Click here to switch to the map view.

The map label for this gene is acsA1 [H]

Identifier: 156976646

GI number: 156976646

Start: 641683

End: 643653

Strand: Reverse

Name: acsA1 [H]

Synonym: VIBHAR_05420

Alternate gene names: 156976646

Gene position: 643653-641683 (Counterclockwise)

Preceding gene: 156976649

Following gene: 156976644

Centisome position: 29.2

GC content: 47.89

Gene sequence:

>1971_bases
ATGCGCGAGAGCAACAGAGTCTGGCATCCGACGGAAGATCGAACCGAGCAAGCCAATATCACGCAGTTTATCGAACACAT
TAATCGACAGGGTTTCGAGCTCAAAAACTACTCTGATTTGCACCAATGGTCATTGGAGCACAACGAGCATTTTTGGAAAG
AGGTTTGGCAGTTTTGTGACTTGATCGGAACGCAAGGAAATACAATCAAAACGCAAGGTGAGAGCCGCTGGCAATCGCCT
ATGTCAAACCGCGACACCATATGGTTCCCTCAAGCACAAGTTAACTATGCAGAAAATCTACTCAGCTTGGCAGAGAAACA
AGCCGATGAGCTGGCAATTTGGTTCGAAAATGAACGCGGAGATAAACATACCTACACATGGAAAGAGCTGTGTAATGAGG
TCTCGAGCGTTCAGCAATGGTTGGTAGAGTGCGGCATCAAGCGAGGTGATGTGGTTGCAGGCTATTTACCGCATATGCCA
CAAACCGTTATTGCAATGCTAGCCACCACCAGCCTAGGTGCAACTTGGACGTCTACCTCTCCTGATTTTGGGGTAGAAAG
CGTCATCGAGCGCTTCGGGCAAGTGAAGCCGAAAGTCCTGTTCACCTGCGATGGTTATACCTTCAGTGGCAAGACCTTCG
ATATGTCGGAGAAGAACCATCACATCGCGGATCATCTTGATGGGCTAAGACAAGTGTGTCAGATCAGTTACCTCAAACCG
AATTTGTTTGAGTGCGACGTTTGTACTCACGATTGGCAAAACATCACTAATCAGTATTCCCCTGCTCCATTGCATTTCAC
TCGTGTGGAATTCAATAGCCCGCTGTTTGTGCTTTATTCCTCCGGCACGACGGGCAAGCCTAAGTGCATCGTGCACTCTG
TTGGCGGCACGATTCTTAATCACCTAAAGGAGCATCAACTCCATTCAGATATCCAGCCTAAAGATCGTGTTTTTTATTAC
ACCACATGTGGTTGGATGATGTGGAACTGGCACGTGTCTGCCCTTGCAAGCGGCGCCTGCTTGGTGATTTTCGATGGTAG
CCCTGTTTATCCGACATCTAATGTGTTATGGGATTTAGCGCAGCGTGCAGAAGTAAGTCTCTTCGGAACTGCCGCCAAGT
ATCTAGAAGCCATAGAAAAAACCGGACTGTCGCCAATCAAAGATTACTCACTCCCTGCTTTAAAAACGTTGTGCTCTACT
GGCTCAGTGCTTTATCCAGAGCAGTTTGATTACGTGTATCAACACATCAAGCAAGACCTCCATTTGGCTTCCATCTCAGG
CGGCACAGACATCTGTGGTTGCTTTGTATTAGGCAACCCTATCTCGCCTGTTTATCGTGGTGAGTGCCAATACGCGGGCT
TGGGCATTGATGTTCAAGTGTTCGACTCACGAGGTCAAAGTGTTAATGAGCAGCGCGGAGAGCTCGTCTGCACCAACTCC
ATGCCTAACTTCCCTGTCGGCTTTTGGAACGATACAGGTGAACGCTACCACAGTGCCTATTGGAACAAGTTCGATAATAT
CTGGCACCACGGTGATGATGTAGAACGCAGCGCGAACGGTGGCCTCATTTTCTATGGTCGCAGCGATGCATTGTTGAACC
CTGGCGGTGTGCGCATCGGTACTGCGGAAATTTATCAGCAGGTAAATGCCATTGATGGTATCGTCGATTCTATCGCTGTA
GGTAAAGAGGTCAATAGCAATGAGCAAATCTGGCTGTTTGTGCAGACCGCTTCGGGTGTCACTTTAGGTGACGGATTAGT
ATCAGAGATTAAGTCGCGCCTTAAAACGTCCTGCTCACCAAGGCATGTACCAAGCCAAATATTCGCTATCAGCGACATTC
CAAAAACGCGCTCGGGAAAGTTGGTAGAACTTGCGGTCAAACAAGTCATAAATGGTAAGGAAGTTGAGAACTTAGGTGCG
ATTGCGAATCCAGACGTTTTAGAGGAAATTCGACAACTCACCTTTGTCTAG

Upstream 100 bases:

>100_bases
CGCCTTGATATAACTGAAAAGCCACATTCACTCATTGGTTTGACTTTGTTGAAGCTTCACTTCAGACTGAAAACGTTAAA
ACTTTGTTATAGAGGGAACT

Downstream 100 bases:

>100_bases
CGAATCAAAGGAAACAAAAAAGCGAGCTAAATAGCTCGCTTTTCTTATGTTCTTTGTCGGGGGGGTTAACGGCGACCTAC
GCCCATTAAAACTGACATTG

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MRESNRVWHPTEDRTEQANITQFIEHINRQGFELKNYSDLHQWSLEHNEHFWKEVWQFCDLIGTQGNTIKTQGESRWQSP
MSNRDTIWFPQAQVNYAENLLSLAEKQADELAIWFENERGDKHTYTWKELCNEVSSVQQWLVECGIKRGDVVAGYLPHMP
QTVIAMLATTSLGATWTSTSPDFGVESVIERFGQVKPKVLFTCDGYTFSGKTFDMSEKNHHIADHLDGLRQVCQISYLKP
NLFECDVCTHDWQNITNQYSPAPLHFTRVEFNSPLFVLYSSGTTGKPKCIVHSVGGTILNHLKEHQLHSDIQPKDRVFYY
TTCGWMMWNWHVSALASGACLVIFDGSPVYPTSNVLWDLAQRAEVSLFGTAAKYLEAIEKTGLSPIKDYSLPALKTLCST
GSVLYPEQFDYVYQHIKQDLHLASISGGTDICGCFVLGNPISPVYRGECQYAGLGIDVQVFDSRGQSVNEQRGELVCTNS
MPNFPVGFWNDTGERYHSAYWNKFDNIWHHGDDVERSANGGLIFYGRSDALLNPGGVRIGTAEIYQQVNAIDGIVDSIAV
GKEVNSNEQIWLFVQTASGVTLGDGLVSEIKSRLKTSCSPRHVPSQIFAISDIPKTRSGKLVELAVKQVINGKEVENLGA
IANPDVLEEIRQLTFV

Sequences:

>Translated_656_residues
MRESNRVWHPTEDRTEQANITQFIEHINRQGFELKNYSDLHQWSLEHNEHFWKEVWQFCDLIGTQGNTIKTQGESRWQSP
MSNRDTIWFPQAQVNYAENLLSLAEKQADELAIWFENERGDKHTYTWKELCNEVSSVQQWLVECGIKRGDVVAGYLPHMP
QTVIAMLATTSLGATWTSTSPDFGVESVIERFGQVKPKVLFTCDGYTFSGKTFDMSEKNHHIADHLDGLRQVCQISYLKP
NLFECDVCTHDWQNITNQYSPAPLHFTRVEFNSPLFVLYSSGTTGKPKCIVHSVGGTILNHLKEHQLHSDIQPKDRVFYY
TTCGWMMWNWHVSALASGACLVIFDGSPVYPTSNVLWDLAQRAEVSLFGTAAKYLEAIEKTGLSPIKDYSLPALKTLCST
GSVLYPEQFDYVYQHIKQDLHLASISGGTDICGCFVLGNPISPVYRGECQYAGLGIDVQVFDSRGQSVNEQRGELVCTNS
MPNFPVGFWNDTGERYHSAYWNKFDNIWHHGDDVERSANGGLIFYGRSDALLNPGGVRIGTAEIYQQVNAIDGIVDSIAV
GKEVNSNEQIWLFVQTASGVTLGDGLVSEIKSRLKTSCSPRHVPSQIFAISDIPKTRSGKLVELAVKQVINGKEVENLGA
IANPDVLEEIRQLTFV
>Mature_656_residues
MRESNRVWHPTEDRTEQANITQFIEHINRQGFELKNYSDLHQWSLEHNEHFWKEVWQFCDLIGTQGNTIKTQGESRWQSP
MSNRDTIWFPQAQVNYAENLLSLAEKQADELAIWFENERGDKHTYTWKELCNEVSSVQQWLVECGIKRGDVVAGYLPHMP
QTVIAMLATTSLGATWTSTSPDFGVESVIERFGQVKPKVLFTCDGYTFSGKTFDMSEKNHHIADHLDGLRQVCQISYLKP
NLFECDVCTHDWQNITNQYSPAPLHFTRVEFNSPLFVLYSSGTTGKPKCIVHSVGGTILNHLKEHQLHSDIQPKDRVFYY
TTCGWMMWNWHVSALASGACLVIFDGSPVYPTSNVLWDLAQRAEVSLFGTAAKYLEAIEKTGLSPIKDYSLPALKTLCST
GSVLYPEQFDYVYQHIKQDLHLASISGGTDICGCFVLGNPISPVYRGECQYAGLGIDVQVFDSRGQSVNEQRGELVCTNS
MPNFPVGFWNDTGERYHSAYWNKFDNIWHHGDDVERSANGGLIFYGRSDALLNPGGVRIGTAEIYQQVNAIDGIVDSIAV
GKEVNSNEQIWLFVQTASGVTLGDGLVSEIKSRLKTSCSPRHVPSQIFAISDIPKTRSGKLVELAVKQVINGKEVENLGA
IANPDVLEEIRQLTFV

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=662, Percent_Identity=40.1812688821752, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI8923896, Length=703, Percent_Identity=24.6088193456615, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI28416953, Length=589, Percent_Identity=25.9762308998302, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI13375727, Length=600, Percent_Identity=24.5, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI253970489, Length=384, Percent_Identity=26.5625, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI115511026, Length=539, Percent_Identity=21.8923933209648, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI157311624, Length=592, Percent_Identity=23.1418918918919, Blast_Score=106, Evalue=9e-23,
Organism=Homo sapiens, GI157311622, Length=592, Percent_Identity=23.1418918918919, Blast_Score=106, Evalue=9e-23,
Organism=Homo sapiens, GI58082049, Length=590, Percent_Identity=22.2033898305085, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI42544132, Length=543, Percent_Identity=22.4677716390424, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI38505220, Length=541, Percent_Identity=20.1478743068392, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790505, Length=632, Percent_Identity=26.2658227848101, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786529, Length=654, Percent_Identity=24.7706422018349, Blast_Score=168, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17569507, Length=645, Percent_Identity=36.4341085271318, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71983001, Length=629, Percent_Identity=26.3910969793323, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71982997, Length=629, Percent_Identity=26.3910969793323, Blast_Score=183, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319264, Length=673, Percent_Identity=26.8945022288262, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323182, Length=653, Percent_Identity=25.5742725880551, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24667955, Length=677, Percent_Identity=25.1107828655835, Blast_Score=213, Evalue=5e-55,
Organism=Drosophila melanogaster, GI62472339, Length=547, Percent_Identity=26.1425959780622, Blast_Score=199, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24667959, Length=517, Percent_Identity=25.531914893617, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21355225, Length=654, Percent_Identity=21.1009174311927, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 73830; Mature: 73830

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESNRVWHPTEDRTEQANITQFIEHINRQGFELKNYSDLHQWSLEHNEHFWKEVWQFCD
CCCCCCCCCCCCCCCHHCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
LIGTQGNTIKTQGESRWQSPMSNRDTIWFPQAQVNYAENLLSLAEKQADELAIWFENERG
HHCCCCCEEECCCCHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCC
DKHTYTWKELCNEVSSVQQWLVECGIKRGDVVAGYLPHMPQTVIAMLATTSLGATWTSTS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCEECCCC
PDFGVESVIERFGQVKPKVLFTCDGYTFSGKTFDMSEKNHHIADHLDGLRQVCQISYLKP
CCCCHHHHHHHHCCCCCCEEEEECCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCC
NLFECDVCTHDWQNITNQYSPAPLHFTRVEFNSPLFVLYSSGTTGKPKCIVHSVGGTILN
CCEEECCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEHHHHHHHH
HLKEHQLHSDIQPKDRVFYYTTCGWMMWNWHVSALASGACLVIFDGSPVYPTSNVLWDLA
HHHHHHHHCCCCCCCCEEEEEECCEEEEEEEHHHHCCCCEEEEECCCCCCCCHHHHHHHH
QRAEVSLFGTAAKYLEAIEKTGLSPIKDYSLPALKTLCSTGSVLYPEQFDYVYQHIKQDL
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEECCHHHHHHHHHHHHHC
HLASISGGTDICGCFVLGNPISPVYRGECQYAGLGIDVQVFDSRGQSVNEQRGELVCTNS
EEEECCCCCCEEEEEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEECC
MPNFPVGFWNDTGERYHSAYWNKFDNIWHHGDDVERSANGGLIFYGRSDALLNPGGVRIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEECCCCCEEC
TAEIYQQVNAIDGIVDSIAVGKEVNSNEQIWLFVQTASGVTLGDGLVSEIKSRLKTSCSP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEECHHHHHHHHHHHHCCCCC
RHVPSQIFAISDIPKTRSGKLVELAVKQVINGKEVENLGAIANPDVLEEIRQLTFV
CCCCHHEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRESNRVWHPTEDRTEQANITQFIEHINRQGFELKNYSDLHQWSLEHNEHFWKEVWQFCD
CCCCCCCCCCCCCCCHHCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
LIGTQGNTIKTQGESRWQSPMSNRDTIWFPQAQVNYAENLLSLAEKQADELAIWFENERG
HHCCCCCEEECCCCHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCC
DKHTYTWKELCNEVSSVQQWLVECGIKRGDVVAGYLPHMPQTVIAMLATTSLGATWTSTS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCEECCCC
PDFGVESVIERFGQVKPKVLFTCDGYTFSGKTFDMSEKNHHIADHLDGLRQVCQISYLKP
CCCCHHHHHHHHCCCCCCEEEEECCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCC
NLFECDVCTHDWQNITNQYSPAPLHFTRVEFNSPLFVLYSSGTTGKPKCIVHSVGGTILN
CCEEECCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEHHHHHHHH
HLKEHQLHSDIQPKDRVFYYTTCGWMMWNWHVSALASGACLVIFDGSPVYPTSNVLWDLA
HHHHHHHHCCCCCCCCEEEEEECCEEEEEEEHHHHCCCCEEEEECCCCCCCCHHHHHHHH
QRAEVSLFGTAAKYLEAIEKTGLSPIKDYSLPALKTLCSTGSVLYPEQFDYVYQHIKQDL
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEECCHHHHHHHHHHHHHC
HLASISGGTDICGCFVLGNPISPVYRGECQYAGLGIDVQVFDSRGQSVNEQRGELVCTNS
EEEECCCCCCEEEEEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEECC
MPNFPVGFWNDTGERYHSAYWNKFDNIWHHGDDVERSANGGLIFYGRSDALLNPGGVRIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEECCCCCEEC
TAEIYQQVNAIDGIVDSIAVGKEVNSNEQIWLFVQTASGVTLGDGLVSEIKSRLKTSCSP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEECHHHHHHHHHHHHCCCCC
RHVPSQIFAISDIPKTRSGKLVELAVKQVINGKEVENLGAIANPDVLEEIRQLTFV
CCCCHHEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]