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The map label for this gene is emrD [H]

Identifier: 156977508

GI number: 156977508

Start: 1470616

End: 1471779

Strand: Reverse

Name: emrD [H]

Synonym: VIBHAR_06295

Alternate gene names: 156977508

Gene position: 1471779-1470616 (Counterclockwise)

Preceding gene: 156977510

Following gene: 156977507

Centisome position: 66.78

GC content: 47.77

Gene sequence:

>1164_bases
ATGATGATCATCGCGACCGGTCAAGTGGGCGTCAGTATTTATCTCCCTTCTTTGCCTCTGATCGGTCATGATCTTGCTTT
GCCACAACACACGGTTCAAAACCTTGTGACTCTGTTTCTTGTTGGCTTTGGCGTCTCACAGTTGTTTTATGGGCCTCTGT
CGGATGCCATTGGCCGAAGACCTGTATTTCTGCTTGGACAGAGTGTCTATTTGGTTGGTACGGTCATCTGTATTGCGTTT
GCTGATCATATTGTTGCCCTTGAAGCGGGGCGTCTATTACAGGGGCTCGGTGCGGGTAGCGCCTCTGTACTTGGACGTTC
GGTATTGCGAGATAGTTATGACGGAGCACAACTTACCAAAGCCTTGTCTTATATCTCGGTGACAGCTTCTGTGATGCCGA
TTGTGGCGCCTTTGTTTGGTGGATGGATTGCTTATCACATCAGCTGGCATGCGGTTTTCGTGTTCGTTCTCATTTATCTT
GCGGCGATTTTTACCCTTGGTTTTGTCGTTTTGCATGAAACGCTGCCATATCCAAAGCGTCGTTTCGAACCAAAGCGGGT
GTTACTGAATTACTTTGAGTTGTTGACCAATAAGCAAGTCATTGGCAGTGCAAGCTATAACTGGCTTAGCTACTTATCTG
CATTAGTGACCCTGTCTCTTTACCCGTTCCTCATGCAGCAAGAACTTGGGCTGACTGCGGCAGATTACGGAACCTTGATG
ATCGTGCCTTCGGCTGGGTTGTTGATGGGGAGTTTGGTCCTTAACTTCATTAATGCTCGATATAAAGAGCAGCAAATATT
ATTCATCAGCTTTGTTATTGTGGCGTGCTCAGGGGCAATGCTCCTCATACTGCCGTTCACGGTGGCGTCATTATTGGTTG
CGTTTACCTGCTTGAGTTTCGCGCAAGGGATGTCTTTTCCTGTTTCTATCAGTCTGTTGTTGTCGCCGCACAAGCAGCAA
GCGGGGGCCGTATCGGCTTTATCAGGTTCGATTCAAATGTGCTTAGCAGGCTTGTTTGGCGGCTACTTAGTTGAAACCTG
GGTAACAAGCCAACATCAATTGGGGATCTTTTATATTTCGATTGCGGTGATCTCCTGCTTAGTTCTCGTGTTTGGGCAGT
TCCGAAAGCCTTCAGGAGGTCTAGTGCAGCCAGAACGAACATAG

Upstream 100 bases:

>100_bases
AAGCTTATTATCATCTTTGAGTAACAAATATACACTGTCTGTCGTAAAACTGTCATGTTGTAAGGAGGATATATTGCGTA
AAACACCATTATTGTTGGCG

Downstream 100 bases:

>100_bases
TTGAATCTGGTTGCAAGGGCAGAAGGTCCTCTCTAAAATGCGCCAACTATTGTGTCGTTATCTACACTTGGCTAATAAAG
TGGTATATCGGCAACACCCG

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MMIIATGQVGVSIYLPSLPLIGHDLALPQHTVQNLVTLFLVGFGVSQLFYGPLSDAIGRRPVFLLGQSVYLVGTVICIAF
ADHIVALEAGRLLQGLGAGSASVLGRSVLRDSYDGAQLTKALSYISVTASVMPIVAPLFGGWIAYHISWHAVFVFVLIYL
AAIFTLGFVVLHETLPYPKRRFEPKRVLLNYFELLTNKQVIGSASYNWLSYLSALVTLSLYPFLMQQELGLTAADYGTLM
IVPSAGLLMGSLVLNFINARYKEQQILFISFVIVACSGAMLLILPFTVASLLVAFTCLSFAQGMSFPVSISLLLSPHKQQ
AGAVSALSGSIQMCLAGLFGGYLVETWVTSQHQLGIFYISIAVISCLVLVFGQFRKPSGGLVQPERT

Sequences:

>Translated_387_residues
MMIIATGQVGVSIYLPSLPLIGHDLALPQHTVQNLVTLFLVGFGVSQLFYGPLSDAIGRRPVFLLGQSVYLVGTVICIAF
ADHIVALEAGRLLQGLGAGSASVLGRSVLRDSYDGAQLTKALSYISVTASVMPIVAPLFGGWIAYHISWHAVFVFVLIYL
AAIFTLGFVVLHETLPYPKRRFEPKRVLLNYFELLTNKQVIGSASYNWLSYLSALVTLSLYPFLMQQELGLTAADYGTLM
IVPSAGLLMGSLVLNFINARYKEQQILFISFVIVACSGAMLLILPFTVASLLVAFTCLSFAQGMSFPVSISLLLSPHKQQ
AGAVSALSGSIQMCLAGLFGGYLVETWVTSQHQLGIFYISIAVISCLVLVFGQFRKPSGGLVQPERT
>Mature_387_residues
MMIIATGQVGVSIYLPSLPLIGHDLALPQHTVQNLVTLFLVGFGVSQLFYGPLSDAIGRRPVFLLGQSVYLVGTVICIAF
ADHIVALEAGRLLQGLGAGSASVLGRSVLRDSYDGAQLTKALSYISVTASVMPIVAPLFGGWIAYHISWHAVFVFVLIYL
AAIFTLGFVVLHETLPYPKRRFEPKRVLLNYFELLTNKQVIGSASYNWLSYLSALVTLSLYPFLMQQELGLTAADYGTLM
IVPSAGLLMGSLVLNFINARYKEQQILFISFVIVACSGAMLLILPFTVASLLVAFTCLSFAQGMSFPVSISLLLSPHKQQ
AGAVSALSGSIQMCLAGLFGGYLVETWVTSQHQLGIFYISIAVISCLVLVFGQFRKPSGGLVQPERT

Specific function: Multidrug resistance pump that participates in a low energy shock adaptative response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87082312, Length=337, Percent_Identity=30.2670623145401, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790146, Length=370, Percent_Identity=26.4864864864865, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788509, Length=343, Percent_Identity=25.3644314868805, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI48994889, Length=351, Percent_Identity=26.4957264957265, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787065, Length=306, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790794, Length=306, Percent_Identity=23.8562091503268, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=165, Percent_Identity=29.0909090909091, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41827; Mature: 41827

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIIATGQVGVSIYLPSLPLIGHDLALPQHTVQNLVTLFLVGFGVSQLFYGPLSDAIGRR
CEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
PVFLLGQSVYLVGTVICIAFADHIVALEAGRLLQGLGAGSASVLGRSVLRDSYDGAQLTK
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHH
ALSYISVTASVMPIVAPLFGGWIAYHISWHAVFVFVLIYLAAIFTLGFVVLHETLPYPKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RFEPKRVLLNYFELLTNKQVIGSASYNWLSYLSALVTLSLYPFLMQQELGLTAADYGTLM
HCCHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEE
IVPSAGLLMGSLVLNFINARYKEQQILFISFVIVACSGAMLLILPFTVASLLVAFTCLSF
EECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AQGMSFPVSISLLLSPHKQQAGAVSALSGSIQMCLAGLFGGYLVETWVTSQHQLGIFYIS
HCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IAVISCLVLVFGQFRKPSGGLVQPERT
HHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMIIATGQVGVSIYLPSLPLIGHDLALPQHTVQNLVTLFLVGFGVSQLFYGPLSDAIGRR
CEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
PVFLLGQSVYLVGTVICIAFADHIVALEAGRLLQGLGAGSASVLGRSVLRDSYDGAQLTK
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHH
ALSYISVTASVMPIVAPLFGGWIAYHISWHAVFVFVLIYLAAIFTLGFVVLHETLPYPKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RFEPKRVLLNYFELLTNKQVIGSASYNWLSYLSALVTLSLYPFLMQQELGLTAADYGTLM
HCCHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEE
IVPSAGLLMGSLVLNFINARYKEQQILFISFVIVACSGAMLLILPFTVASLLVAFTCLSF
EECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AQGMSFPVSISLLLSPHKQQAGAVSALSGSIQMCLAGLFGGYLVETWVTSQHQLGIFYIS
HCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IAVISCLVLVFGQFRKPSGGLVQPERT
HHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8240355; 7686882; 9278503 [H]