Click here to switch to the map view.

The map label for this gene is phhA [H]

Identifier: 156976647

GI number: 156976647

Start: 643875

End: 644669

Strand: Direct

Name: phhA [H]

Synonym: VIBHAR_05421

Alternate gene names: 156976647

Gene position: 643875-644669 (Clockwise)

Preceding gene: 156976645

Following gene: 156976648

Centisome position: 29.21

GC content: 47.55

Gene sequence:

>795_bases
ATGACTCAGTATCATTCAAAACCCGTCGATCAGGATGGAAGGGTAGAATGGAGCCATGAAGAGGATGCCATTTGGCGCGA
CTTGGTAACCAGACAAATGAGCGTGATTCAAGACCGTGCATGCGAGGCGTATCTGCATGGACTTAAGCTGCTTGATTTAC
CCCAGGACCGAGTGCCACAACTGCCCGAAATCAATCGTGTTTTGATGGAAACCACGGGCTGGCAAGTGGAGCCAGTGCCA
GCATTGATCGACTTTGATCGTTTCTTCAATCTGCTTGGCAACAAACGCTTCCCAGTCGCGACGTTTTTGAGAACGCGAGA
AGAGTTTGATTACCTACAAGAGCCGGATTTCTTCCATGAGATTTTTGGTCATTGCGCCATGCTCACCAACCCTGATTTTG
CAGCCTTTACCGAGCACTACGGACAGCTTGGACAAGCTGCGACACCAAAGCAGCGAGGGTACCTTGCGCGTCTATATTGG
TTTACAGTCGAGTTTGGCTTGGTCCGAGAAGGTAATAAAACCAAAATCTATGGTGGCGGCATCCTTTCATCTCCGGGAGA
AACCATCTATTCATTGGAAAGCGACATCGCGATTAGAGGCGAATTCGATCTGCAAACTGTGCTAAGAACCCCTTATCGCA
TCGATATTATGCAGCCGAAATACTACGTGATTGAAGAATTGTCCCAGCTTTTCCAAATCAGCCAACTGAATTTATTGAAA
CAAGCCGATCTAGCGATTGAAGCCGGATTGCTTCCACCACTTTTTGAACCAAAGGAACCTGCTCATGTTGAATGA

Upstream 100 bases:

>100_bases
ATGTTACACCTACATTTTGATTGAAAAATCGTCGGGGGATTGGAAGGTGAAAAGAGTGCAGATAGGCTTAATGTAAAGGA
TTTGTTAACGGAGATGTGCA

Downstream 100 bases:

>100_bases
ACAAAAATGCGAAGCTTGTAGTATCGATGCCATTGCACTTAGTAAAGAGGAACAACAGTCTCTGCTGCTGCAATTGTCTG
ATTGGCAGATCATTGAGAGA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTQYHSKPVDQDGRVEWSHEEDAIWRDLVTRQMSVIQDRACEAYLHGLKLLDLPQDRVPQLPEINRVLMETTGWQVEPVP
ALIDFDRFFNLLGNKRFPVATFLRTREEFDYLQEPDFFHEIFGHCAMLTNPDFAAFTEHYGQLGQAATPKQRGYLARLYW
FTVEFGLVREGNKTKIYGGGILSSPGETIYSLESDIAIRGEFDLQTVLRTPYRIDIMQPKYYVIEELSQLFQISQLNLLK
QADLAIEAGLLPPLFEPKEPAHVE

Sequences:

>Translated_264_residues
MTQYHSKPVDQDGRVEWSHEEDAIWRDLVTRQMSVIQDRACEAYLHGLKLLDLPQDRVPQLPEINRVLMETTGWQVEPVP
ALIDFDRFFNLLGNKRFPVATFLRTREEFDYLQEPDFFHEIFGHCAMLTNPDFAAFTEHYGQLGQAATPKQRGYLARLYW
FTVEFGLVREGNKTKIYGGGILSSPGETIYSLESDIAIRGEFDLQTVLRTPYRIDIMQPKYYVIEELSQLFQISQLNLLK
QADLAIEAGLLPPLFEPKEPAHVE
>Mature_263_residues
TQYHSKPVDQDGRVEWSHEEDAIWRDLVTRQMSVIQDRACEAYLHGLKLLDLPQDRVPQLPEINRVLMETTGWQVEPVPA
LIDFDRFFNLLGNKRFPVATFLRTREEFDYLQEPDFFHEIFGHCAMLTNPDFAAFTEHYGQLGQAATPKQRGYLARLYWF
TVEFGLVREGNKTKIYGGGILSSPGETIYSLESDIAIRGEFDLQTVLRTPYRIDIMQPKYYVIEELSQLFQISQLNLLKQ
ADLAIEAGLLPPLFEPKEPAHVE

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=228, Percent_Identity=34.2105263157895, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI88900501, Length=228, Percent_Identity=34.2105263157895, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI88900505, Length=228, Percent_Identity=34.2105263157895, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557819, Length=228, Percent_Identity=32.0175438596491, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI31795563, Length=221, Percent_Identity=33.4841628959276, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4759248, Length=231, Percent_Identity=29.4372294372294, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=222, Percent_Identity=31.0810810810811, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=229, Percent_Identity=31.4410480349345, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=254, Percent_Identity=28.740157480315, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI115533973, Length=235, Percent_Identity=29.3617021276596, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=28.3870967741935, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17136776, Length=215, Percent_Identity=31.6279069767442, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136774, Length=217, Percent_Identity=31.3364055299539, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI62472054, Length=227, Percent_Identity=29.9559471365639, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24660393, Length=227, Percent_Identity=29.9559471365639, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24654994, Length=230, Percent_Identity=29.1304347826087, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30555; Mature: 30424

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYHSKPVDQDGRVEWSHEEDAIWRDLVTRQMSVIQDRACEAYLHGLKLLDLPQDRVPQ
CCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHCCC
LPEINRVLMETTGWQVEPVPALIDFDRFFNLLGNKRFPVATFLRTREEFDYLQEPDFFHE
CCHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHH
IFGHCAMLTNPDFAAFTEHYGQLGQAATPKQRGYLARLYWFTVEFGLVREGNKTKIYGGG
HHHHEEECCCCCHHHHHHHHHHHCCCCCCHHCCCEEEEEEEEEEEHEEECCCCEEEEECC
ILSSPGETIYSLESDIAIRGEFDLQTVLRTPYRIDIMQPKYYVIEELSQLFQISQLNLLK
EECCCCCEEEECCCCEEEECCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
QADLAIEAGLLPPLFEPKEPAHVE
HHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQYHSKPVDQDGRVEWSHEEDAIWRDLVTRQMSVIQDRACEAYLHGLKLLDLPQDRVPQ
CCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHCCC
LPEINRVLMETTGWQVEPVPALIDFDRFFNLLGNKRFPVATFLRTREEFDYLQEPDFFHE
CCHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHH
IFGHCAMLTNPDFAAFTEHYGQLGQAATPKQRGYLARLYWFTVEFGLVREGNKTKIYGGG
HHHHEEECCCCCHHHHHHHHHHHCCCCCCHHCCCEEEEEEEEEEEHEEECCCCEEEEECC
ILSSPGETIYSLESDIAIRGEFDLQTVLRTPYRIDIMQPKYYVIEELSQLFQISQLNLLK
EECCCCCEEEECCCCEEEECCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
QADLAIEAGLLPPLFEPKEPAHVE
HHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]