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The map label for this gene is emrK [H]

Identifier: 156978099

GI number: 156978099

Start: 2002034

End: 2003059

Strand: Reverse

Name: emrK [H]

Synonym: VIBHAR_06903

Alternate gene names: 156978099

Gene position: 2003059-2002034 (Counterclockwise)

Preceding gene: 156978100

Following gene: 156978098

Centisome position: 90.88

GC content: 48.93

Gene sequence:

>1026_bases
ATGAGCGACGATATCGCGAAGAAATCCACTTCGAAATCCAAACTGACCAAAATCCTTTTCCTTCTCGTTTGTGTTATCGC
CTTCGGTGCGATGTACTGGTCTTGGCAATACTCTGACAGTCACCCAAGTACGGAAGACGCCTACGTAAGAGCTAAAATCC
TGTCTGTCGCTCCTCAGGTTCAAGGCCAAGTGATCTCGGTAGAAGCCAAAGATTTTCAAGTGGTGAACAAAGGCGACCTG
CTATTAAAGATTGATTCTCGCCCTTACCTGCTCGCAGTTAAACAAGCGAAAGCGGCTTATCAATTGGCGGTGCAACAGCA
CGACGTAGCCGACAAGCAAGTGACCGAAGCGGTGGCGGGATTGGATGCTGCACGCTCGAACCTGACCGAAGCGCAGTTGG
AGTACAAACGTACTAACTCGCTAGTGAAACGCAAATTAGCGTCTGACCAAGATTTGGATACCGCGAAGAACAAACTCGCG
AACGCTCAAGCGAGTTTAGAACAAGCACGTGCAACGGTTGAAAAAGCGATCGCGAACCGCGGTGAAGAAGGTGCAGAAGC
AGCGGTTGTTCAGCAAGCAGCGGCGCAACTTGCACAAGCTGAATTGAACCTGAGCTACACCGACATCACTTCTCCTGTCG
ATGGTATCGCGGGTGAAATCAACACACATACTGGTTCTGTTGTCGGCATTGGCCAAACACTGTTCCCTGTGATTGTAAAA
GACAGTTACTGGGTACGCGCAAACTTTAAAGAAACTGACCTAACACACATCAAAGCAGGCATGCATGCTGAAGTCGTGAT
CGACATGTACCCAGACGTAGTTTGGGATGCGAAAGTGGAAGAACTGTCGCCAGCAAGTGGTACCTCTTTCTCTTTGATGC
CACCAGAAAATGCAACTGGTAACTGGGTGAAAATCAAACAACGTTTCCCTGTGCGTTTGACGCTTGAAGTACCTGAAGGT
GCGCCACAATTACGTGTGGGTGCAAGCTCCGAAGTGACTGTTGATCTGAAAAGTAACGCACAATGA

Upstream 100 bases:

>100_bases
TCAACGCTTAAAATCGAAACTTAACCTTTCAGATCGTCTTGTTGTTCGGAAGCTGAAAAATCCTACACTAATCACATAAT
TGAACACTTGGACAATATAA

Downstream 100 bases:

>100_bases
GTAACGAGATTACGGCCGACAAACGGGGAATAGCCACCGTCGCCGTGATGCTTTCGGCCATCATGGTGCTGATAGACATG
ACCGTTGCTAACGTGTCGCT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSDDIAKKSTSKSKLTKILFLLVCVIAFGAMYWSWQYSDSHPSTEDAYVRAKILSVAPQVQGQVISVEAKDFQVVNKGDL
LLKIDSRPYLLAVKQAKAAYQLAVQQHDVADKQVTEAVAGLDAARSNLTEAQLEYKRTNSLVKRKLASDQDLDTAKNKLA
NAQASLEQARATVEKAIANRGEEGAEAAVVQQAAAQLAQAELNLSYTDITSPVDGIAGEINTHTGSVVGIGQTLFPVIVK
DSYWVRANFKETDLTHIKAGMHAEVVIDMYPDVVWDAKVEELSPASGTSFSLMPPENATGNWVKIKQRFPVRLTLEVPEG
APQLRVGASSEVTVDLKSNAQ

Sequences:

>Translated_341_residues
MSDDIAKKSTSKSKLTKILFLLVCVIAFGAMYWSWQYSDSHPSTEDAYVRAKILSVAPQVQGQVISVEAKDFQVVNKGDL
LLKIDSRPYLLAVKQAKAAYQLAVQQHDVADKQVTEAVAGLDAARSNLTEAQLEYKRTNSLVKRKLASDQDLDTAKNKLA
NAQASLEQARATVEKAIANRGEEGAEAAVVQQAAAQLAQAELNLSYTDITSPVDGIAGEINTHTGSVVGIGQTLFPVIVK
DSYWVRANFKETDLTHIKAGMHAEVVIDMYPDVVWDAKVEELSPASGTSFSLMPPENATGNWVKIKQRFPVRLTLEVPEG
APQLRVGASSEVTVDLKSNAQ
>Mature_340_residues
SDDIAKKSTSKSKLTKILFLLVCVIAFGAMYWSWQYSDSHPSTEDAYVRAKILSVAPQVQGQVISVEAKDFQVVNKGDLL
LKIDSRPYLLAVKQAKAAYQLAVQQHDVADKQVTEAVAGLDAARSNLTEAQLEYKRTNSLVKRKLASDQDLDTAKNKLAN
AQASLEQARATVEKAIANRGEEGAEAAVVQQAAAQLAQAELNLSYTDITSPVDGIAGEINTHTGSVVGIGQTLFPVIVKD
SYWVRANFKETDLTHIKAGMHAEVVIDMYPDVVWDAKVEELSPASGTSFSLMPPENATGNWVKIKQRFPVRLTLEVPEGA
PQLRVGASSEVTVDLKSNAQ

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=345, Percent_Identity=33.6231884057971, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1789041, Length=322, Percent_Identity=31.6770186335404, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790519, Length=311, Percent_Identity=30.8681672025724, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081951, Length=327, Percent_Identity=30.5810397553517, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789637, Length=314, Percent_Identity=26.4331210191083, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787013, Length=262, Percent_Identity=29.7709923664122, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790012, Length=253, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790024, Length=259, Percent_Identity=26.2548262548263, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789929, Length=181, Percent_Identity=27.0718232044199, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37026; Mature: 36895

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDIAKKSTSKSKLTKILFLLVCVIAFGAMYWSWQYSDSHPSTEDAYVRAKILSVAPQV
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCC
QGQVISVEAKDFQVVNKGDLLLKIDSRPYLLAVKQAKAAYQLAVQQHDVADKQVTEAVAG
CCEEEEEECCCEEEECCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHH
LDAARSNLTEAQLEYKRTNSLVKRKLASDQDLDTAKNKLANAQASLEQARATVEKAIANR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GEEGAEAAVVQQAAAQLAQAELNLSYTDITSPVDGIAGEINTHTGSVVGIGQTLFPVIVK
CCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCCCCCCCCEEECCHHHHHEEEC
DSYWVRANFKETDLTHIKAGMHAEVVIDMYPDVVWDAKVEELSPASGTSFSLMPPENATG
CCEEEEECCCCCCHHHHHCCCCEEEEEECCCCCEECCCHHHCCCCCCCEEEEECCCCCCC
NWVKIKQRFPVRLTLEVPEGAPQLRVGASSEVTVDLKSNAQ
CEEEEEECCCEEEEEECCCCCCCEEECCCCEEEEEECCCCC
>Mature Secondary Structure 
SDDIAKKSTSKSKLTKILFLLVCVIAFGAMYWSWQYSDSHPSTEDAYVRAKILSVAPQV
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCC
QGQVISVEAKDFQVVNKGDLLLKIDSRPYLLAVKQAKAAYQLAVQQHDVADKQVTEAVAG
CCEEEEEECCCEEEECCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHH
LDAARSNLTEAQLEYKRTNSLVKRKLASDQDLDTAKNKLANAQASLEQARATVEKAIANR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GEEGAEAAVVQQAAAQLAQAELNLSYTDITSPVDGIAGEINTHTGSVVGIGQTLFPVIVK
CCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCCCCCCCCEEECCHHHHHEEEC
DSYWVRANFKETDLTHIKAGMHAEVVIDMYPDVVWDAKVEELSPASGTSFSLMPPENATG
CCEEEEECCCCCCHHHHHCCCCEEEEEECCCCCEECCCHHHCCCCCCCEEEEECCCCCCC
NWVKIKQRFPVRLTLEVPEGAPQLRVGASSEVTVDLKSNAQ
CEEEEEECCCEEEEEECCCCCCCEEECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]