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The map label for this gene is pdhB [H]

Identifier: 156976779

GI number: 156976779

Start: 758448

End: 759431

Strand: Reverse

Name: pdhB [H]

Synonym: VIBHAR_05554

Alternate gene names: 156976779

Gene position: 759431-758448 (Counterclockwise)

Preceding gene: 156976780

Following gene: 156976778

Centisome position: 34.46

GC content: 51.42

Gene sequence:

>984_bases
ATGGCTGAACTGACGTTAGTTGAAGCAGTGAACCTCGCACTGCACCATGAAATGGAACGCGACCCGAATGTCATCGTCCT
TGGCGAAGATGTGGGTGACAACGGCGGTGTATTCCGCGCCACTGTCGGACTCAAGCAAAAATACGGCCTTAAGCGCGTTA
TCGACACGCCATTAGCCGAAGCACTTATTGGCGGTGTCACTGTCGGGATGGCAACGCAAGGCTTAAGACCTGTCGCAGAG
TTTCAATTCCAAGGCTTTGTCTTCCCCGCGCTGGAGCATTTAATGTGTCACGCAGCGCGAATGCGTAACCGTACTCGTGG
TCGACTTACCTGCCCCGCAGTGTTCCGTGCACCTTTTGGTGGCGGTATTCACGCACCAGAACATCACTCTGAAAGTGTTG
AAGCTCTGTTTGCTCACACCGCAGGTTTTAAGGTTGTGATTCCTTCCTCACCGCAACGTGCTTACGGTTTGCTCCTTGCA
GCCATACGTAGCAACGATCCGGTAATGTTCTTCGAGCCGAAACGTACCTATCGCACTGTGAAATCAGAAGTGATTGATAA
CGGCGAGGCACTTCCTCTGGATACTTGCTTTACCTTACGCAAAGGTCGCGACGTCACATTAGTGACTTGGGGCGCATGCG
TGGTTGAATCACTGCAAGCAGCTCAAACGCTGTCTAATCAGGGTATCGAAGTTGAGGTGATTGATTTAGCCAGCATCAAA
CCCATTGATACCGCGACCATCTTCCGTTCACTTGAGAAAACCGGACGCCTCTTGGTGGTACATGAAGCCAGTAAAACCTG
TGGTGTCGGCTCAGAACTGCTAGCCAGAACCGCAGAACATGCGATGTGCCTACTCAAAGCGCCACCAAAACGCGTCACAG
GTATGGATACCATTATGCCGTACTACCGCAACGAAGATTATTACATGGTTCAGGAAGAAGACATTGTACTCGCCGCGCGC
GAACTCGTGGAGGATTGGAAATGA

Upstream 100 bases:

>100_bases
GAAACGGGCTTTGACTTCCTTTATGAATCCCTACCCCAAGAGCTTCATGCACAAAGAGATGAACTGATCAACAAAGCAAT
GCGAATGCAGGGAGGGAAAC

Downstream 100 bases:

>100_bases
AGACGTTTAACTTACCCGATCTCGGCGAAGGTCTCGCTGAGTCAGAAATTGTGAAATGGCATATTAGTGTTGGCGATATG
GTCCAACTCGATCAAATAGT

Product: pyruvate dehydrogenase E1 component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAELTLVEAVNLALHHEMERDPNVIVLGEDVGDNGGVFRATVGLKQKYGLKRVIDTPLAEALIGGVTVGMATQGLRPVAE
FQFQGFVFPALEHLMCHAARMRNRTRGRLTCPAVFRAPFGGGIHAPEHHSESVEALFAHTAGFKVVIPSSPQRAYGLLLA
AIRSNDPVMFFEPKRTYRTVKSEVIDNGEALPLDTCFTLRKGRDVTLVTWGACVVESLQAAQTLSNQGIEVEVIDLASIK
PIDTATIFRSLEKTGRLLVVHEASKTCGVGSELLARTAEHAMCLLKAPPKRVTGMDTIMPYYRNEDYYMVQEEDIVLAAR
ELVEDWK

Sequences:

>Translated_327_residues
MAELTLVEAVNLALHHEMERDPNVIVLGEDVGDNGGVFRATVGLKQKYGLKRVIDTPLAEALIGGVTVGMATQGLRPVAE
FQFQGFVFPALEHLMCHAARMRNRTRGRLTCPAVFRAPFGGGIHAPEHHSESVEALFAHTAGFKVVIPSSPQRAYGLLLA
AIRSNDPVMFFEPKRTYRTVKSEVIDNGEALPLDTCFTLRKGRDVTLVTWGACVVESLQAAQTLSNQGIEVEVIDLASIK
PIDTATIFRSLEKTGRLLVVHEASKTCGVGSELLARTAEHAMCLLKAPPKRVTGMDTIMPYYRNEDYYMVQEEDIVLAAR
ELVEDWK
>Mature_326_residues
AELTLVEAVNLALHHEMERDPNVIVLGEDVGDNGGVFRATVGLKQKYGLKRVIDTPLAEALIGGVTVGMATQGLRPVAEF
QFQGFVFPALEHLMCHAARMRNRTRGRLTCPAVFRAPFGGGIHAPEHHSESVEALFAHTAGFKVVIPSSPQRAYGLLLAA
IRSNDPVMFFEPKRTYRTVKSEVIDNGEALPLDTCFTLRKGRDVTLVTWGACVVESLQAAQTLSNQGIEVEVIDLASIKP
IDTATIFRSLEKTGRLLVVHEASKTCGVGSELLARTAEHAMCLLKAPPKRVTGMDTIMPYYRNEDYYMVQEEDIVLAARE
LVEDWK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=41.0493827160494, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=41.0493827160494, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI156564403, Length=324, Percent_Identity=36.4197530864198, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=34.8765432098765, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17506935, Length=309, Percent_Identity=39.8058252427184, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17538422, Length=302, Percent_Identity=38.0794701986755, Blast_Score=201, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=35.2760736196319, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI160714828, Length=323, Percent_Identity=40.8668730650155, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI160714832, Length=323, Percent_Identity=40.8668730650155, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21358145, Length=321, Percent_Identity=40.4984423676012, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24650940, Length=321, Percent_Identity=40.4984423676012, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=45.0549450549451, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=45.0549450549451, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35971; Mature: 35840

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTLVEAVNLALHHEMERDPNVIVLGEDVGDNGGVFRATVGLKQKYGLKRVIDTPLAE
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHCCHHHHHCCHHHH
ALIGGVTVGMATQGLRPVAEFQFQGFVFPALEHLMCHAARMRNRTRGRLTCPAVFRAPFG
HHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCHHEECCCC
GGIHAPEHHSESVEALFAHTAGFKVVIPSSPQRAYGLLLAAIRSNDPVMFFEPKRTYRTV
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHEECCCCCEEEECCHHHHHHH
KSEVIDNGEALPLDTCFTLRKGRDVTLVTWGACVVESLQAAQTLSNQGIEVEVIDLASIK
HHHHHCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
PIDTATIFRSLEKTGRLLVVHEASKTCGVGSELLARTAEHAMCLLKAPPKRVTGMDTIMP
CCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEECCCCCHHCCHHHHHH
YYRNEDYYMVQEEDIVLAARELVEDWK
HEECCCEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AELTLVEAVNLALHHEMERDPNVIVLGEDVGDNGGVFRATVGLKQKYGLKRVIDTPLAE
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHCCHHHHHCCHHHH
ALIGGVTVGMATQGLRPVAEFQFQGFVFPALEHLMCHAARMRNRTRGRLTCPAVFRAPFG
HHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCHHEECCCC
GGIHAPEHHSESVEALFAHTAGFKVVIPSSPQRAYGLLLAAIRSNDPVMFFEPKRTYRTV
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHEECCCCCEEEECCHHHHHHH
KSEVIDNGEALPLDTCFTLRKGRDVTLVTWGACVVESLQAAQTLSNQGIEVEVIDLASIK
HHHHHCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
PIDTATIFRSLEKTGRLLVVHEASKTCGVGSELLARTAEHAMCLLKAPPKRVTGMDTIMP
CCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEECCCCCHHCCHHHHHH
YYRNEDYYMVQEEDIVLAARELVEDWK
HEECCCEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]