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The map label for this gene is zitB [H]

Identifier: 156977622

GI number: 156977622

Start: 1574134

End: 1575048

Strand: Reverse

Name: zitB [H]

Synonym: VIBHAR_06410

Alternate gene names: 156977622

Gene position: 1575048-1574134 (Counterclockwise)

Preceding gene: 156977623

Following gene: 156977621

Centisome position: 71.46

GC content: 46.01

Gene sequence:

>915_bases
ATGGCTGTATCGCAACATTCACATGATTTCGTTTCTGATAACCAGAAGGGTGAAAAACGCACGCTCTACGTATTGATTCT
AACCGTGACCACTATGGTGGTGGAGATTGCTGCCGGAACCATGTTTGGCTCAATGGCATTGCTAGCAGATGGTTGGCATA
TGGGGACACACGCAGCGGCATTTTGTATTACCTTGTTTGCTTACCGCTACGCGAAACAAAACGCCCATAATGACCGCTTC
TCATTTGGTACGGGTAAGGTGAGTGTGCTCGGCGGTTTTACCAGTGCGATTGCGTTGGGGATTGTGGCATTGATGATGAT
GGTTGAGTCGATTCATCGTCTCTTCAACCCAGAAAGCATTCAGTTTAACGAAGCAATTATGGTGGCGGTGATTGGTTTAA
TGGTAAACCTTGCAAGCATGCTGCTTCTGCAAGATCACCATCATCATGGGCATGACCATCATGATCACCATTCTCACGAT
CATGAGCACGAACATCATCACGACCACAACTTAACCGCAGCGTATTTCCACGTACTGGCGGATACGTTGACGTCTCTGCT
GGCGATTGTCGCGTTGATTGTCGGTAAGTTTTACGGTTGGATTTGGTTAGACGCCATGATGGGGATCGTTGGTGCCGTTG
TGATTGGTAAATGGACTTTGGGTTTAATGAAGCAAACAGCGCCAGTGTTGTTGGATGAGAGCATCAACAAGTCTTACCGA
GATGAGATTACAGAGACGCTTGCACCTTATGCTGAGACTGTTGATTTACACATCTGGAAGGTGAGTGGCCACCATTACTC
TGCGGCAATTGCGCTTAAAAATCACAGTGACAAAACGCTGGATGATTTTAAGCAATTGTTGAGTAAATTTGATAAGATTC
ACCACCTAACTTTGGAAGTTCAAACGACTGAGTGA

Upstream 100 bases:

>100_bases
TGGTGATGTTGGCTTTCCATATTGACATTGTTTGATTATCAAACTAAATTAAAATCAAATAATTTGATAATCAAACTAAA
ATTGGAAGGTAAGTGTCTCA

Downstream 100 bases:

>100_bases
TGCGCGAATTAGAAAAGCTGAATCAAACGCTTACCGAGTTCTATGACAAAATGTCTTCTTGGGAGCAATCTGTAGTAAAA
GGCACGGGTTATTCACTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAVSQHSHDFVSDNQKGEKRTLYVLILTVTTMVVEIAAGTMFGSMALLADGWHMGTHAAAFCITLFAYRYAKQNAHNDRF
SFGTGKVSVLGGFTSAIALGIVALMMMVESIHRLFNPESIQFNEAIMVAVIGLMVNLASMLLLQDHHHHGHDHHDHHSHD
HEHEHHHDHNLTAAYFHVLADTLTSLLAIVALIVGKFYGWIWLDAMMGIVGAVVIGKWTLGLMKQTAPVLLDESINKSYR
DEITETLAPYAETVDLHIWKVSGHHYSAAIALKNHSDKTLDDFKQLLSKFDKIHHLTLEVQTTE

Sequences:

>Translated_304_residues
MAVSQHSHDFVSDNQKGEKRTLYVLILTVTTMVVEIAAGTMFGSMALLADGWHMGTHAAAFCITLFAYRYAKQNAHNDRF
SFGTGKVSVLGGFTSAIALGIVALMMMVESIHRLFNPESIQFNEAIMVAVIGLMVNLASMLLLQDHHHHGHDHHDHHSHD
HEHEHHHDHNLTAAYFHVLADTLTSLLAIVALIVGKFYGWIWLDAMMGIVGAVVIGKWTLGLMKQTAPVLLDESINKSYR
DEITETLAPYAETVDLHIWKVSGHHYSAAIALKNHSDKTLDDFKQLLSKFDKIHHLTLEVQTTE
>Mature_303_residues
AVSQHSHDFVSDNQKGEKRTLYVLILTVTTMVVEIAAGTMFGSMALLADGWHMGTHAAAFCITLFAYRYAKQNAHNDRFS
FGTGKVSVLGGFTSAIALGIVALMMMVESIHRLFNPESIQFNEAIMVAVIGLMVNLASMLLLQDHHHHGHDHHDHHSHDH
EHEHHHDHNLTAAYFHVLADTLTSLLAIVALIVGKFYGWIWLDAMMGIVGAVVIGKWTLGLMKQTAPVLLDESINKSYRD
EITETLAPYAETVDLHIWKVSGHHYSAAIALKNHSDKTLDDFKQLLSKFDKIHHLTLEVQTTE

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=337, Percent_Identity=25.8160237388724, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI222080086, Length=330, Percent_Identity=23.6363636363636, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40255009, Length=330, Percent_Identity=23.6363636363636, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=32.2834645669291, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI52352805, Length=284, Percent_Identity=24.6478873239437, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=295, Percent_Identity=28.4745762711864, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32564488, Length=195, Percent_Identity=32.8205128205128, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193210990, Length=308, Percent_Identity=24.6753246753247, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17555794, Length=309, Percent_Identity=25.5663430420712, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555796, Length=296, Percent_Identity=24.3243243243243, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=161, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324892, Length=161, Percent_Identity=24.223602484472, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24645863, Length=288, Percent_Identity=23.9583333333333, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656728, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656724, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656720, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656715, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357035, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33938; Mature: 33807

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSQHSHDFVSDNQKGEKRTLYVLILTVTTMVVEIAAGTMFGSMALLADGWHMGTHAAA
CCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FCITLFAYRYAKQNAHNDRFSFGTGKVSVLGGFTSAIALGIVALMMMVESIHRLFNPESI
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QFNEAIMVAVIGLMVNLASMLLLQDHHHHGHDHHDHHSHDHEHEHHHDHNLTAAYFHVLA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DTLTSLLAIVALIVGKFYGWIWLDAMMGIVGAVVIGKWTLGLMKQTAPVLLDESINKSYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DEITETLAPYAETVDLHIWKVSGHHYSAAIALKNHSDKTLDDFKQLLSKFDKIHHLTLEV
HHHHHHHHHHHHEEEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEE
QTTE
EECC
>Mature Secondary Structure 
AVSQHSHDFVSDNQKGEKRTLYVLILTVTTMVVEIAAGTMFGSMALLADGWHMGTHAAA
CCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FCITLFAYRYAKQNAHNDRFSFGTGKVSVLGGFTSAIALGIVALMMMVESIHRLFNPESI
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QFNEAIMVAVIGLMVNLASMLLLQDHHHHGHDHHDHHSHDHEHEHHHDHNLTAAYFHVLA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DTLTSLLAIVALIVGKFYGWIWLDAMMGIVGAVVIGKWTLGLMKQTAPVLLDESINKSYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DEITETLAPYAETVDLHIWKVSGHHYSAAIALKNHSDKTLDDFKQLLSKFDKIHHLTLEV
HHHHHHHHHHHHEEEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEE
QTTE
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]