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The map label for this gene is mmsB [H]

Identifier: 156976712

GI number: 156976712

Start: 700099

End: 701004

Strand: Direct

Name: mmsB [H]

Synonym: VIBHAR_05487

Alternate gene names: 156976712

Gene position: 700099-701004 (Clockwise)

Preceding gene: 156976711

Following gene: 156976713

Centisome position: 31.76

GC content: 49.01

Gene sequence:

>906_bases
ATGAGTACCATTGCATTTATTGGCTTGGGCAACATGGGCAGTCCAATGGCACAAAACCTATTGGCGTCAGGGTTTCATGT
GCAAGTGTTCGATGTGGATGTGAACGCCGCGAAGCAACTCGAACCGTTTGGCGCAGTGGTTGCTAGTACCTTAGAAGAAG
CCGTGGATGGCGCTGGCACGGTGATCACCATGCTACCTGCAGGTGCACACGTGCGTGCGGTGTATTTGGGGGATTTACGT
GGTGGTGTTGGTTTGCTCAACATTGTGCAGGACAATGCATTGCTGATTGACTGTTCGACCATTGATCCAGATTCTGCTCG
TTTGGTGGCGAACGAAGCACAGAACAAACGATTGTTGTTTGTTGATTCTCCTGTCTCAGGCGGCGTGGCAGGTGCAAAAG
CGGCAACGCTGACCTTTATTGTTGGCGGTTCGGACGAAGCATTCTCCAAAGCCAATGCGATCTTGCGATACATGGGTAAA
AACGTATTCCACGCAGGGAAAGCAGGCGATGGTCAGATGGCGAAGATCTGTAACAACCTGATGCTGGGCATTTTGATGTC
GGGAACTTGCGAAGCGCTCAATCTTGGTATTGACCACGGACTTGATCCGAAAGTATTATCCAACATCATGCTGCAAAGCT
CAGGTCGAAACTGGGCGTTAGAGCTTTATAACCCATGTCCCGGAGTGATGGACTCTGCACCAGCGAGCAATCAATACAAC
CCTGGTTTTATGAGTAAGCTGATGTTGAAAGATCTTGGCTTAGGTTTGGATGCAGCGCTGCAAACTAACTCTTCTGTTCC
GATGGGCTCTTTGGCTCGTAATCTTTATGTATTCCACAATGCCAGCGGTCATGCGGAACTCGATTTCTCAAGCTTGTTTG
AATTCTATAAGAACCAGAAGGGCTAA

Upstream 100 bases:

>100_bases
TCAGTGAAGTCGATGAAAGCGTCATCGACACCTTGTTTACTTCTCTTTGGTCAGAAGAGGAACATCCACTTGCACAGCTA
GGAAAATAAGGAGAAACAAC

Downstream 100 bases:

>100_bases
AAGAGAGATTCCCTATCACGCTCGTTCTTCGCTGTAGGGAATGACGGTTTTGGCGAGGCTAAGACTGCCATTCACTTTAT
CTGGACGAGCTCGATAGTTT

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSTIAFIGLGNMGSPMAQNLLASGFHVQVFDVDVNAAKQLEPFGAVVASTLEEAVDGAGTVITMLPAGAHVRAVYLGDLR
GGVGLLNIVQDNALLIDCSTIDPDSARLVANEAQNKRLLFVDSPVSGGVAGAKAATLTFIVGGSDEAFSKANAILRYMGK
NVFHAGKAGDGQMAKICNNLMLGILMSGTCEALNLGIDHGLDPKVLSNIMLQSSGRNWALELYNPCPGVMDSAPASNQYN
PGFMSKLMLKDLGLGLDAALQTNSSVPMGSLARNLYVFHNASGHAELDFSSLFEFYKNQKG

Sequences:

>Translated_301_residues
MSTIAFIGLGNMGSPMAQNLLASGFHVQVFDVDVNAAKQLEPFGAVVASTLEEAVDGAGTVITMLPAGAHVRAVYLGDLR
GGVGLLNIVQDNALLIDCSTIDPDSARLVANEAQNKRLLFVDSPVSGGVAGAKAATLTFIVGGSDEAFSKANAILRYMGK
NVFHAGKAGDGQMAKICNNLMLGILMSGTCEALNLGIDHGLDPKVLSNIMLQSSGRNWALELYNPCPGVMDSAPASNQYN
PGFMSKLMLKDLGLGLDAALQTNSSVPMGSLARNLYVFHNASGHAELDFSSLFEFYKNQKG
>Mature_300_residues
STIAFIGLGNMGSPMAQNLLASGFHVQVFDVDVNAAKQLEPFGAVVASTLEEAVDGAGTVITMLPAGAHVRAVYLGDLRG
GVGLLNIVQDNALLIDCSTIDPDSARLVANEAQNKRLLFVDSPVSGGVAGAKAATLTFIVGGSDEAFSKANAILRYMGKN
VFHAGKAGDGQMAKICNNLMLGILMSGTCEALNLGIDHGLDPKVLSNIMLQSSGRNWALELYNPCPGVMDSAPASNQYNP
GFMSKLMLKDLGLGLDAALQTNSSVPMGSLARNLYVFHNASGHAELDFSSLFEFYKNQKG

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=45.1505016722408, Blast_Score=267, Evalue=8e-72,
Organism=Homo sapiens, GI40556376, Length=293, Percent_Identity=24.2320819112628, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1790315, Length=312, Percent_Identity=34.9358974358974, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI145693186, Length=295, Percent_Identity=30.5084745762712, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786719, Length=300, Percent_Identity=28.3333333333333, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789092, Length=298, Percent_Identity=25.8389261744966, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=301, Percent_Identity=41.8604651162791, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24655230, Length=297, Percent_Identity=43.7710437710438, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19922568, Length=297, Percent_Identity=43.7710437710438, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI28574115, Length=304, Percent_Identity=24.6710526315789, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 31543; Mature: 31411

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIAFIGLGNMGSPMAQNLLASGFHVQVFDVDVNAAKQLEPFGAVVASTLEEAVDGAGT
CCEEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHCCCCE
VITMLPAGAHVRAVYLGDLRGGVGLLNIVQDNALLIDCSTIDPDSARLVANEAQNKRLLF
EEEEECCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCEEEECCCCCCEEEE
VDSPVSGGVAGAKAATLTFIVGGSDEAFSKANAILRYMGKNVFHAGKAGDGQMAKICNNL
EECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHH
MLGILMSGTCEALNLGIDHGLDPKVLSNIMLQSSGRNWALELYNPCPGVMDSAPASNQYN
HHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
PGFMSKLMLKDLGLGLDAALQTNSSVPMGSLARNLYVFHNASGHAELDFSSLFEFYKNQK
CHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHCEEEEEECCCCCCEECHHHHHHHHHCCC
G
C
>Mature Secondary Structure 
STIAFIGLGNMGSPMAQNLLASGFHVQVFDVDVNAAKQLEPFGAVVASTLEEAVDGAGT
CEEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHCCCCE
VITMLPAGAHVRAVYLGDLRGGVGLLNIVQDNALLIDCSTIDPDSARLVANEAQNKRLLF
EEEEECCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCEEEECCCCCCEEEE
VDSPVSGGVAGAKAATLTFIVGGSDEAFSKANAILRYMGKNVFHAGKAGDGQMAKICNNL
EECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHH
MLGILMSGTCEALNLGIDHGLDPKVLSNIMLQSSGRNWALELYNPCPGVMDSAPASNQYN
HHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
PGFMSKLMLKDLGLGLDAALQTNSSVPMGSLARNLYVFHNASGHAELDFSSLFEFYKNQK
CHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHCEEEEEECCCCCCEECHHHHHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]