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The map label for this gene is uhpB [H]

Identifier: 157368382

GI number: 157368382

Start: 141667

End: 143208

Strand: Direct

Name: uhpB [H]

Synonym: Spro_0133

Alternate gene names: 157368382

Gene position: 141667-143208 (Clockwise)

Preceding gene: 157368381

Following gene: 157368383

Centisome position: 2.6

GC content: 61.48

Gene sequence:

>1542_bases
ATGCAACGCCTGATCACCCAACTGGCGTTGTTCTTTATCTATGCCACCAGTGCATTTTGCCTGTGGGGGATTGGCACCGC
GCTGATCGACCCGCCGTGGCAGGCGTTGTTGCTGTTCCCGTTTGGTCTGCGTATGGGCATTCTGCTGCAAAGCCCTTACC
GCTTCTGGCCGGGCATCCTGTTGGCCGACCTACTGCTGATGGTGGTGTTGGCCGATCAGTTCGGTTACGGGCCGGCACTG
TGGGCTTCGGTGGTGGTGCTGCTACTGACGGTGTTGCTTAGCCTGGTGGCCTCCCCCTGGTTGCTGCGGCATCAGGAAAG
TGACAGCGAATGGCAATGGCCATTGATGCAGGGCGCGGTAGTGGCGGTGGCCGCGTTGCTGCAGGCGCTGGTGTGGCAGT
TAGTGAACGGCGAGGGTGCCCGTGCGCTGCTGCTCGGGTTGGCTGGCGGTTTTACCATTGCCCCAACCTGTCTGCTGCTG
TGGCACTATCTGGCGCGGCAGATCTGGGTGCCGCTTGAACCGGGCCTGATCCATAAGCCGGTGACGCTAAGGTTGCGCCA
TCTGGCCAGCTATTTGCTGCTGTTTGCGCTCAGTATCTGGCTGCAACAGCAGGTTAATGCCGCTGAGCTGCGTCGCTTCG
CGCCGTTTTGTCTGGCCATCCCGATAGTCTTTATGTCCTATCGCTACGGCTGGCAGGGCGCGCTGTTGGCAACCTTGCTT
AATGGGGTGGTGCTGGTAGCCAACGAACCGCCACAGCCCGAATCGCACCGTGATTTACTGTTGTCGCTGCTGGCCCAGAG
CCTGACCGGTCTGTTGCTCGGCGCGGGTATTCAACGCCAGCGCGAGCTGAACCAGCAACTGCGGCTGCGGCTGACGGAAA
ACCGCCAACTGGCGCGCGCGCTGGTCACGGCAGAAGAACAGACCCGGCGCGAGGTGGCGCGGGAGCTGCACGACGAGGTC
GGTCAAACCATCACCGTGATCCGCACCCAGGCCAGTATTATCAAGCGTTTGGCACCGCAGCCGCAGGTGATGGGCTGCGC
CGAGGCGATAGATACCCTGGCGCTGCGGGTGTATGACGGCGTCCACGACGTGTTGACGCAACTGTGGCCGGCTGCGTTGA
ATAATTTGCCGCTGTCGGCGGCGGTGGCGGCGATGCTGCGCGAATCGCTGCCGCAGGATACGTCGCTGGTGAGCGTGATG
CAGTGGCAGGTACCGGATGAGTTGCTGGATGAGACGTTGAAAATTACGCTGTATCGGGTGTGTCAGGAAGGGGTGACCAA
TGTCTGTCGTCACGCCACCGCCAGCCGGATTGAGCTGGATGCACGTCTTCGTCAGCGCAAAGGGCGGTTGCCGCAAGTCT
TGCTGACCATTCGCGATAACGGCGTCGGTATCGATCTGGCCCATCATGAGCCGGGTTATGGTCTGCGCGGCATGCAGGAG
CGCATCAGTGCGCTGGGCGGCCGCCTGCGGCTGACGTCGGAGAATGGCACCTGTTTGAATGTGATCTTACCCACAGTTTC
ACCGGCGGAAGGGCCAAACTAG

Upstream 100 bases:

>100_bases
GGCTGTCACCCAAAACGGTACACGTGCATCGCGCCAATCTGTTCGCCAAGCTGGGTATCAACAACAACGTCGAGCTGGCG
AAGCGGATGCTGAACCTGTG

Downstream 100 bases:

>100_bases
GAAATACTCCTAGCCGCGTCGGGAATCCGGCGTAAGTCATTTTCGCGCGCGCGCAGCATGATAGCGGCACTTTTCATATT
CTCTGAGGTTTCACATGTGG

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQRLITQLALFFIYATSAFCLWGIGTALIDPPWQALLLFPFGLRMGILLQSPYRFWPGILLADLLLMVVLADQFGYGPAL
WASVVVLLLTVLLSLVASPWLLRHQESDSEWQWPLMQGAVVAVAALLQALVWQLVNGEGARALLLGLAGGFTIAPTCLLL
WHYLARQIWVPLEPGLIHKPVTLRLRHLASYLLLFALSIWLQQQVNAAELRRFAPFCLAIPIVFMSYRYGWQGALLATLL
NGVVLVANEPPQPESHRDLLLSLLAQSLTGLLLGAGIQRQRELNQQLRLRLTENRQLARALVTAEEQTRREVARELHDEV
GQTITVIRTQASIIKRLAPQPQVMGCAEAIDTLALRVYDGVHDVLTQLWPAALNNLPLSAAVAAMLRESLPQDTSLVSVM
QWQVPDELLDETLKITLYRVCQEGVTNVCRHATASRIELDARLRQRKGRLPQVLLTIRDNGVGIDLAHHEPGYGLRGMQE
RISALGGRLRLTSENGTCLNVILPTVSPAEGPN

Sequences:

>Translated_513_residues
MQRLITQLALFFIYATSAFCLWGIGTALIDPPWQALLLFPFGLRMGILLQSPYRFWPGILLADLLLMVVLADQFGYGPAL
WASVVVLLLTVLLSLVASPWLLRHQESDSEWQWPLMQGAVVAVAALLQALVWQLVNGEGARALLLGLAGGFTIAPTCLLL
WHYLARQIWVPLEPGLIHKPVTLRLRHLASYLLLFALSIWLQQQVNAAELRRFAPFCLAIPIVFMSYRYGWQGALLATLL
NGVVLVANEPPQPESHRDLLLSLLAQSLTGLLLGAGIQRQRELNQQLRLRLTENRQLARALVTAEEQTRREVARELHDEV
GQTITVIRTQASIIKRLAPQPQVMGCAEAIDTLALRVYDGVHDVLTQLWPAALNNLPLSAAVAAMLRESLPQDTSLVSVM
QWQVPDELLDETLKITLYRVCQEGVTNVCRHATASRIELDARLRQRKGRLPQVLLTIRDNGVGIDLAHHEPGYGLRGMQE
RISALGGRLRLTSENGTCLNVILPTVSPAEGPN
>Mature_513_residues
MQRLITQLALFFIYATSAFCLWGIGTALIDPPWQALLLFPFGLRMGILLQSPYRFWPGILLADLLLMVVLADQFGYGPAL
WASVVVLLLTVLLSLVASPWLLRHQESDSEWQWPLMQGAVVAVAALLQALVWQLVNGEGARALLLGLAGGFTIAPTCLLL
WHYLARQIWVPLEPGLIHKPVTLRLRHLASYLLLFALSIWLQQQVNAAELRRFAPFCLAIPIVFMSYRYGWQGALLATLL
NGVVLVANEPPQPESHRDLLLSLLAQSLTGLLLGAGIQRQRELNQQLRLRLTENRQLARALVTAEEQTRREVARELHDEV
GQTITVIRTQASIIKRLAPQPQVMGCAEAIDTLALRVYDGVHDVLTQLWPAALNNLPLSAAVAAMLRESLPQDTSLVSVM
QWQVPDELLDETLKITLYRVCQEGVTNVCRHATASRIELDARLRQRKGRLPQVLLTIRDNGVGIDLAHHEPGYGLRGMQE
RISALGGRLRLTSENGTCLNVILPTVSPAEGPN

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=507, Percent_Identity=46.5483234714004, Blast_Score=350, Evalue=9e-98,
Organism=Escherichia coli, GI1788812, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56968; Mature: 56968

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLITQLALFFIYATSAFCLWGIGTALIDPPWQALLLFPFGLRMGILLQSPYRFWPGIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCHHHH
LADLLLMVVLADQFGYGPALWASVVVLLLTVLLSLVASPWLLRHQESDSEWQWPLMQGAV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHH
VAVAALLQALVWQLVNGEGARALLLGLAGGFTIAPTCLLLWHYLARQIWVPLEPGLIHKP
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VTLRLRHLASYLLLFALSIWLQQQVNAAELRRFAPFCLAIPIVFMSYRYGWQGALLATLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NGVVLVANEPPQPESHRDLLLSLLAQSLTGLLLGAGIQRQRELNQQLRLRLTENRQLARA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
LVTAEEQTRREVARELHDEVGQTITVIRTQASIIKRLAPQPQVMGCAEAIDTLALRVYDG
HHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VHDVLTQLWPAALNNLPLSAAVAAMLRESLPQDTSLVSVMQWQVPDELLDETLKITLYRV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
CQEGVTNVCRHATASRIELDARLRQRKGRLPQVLLTIRDNGVGIDLAHHEPGYGLRGMQE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCCHHH
RISALGGRLRLTSENGTCLNVILPTVSPAEGPN
HHHHCCCEEEEECCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MQRLITQLALFFIYATSAFCLWGIGTALIDPPWQALLLFPFGLRMGILLQSPYRFWPGIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCHHHH
LADLLLMVVLADQFGYGPALWASVVVLLLTVLLSLVASPWLLRHQESDSEWQWPLMQGAV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHH
VAVAALLQALVWQLVNGEGARALLLGLAGGFTIAPTCLLLWHYLARQIWVPLEPGLIHKP
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VTLRLRHLASYLLLFALSIWLQQQVNAAELRRFAPFCLAIPIVFMSYRYGWQGALLATLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NGVVLVANEPPQPESHRDLLLSLLAQSLTGLLLGAGIQRQRELNQQLRLRLTENRQLARA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
LVTAEEQTRREVARELHDEVGQTITVIRTQASIIKRLAPQPQVMGCAEAIDTLALRVYDG
HHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VHDVLTQLWPAALNNLPLSAAVAAMLRESLPQDTSLVSVMQWQVPDELLDETLKITLYRV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
CQEGVTNVCRHATASRIELDARLRQRKGRLPQVLLTIRDNGVGIDLAHHEPGYGLRGMQE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCCHHH
RISALGGRLRLTSENGTCLNVILPTVSPAEGPN
HHHHCCCEEEEECCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]