGCTATACTTGCGCACTTTCC
CCCTCGGACCGGAGATTTCC

Downstream 100 bases:

>100_bases
TGCAACGCCTGATCACCCAACTGGCGTTGTTCTTTATCTATGCCACCAGTGCATTTTGCCTGTGGGGGATTGGCACCGCG
CTGATCGACCCGCCGTGGCA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTLRVAFIDDHDIVRSGFVQLLSLEPDIQVVGEFSSAAQARAGLPGLEAEICICDISMPDGSGLDLLADIPSGIRVVMLS
MHDNPALVELALERGACGFLSKRCKPEDLITAVRTVASGGVYLMPEIAQQLARVKVDPLTRREREIALLLAQGQEVREIA
VALGLSPKTVHVHRANLFAKLGINNNVELAKRMLNL

Sequences:

>Translated_196_residues
MTLRVAFIDDHDIVRSGFVQLLSLEPDIQVVGEFSSAAQARAGLPGLEAEICICDISMPDGSGLDLLADIPSGIRVVMLS
MHDNPALVELALERGACGFLSKRCKPEDLITAVRTVASGGVYLMPEIAQQLARVKVDPLTRREREIALLLAQGQEVREIA
VALGLSPKTVHVHRANLFAKLGINNNVELAKRMLNL
>Mature_195_residues
TLRVAFIDDHDIVRSGFVQLLSLEPDIQVVGEFSSAAQARAGLPGLEAEICICDISMPDGSGLDLLADIPSGIRVVMLSM
HDNPALVELALERGACGFLSKRCKPEDLITAVRTVASGGVYLMPEIAQQLARVKVDPLTRREREIALLLAQGQEVREIAV
ALGLSPKTVHVHRANLFAKLGINNNVELAKRMLNL

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=65.2849740932643, Blast_Score=257, Evalue=4e-70,
Organism=Escherichia coli, GI1788222, Length=200, Percent_Identity=35, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1788521, Length=196, Percent_Identity=33.1632653061224, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=37.1584699453552, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1788546, Length=200, Percent_Identity=30.5, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1786747, Length=195, Percent_Identity=30.2564102564103, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788712, Length=183, Percent_Identity=24.5901639344262, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21200; Mature: 21069

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRVAFIDDHDIVRSGFVQLLSLEPDIQVVGEFSSAAQARAGLPGLEAEICICDISMPD
CEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCEEEEEEEECCC
GSGLDLLADIPSGIRVVMLSMHDNPALVELALERGACGFLSKRCKPEDLITAVRTVASGG
CCCCEEEECCCCCEEEEEEEECCCCEEEEEEHHCCCCHHHHCCCCHHHHHHHHHHHHCCC
VYLMPEIAQQLARVKVDPLTRREREIALLLAQGQEVREIAVALGLSPKTVHVHRANLFAK
EEECHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCEEEE
LGINNNVELAKRMLNL
ECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TLRVAFIDDHDIVRSGFVQLLSLEPDIQVVGEFSSAAQARAGLPGLEAEICICDISMPD
EEEEEEECCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCEEEEEEEECCC
GSGLDLLADIPSGIRVVMLSMHDNPALVELALERGACGFLSKRCKPEDLITAVRTVASGG
CCCCEEEECCCCCEEEEEEEECCCCEEEEEEHHCCCCHHHHCCCCHHHHHHHHHHHHCCC
VYLMPEIAQQLARVKVDPLTRREREIALLLAQGQEVREIAVALGLSPKTVHVHRANLFAK
EEECHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCEEEE
LGINNNVELAKRMLNL
ECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]