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The map label for this gene is cpxA [H]

Identifier: 156977966

GI number: 156977966

Start: 1893659

End: 1895032

Strand: Reverse

Name: cpxA [H]

Synonym: VIBHAR_06762

Alternate gene names: 156977966

Gene position: 1895032-1893659 (Counterclockwise)

Preceding gene: 156977967

Following gene: 156977965

Centisome position: 85.98

GC content: 44.69

Gene sequence:

>1374_bases
ATGAAGTTCGTTTGCCCATCCTACATCGCTAAGCGCAGAGACAGTCTTGCCTTTCAGCTCTTTAGTTATATGACGGCTAT
TGTCATTAGCATTTTGGCTGTTCAAGCGGTTGCAGAACAAGCTTTGGTGAAAGCCATGCTTAAAGTGCCAGCGAGTGTAA
AAGTTGAAATGCTAGAGCTCGCTCATCAGGCAAATATCCTCATTGAGGAAGGCGACATGGATGAACTAGCGGACTGGGCA
AATGCACAACACTTCTATCTATTCGTGCTCGACGAAAACCAACATCCGTTGACGCACCGTATGATGCACCCTCACTTTGA
GTTCAAATTAAAATTCAAAAGAAGCTTGGACGAGCAACTAGAAGACCGAGTAAGTCGCCCAATATTTAGCATCCCTTTGG
TTGGCAATAACAGCTTGATGATCCAATTGCCACACCAACTACATCCGGCACATGATTTCATTCTTTATTTTTCTATTCTA
AAGGTTGTGATTGCTGGAGTGATATTGGCACTGTTTTCATTGCTGATGGCGCGTAATCTACAGCAGCCTTTGGACCGATT
GAGAGAGGCGAGCAAGAAGCTTTCTAATGGTGACTTCAATGTCAGTGTGGTAGATGAGTTGAAATCGAATACGCGAGAAT
TTAATGAACTCGCGCGAGATTTTGACCACATGACCAAAGAGATCCATTCATTGGCGGAGAAGCAGCGCCGGTTAATTCGT
GATGTTTCCCATGAATTGCGTACGCCTCTTGCTCGACAAAATCTCGTGCTGCATCTATTGCGAAAGCGAGTCGGTGACAG
TGAACAGAGCTTAGTGAATCGAATGGAAGAAGAAGCCAATGAACTTAACCACTTGATTGGCGAGATTCTGGAGTTCAGCC
GATTAGAGAATGCTCGTTACGATACAGAGCTAAAGCGCATTGATCTCGAGGTCTTGCTTGCTCCTCAAGTGGAACGATGC
AAGATAGATTTAAAAGCTCAGCAGAGCCTTTCATTTGTTTCAGACGCGACAAGGGCTAAGGCTCAATGTGATGACACTTT
AGTGGTGCGATGCTTAAACAATCTGATTGGTAATGCGATTAAGTATGCAGGGGACTCTGCTCAAATAGAAGTTCGCTTAT
CGAATAAAGCTTCTGATACACAGAGTTACTTGGCGGTAACGATTTCTGACAACGGTCCTGGTATTCCACAAAATAAGTTG
TCAGATATATTCGACCCATTCACTCGTTTAGATGCCTCTCGTGACAAGAAGTTAGGTGGCTATGGTCTAGGGCTAGCGAT
AGTCAAAGAGTCGATGAGAATGATGGGGGGCAAGGCTGTCGCATCAAATAGACCTGAAGGTGGACTTGCCGTTACTTTGC
TGTTTCGGCAGTAA

Upstream 100 bases:

>100_bases
GCAATATTCGTCGAAAATTAGTGGAAGCTGGCTTGTCCAAACAGCATATAAAAACGTTTCGTGGGAAAGGCTACAGCTAC
CTTGAAGCGGTAACGAGTTA

Downstream 100 bases:

>100_bases
GCGAAATCACGCTCACGAGTAATAATGTGACTCGCATCTAGTTCATGAATCAAATTGAACACGGCCTCTTTACAAATCTT
TACGAATGCAAAGAATGTAA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKFVCPSYIAKRRDSLAFQLFSYMTAIVISILAVQAVAEQALVKAMLKVPASVKVEMLELAHQANILIEEGDMDELADWA
NAQHFYLFVLDENQHPLTHRMMHPHFEFKLKFKRSLDEQLEDRVSRPIFSIPLVGNNSLMIQLPHQLHPAHDFILYFSIL
KVVIAGVILALFSLLMARNLQQPLDRLREASKKLSNGDFNVSVVDELKSNTREFNELARDFDHMTKEIHSLAEKQRRLIR
DVSHELRTPLARQNLVLHLLRKRVGDSEQSLVNRMEEEANELNHLIGEILEFSRLENARYDTELKRIDLEVLLAPQVERC
KIDLKAQQSLSFVSDATRAKAQCDDTLVVRCLNNLIGNAIKYAGDSAQIEVRLSNKASDTQSYLAVTISDNGPGIPQNKL
SDIFDPFTRLDASRDKKLGGYGLGLAIVKESMRMMGGKAVASNRPEGGLAVTLLFRQ

Sequences:

>Translated_457_residues
MKFVCPSYIAKRRDSLAFQLFSYMTAIVISILAVQAVAEQALVKAMLKVPASVKVEMLELAHQANILIEEGDMDELADWA
NAQHFYLFVLDENQHPLTHRMMHPHFEFKLKFKRSLDEQLEDRVSRPIFSIPLVGNNSLMIQLPHQLHPAHDFILYFSIL
KVVIAGVILALFSLLMARNLQQPLDRLREASKKLSNGDFNVSVVDELKSNTREFNELARDFDHMTKEIHSLAEKQRRLIR
DVSHELRTPLARQNLVLHLLRKRVGDSEQSLVNRMEEEANELNHLIGEILEFSRLENARYDTELKRIDLEVLLAPQVERC
KIDLKAQQSLSFVSDATRAKAQCDDTLVVRCLNNLIGNAIKYAGDSAQIEVRLSNKASDTQSYLAVTISDNGPGIPQNKL
SDIFDPFTRLDASRDKKLGGYGLGLAIVKESMRMMGGKAVASNRPEGGLAVTLLFRQ
>Mature_457_residues
MKFVCPSYIAKRRDSLAFQLFSYMTAIVISILAVQAVAEQALVKAMLKVPASVKVEMLELAHQANILIEEGDMDELADWA
NAQHFYLFVLDENQHPLTHRMMHPHFEFKLKFKRSLDEQLEDRVSRPIFSIPLVGNNSLMIQLPHQLHPAHDFILYFSIL
KVVIAGVILALFSLLMARNLQQPLDRLREASKKLSNGDFNVSVVDELKSNTREFNELARDFDHMTKEIHSLAEKQRRLIR
DVSHELRTPLARQNLVLHLLRKRVGDSEQSLVNRMEEEANELNHLIGEILEFSRLENARYDTELKRIDLEVLLAPQVERC
KIDLKAQQSLSFVSDATRAKAQCDDTLVVRCLNNLIGNAIKYAGDSAQIEVRLSNKASDTQSYLAVTISDNGPGIPQNKL
SDIFDPFTRLDASRDKKLGGYGLGLAIVKESMRMMGGKAVASNRPEGGLAVTLLFRQ

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=31.6546762589928, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1787894, Length=293, Percent_Identity=31.0580204778157, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=25.9649122807018, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786912, Length=214, Percent_Identity=29.4392523364486, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=27.0642201834862, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=29.1828793774319, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=26.0135135135135, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787374, Length=340, Percent_Identity=25.5882352941176, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=24.0131578947368, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=24.6666666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=356, Percent_Identity=23.314606741573, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=26.1410788381743, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=294, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=25.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=28.2407407407407, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=27.1493212669683, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=24.8, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=27.6785714285714, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51752; Mature: 51752

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVCPSYIAKRRDSLAFQLFSYMTAIVISILAVQAVAEQALVKAMLKVPASVKVEMLEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AHQANILIEEGDMDELADWANAQHFYLFVLDENQHPLTHRMMHPHFEFKLKFKRSLDEQL
HHHCCEEEECCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCHHEEEHHHHHHHHHH
EDRVSRPIFSIPLVGNNSLMIQLPHQLHPAHDFILYFSILKVVIAGVILALFSLLMARNL
HHHHCCCEEEEEEECCCEEEEEECHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQPLDRLREASKKLSNGDFNVSVVDELKSNTREFNELARDFDHMTKEIHSLAEKQRRLIR
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVSHELRTPLARQNLVLHLLRKRVGDSEQSLVNRMEEEANELNHLIGEILEFSRLENARY
HHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DTELKRIDLEVLLAPQVERCKIDLKAQQSLSFVSDATRAKAQCDDTLVVRCLNNLIGNAI
HHHHHHHHHHEEECCCHHHHEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KYAGDSAQIEVRLSNKASDTQSYLAVTISDNGPGIPQNKLSDIFDPFTRLDASRDKKLGG
HHCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
YGLGLAIVKESMRMMGGKAVASNRPEGGLAVTLLFRQ
CHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKFVCPSYIAKRRDSLAFQLFSYMTAIVISILAVQAVAEQALVKAMLKVPASVKVEMLEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AHQANILIEEGDMDELADWANAQHFYLFVLDENQHPLTHRMMHPHFEFKLKFKRSLDEQL
HHHCCEEEECCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCHHEEEHHHHHHHHHH
EDRVSRPIFSIPLVGNNSLMIQLPHQLHPAHDFILYFSILKVVIAGVILALFSLLMARNL
HHHHCCCEEEEEEECCCEEEEEECHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQPLDRLREASKKLSNGDFNVSVVDELKSNTREFNELARDFDHMTKEIHSLAEKQRRLIR
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVSHELRTPLARQNLVLHLLRKRVGDSEQSLVNRMEEEANELNHLIGEILEFSRLENARY
HHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DTELKRIDLEVLLAPQVERCKIDLKAQQSLSFVSDATRAKAQCDDTLVVRCLNNLIGNAI
HHHHHHHHHHEEECCCHHHHEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KYAGDSAQIEVRLSNKASDTQSYLAVTISDNGPGIPQNKLSDIFDPFTRLDASRDKKLGG
HHCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
YGLGLAIVKESMRMMGGKAVASNRPEGGLAVTLLFRQ
CHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]