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The map label for this gene is gnd [H]

Identifier: 157161537

GI number: 157161537

Start: 2161862

End: 2163268

Strand: Reverse

Name: gnd [H]

Synonym: EcHS_A2183

Alternate gene names: 157161537

Gene position: 2163268-2161862 (Counterclockwise)

Preceding gene: 157161538

Following gene: 157161536

Centisome position: 46.59

GC content: 51.53

Gene sequence:

>1407_bases
ATGTCCAAGCAACAGATCGGAGTTGTCGGTATGGCTGTGATGGGGCGTAACCTAGCGCTGAACATCGAAAGCCGTGGTTA
TACCGTCTCCGTTTTCAACCGCTCCCGTGAAAAGACCGAAGAAGTGATTGCCGAAAATCCAGGCAAGAAGCTGGTCCCTT
ACTATACAGTACAAGAGTTCGTTGAATCCCTTGAGACACCACGCCGTATCCTGTTGATGGTGAAGGCCGGGGCTGGCACC
GACAGCGCCATCGATTCCCTGAAGCCTTACCTCGACAAAGGCGACATCATCATTGATGGCGGCAACACCTTCTTCCAGGA
CACCATCCGTCGTAACCGTGAGCTGTCTGCCGAAGGTTTTAACTTTATCGGTACCGGTGTTTCCGGTGGTGAAGAGGGGG
CCCTGAAAGGGCCTTCCATCATGCCTGGTGGGCAGAAAGAAGCCTATGAGCTGGTTGCTCCGATTCTGGAGCAGATTGCT
GCAGTTGCTGAAGATGGTGAGCCATGTGTGACCTATATCGGTGCTGATGGCGCTGGCCATTATGTGAAGATGGTTCATAA
CGGCATCGAGTATGGAGACATGCAGCTGATTGCTGAAGCTTATGCGCTGTTGAAAGGCGGTCTGGCACTTTCCAACGAAG
AGCTGGCGCAAACCTTCACCGAATGGAACGAAGGCGAGCTAAGCAGCTACCTGATCGATATTACCAAAGATATCTTCACC
AAGAAGGATGAAGAGGGTAAATACCTCGTTGATGTTATTCTTGATGAAGCAGCAAACAAAGGTACCGGCAAGTGGACCAG
CCAGAGCTCACTGGATCTTGGCGAACCTCTGTCTCTGATCACCGAGTCCGTGTTTGCTCGCTATATTTCTTCGCTTAAAG
ACCAGCGTGTAGCCGCGTCGAAAGTGCTGAGTGGTCCGCAGGCTCAACCGGCCGGTGATAAAGCGGAATTTATCGAAAAA
GTGCGTCGCGCGTTGTACCTCGGTAAAATCGTTTCCTATGCTCAGGGCTTCTCCCAGCTGCGTGCAGCTTCTGATGAATA
CAACTGGGATCTTAACTACGGCGAGATCGCTAAGATTTTCCGCGCTGGCTGTATCATTCGTGCGCAGTTCCTGCAGAAGA
TCACCGATGCTTATGCGCAAAACGCTGGCATTGCTAACCTCTTGCTGGCGCCGTACTTCAAACAGATCGCTGATGACTAT
CAGCAAGCGCTGCGTGATGTCGTGGCTTATGCTGTGCAGAATGGTATTCCGGTACCGACGTTCTCTGCTGCAATTGCCTA
CTATGACAGCTACCGTTCTGCGGTTCTGCCGGCTAACCTGATTCAGGCTCAGCGTGATTACTTTGGTGCGCACACCTATA
AGCGCACTGATAAGGAAGGCGTTTTCCATACTGAGTGGTTAGATTAA

Upstream 100 bases:

>100_bases
TTTTTGTTATACTTTTAATCAAAAATTATAGTATAACTAGTTAGCTGGTCAAGGTCAGTTATTAATGTGATATTGTTTGA
TTCACCTACAGGAGTATGTA

Downstream 100 bases:

>100_bases
TATTTATCTTATTAGACCTCCTGAAATTTATTGGAGGTCTAATATTAAAGTACATATATAATCAAGTTCTATTCTGACAA
ATAGCAGAAAATTAAGAGTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVQEFVESLETPRRILLMVKAGAGT
DSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIA
AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEWNEGELSSYLIDITKDIFT
KKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEK
VRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADDY
QQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWLD

Sequences:

>Translated_468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVQEFVESLETPRRILLMVKAGAGT
DSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIA
AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEWNEGELSSYLIDITKDIFT
KKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEK
VRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADDY
QQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWLD
>Mature_467_residues
SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVQEFVESLETPRRILLMVKAGAGTD
SAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAA
VAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEWNEGELSSYLIDITKDIFTK
KDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKV
RRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADDYQ
QALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWLD

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=469, Percent_Identity=53.5181236673774, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=95.9401709401709, Blast_Score=926, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=50.1061571125265, Blast_Score=492, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=50.1089324618736, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=49.5575221238938, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=51.063829787234, Blast_Score=457, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51404; Mature: 51272

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVQEF
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VESLETPRRILLMVKAGAGTDSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGF
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAAVAEDGEPCVTYIGADGAGH
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
YVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEWNEGELSSYLIDITKDIFT
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAAS
CCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIF
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADDYQQALRDVVAYAVQNGIPVPT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWLD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCC
>Mature Secondary Structure 
SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVQEF
CCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VESLETPRRILLMVKAGAGTDSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGF
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEQIAAVAEDGEPCVTYIGADGAGH
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
YVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEWNEGELSSYLIDITKDIFT
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAAS
CCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIF
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADDYQQALRDVVAYAVQNGIPVPT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFHTEWLD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]