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The map label for this gene is crt [H]

Identifier: 156976711

GI number: 156976711

Start: 698963

End: 700087

Strand: Direct

Name: crt [H]

Synonym: VIBHAR_05486

Alternate gene names: 156976711

Gene position: 698963-700087 (Clockwise)

Preceding gene: 156976710

Following gene: 156976712

Centisome position: 31.71

GC content: 47.2

Gene sequence:

>1125_bases
ATGACAGGGAAAGTAACCATTAGCGAAATAGATTGCTTAGACGGCGTGCACCGAATTGGTATCGCGACGTTAGACAACAC
GGCTTCTTTGAATGCGTTGACTTACGACATGTTGGCAGAGCTCAACGACCAACTTATCGAATGGCAAGATGACCCTGATT
TGGTTTGTGTCATCCTCAATGGGGCGGGCGAAAAAGCGTTTTGTGCAGGGGGCGATGTACGAACCATGTACCATGTCATG
CACGAGAAAAGCAAAGAAGAAACTGCCGAATTCTGCTCTAACTACTTCTCGCTCGAATACGAGTGTGACTACCTGATTCA
TACCTACCAAAAGCCAATCATTGGCTGGGGTGAGGGCATTGTGATGGGCGGAGGTATGGGCTTGTTTATGGGCACTAGCC
ACAGGGTTGTTACCCCTAAATCTCGTCTTGCGATGCCAGAGATCAATATCGGGCTTTATCCAGACGTGGGTGGCACTTGG
TTCTTAAGCCAAATCGACCCAGAAGTAGGTTTGTTCTTAGGACTGACTGGCGCAATGGTGAATTCAAGTGACGCGGTCAC
TGTTGGTTTGGCAGAATGGTTGCTGTTGGAAGAGCAATATCCGGCATTGCTTGAAGAATTGAAGCAAGTAGCTTGGGGTT
CTGCTGATGCCAAATCGCTAGTCAGCGCGTTACTTCAATTAATGGAAGAGGAAGTTATCGACAGTAAACCAACCACACAA
ATCTGCCCGTATCTCGACCAAATTAAAGAAGCCTGCAAAGGTTCAGATTTAAATCAGATTGCCCAACGCATTCAAGCAAT
AGAAGGCGGCACTCAATGGCTTGAGATCGCGCAAAAGTCATTTGCCTCGGGCAGTCCGATCACCGCGCATATCTGCTTTA
GACAAGTCAAAGAGTACCACCGTTTATCGTTGGCGGATTGTTTCCGTCTAGAGCTAACCTTGTCAGTTCGTAGCGCATTA
CTCGGTGAGTTTGAAGAGGGCGTGCGCTCTCGATTAGTTGATAAAGACGGCAATCCAAAATGGATGTTTAACAGCGTCAG
TGAAGTCGATGAAAGCGTCATCGACACCTTGTTTACTTCTCTTTGGTCAGAAGAGGAACATCCACTTGCACAGCTAGGAA
AATAA

Upstream 100 bases:

>100_bases
AACTGTTTCTAAACTTATTCGATACCGAAGATCAAACCGAGGGGGTTCGTGCCTTCTTGGAAAAACGTAAACCCAACTGG
AAGAATCAATAGGAGGTCGC

Downstream 100 bases:

>100_bases
GGAGAAACAACATGAGTACCATTGCATTTATTGGCTTGGGCAACATGGGCAGTCCAATGGCACAAAACCTATTGGCGTCA
GGGTTTCATGTGCAAGTGTT

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTGKVTISEIDCLDGVHRIGIATLDNTASLNALTYDMLAELNDQLIEWQDDPDLVCVILNGAGEKAFCAGGDVRTMYHVM
HEKSKEETAEFCSNYFSLEYECDYLIHTYQKPIIGWGEGIVMGGGMGLFMGTSHRVVTPKSRLAMPEINIGLYPDVGGTW
FLSQIDPEVGLFLGLTGAMVNSSDAVTVGLAEWLLLEEQYPALLEELKQVAWGSADAKSLVSALLQLMEEEVIDSKPTTQ
ICPYLDQIKEACKGSDLNQIAQRIQAIEGGTQWLEIAQKSFASGSPITAHICFRQVKEYHRLSLADCFRLELTLSVRSAL
LGEFEEGVRSRLVDKDGNPKWMFNSVSEVDESVIDTLFTSLWSEEEHPLAQLGK

Sequences:

>Translated_374_residues
MTGKVTISEIDCLDGVHRIGIATLDNTASLNALTYDMLAELNDQLIEWQDDPDLVCVILNGAGEKAFCAGGDVRTMYHVM
HEKSKEETAEFCSNYFSLEYECDYLIHTYQKPIIGWGEGIVMGGGMGLFMGTSHRVVTPKSRLAMPEINIGLYPDVGGTW
FLSQIDPEVGLFLGLTGAMVNSSDAVTVGLAEWLLLEEQYPALLEELKQVAWGSADAKSLVSALLQLMEEEVIDSKPTTQ
ICPYLDQIKEACKGSDLNQIAQRIQAIEGGTQWLEIAQKSFASGSPITAHICFRQVKEYHRLSLADCFRLELTLSVRSAL
LGEFEEGVRSRLVDKDGNPKWMFNSVSEVDESVIDTLFTSLWSEEEHPLAQLGK
>Mature_373_residues
TGKVTISEIDCLDGVHRIGIATLDNTASLNALTYDMLAELNDQLIEWQDDPDLVCVILNGAGEKAFCAGGDVRTMYHVMH
EKSKEETAEFCSNYFSLEYECDYLIHTYQKPIIGWGEGIVMGGGMGLFMGTSHRVVTPKSRLAMPEINIGLYPDVGGTWF
LSQIDPEVGLFLGLTGAMVNSSDAVTVGLAEWLLLEEQYPALLEELKQVAWGSADAKSLVSALLQLMEEEVIDSKPTTQI
CPYLDQIKEACKGSDLNQIAQRIQAIEGGTQWLEIAQKSFASGSPITAHICFRQVKEYHRLSLADCFRLELTLSVRSALL
GEFEEGVRSRLVDKDGNPKWMFNSVSEVDESVIDTLFTSLWSEEEHPLAQLGK

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=346, Percent_Identity=34.1040462427746, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI37594469, Length=296, Percent_Identity=33.445945945946, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI194097323, Length=211, Percent_Identity=29.3838862559242, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI221142681, Length=205, Percent_Identity=26.3414634146341, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=341, Percent_Identity=33.1378299120235, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI25144157, Length=341, Percent_Identity=33.1378299120235, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17558304, Length=175, Percent_Identity=27.4285714285714, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=178, Percent_Identity=29.2134831460674, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=342, Percent_Identity=28.6549707602339, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI28571730, Length=347, Percent_Identity=33.1412103746398, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28571729, Length=347, Percent_Identity=33.1412103746398, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129971, Length=189, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653477, Length=189, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 41373; Mature: 41241

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKVTISEIDCLDGVHRIGIATLDNTASLNALTYDMLAELNDQLIEWQDDPDLVCVILN
CCCCEEHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
GAGEKAFCAGGDVRTMYHVMHEKSKEETAEFCSNYFSLEYECDYLIHTYQKPIIGWGEGI
CCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCEEEECHHHHHHHCCCCEECCCCE
VMGGGMGLFMGTSHRVVTPKSRLAMPEINIGLYPDVGGTWFLSQIDPEVGLFLGLTGAMV
EEECCCEEEECCCCCEECCHHHCCCCCCCCEECCCCCCEEEHHHCCCCHHHHHHHHHHHC
NSSDAVTVGLAEWLLLEEQYPALLEELKQVAWGSADAKSLVSALLQLMEEEVIDSKPTTQ
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHH
ICPYLDQIKEACKGSDLNQIAQRIQAIEGGTQWLEIAQKSFASGSPITAHICFRQVKEYH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RLSLADCFRLELTLSVRSALLGEFEEGVRSRLVDKDGNPKWMFNSVSEVDESVIDTLFTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHH
LWSEEEHPLAQLGK
HHCCCCCCHHHCCC
>Mature Secondary Structure 
TGKVTISEIDCLDGVHRIGIATLDNTASLNALTYDMLAELNDQLIEWQDDPDLVCVILN
CCCEEHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
GAGEKAFCAGGDVRTMYHVMHEKSKEETAEFCSNYFSLEYECDYLIHTYQKPIIGWGEGI
CCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCEEEECHHHHHHHCCCCEECCCCE
VMGGGMGLFMGTSHRVVTPKSRLAMPEINIGLYPDVGGTWFLSQIDPEVGLFLGLTGAMV
EEECCCEEEECCCCCEECCHHHCCCCCCCCEECCCCCCEEEHHHCCCCHHHHHHHHHHHC
NSSDAVTVGLAEWLLLEEQYPALLEELKQVAWGSADAKSLVSALLQLMEEEVIDSKPTTQ
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHH
ICPYLDQIKEACKGSDLNQIAQRIQAIEGGTQWLEIAQKSFASGSPITAHICFRQVKEYH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RLSLADCFRLELTLSVRSALLGEFEEGVRSRLVDKDGNPKWMFNSVSEVDESVIDTLFTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHH
LWSEEEHPLAQLGK
HHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]