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The map label for this gene is cpxR [H]

Identifier: 156977967

GI number: 156977967

Start: 1895032

End: 1895697

Strand: Reverse

Name: cpxR [H]

Synonym: VIBHAR_06763

Alternate gene names: 156977967

Gene position: 1895697-1895032 (Counterclockwise)

Preceding gene: 156977970

Following gene: 156977966

Centisome position: 86.01

GC content: 46.1

Gene sequence:

>666_bases
ATGTCTCGAGTTTTGATCGTTGATGATGACGTTCCGTTGTGCGAACTGTTAGAAACTGTGCTGCAAGAAGAAGGCTACAC
GGTCTCATCGGTACACTGCGGTGAGAGTGCACTGCAGTACATGGAAAAAACACCAGTTGATCTCGTTCTCCTTGATGTAA
TGCTACCAAACTTAAACGGGATGCAAGTTGCTCGTCGTATTTGCCAACGTTTTGCCACGCCGATTTTGATGCTGACTGCG
CTCAATGATGAGAACTCAATGTTAGATGGTTATCAAGCGGGAGCTGACCAGTACATCGGTAAGCCATTTAACGTTGCAGA
GCTGTTGATGCGTATAAAAGCAATTCTTCGCCGCGTAGGGTTAGAGCGCCAGAGGCAAGCGATGTGTAATACGGTTCAAA
GTATCAGCGGCCAGTTGAACAGTTTGCCTCTGACTGGCACGGAAGCGGAACTACTTTGCTACTTGGTGAAAAACCAAGGT
GTTGTCATCTCCAAAGCTGAACTACAGACCCAAGTTTTGAAGAAAGAGCTCAGCCCTTTTGATCGCAACCTAGATATGCA
CATCAGCAATATTCGTCGAAAATTAGTGGAAGCTGGCTTGTCCAAACAGCATATAAAAACGTTTCGTGGGAAAGGCTACA
GCTACCTTGAAGCGGTAACGAGTTAA

Upstream 100 bases:

>100_bases
TTTGAGCCATTTACTGAAATAAAAACCACAAAAACTATGGTTGTTTAATTTGCAAATGAGTAATAGAATGCGAACCATTT
TTATTTAATGGTGGTTGGTA

Downstream 100 bases:

>100_bases
TGAAGTTCGTTTGCCCATCCTACATCGCTAAGCGCAGAGACAGTCTTGCCTTTCAGCTCTTTAGTTATATGACGGCTATT
GTCATTAGCATTTTGGCTGT

Product: transcriptional regulatory protein CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSRVLIVDDDVPLCELLETVLQEEGYTVSSVHCGESALQYMEKTPVDLVLLDVMLPNLNGMQVARRICQRFATPILMLTA
LNDENSMLDGYQAGADQYIGKPFNVAELLMRIKAILRRVGLERQRQAMCNTVQSISGQLNSLPLTGTEAELLCYLVKNQG
VVISKAELQTQVLKKELSPFDRNLDMHISNIRRKLVEAGLSKQHIKTFRGKGYSYLEAVTS

Sequences:

>Translated_221_residues
MSRVLIVDDDVPLCELLETVLQEEGYTVSSVHCGESALQYMEKTPVDLVLLDVMLPNLNGMQVARRICQRFATPILMLTA
LNDENSMLDGYQAGADQYIGKPFNVAELLMRIKAILRRVGLERQRQAMCNTVQSISGQLNSLPLTGTEAELLCYLVKNQG
VVISKAELQTQVLKKELSPFDRNLDMHISNIRRKLVEAGLSKQHIKTFRGKGYSYLEAVTS
>Mature_220_residues
SRVLIVDDDVPLCELLETVLQEEGYTVSSVHCGESALQYMEKTPVDLVLLDVMLPNLNGMQVARRICQRFATPILMLTAL
NDENSMLDGYQAGADQYIGKPFNVAELLMRIKAILRRVGLERQRQAMCNTVQSISGQLNSLPLTGTEAELLCYLVKNQGV
VISKAELQTQVLKKELSPFDRNLDMHISNIRRKLVEAGLSKQHIKTFRGKGYSYLEAVTS

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=42.3076923076923, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.7719298245614, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=35.5855855855856, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=31.8385650224215, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=32.7272727272727, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.0748898678414, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=31.5068493150685, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=31.25, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=29.2237442922374, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=32.5688073394495, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=27.6785714285714, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=28.6363636363636, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=27.7272727272727, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=27.0042194092827, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=131, Percent_Identity=29.7709923664122, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788550, Length=138, Percent_Identity=24.6376811594203, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=106, Percent_Identity=31.1320754716981, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24746; Mature: 24615

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLIVDDDVPLCELLETVLQEEGYTVSSVHCGESALQYMEKTPVDLVLLDVMLPNLNG
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCH
MQVARRICQRFATPILMLTALNDENSMLDGYQAGADQYIGKPFNVAELLMRIKAILRRVG
HHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHC
LERQRQAMCNTVQSISGQLNSLPLTGTEAELLCYLVKNQGVVISKAELQTQVLKKELSPF
CHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCHH
DRNLDMHISNIRRKLVEAGLSKQHIKTFRGKGYSYLEAVTS
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SRVLIVDDDVPLCELLETVLQEEGYTVSSVHCGESALQYMEKTPVDLVLLDVMLPNLNG
CCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCH
MQVARRICQRFATPILMLTALNDENSMLDGYQAGADQYIGKPFNVAELLMRIKAILRRVG
HHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHC
LERQRQAMCNTVQSISGQLNSLPLTGTEAELLCYLVKNQGVVISKAELQTQVLKKELSPF
CHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCHH
DRNLDMHISNIRRKLVEAGLSKQHIKTFRGKGYSYLEAVTS
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]