Click here to switch to the map view.

The map label for this gene is hlyB [H]

Identifier: 156978217

GI number: 156978217

Start: 2097579

End: 2099240

Strand: Direct

Name: hlyB [H]

Synonym: VIBHAR_07022

Alternate gene names: 156978217

Gene position: 2097579-2099240 (Clockwise)

Preceding gene: 156978216

Following gene: 156978218

Centisome position: 95.17

GC content: 48.92

Gene sequence:

>1662_bases
ATGAATCTGACGATCAGAAAACGACTATATATCCTTTCAATAATTCCAATTCTAACCATGGCAATAGGCATGATGTGGTT
TACCTATCTGCAAACCACGGCCTATAACGAACAAGAAATTGAGCAGACTCGAAGTCAAATGATGGAGATGAAAAAAGCTG
AGCTCAAAAACTACGTTCAACTCGCTCGCTCTGCTGTTGAGCCACTGCTCGCTCAAAACGCCCCACTAGATGAAGCATTG
CCTATTTTGCAGCAGTTGGAGTTTGGCCAATCCGGCTACATCTTTGGCTACGATTCAAAAGGCGTTCGCGTTGTGACGGG
TCAAAACACCAAAGGCATCGGAGAAAATTTCTATAACTTGCAAGACAAGAAAGGCAATTACCTGATTCAGGATTTGCTCA
ACAATTCCAAAACCGGAGAGTTCACGACTTATTACTTCCCGAAACTCGGTCAGAGCGAAGCACTACCGAAACTGAGCTAC
TCGGTGTTTATTCCTGAATGGGATTTGATGCTGGGTACAGGCTTTTACACTGACGATATCGACGCCATTATCGCGAGCAT
GGAAGACTCAGCGCATCAAGCCTTGAATACCACACTGACTGCAATCGCCCTGTTCTGTGTCTCGATTGCCGCCATCGTTG
CGATCTTCGCGGTGTTCGTTAACCGCAGCATCATGAAGCCGATTGAACAGTTTGATGCTTCGATTCACTCTTTCGCACAA
GGCGATGCAGACCTGACCGCACGCATGGAAGAATCAAGCGTACCGGAGTTCACCCAGCTTAGCCGCAACTTCAATACCTT
TGTTGAGAGCCTACAAAGCATCATCAAGAGCGTTAGCCACGTAGGGCAAGAAGTGGTTTCAGAAACCAATCACATGTCAC
AGCGAGCTTCTCAGGTGGATGAGCTGGCGTCTGGCCAACGAGAAGAGACGGAACAAGTCGCTGCGGCAATGACTGAAATG
ACGGCAACAGCGCACGAGATTTCAAGCAACGCTAATCAGGCTGCGCAATCAGCAAAAGATGCCGATAAAAACTCACAGCA
AGCGAAGCACATTGTTGATTCAGCAGCGAACTCCGTCGAAGCCCTTGCTTTAGAAGTTTCAGAAGCCAGCACGGTGATTT
CTCGTTTAGAGAGCGATGTACAAAACATTTCTTCTTCGCTAGAAGTGATTCAAGATATTGCCGAGCAAACCAACCTATTG
GCACTAAACGCCGCTATTGAAGCAGCCCGTGCAGGCGAACAAGGTCGCGGCTTCGCAGTCGTTGCCGATGAGGTTCGTAA
ACTGGCGAGTCGCACTCAAGACAGCACAGGCGAAATTCACCAAATGATTGAGCAGTTGAAGTCTGGCTCGGATGCGGCAG
TGAAAGCGATGGGCTCAAGCCAAGCGCGTGGTGAAGCTACGGTTGAAGAGGCAAGAGCTGCCTCTGCCGCACTGCAAGAA
ATCCAAGCCGCAATTGCTAACATCATGGACATGAACACACTGATCGCAACGGCAACCGAAGAGCAAAGCCAAGTTGGGCA
AGAGATTTCACAGCGCATCGAAGTGATCTCTCAACAAAGCAGTCAGTCGGCAAGCCTTGCGAATCAAAACCGTGCAGGCA
GTGGCAACCTTAACCACAAAGCCAACGAGCTGTACGACTTAGTCGGTCGCTTTACGGTCTAG

Upstream 100 bases:

>100_bases
GTTAATCTCTAAGCATTACAACAATAAGTATTAATAATTTCATCAGGCAAGCTTGTTCAGCTTGTTACTTGTAACGCTGC
GCCGAGAGAAGGACGTCTCT

Downstream 100 bases:

>100_bases
AGCTTTCCTCAAGCCCTCAACATGCAAACAGCGACGCCAAAACGTCGCTGTTTTTATTTCTGCTATCATAATGCGACTTA
GCTATAATGCCGCCAACTTA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MNLTIRKRLYILSIIPILTMAIGMMWFTYLQTTAYNEQEIEQTRSQMMEMKKAELKNYVQLARSAVEPLLAQNAPLDEAL
PILQQLEFGQSGYIFGYDSKGVRVVTGQNTKGIGENFYNLQDKKGNYLIQDLLNNSKTGEFTTYYFPKLGQSEALPKLSY
SVFIPEWDLMLGTGFYTDDIDAIIASMEDSAHQALNTTLTAIALFCVSIAAIVAIFAVFVNRSIMKPIEQFDASIHSFAQ
GDADLTARMEESSVPEFTQLSRNFNTFVESLQSIIKSVSHVGQEVVSETNHMSQRASQVDELASGQREETEQVAAAMTEM
TATAHEISSNANQAAQSAKDADKNSQQAKHIVDSAANSVEALALEVSEASTVISRLESDVQNISSSLEVIQDIAEQTNLL
ALNAAIEAARAGEQGRGFAVVADEVRKLASRTQDSTGEIHQMIEQLKSGSDAAVKAMGSSQARGEATVEEARAASAALQE
IQAAIANIMDMNTLIATATEEQSQVGQEISQRIEVISQQSSQSASLANQNRAGSGNLNHKANELYDLVGRFTV

Sequences:

>Translated_553_residues
MNLTIRKRLYILSIIPILTMAIGMMWFTYLQTTAYNEQEIEQTRSQMMEMKKAELKNYVQLARSAVEPLLAQNAPLDEAL
PILQQLEFGQSGYIFGYDSKGVRVVTGQNTKGIGENFYNLQDKKGNYLIQDLLNNSKTGEFTTYYFPKLGQSEALPKLSY
SVFIPEWDLMLGTGFYTDDIDAIIASMEDSAHQALNTTLTAIALFCVSIAAIVAIFAVFVNRSIMKPIEQFDASIHSFAQ
GDADLTARMEESSVPEFTQLSRNFNTFVESLQSIIKSVSHVGQEVVSETNHMSQRASQVDELASGQREETEQVAAAMTEM
TATAHEISSNANQAAQSAKDADKNSQQAKHIVDSAANSVEALALEVSEASTVISRLESDVQNISSSLEVIQDIAEQTNLL
ALNAAIEAARAGEQGRGFAVVADEVRKLASRTQDSTGEIHQMIEQLKSGSDAAVKAMGSSQARGEATVEEARAASAALQE
IQAAIANIMDMNTLIATATEEQSQVGQEISQRIEVISQQSSQSASLANQNRAGSGNLNHKANELYDLVGRFTV
>Mature_553_residues
MNLTIRKRLYILSIIPILTMAIGMMWFTYLQTTAYNEQEIEQTRSQMMEMKKAELKNYVQLARSAVEPLLAQNAPLDEAL
PILQQLEFGQSGYIFGYDSKGVRVVTGQNTKGIGENFYNLQDKKGNYLIQDLLNNSKTGEFTTYYFPKLGQSEALPKLSY
SVFIPEWDLMLGTGFYTDDIDAIIASMEDSAHQALNTTLTAIALFCVSIAAIVAIFAVFVNRSIMKPIEQFDASIHSFAQ
GDADLTARMEESSVPEFTQLSRNFNTFVESLQSIIKSVSHVGQEVVSETNHMSQRASQVDELASGQREETEQVAAAMTEM
TATAHEISSNANQAAQSAKDADKNSQQAKHIVDSAANSVEALALEVSEASTVISRLESDVQNISSSLEVIQDIAEQTNLL
ALNAAIEAARAGEQGRGFAVVADEVRKLASRTQDSTGEIHQMIEQLKSGSDAAVKAMGSSQARGEATVEEARAASAALQE
IQAAIANIMDMNTLIATATEEQSQVGQEISQRIEVISQQSSQSASLANQNRAGSGNLNHKANELYDLVGRFTV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=367, Percent_Identity=30.7901907356948, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI2367378, Length=540, Percent_Identity=28.3333333333333, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788194, Length=362, Percent_Identity=30.6629834254144, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788195, Length=307, Percent_Identity=30.6188925081433, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789453, Length=353, Percent_Identity=28.0453257790368, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 60277; Mature: 60277

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTIRKRLYILSIIPILTMAIGMMWFTYLQTTAYNEQEIEQTRSQMMEMKKAELKNYVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LARSAVEPLLAQNAPLDEALPILQQLEFGQSGYIFGYDSKGVRVVTGQNTKGIGENFYNL
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCHHCCC
QDKKGNYLIQDLLNNSKTGEFTTYYFPKLGQSEALPKLSYSVFIPEWDLMLGTGFYTDDI
CCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHCCCCCCHHHH
DAIIASMEDSAHQALNTTLTAIALFCVSIAAIVAIFAVFVNRSIMKPIEQFDASIHSFAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDADLTARMEESSVPEFTQLSRNFNTFVESLQSIIKSVSHVGQEVVSETNHMSQRASQVD
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELASGQREETEQVAAAMTEMTATAHEISSNANQAAQSAKDADKNSQQAKHIVDSAANSVE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ALALEVSEASTVISRLESDVQNISSSLEVIQDIAEQTNLLALNAAIEAARAGEQGRGFAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHHCCCCCCCEEH
VADEVRKLASRTQDSTGEIHQMIEQLKSGSDAAVKAMGSSQARGEATVEEARAASAALQE
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IQAAIANIMDMNTLIATATEEQSQVGQEISQRIEVISQQSSQSASLANQNRAGSGNLNHK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCH
ANELYDLVGRFTV
HHHHHHHHHHCCC
>Mature Secondary Structure
MNLTIRKRLYILSIIPILTMAIGMMWFTYLQTTAYNEQEIEQTRSQMMEMKKAELKNYVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LARSAVEPLLAQNAPLDEALPILQQLEFGQSGYIFGYDSKGVRVVTGQNTKGIGENFYNL
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCHHCCC
QDKKGNYLIQDLLNNSKTGEFTTYYFPKLGQSEALPKLSYSVFIPEWDLMLGTGFYTDDI
CCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHCCCCCCHHHH
DAIIASMEDSAHQALNTTLTAIALFCVSIAAIVAIFAVFVNRSIMKPIEQFDASIHSFAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDADLTARMEESSVPEFTQLSRNFNTFVESLQSIIKSVSHVGQEVVSETNHMSQRASQVD
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELASGQREETEQVAAAMTEMTATAHEISSNANQAAQSAKDADKNSQQAKHIVDSAANSVE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ALALEVSEASTVISRLESDVQNISSSLEVIQDIAEQTNLLALNAAIEAARAGEQGRGFAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHHCCCCCCCEEH
VADEVRKLASRTQDSTGEIHQMIEQLKSGSDAAVKAMGSSQARGEATVEEARAASAALQE
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IQAAIANIMDMNTLIATATEEQSQVGQEISQRIEVISQQSSQSASLANQNRAGSGNLNHK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCH
ANELYDLVGRFTV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]