Click here to switch to the map view.

The map label for this gene is fhuB [H]

Identifier: 156977510

GI number: 156977510

Start: 1472993

End: 1474987

Strand: Reverse

Name: fhuB [H]

Synonym: VIBHAR_06297

Alternate gene names: 156977510

Gene position: 1474987-1472993 (Counterclockwise)

Preceding gene: 156977511

Following gene: 156977508

Centisome position: 66.92

GC content: 47.77

Gene sequence:

>1995_bases
ATGAAATCCAGTGGTTTGATGGTGGGGGCAGCGTTATTTCTCGCTGCCCTTGTTCATTTATGGCTAGGTCAATCTGAATT
TGGTCCCGTTGATGAGTTGTTCTGGCAAATCTCGCAGCTCAGCAACATCGCTTCGTTCGATCGAATGGTCGATGATTCAT
TCGAGTTGATGGCGTTAGCCTATGTCAACTTACCTCGTTTGGTGATGGCGCTTTTGGTTGGTGGAACACTCGGCACGATA
GGTAGCCTGTTTCAACAGTTAACACAGAATCGCATGATGTCTCCGCTTACCTTAGGTACATCGTCTGGTGCATGGCTTGG
TCTGGTCATTCTAAATGTGGTCGCGCCGATGTTGGTGGCTCAGTATTCAGTTTGGTTTGCGCTGGTTGGAGCTCTGCTTG
CAATGGGGCTTATTGTTTCCATTGTTGGCATCAAAAACATGAGCGGCTTGCCAATTGTTTTGGCAGGTATGGCGGTTAAC
TTACTGTTAGGCGCATTTGCGACCGCGATTATCTTGCTTAACGACCAGTACGCACAAAACCTGTTTGTATGGGGAGCTGG
CGATCTTGGGCAAAACGGTTGGGAACAAGTGCTTTGGTTAATGCCTAAGTTACTGCCAATCTTTGCTATTTTTCTGTTGG
CACCGAGGGTTTTGACGTTGCTTTCGATTGGTACGGAAGGGGCTGCTGCGCGTGGCCTTAACATAGGTACAACCTTCTTT
GTGCTAATGGCAATCGGCGTGTGGTTGGTTTCAGTGTCGATTACCTCGGTGGGTGTTATCAGCTTTATTGGTTTGATTGC
CCCAAATATCGCTAGGCACTTGGGCTTTTTAAAGGCGAAATCAGAACTCATTGCAAGCTGTGCGTTAGGCGCACTATTAC
TCTGTGTGACCGACAGTCTGGCTTTATTCTTAGCTCAATGGTCTTTGGATATGATTCCAACAGGAACGGCAACCGCGGTG
ATCGGGGCTCCTGCTCTCATCATTATTGCCCGCAAACAAATGTCTGCCCAAGATCAAATGTTTTTCTCTATGCCGAAAGG
TCCAAAGTCTATCTCATCTTTGGCTTATTTCTTGTTGTTCATCATGATCTTTGGTTTGCTGGCGTTAAGTACATTGTCGC
AACCGGCGTCTGATTTGGGCTACTTTACAATTCCAGACGCGTTTGAATGGTCAATCCGCTGGCCTAGGATGTTAACTGCG
ATATTTGCTGGTGGGGGTCTTGCTGTCGCTGGTGTGATTTTACAACGGTTGGTTTATAACCCGCTTGCGAGCCCAGACAT
CCTCGGTGTATCGGCGGGTGCGGTTTTAGCATTGATCTTCAGTAGCCTGTTTATGGGATACTCGATTCATTCACTAAGCC
CGTGGATTGCGTTTTTGGGCAGCGCTATTGCACTGTGTTTGCTGTTATTCCTTGGTAAGAAGCATCAGTTTGCACCCTCG
ATTCTCATCCTGACGGGTATCTCGCTGACCGCAGTGTTGGAGGCTTTAGTACAATTTTCTTTAACGCGAGTAGGGGAAGG
GAAGTACACCTTGTTGGCTTGGTTAGCTGGCTCTACTTATCGTGTTGAACCTGATGCGGCAACGATCATGGCTATCGTGA
TAACCGTTTGTATTGGCGTTGCTTTACTGTTGAGCCGTTGGGTGACATTAATTGCTACTGGTCGTCAGTTTGCCAGTGCA
AGAGGGTTGAACATCAACATCGCCTATGTTGCTCTATTGTGCATTGTCGCGACTTTATGTTCGATGGTGACAACCACCAT
GGGGCCGGTTGCTTTTGTTGGGTTACTGGCTCCACATATTGCAGCTATGGTTGGTGCGCGCTTGGTTCGAGAGCAGATCA
TCTTATCGTTTTTGATTGGTGCGGCACTAATGTTGTTCTCCGACTGGTTGGGACAAGTGGTTGTTTTCCCCACTCAGCTT
GCGGCAGGCACGTTGGTTTCTATTATAGGTGGCAGCTACTTCATCTTCTTGTTGCTGAAATCCCGAAATTCGTAG

Upstream 100 bases:

>100_bases
TTAGCCCAGTGGAGGCAAGTTGGAGCTACGGCGGGGCGATGTCGATTTTGTATAATGCAGAAGCCATGGCGCAATCATTA
TTGGCTTTAGCGGAGCAGTA

Downstream 100 bases:

>100_bases
GCTTGTGAGCAGGTTGAAGGTTTTTGTCATCAAATATCAGCGAACCTTGTTCTTAGTATGATTTGGTGCGTTGGCTCTTT
TAGAGTGAGGAAAGTGATAA

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MKSSGLMVGAALFLAALVHLWLGQSEFGPVDELFWQISQLSNIASFDRMVDDSFELMALAYVNLPRLVMALLVGGTLGTI
GSLFQQLTQNRMMSPLTLGTSSGAWLGLVILNVVAPMLVAQYSVWFALVGALLAMGLIVSIVGIKNMSGLPIVLAGMAVN
LLLGAFATAIILLNDQYAQNLFVWGAGDLGQNGWEQVLWLMPKLLPIFAIFLLAPRVLTLLSIGTEGAAARGLNIGTTFF
VLMAIGVWLVSVSITSVGVISFIGLIAPNIARHLGFLKAKSELIASCALGALLLCVTDSLALFLAQWSLDMIPTGTATAV
IGAPALIIIARKQMSAQDQMFFSMPKGPKSISSLAYFLLFIMIFGLLALSTLSQPASDLGYFTIPDAFEWSIRWPRMLTA
IFAGGGLAVAGVILQRLVYNPLASPDILGVSAGAVLALIFSSLFMGYSIHSLSPWIAFLGSAIALCLLLFLGKKHQFAPS
ILILTGISLTAVLEALVQFSLTRVGEGKYTLLAWLAGSTYRVEPDAATIMAIVITVCIGVALLLSRWVTLIATGRQFASA
RGLNINIAYVALLCIVATLCSMVTTTMGPVAFVGLLAPHIAAMVGARLVREQIILSFLIGAALMLFSDWLGQVVVFPTQL
AAGTLVSIIGGSYFIFLLLKSRNS

Sequences:

>Translated_664_residues
MKSSGLMVGAALFLAALVHLWLGQSEFGPVDELFWQISQLSNIASFDRMVDDSFELMALAYVNLPRLVMALLVGGTLGTI
GSLFQQLTQNRMMSPLTLGTSSGAWLGLVILNVVAPMLVAQYSVWFALVGALLAMGLIVSIVGIKNMSGLPIVLAGMAVN
LLLGAFATAIILLNDQYAQNLFVWGAGDLGQNGWEQVLWLMPKLLPIFAIFLLAPRVLTLLSIGTEGAAARGLNIGTTFF
VLMAIGVWLVSVSITSVGVISFIGLIAPNIARHLGFLKAKSELIASCALGALLLCVTDSLALFLAQWSLDMIPTGTATAV
IGAPALIIIARKQMSAQDQMFFSMPKGPKSISSLAYFLLFIMIFGLLALSTLSQPASDLGYFTIPDAFEWSIRWPRMLTA
IFAGGGLAVAGVILQRLVYNPLASPDILGVSAGAVLALIFSSLFMGYSIHSLSPWIAFLGSAIALCLLLFLGKKHQFAPS
ILILTGISLTAVLEALVQFSLTRVGEGKYTLLAWLAGSTYRVEPDAATIMAIVITVCIGVALLLSRWVTLIATGRQFASA
RGLNINIAYVALLCIVATLCSMVTTTMGPVAFVGLLAPHIAAMVGARLVREQIILSFLIGAALMLFSDWLGQVVVFPTQL
AAGTLVSIIGGSYFIFLLLKSRNS
>Mature_664_residues
MKSSGLMVGAALFLAALVHLWLGQSEFGPVDELFWQISQLSNIASFDRMVDDSFELMALAYVNLPRLVMALLVGGTLGTI
GSLFQQLTQNRMMSPLTLGTSSGAWLGLVILNVVAPMLVAQYSVWFALVGALLAMGLIVSIVGIKNMSGLPIVLAGMAVN
LLLGAFATAIILLNDQYAQNLFVWGAGDLGQNGWEQVLWLMPKLLPIFAIFLLAPRVLTLLSIGTEGAAARGLNIGTTFF
VLMAIGVWLVSVSITSVGVISFIGLIAPNIARHLGFLKAKSELIASCALGALLLCVTDSLALFLAQWSLDMIPTGTATAV
IGAPALIIIARKQMSAQDQMFFSMPKGPKSISSLAYFLLFIMIFGLLALSTLSQPASDLGYFTIPDAFEWSIRWPRMLTA
IFAGGGLAVAGVILQRLVYNPLASPDILGVSAGAVLALIFSSLFMGYSIHSLSPWIAFLGSAIALCLLLFLGKKHQFAPS
ILILTGISLTAVLEALVQFSLTRVGEGKYTLLAWLAGSTYRVEPDAATIMAIVITVCIGVALLLSRWVTLIATGRQFASA
RGLNINIAYVALLCIVATLCSMVTTTMGPVAFVGLLAPHIAAMVGARLVREQIILSFLIGAALMLFSDWLGQVVVFPTQL
AAGTLVSIIGGSYFIFLLLKSRNS

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=630, Percent_Identity=34.1269841269841, Blast_Score=259, Evalue=5e-70,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=32.9787234042553, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1790740, Length=271, Percent_Identity=35.0553505535055, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1786805, Length=273, Percent_Identity=34.4322344322344, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788004, Length=267, Percent_Identity=30.3370786516854, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786804, Length=282, Percent_Identity=30.1418439716312, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70517; Mature: 70517

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSGLMVGAALFLAALVHLWLGQSEFGPVDELFWQISQLSNIASFDRMVDDSFELMALA
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YVNLPRLVMALLVGGTLGTIGSLFQQLTQNRMMSPLTLGTSSGAWLGLVILNVVAPMLVA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHH
QYSVWFALVGALLAMGLIVSIVGIKNMSGLPIVLAGMAVNLLLGAFATAIILLNDQYAQN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
LFVWGAGDLGQNGWEQVLWLMPKLLPIFAIFLLAPRVLTLLSIGTEGAAARGLNIGTTFF
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
VLMAIGVWLVSVSITSVGVISFIGLIAPNIARHLGFLKAKSELIASCALGALLLCVTDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFLAQWSLDMIPTGTATAVIGAPALIIIARKQMSAQDQMFFSMPKGPKSISSLAYFLLF
HHHHHHHHHCCCCCCCHHHHHCCCHHEEEEHHHHCHHHHHHHCCCCCHHHHHHHHHHHHH
IMIFGLLALSTLSQPASDLGYFTIPDAFEWSIRWPRMLTAIFAGGGLAVAGVILQRLVYN
HHHHHHHHHHHHCCCHHHCCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
PLASPDILGVSAGAVLALIFSSLFMGYSIHSLSPWIAFLGSAIALCLLLFLGKKHQFAPS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILILTGISLTAVLEALVQFSLTRVGEGKYTLLAWLAGSTYRVEPDAATIMAIVITVCIGV
CHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHH
ALLLSRWVTLIATGRQFASARGLNINIAYVALLCIVATLCSMVTTTMGPVAFVGLLAPHI
HHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAMVGARLVREQIILSFLIGAALMLFSDWLGQVVVFPTQLAAGTLVSIIGGSYFIFLLLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEE
SRNS
CCCC
>Mature Secondary Structure
MKSSGLMVGAALFLAALVHLWLGQSEFGPVDELFWQISQLSNIASFDRMVDDSFELMALA
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YVNLPRLVMALLVGGTLGTIGSLFQQLTQNRMMSPLTLGTSSGAWLGLVILNVVAPMLVA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHH
QYSVWFALVGALLAMGLIVSIVGIKNMSGLPIVLAGMAVNLLLGAFATAIILLNDQYAQN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
LFVWGAGDLGQNGWEQVLWLMPKLLPIFAIFLLAPRVLTLLSIGTEGAAARGLNIGTTFF
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
VLMAIGVWLVSVSITSVGVISFIGLIAPNIARHLGFLKAKSELIASCALGALLLCVTDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFLAQWSLDMIPTGTATAVIGAPALIIIARKQMSAQDQMFFSMPKGPKSISSLAYFLLF
HHHHHHHHHCCCCCCCHHHHHCCCHHEEEEHHHHCHHHHHHHCCCCCHHHHHHHHHHHHH
IMIFGLLALSTLSQPASDLGYFTIPDAFEWSIRWPRMLTAIFAGGGLAVAGVILQRLVYN
HHHHHHHHHHHHCCCHHHCCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
PLASPDILGVSAGAVLALIFSSLFMGYSIHSLSPWIAFLGSAIALCLLLFLGKKHQFAPS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILILTGISLTAVLEALVQFSLTRVGEGKYTLLAWLAGSTYRVEPDAATIMAIVITVCIGV
CHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHH
ALLLSRWVTLIATGRQFASARGLNINIAYVALLCIVATLCSMVTTTMGPVAFVGLLAPHI
HHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAMVGARLVREQIILSFLIGAALMLFSDWLGQVVVFPTQLAAGTLVSIIGGSYFIFLLLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEE
SRNS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]