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The map label for this gene is betA

Identifier: 156977392

GI number: 156977392

Start: 1357935

End: 1359644

Strand: Reverse

Name: betA

Synonym: VIBHAR_06179

Alternate gene names: 156977392

Gene position: 1359644-1357935 (Counterclockwise)

Preceding gene: 156977393

Following gene: 156977391

Centisome position: 61.69

GC content: 49.47

Gene sequence:

>1710_bases
ATGCAACAACACTACGATTACATCATCGTCGGTGCTGGCTCGGCAGGCTGTGTTTTGGCGGATCGCCTGAGTGAAAGCGG
TCAGCACCAAGTCTTGCTGTTGGAAGCGGGTGGCTCAGACAAGAGCATCTTCATTCAAATGCCAACGGCGCTGTCATACC
CAATGAACACCGAAAAGTACGCATGGCAGTTCGAAACTGTTGCGGAAGAGGGGTTAGACGGACGTCAACTGCATTGTCCA
CGCGGCAAAGTGTTAGGCGGAAGCTCTTCGATCAACGGCATGGTTTACGTTCGTGGTCATGCCTGTGACTTTGACGAATG
GGAAGCAGAAGGCGCGAAAGGCTGGAACTACCAAGCTTGTCTACCGTACTTCCGTAAAGCGGAAACGTGGACAGGCGGCG
CAGACGAATACCGTGGCGGCAGCGGTCCGGTAGGGACGTGTAACGGCAACGATATGAAGCTGAATCCACTTTACCAAGCG
TTTATTGAAGCTGGCAAAGATGCAGGCTACCCAGAAACGCAAGATTACAACGGTTACCAGCAAGAGGGCTTTGGTCCGAT
GCATATGACGGTAGATAAAGGCGTGCGCGCTTCTACCTCTAACGCTTACTTAAGCCGTGCAAAAAAACGAAGTAATTTCA
CCTTGATGAAAGGCGTAACGGCTCATCGAATTTTGCTTGAAGGCAAGAAAGCGGTCGGTATCGAGTTCGAGCAATCTGGC
GAAATCAAACAGTGCTTTGCCAACAAAGAGGTTGTGTCGAGCGCAGGTTCTATCGGCTCGGTACAACTGCTGCAACTTTC
GGGTATTGGTCCTAAGACTGTGCTTGATAAAGCGGGCATTGAAGTGAAACACACACTAGAAGGCGTGGGTAAGAACCTTC
AAGACCACCTTGAAGTGTACTTCCAGTACCACTGTAAACAGCCGATCACGCTTAACAGCAAGTTAGGTTTGATCAGCAAA
GGTTTGATTGGTACGGAGTGGATTCTGACGCGCAAGGGTTTGGGGGCAACTAACCACTTTGAATCGTGCGCGTTCATCCG
TTCTCGTGAAGGATTGAAATCGCCAAATATTCAATTTCACTTCTTACCAGCCGCCATGCGTTATGACGGACGCGCGGCAT
TTGATGGTCACGGCTTCCAAGTACATGTTGGTCCAAACAAGCCAGAGAGTCGCGGTAGTGTCGAAGTGGTTTCTGCCAAT
CCAAATGACAAACCAAAAATCGAGTTCAACTACATCTCTACGGAACAAGATAAGCAAGATTGGCGAGACTGTATTCGTCT
AACGCGTGAAATCCTCAATCAACCTGCAATGGATGCGTTCCGCGGTGAAGAAATTCAACCCGGTCTTAACATCACCAGTG
ACGAAGCGATTGGTGAATGGGTGAAGCAAAATGTAGAAAGTGCTTACCACCCATCGTGTAGCTGCAAAATGGGCTCGAAC
GATGACCCAATGGCAGTTCTGAATGAAGCTTGCCAAGTGCGAGGCATTGAAGGCTTGCGCGTGGTGGATTCATCCATCTT
CCCAACCATTCCGAATGGGAACTTAAACGCACCAACTATCATGGTTGCAGAGCGTGCTGCGGACATGATCTTGGGTAATA
CCCTTGAACAATCGAATAACACACCGGTTTGGATTGCTCCGAACTGGCAAGAGACGCAAAGAATGCGTCCGCCGAAAAGA
GACTTAAGCTCGATCTCTTCTATCGCTTAA

Upstream 100 bases:

>100_bases
GGCGTTGAGACCCTTACGCATTACACCCAAACCAAGAGCGTGTTAGTGCATTTGGGCGATTTCGATAGCCCGTACGCGTA
ATTAGCTTGGAGGATTTGTA

Downstream 100 bases:

>100_bases
TAACTCAAAGAAAAGTCAGTAATCATTACAAGGAATTTAAACATGTCTACGATGACAAAAATCTTTTCATCTATCGCGCT
GAGTGCAGTAGCGACAGGTG

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MQQHYDYIIVGAGSAGCVLADRLSESGQHQVLLLEAGGSDKSIFIQMPTALSYPMNTEKYAWQFETVAEEGLDGRQLHCP
RGKVLGGSSSINGMVYVRGHACDFDEWEAEGAKGWNYQACLPYFRKAETWTGGADEYRGGSGPVGTCNGNDMKLNPLYQA
FIEAGKDAGYPETQDYNGYQQEGFGPMHMTVDKGVRASTSNAYLSRAKKRSNFTLMKGVTAHRILLEGKKAVGIEFEQSG
EIKQCFANKEVVSSAGSIGSVQLLQLSGIGPKTVLDKAGIEVKHTLEGVGKNLQDHLEVYFQYHCKQPITLNSKLGLISK
GLIGTEWILTRKGLGATNHFESCAFIRSREGLKSPNIQFHFLPAAMRYDGRAAFDGHGFQVHVGPNKPESRGSVEVVSAN
PNDKPKIEFNYISTEQDKQDWRDCIRLTREILNQPAMDAFRGEEIQPGLNITSDEAIGEWVKQNVESAYHPSCSCKMGSN
DDPMAVLNEACQVRGIEGLRVVDSSIFPTIPNGNLNAPTIMVAERAADMILGNTLEQSNNTPVWIAPNWQETQRMRPPKR
DLSSISSIA

Sequences:

>Translated_569_residues
MQQHYDYIIVGAGSAGCVLADRLSESGQHQVLLLEAGGSDKSIFIQMPTALSYPMNTEKYAWQFETVAEEGLDGRQLHCP
RGKVLGGSSSINGMVYVRGHACDFDEWEAEGAKGWNYQACLPYFRKAETWTGGADEYRGGSGPVGTCNGNDMKLNPLYQA
FIEAGKDAGYPETQDYNGYQQEGFGPMHMTVDKGVRASTSNAYLSRAKKRSNFTLMKGVTAHRILLEGKKAVGIEFEQSG
EIKQCFANKEVVSSAGSIGSVQLLQLSGIGPKTVLDKAGIEVKHTLEGVGKNLQDHLEVYFQYHCKQPITLNSKLGLISK
GLIGTEWILTRKGLGATNHFESCAFIRSREGLKSPNIQFHFLPAAMRYDGRAAFDGHGFQVHVGPNKPESRGSVEVVSAN
PNDKPKIEFNYISTEQDKQDWRDCIRLTREILNQPAMDAFRGEEIQPGLNITSDEAIGEWVKQNVESAYHPSCSCKMGSN
DDPMAVLNEACQVRGIEGLRVVDSSIFPTIPNGNLNAPTIMVAERAADMILGNTLEQSNNTPVWIAPNWQETQRMRPPKR
DLSSISSIA
>Mature_569_residues
MQQHYDYIIVGAGSAGCVLADRLSESGQHQVLLLEAGGSDKSIFIQMPTALSYPMNTEKYAWQFETVAEEGLDGRQLHCP
RGKVLGGSSSINGMVYVRGHACDFDEWEAEGAKGWNYQACLPYFRKAETWTGGADEYRGGSGPVGTCNGNDMKLNPLYQA
FIEAGKDAGYPETQDYNGYQQEGFGPMHMTVDKGVRASTSNAYLSRAKKRSNFTLMKGVTAHRILLEGKKAVGIEFEQSG
EIKQCFANKEVVSSAGSIGSVQLLQLSGIGPKTVLDKAGIEVKHTLEGVGKNLQDHLEVYFQYHCKQPITLNSKLGLISK
GLIGTEWILTRKGLGATNHFESCAFIRSREGLKSPNIQFHFLPAAMRYDGRAAFDGHGFQVHVGPNKPESRGSVEVVSAN
PNDKPKIEFNYISTEQDKQDWRDCIRLTREILNQPAMDAFRGEEIQPGLNITSDEAIGEWVKQNVESAYHPSCSCKMGSN
DDPMAVLNEACQVRGIEGLRVVDSSIFPTIPNGNLNAPTIMVAERAADMILGNTLEQSNNTPVWIAPNWQETQRMRPPKR
DLSSISSIA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=557, Percent_Identity=49.9102333931777, Blast_Score=540, Evalue=1e-154,
Organism=Escherichia coli, GI1786503, Length=535, Percent_Identity=50.8411214953271, Blast_Score=533, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17532301, Length=544, Percent_Identity=45.5882352941176, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=34.3859649122807, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=34.3859649122807, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642048, Length=568, Percent_Identity=34.8591549295775, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17137792, Length=554, Percent_Identity=34.2960288808664, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24642055, Length=583, Percent_Identity=33.9622641509434, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24642042, Length=564, Percent_Identity=34.2198581560284, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24642059, Length=567, Percent_Identity=34.3915343915344, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24642039, Length=567, Percent_Identity=31.5696649029982, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24642037, Length=576, Percent_Identity=32.8125, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24642051, Length=570, Percent_Identity=31.9298245614035, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24650267, Length=592, Percent_Identity=32.6013513513513, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24642035, Length=574, Percent_Identity=32.5783972125435, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI18859995, Length=584, Percent_Identity=31.3356164383562, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI18859993, Length=570, Percent_Identity=32.1052631578947, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24642057, Length=596, Percent_Identity=26.8456375838926, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645930, Length=581, Percent_Identity=26.8502581755594, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_VIBHB (A7N2P9)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001448298.1
- ProteinModelPortal:   A7N2P9
- SMR:   A7N2P9
- STRING:   A7N2P9
- GeneID:   5558185
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_06179
- NMPDR:   fig|338187.4.peg.3647
- eggNOG:   COG2303
- HOGENOM:   HBG734713
- OMA:   DNRRMHC
- ProtClustDB:   PRK02106
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 62530; Mature: 62530

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 470-470

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQHYDYIIVGAGSAGCVLADRLSESGQHQVLLLEAGGSDKSIFIQMPTALSYPMNTEKY
CCCCCCEEEEECCCCCEEEHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCHH
AWQFETVAEEGLDGRQLHCPRGKVLGGSSSINGMVYVRGHACDFDEWEAEGAKGWNYQAC
EEEEHHHHHCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCCHHHHCCCCCCCCCHHH
LPYFRKAETWTGGADEYRGGSGPVGTCNGNDMKLNPLYQAFIEAGKDAGYPETQDYNGYQ
HHHHHHCCCCCCCCHHCCCCCCCEECCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCHH
QEGFGPMHMTVDKGVRASTSNAYLSRAKKRSNFTLMKGVTAHRILLEGKKAVGIEFEQSG
HCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEEECCCEEEEEECCCC
EIKQCFANKEVVSSAGSIGSVQLLQLSGIGPKTVLDKAGIEVKHTLEGVGKNLQDHLEVY
CHHHHHCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
FQYHCKQPITLNSKLGLISKGLIGTEWILTRKGLGATNHFESCAFIRSREGLKSPNIQFH
HHHHCCCCEEECCCCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEE
FLPAAMRYDGRAAFDGHGFQVHVGPNKPESRGSVEVVSANPNDKPKIEFNYISTEQDKQD
EECCEECCCCCEEECCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHH
WRDCIRLTREILNQPAMDAFRGEEIQPGLNITSDEAIGEWVKQNVESAYHPSCSCKMGSN
HHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCC
DDPMAVLNEACQVRGIEGLRVVDSSIFPTIPNGNLNAPTIMVAERAADMILGNTLEQSNN
CCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCHHHCCCC
TPVWIAPNWQETQRMRPPKRDLSSISSIA
CCEEEECCHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MQQHYDYIIVGAGSAGCVLADRLSESGQHQVLLLEAGGSDKSIFIQMPTALSYPMNTEKY
CCCCCCEEEEECCCCCEEEHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCHH
AWQFETVAEEGLDGRQLHCPRGKVLGGSSSINGMVYVRGHACDFDEWEAEGAKGWNYQAC
EEEEHHHHHCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCCHHHHCCCCCCCCCHHH
LPYFRKAETWTGGADEYRGGSGPVGTCNGNDMKLNPLYQAFIEAGKDAGYPETQDYNGYQ
HHHHHHCCCCCCCCHHCCCCCCCEECCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCHH
QEGFGPMHMTVDKGVRASTSNAYLSRAKKRSNFTLMKGVTAHRILLEGKKAVGIEFEQSG
HCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEEECCCEEEEEECCCC
EIKQCFANKEVVSSAGSIGSVQLLQLSGIGPKTVLDKAGIEVKHTLEGVGKNLQDHLEVY
CHHHHHCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
FQYHCKQPITLNSKLGLISKGLIGTEWILTRKGLGATNHFESCAFIRSREGLKSPNIQFH
HHHHCCCCEEECCCCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEE
FLPAAMRYDGRAAFDGHGFQVHVGPNKPESRGSVEVVSANPNDKPKIEFNYISTEQDKQD
EECCEECCCCCEEECCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHH
WRDCIRLTREILNQPAMDAFRGEEIQPGLNITSDEAIGEWVKQNVESAYHPSCSCKMGSN
HHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCC
DDPMAVLNEACQVRGIEGLRVVDSSIFPTIPNGNLNAPTIMVAERAADMILGNTLEQSNN
CCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCHHHCCCC
TPVWIAPNWQETQRMRPPKRDLSSISSIA
CCEEEECCHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA