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The map label for this gene is ptxR [H]

Identifier: 156978226

GI number: 156978226

Start: 2106697

End: 2107617

Strand: Reverse

Name: ptxR [H]

Synonym: VIBHAR_07031

Alternate gene names: 156978226

Gene position: 2107617-2106697 (Counterclockwise)

Preceding gene: 156978230

Following gene: 156978225

Centisome position: 95.63

GC content: 49.29

Gene sequence:

>921_bases
ATGAATTCCATATTTGGAAACGTTGATGATCTTTACCTGTTTTGCTCAGTGGTTGAGCAAGGCTCTCTGCTCGCGGCGGC
GAAAAAGCTCGAACTGCCGGTCTCTACTATGTCTCGTCGTTTATCCGCGCTGGAAGCGCGCCTAGGATTGAGATTGCTGG
AGAAGAAAGGACGTGAGTTGGTGGCAACTGAGACAGGCTTACAGGCGTTTGATCAGCTCAGCAGTGCGATGGCGCAGATT
GAATCCGGCATCTTGCAGCTCAACCAGCAAAGCCAACAAGTCGAAGGGCGAATTAGATTGGTGATGCCAAGCCGCTTTTA
CAATGACTTAGTCGATAAGGTGGTTGAGGATTACATCAAAACCTACCCAAAAGTGACCATTGATCTGCTGCTTAGCCAAG
TGAATTCGATTCCAGAAACCGATCGCGATCTGGTGGTGACGTTCGATTTGGATGGTTTGGACGACATGATCGCGCGCCCA
TTGTTTAAAGTAGAGCACGCTTTCTTTGTTAGCCCTGAATATCTAGCGCAAGCGGGCGGCAATATTGAAACATTACAAGA
TTTAGCCAAGCAAGACTGGGTAGCCAGCACACACACCACACAAGTGCCTATCTATCAGCAAGACAAGCTGGTGGACATGC
TCAACTGCAAGCCGCGCTTAGTGGTCAATGACATAGCCGCGGTGATCAAAGCGGTGGAAAACGGTTTGGGAATTGCGTCG
ATCCCATTACGCCACGTTAAGCCTGAATTGAATCTCGTGCGCGTTGCGCCATCTTATAGCCGCGGGGATCGCGAAGCCTA
TTTGGTTTATCGTCAGCGTAACTATCAGCCTAAAGCGCTGACTTTAATGGTCGAAGCGATTTTGCAGGCTTCAGAGGAGC
GAAACCATTCATCCTCTCTCAATACCATTCACTCCGCATAA

Upstream 100 bases:

>100_bases
TCGTTATTACGCGCCGCGTTCACGGCATATTCGGGTCTCTTTTCTACGTGGGCTAGGTTATACTTATCTAAAATTGGAAA
AAATAACCAATGGAAGAAGT

Downstream 100 bases:

>100_bases
CTGCCATTGGTCGCATGTAAAAGCAGCGTGCGATCGTCTCCCTTAATCTGAAACCATCAAATCACGTTCAACTAAGGACA
GTACAGGATGGTTTCTCAAT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNSIFGNVDDLYLFCSVVEQGSLLAAAKKLELPVSTMSRRLSALEARLGLRLLEKKGRELVATETGLQAFDQLSSAMAQI
ESGILQLNQQSQQVEGRIRLVMPSRFYNDLVDKVVEDYIKTYPKVTIDLLLSQVNSIPETDRDLVVTFDLDGLDDMIARP
LFKVEHAFFVSPEYLAQAGGNIETLQDLAKQDWVASTHTTQVPIYQQDKLVDMLNCKPRLVVNDIAAVIKAVENGLGIAS
IPLRHVKPELNLVRVAPSYSRGDREAYLVYRQRNYQPKALTLMVEAILQASEERNHSSSLNTIHSA

Sequences:

>Translated_306_residues
MNSIFGNVDDLYLFCSVVEQGSLLAAAKKLELPVSTMSRRLSALEARLGLRLLEKKGRELVATETGLQAFDQLSSAMAQI
ESGILQLNQQSQQVEGRIRLVMPSRFYNDLVDKVVEDYIKTYPKVTIDLLLSQVNSIPETDRDLVVTFDLDGLDDMIARP
LFKVEHAFFVSPEYLAQAGGNIETLQDLAKQDWVASTHTTQVPIYQQDKLVDMLNCKPRLVVNDIAAVIKAVENGLGIAS
IPLRHVKPELNLVRVAPSYSRGDREAYLVYRQRNYQPKALTLMVEAILQASEERNHSSSLNTIHSA
>Mature_306_residues
MNSIFGNVDDLYLFCSVVEQGSLLAAAKKLELPVSTMSRRLSALEARLGLRLLEKKGRELVATETGLQAFDQLSSAMAQI
ESGILQLNQQSQQVEGRIRLVMPSRFYNDLVDKVVEDYIKTYPKVTIDLLLSQVNSIPETDRDLVVTFDLDGLDDMIARP
LFKVEHAFFVSPEYLAQAGGNIETLQDLAKQDWVASTHTTQVPIYQQDKLVDMLNCKPRLVVNDIAAVIKAVENGLGIAS
IPLRHVKPELNLVRVAPSYSRGDREAYLVYRQRNYQPKALTLMVEAILQASEERNHSSSLNTIHSA

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=285, Percent_Identity=24.9122807017544, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786401, Length=207, Percent_Identity=28.0193236714976, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787589, Length=290, Percent_Identity=24.8275862068966, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789440, Length=295, Percent_Identity=24.7457627118644, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788481, Length=283, Percent_Identity=25.0883392226148, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34215; Mature: 34215

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIFGNVDDLYLFCSVVEQGSLLAAAKKLELPVSTMSRRLSALEARLGLRLLEKKGREL
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
VATETGLQAFDQLSSAMAQIESGILQLNQQSQQVEGRIRLVMPSRFYNDLVDKVVEDYIK
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHH
TYPKVTIDLLLSQVNSIPETDRDLVVTFDLDGLDDMIARPLFKVEHAFFVSPEYLAQAGG
HCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHCCC
NIETLQDLAKQDWVASTHTTQVPIYQQDKLVDMLNCKPRLVVNDIAAVIKAVENGLGIAS
CHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
IPLRHVKPELNLVRVAPSYSRGDREAYLVYRQRNYQPKALTLMVEAILQASEERNHSSSL
CCHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHH
NTIHSA
HHHHCC
>Mature Secondary Structure
MNSIFGNVDDLYLFCSVVEQGSLLAAAKKLELPVSTMSRRLSALEARLGLRLLEKKGREL
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
VATETGLQAFDQLSSAMAQIESGILQLNQQSQQVEGRIRLVMPSRFYNDLVDKVVEDYIK
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHH
TYPKVTIDLLLSQVNSIPETDRDLVVTFDLDGLDDMIARPLFKVEHAFFVSPEYLAQAGG
HCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHCCC
NIETLQDLAKQDWVASTHTTQVPIYQQDKLVDMLNCKPRLVVNDIAAVIKAVENGLGIAS
CHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
IPLRHVKPELNLVRVAPSYSRGDREAYLVYRQRNYQPKALTLMVEAILQASEERNHSSSL
CCHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHH
NTIHSA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]