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The map label for this gene is pcp

Identifier: 156976663

GI number: 156976663

Start: 652493

End: 653131

Strand: Direct

Name: pcp

Synonym: VIBHAR_05437

Alternate gene names: 156976663

Gene position: 652493-653131 (Clockwise)

Preceding gene: 156976660

Following gene: 156976664

Centisome position: 29.6

GC content: 46.32

Gene sequence:

>639_bases
ATGAAGAAAGTGTTAATGACAGGTTTTGAACCATTTGGTGGTGAATCCATCAACCCTGCTTTAGAAGCAGTAAAGCGACT
TGATGGCAAAAAACTCGATGGTGGTGAGGTGATGATTTGCCAAGTACCTGTAACACGTTATGAATCTATCGACACCGTGG
TTAATGCGATTGAGCAATATCAGCCAGACATTGTGATTACAGTAGGGCAGGCAGCTGGGCGTGCAGCGATTACTCCAGAA
CGTGTGGCGATCAATGTGGATGATTTCCGCATTCCTGATAATGGTGGTCATCAACCCATTGACGAGCCGGTAATCCTAGA
CGGCCCAGACGCGTACTTTACCACGCTACCCATTAAGGCGATCACGAGCGCTTTGCACAAGGCAAGTATTCCATGCCAAG
TCTCGAACACGGCAGGGACGTTTGTGTGTAATCATCTGTTTTATGGCATACAGCATTATTTACGCGATAAATCGGTTCGA
CATGGTTTTGTGCATATTCCTCTTTTACCCGAGCAAGACGCTTCCGGTAATCAGCCAACCATGTCATTGGATCTAATTGT
GGAAGGGTTAGCGTTGTTAGCTCAAGCCGTGATCGATAACGAATCTGATGTTGCGATCACTGCCGGACAGATTTGTTAA

Upstream 100 bases:

>100_bases
GACCACCGCCGCGATGCGATAATACTTGGCCTTATGATGCTAAGTTATTGTAAATTCGAGCCTCAACCATTGAGTTTTAC
TATCAAGAGAAAATAGCCCG

Downstream 100 bases:

>100_bases
CCAGCACCATAAGCTCAAGTCTTTACACAAACACCGAGCGATGAACGAGCTCGGTGTTTGTGTATCTGTTAAGTCGCTCA
AATTTTGTGGAGTATGAAAG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKKVLMTGFEPFGGESINPALEAVKRLDGKKLDGGEVMICQVPVTRYESIDTVVNAIEQYQPDIVITVGQAAGRAAITPE
RVAINVDDFRIPDNGGHQPIDEPVILDGPDAYFTTLPIKAITSALHKASIPCQVSNTAGTFVCNHLFYGIQHYLRDKSVR
HGFVHIPLLPEQDASGNQPTMSLDLIVEGLALLAQAVIDNESDVAITAGQIC

Sequences:

>Translated_212_residues
MKKVLMTGFEPFGGESINPALEAVKRLDGKKLDGGEVMICQVPVTRYESIDTVVNAIEQYQPDIVITVGQAAGRAAITPE
RVAINVDDFRIPDNGGHQPIDEPVILDGPDAYFTTLPIKAITSALHKASIPCQVSNTAGTFVCNHLFYGIQHYLRDKSVR
HGFVHIPLLPEQDASGNQPTMSLDLIVEGLALLAQAVIDNESDVAITAGQIC
>Mature_212_residues
MKKVLMTGFEPFGGESINPALEAVKRLDGKKLDGGEVMICQVPVTRYESIDTVVNAIEQYQPDIVITVGQAAGRAAITPE
RVAINVDDFRIPDNGGHQPIDEPVILDGPDAYFTTLPIKAITSALHKASIPCQVSNTAGTFVCNHLFYGIQHYLRDKSVR
HGFVHIPLLPEQDASGNQPTMSLDLIVEGLALLAQAVIDNESDVAITAGQIC

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=200, Percent_Identity=27, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_VIBHB (A7N3R7)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001447569.1
- ProteinModelPortal:   A7N3R7
- SMR:   A7N3R7
- STRING:   A7N3R7
- MEROPS:   C15.001
- GeneID:   5558916
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_05437
- NMPDR:   fig|338187.4.peg.3192
- eggNOG:   COG2039
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22846; Mature: 22846

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLMTGFEPFGGESINPALEAVKRLDGKKLDGGEVMICQVPVTRYESIDTVVNAIEQY
CCCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
QPDIVITVGQAAGRAAITPERVAINVDDFRIPDNGGHQPIDEPVILDGPDAYFTTLPIKA
CCCEEEEECCCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCEEEECCCCEEEECCHHH
ITSALHKASIPCQVSNTAGTFVCNHLFYGIQHYLRDKSVRHGFVHIPLLPEQDASGNQPT
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
MSLDLIVEGLALLAQAVIDNESDVAITAGQIC
CHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
>Mature Secondary Structure
MKKVLMTGFEPFGGESINPALEAVKRLDGKKLDGGEVMICQVPVTRYESIDTVVNAIEQY
CCCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
QPDIVITVGQAAGRAAITPERVAINVDDFRIPDNGGHQPIDEPVILDGPDAYFTTLPIKA
CCCEEEEECCCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCEEEECCCCEEEECCHHH
ITSALHKASIPCQVSNTAGTFVCNHLFYGIQHYLRDKSVRHGFVHIPLLPEQDASGNQPT
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
MSLDLIVEGLALLAQAVIDNESDVAITAGQIC
CHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA