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The map label for this gene is yeaE

Identifier: 157161242

GI number: 157161242

Start: 1882759

End: 1883613

Strand: Reverse

Name: yeaE

Synonym: EcHS_A1866

Alternate gene names: 157161242

Gene position: 1883613-1882759 (Counterclockwise)

Preceding gene: 157161243

Following gene: 157161239

Centisome position: 40.56

GC content: 50.53

Gene sequence:

>855_bases
ATGCAACAAAAAATGATTCAATTTAGTGGCGATGTCTCACTGCCAGCCGTAGGGCAGGGAACATGGTATATGGGCGAAGA
TGCCAGTCAGCGCAAAACAGAAGTTGCTGCACTACGCGCGGGCATTGAACTCGGTTTAACCCTCATTGATACCGCCGAAA
TGTATGCCGATGGCGGTGCCGAAAAGGTGGTTGGGGAAGCATTAACCGGTCTGCGAGAGAAGGTCTTTCTCGTCTCTAAA
GTCTATCCGTGGAATGCTGGCGGGCAAAAAGCGATAAATGCATGCGAAGCCAGTTTACGCCGTCTCAATACTGATTATCT
CGATCTTTACTTATTACACTGGTCTGGCAGTTTCGCTTTTGAAGAGACTGTCGCAGCGATGGAAAAATTGATCGCCCAGG
GAAAAATCCGCCGCTGGGGCGTTTCTAACCTTGATTATGCTGATATGCAGGAACTCTGGCAGCTGCCGGGGGGAAATCAG
TGTGCCACTAATCAGGTGCTTTACCATCTCGGTTCACGAGGAATTGAGTACGATCTACTCCCCTGGTGCCAGCAACAGCA
GATGCCGGTGATGGCTTACAGTCCGTTAGCCCAGGCCGGGCGGTTGCGCAATGGACTGTTAAAAAACGCGGTAGTCAACG
AAATTGCACATGCTCACAATATCAGCGCGGCACAAGTATTGTTGGCGTGGGTGATCAGTCATCAGGGTGTGATGGCGATT
CCAAAAGCGGCCACGATTGCCCATGTCCAACAAAATGCGGCTGTGCTTGAGGTCGAACTTTCTTCAGCGGAATTAGCTAT
GCTGGATAAGGCATATCCGGCACCAAAAGGAAAAACTGCGCTGGATATGGTGTGA

Upstream 100 bases:

>100_bases
ACAAATTCTGATAATGCATCTTTCCAGGGCATTTTGTGCATAAAAACAGGGCGTCACGCCCTGTTTTGCATTACGGTGGT
GCAATACCTGGGAGGAAACA

Downstream 100 bases:

>100_bases
TGTTGTGTGCCGGATGCATCGCACCCGGCACACAACATTAACGTAAATTAACGTTTCGCAACGCGAATGGATTGCGCCAG
ATGTGCAGGTTTCTCTTTGG

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSK
VYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQ
CATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV

Sequences:

>Translated_284_residues
MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSK
VYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQ
CATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
>Mature_284_residues
MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSK
VYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQ
CATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=297, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=30.9433962264151, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=27.8688524590164, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=28.719723183391, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=28.719723183391, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI5174695, Length=302, Percent_Identity=27.4834437086093, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI300116273, Length=288, Percent_Identity=28.4722222222222, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=29.0909090909091, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4502049, Length=290, Percent_Identity=30, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI300116271, Length=281, Percent_Identity=27.7580071174377, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI24497585, Length=290, Percent_Identity=27.9310344827586, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI45446745, Length=295, Percent_Identity=27.4576271186441, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4503285, Length=295, Percent_Identity=27.4576271186441, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310109920, Length=295, Percent_Identity=27.4576271186441, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI5453543, Length=295, Percent_Identity=27.1186440677966, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI24497583, Length=291, Percent_Identity=27.1477663230241, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI223718702, Length=200, Percent_Identity=32, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI41327764, Length=171, Percent_Identity=30.9941520467836, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=100, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1786400, Length=269, Percent_Identity=28.996282527881, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87081735, Length=301, Percent_Identity=28.9036544850498, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788070, Length=313, Percent_Identity=27.4760383386581, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082198, Length=262, Percent_Identity=29.0076335877863, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789199, Length=351, Percent_Identity=28.7749287749288, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789375, Length=323, Percent_Identity=24.1486068111455, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994888, Length=235, Percent_Identity=31.063829787234, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787674, Length=260, Percent_Identity=23.0769230769231, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=30.03663003663, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17561298, Length=280, Percent_Identity=31.7857142857143, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71998625, Length=277, Percent_Identity=30.3249097472924, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=27.6872964169381, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17537077, Length=297, Percent_Identity=29.2929292929293, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17537075, Length=297, Percent_Identity=29.2929292929293, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538386, Length=290, Percent_Identity=29.6551724137931, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561300, Length=293, Percent_Identity=28.6689419795222, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17566692, Length=299, Percent_Identity=25.0836120401338, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=297, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537079, Length=302, Percent_Identity=21.1920529801325, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324694, Length=293, Percent_Identity=27.6450511945392, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320079, Length=291, Percent_Identity=27.1477663230241, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322556, Length=283, Percent_Identity=26.5017667844523, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323998, Length=305, Percent_Identity=24.5901639344262, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319958, Length=294, Percent_Identity=24.1496598639456, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24644950, Length=312, Percent_Identity=32.0512820512821, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221378297, Length=332, Percent_Identity=30.7228915662651, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45553081, Length=290, Percent_Identity=24.8275862068966, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=25.9515570934256, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24663317, Length=299, Percent_Identity=23.4113712374582, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=25.7936507936508, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129731, Length=297, Percent_Identity=25.5892255892256, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356425, Length=298, Percent_Identity=23.489932885906, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=27.2108843537415, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24662781, Length=288, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YEAE_ECOLI (P76234)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   E64938
- RefSeq:   AP_002400.1
- RefSeq:   NP_416295.1
- ProteinModelPortal:   P76234
- SMR:   P76234
- STRING:   P76234
- EnsemblBacteria:   EBESCT00000001426
- EnsemblBacteria:   EBESCT00000017499
- GeneID:   946302
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1770
- KEGG:   eco:b1781
- EchoBASE:   EB3264
- EcoGene:   EG13491
- eggNOG:   COG0656
- GeneTree:   EBGT00050000009262
- HOGENOM:   HBG605727
- OMA:   ENRDCVS
- ProtClustDB:   CLSK880198
- BioCyc:   EcoCyc:G6967-MONOMER
- BioCyc:   MetaCyc:G6967-MONOMER
- Genevestigator:   P76234
- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210
- Gene3D:   G3DSA:3.20.20.100
- PANTHER:   PTHR11732
- PRINTS:   PR00069

Pfam domain/function: PF00248 Aldo_ket_red; SSF51430 Aldo/ket_red

EC number: NA

Molecular weight: Translated: 30987; Mature: 30987

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGA
CCCCEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
EKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAF
HHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHH
EETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
PWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEC
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
CCHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGA
CCCCEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
EKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAF
HHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHH
EETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
PWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEC
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
CCHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503