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The map label for this gene is norR

Identifier: 157157873

GI number: 157157873

Start: 2991444

End: 2992958

Strand: Reverse

Name: norR

Synonym: EcE24377A_2992

Alternate gene names: 157157873

Gene position: 2992958-2991444 (Counterclockwise)

Preceding gene: 157156292

Following gene: 157155764

Centisome position: 60.1

GC content: 56.83

Gene sequence:

>1515_bases
ATGAGTTTTTCCGTTGATGTGCTGGCGAATATCGCCATCGAATTGCAGCGTGGGATTGGTCATCAGGATCGTTTTCAGCG
CCTGATCACCACGCTACGTCAGGTGCTGGAGTGCGATGCGTCTGCGTTGCTACGTTACGATTCGCGGCAGTTTATTCCGC
TTGCCATCGACGGTCTGGCAAAGGATGTACTCGGTAGACGCTTTGCGCTGGAAGGGCATCCACGGCTGGAAGCGATTGCC
CGCGCCGGGGATGTGGTGCGCTTTCCTGCAGACAGCGAATTGCCCGATCCCTATGACGGTTTGATTCCTGGGCAGGAGAG
TCTGAAGGTTCACGCCTGCGTTGGTCTGCCATTGTTTGCCGGGCAAAACCTGATCGGCGCACTGACGCTCGACGGGATGC
AGCCCGATCAGTTCGATGTTTTCAGCGACGAAGAGCTACGGCTGATTGCTGCGCTGGCGGCGGGAGCGTTAAGCAATGCG
TTGCTGATTGAACAACTGGAAAGCCAGAATATGATGCCAGGCGATGCCACGCCGTTTGAAGCGGTGAAACAGACGCAGAT
GATTGGCTTGTCCCCTGGCATGACGCAACTGAAAAAAGAGATTGAGATTGTGGCGGCGTCCGATCTCAACGTCCTGATCA
GCGGTGAGACGGGAACCGGTAAGGAGCTGGTGGCGAAAGCGATTCATGAAGCCTCGCCACGGGCGGTGAATCCGCTGGTC
TATCTCAACTGTGCCGCACTGCCGGAAAGTGTGGCGGAAAGTGAGTTGTTCGGGCATGTGAAAGGAGCGTTTACTGGCGC
TATCAGTAACCGCAGCGGGAAGTTTGAAATGGCGGATAACGGCACTCTGTTTCTGGATGAGATCGGCGAGTTGTCGTTGG
CATTGCAGGCCAAGCTGCTGAGGGTGTTGCAGTATGGCGATATTCAGCGCGTTGGCGATGACCGCAGTTTGCGGGTCGAT
GTGCGCGTGCTGGCGGCGACTAACCGCGACTTACGCGAAGAGGTGCTGGCAGGGCGATTTCGCGCTGACTTGTTTCATCG
CCTGAGCGTGTTTCCACTTTCGGTGCCGCCGCTGCGTGAGCGGGGCGATGATGTCATTCTGCTGGCGGGGTATTTCTGCG
AGCAGTGTCGTTTGCGGCTGGGGCTCTCCCGCGTGGTATTAAGTGCCGGGGCGCGAAATTTACTGCAACACTACAGTTTT
CCGGGGAACGTGCGCGAACTGGAACATGCTATTCATCGGGCGGTAGTACTGTCGAGAGCCACTCGCAGCGGCGATGAAGT
GATTCTTGAGGCGCAACATTTTGCTTTTCCTGAGGTGACGTTGCCGCCGCCAGAAGCGGCAGCGGTGCCCGTTGTTAAGC
AAAATCTGCGTGAAGCGACAGAAGCGTTCCAGCGTGAAACCATTCGCCAGGCACTGGCACAAAATCATCACAACTGGGCT
GCCTGCGCGCGAATGCTGGAAACTGACGTCGCCAACCTGCATCGGCTGGCGAAACGTCTGGGATTGAAGGATTAA

Upstream 100 bases:

>100_bases
TCTATAAATAAAATTATGCTCATTAATGAGTAGTCAAAATGACTATCAATCAAATGGTCAATATGACAATATCTATAGTC
AAATTGACAGTGAGGCAAAG

Downstream 100 bases:

>100_bases
ATAATCCCGGCCTGATAGAAATCCTGCAAGTTAATTGCGCCGGTGAGTTTGCCGTTTTCATCTACCACCGGTGCGGCAGT
GATTTTGCGCTTCATCAGGA

Product: anaerobic nitric oxide reductase transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIA
RAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNA
LLIEQLESQNMMPGDATPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLV
YLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVD
VRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYSF
PGNVRELEHAIHRAVVLSRATRSGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWA
ACARMLETDVANLHRLAKRLGLKD

Sequences:

>Translated_504_residues
MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIA
RAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNA
LLIEQLESQNMMPGDATPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLV
YLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVD
VRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYSF
PGNVRELEHAIHRAVVLSRATRSGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWA
ACARMLETDVANLHRLAKRLGLKD
>Mature_503_residues
SFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIAR
AGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNAL
LIEQLESQNMMPGDATPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLVY
LNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDV
RVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYSFP
GNVRELEHAIHRAVVLSRATRSGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWAA
CARMLETDVANLHRLAKRLGLKD

Specific function: Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain

Homologues:

Organism=Escherichia coli, GI87082152, Length=504, Percent_Identity=98.8095238095238, Blast_Score=1003, Evalue=0.0,
Organism=Escherichia coli, GI1789087, Length=363, Percent_Identity=41.0468319559229, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI87082117, Length=316, Percent_Identity=47.1518987341772, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1790437, Length=313, Percent_Identity=46.9648562300319, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788550, Length=299, Percent_Identity=46.4882943143813, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI1788905, Length=316, Percent_Identity=39.873417721519, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1790299, Length=336, Percent_Identity=40.4761904761905, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1789233, Length=333, Percent_Identity=39.3393393393393, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=38.8198757763975, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1787583, Length=338, Percent_Identity=37.8698224852071, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1786524, Length=249, Percent_Identity=46.5863453815261, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789828, Length=247, Percent_Identity=36.0323886639676, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87081858, Length=207, Percent_Identity=34.2995169082126, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NORR_ECO24 (A7ZQD8)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001464017.1
- ProteinModelPortal:   A7ZQD8
- STRING:   A7ZQD8
- EnsemblBacteria:   EBESCT00000019590
- GeneID:   5587146
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_2992
- NMPDR:   fig|331111.3.peg.708
- eggNOG:   COG3604
- GeneTree:   EBGT00050000008657
- HOGENOM:   HBG740884
- OMA:   RATRNGD
- ProtClustDB:   PRK05022
- BioCyc:   ECOL331111:ECE24377A_2992-MONOMER
- GO:   GO:0005622
- GO:   GO:0006350
- HAMAP:   MF_01314
- InterPro:   IPR003593
- InterPro:   IPR003018
- InterPro:   IPR009057
- InterPro:   IPR002078
- SMART:   SM00382
- SMART:   SM00065

Pfam domain/function: PF01590 GAF; PF00158 Sigma54_activat; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 55208; Mature: 55077

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00675 SIGMA54_INTERACT_1; PS00676 SIGMA54_INTERACT_2; PS00688 SIGMA54_INTERACT_3; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEHHHHHHH
KDVLGRRFALEGHPRLEAIARAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFA
HHHHCCEEECCCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHC
GQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMMPGDATPFE
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLV
HHHHHHHCCCCCCHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
YLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLL
EEEEHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHHHHHHHHHHH
RVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRE
HHHHCCCHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYSFPGNVRELEHAIHRAVVLSRA
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TRSGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWA
CCCCCCEEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ACARMLETDVANLHRLAKRLGLKD
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLA
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEHHHHHHH
KDVLGRRFALEGHPRLEAIARAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFA
HHHHCCEEECCCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHC
GQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMMPGDATPFE
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLV
HHHHHHHCCCCCCHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
YLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLL
EEEEHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHHHHHHHHHHH
RVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRE
HHHHCCCHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYSFPGNVRELEHAIHRAVVLSRA
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TRSGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWA
CCCCCCEEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ACARMLETDVANLHRLAKRLGLKD
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA