Click here to switch to the map view.

The map label for this gene is manA [H]

Identifier: 156976410

GI number: 156976410

Start: 438752

End: 439984

Strand: Reverse

Name: manA [H]

Synonym: VIBHAR_05183

Alternate gene names: 156976410

Gene position: 439984-438752 (Counterclockwise)

Preceding gene: 156976411

Following gene: 156976408

Centisome position: 19.96

GC content: 46.15

Gene sequence:

>1233_bases
ATGTCTGATTTAACGATATCCGATACACAAACGATTCAAACTCAAGCTGCGCATCCGATGTTTTTCCTGATGAACAACGT
GATTCAAAACTACGCTTGGGGCAGTACTACTTCTGTTAACCAACTGTTTGGCATTGAAAACCCAACGGGCGAACCACAAG
CAGAAGTATGGATGGGCGCGCATCCAAACGGTTGCTCATTGGTGATGGTAAACGGTGAAGAGACCAAACTGTCTTCACTG
ATTGCTCAAGACATGAATGCCTTTCTGAGTGAAGAAGTCACAAACCGTTTTGGTGAACTTCCATACCTGTTTAAAGTGCT
TGCCGCTGAGAAAGCACTGTCGATTCAGGTTCACCCAAACAAACAGCAAGCAGAATTAGGCTTTGCACTGGAAGAAAAAC
AAGGCATTCCCCTAACCGCTGCAAACCGTAACTACAAAGATCCAAACCACAAGCCTGAATTGGTTTACGCGCTAACCGAA
TACCAAGCGATGAATGGCTTCCGCCCAACCAGTGAAATCATCAGCTTCTTCTCTGAGCTGGCAATTCCTGAGCTACAAGG
CTTGGTGGATGATCTTATCGCAAACCAAACGCCAACGGGCTTAGCAACCTTCTTCTCAGGTCTACTGTCACTAGAAGGCG
AACAGAAAGAGATGGCGTTGACGGTGCTATTGGCTCAAGCTCGCATCACAGACTTGCCTCTGTTCAACCTCATTCTTGAA
CTAGAGAAGCAATACCCTGGTGATATTGGTTTATTTGCACCACTGATGCTTAATGTGATTACTCTACAACCGGGTGATGC
CATGTTCTTGGATGCAGAAACGCCACACGCTTACTTAAAAGGTACAGGTCTTGAGATCATGGCGAACTCAGACAACGTAT
TACGCGCAGGTCTGACACCAAAATACATGGACGTGAAAGAGCTCGTTGCGTGCACACGCTTCAATGAGAAGCCATTCGAC
AGCCTATTGCTTGCACCAAACGAAATCGAAGACATGTTGGAATACCCAATCCCAGTCGACGATTTCAAATTCGCCATCGT
TAAGCAAGCTCACCAGCGTACTCTAGAAGTTCAAACCGCTGAGATCCTTATGCCTCTGGACACCAAACTTGTGCTAACTC
ACGCAAACGGCGAAACATGCGTAATTGAAAAAGGACAATCTGTTTTCATTCCGGCTTACGCAAAACAGGTTACTTTGGAT
TGTGAAGGTCGTGTCGCACGCGCTTACAGTTAA

Upstream 100 bases:

>100_bases
AAAATGATGCAAGCAGCCGCTTAATCACCCCTACCCCCAATGGCTCCTATGGCTTGGGCAATGTCGCCCAAGCCATAATT
TTCTCTCATGGTGACACTCT

Downstream 100 bases:

>100_bases
TCGTTATTATTAATAGTACGCCACTACAACCAACGCCTCGCCACTCGCGGGGCGTTTTGCTTTTAACCTTAGTCTTTTTA
ACCCTAGTAAAGCAATGGTT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSDLTISDTQTIQTQAAHPMFFLMNNVIQNYAWGSTTSVNQLFGIENPTGEPQAEVWMGAHPNGCSLVMVNGEETKLSSL
IAQDMNAFLSEEVTNRFGELPYLFKVLAAEKALSIQVHPNKQQAELGFALEEKQGIPLTAANRNYKDPNHKPELVYALTE
YQAMNGFRPTSEIISFFSELAIPELQGLVDDLIANQTPTGLATFFSGLLSLEGEQKEMALTVLLAQARITDLPLFNLILE
LEKQYPGDIGLFAPLMLNVITLQPGDAMFLDAETPHAYLKGTGLEIMANSDNVLRAGLTPKYMDVKELVACTRFNEKPFD
SLLLAPNEIEDMLEYPIPVDDFKFAIVKQAHQRTLEVQTAEILMPLDTKLVLTHANGETCVIEKGQSVFIPAYAKQVTLD
CEGRVARAYS

Sequences:

>Translated_410_residues
MSDLTISDTQTIQTQAAHPMFFLMNNVIQNYAWGSTTSVNQLFGIENPTGEPQAEVWMGAHPNGCSLVMVNGEETKLSSL
IAQDMNAFLSEEVTNRFGELPYLFKVLAAEKALSIQVHPNKQQAELGFALEEKQGIPLTAANRNYKDPNHKPELVYALTE
YQAMNGFRPTSEIISFFSELAIPELQGLVDDLIANQTPTGLATFFSGLLSLEGEQKEMALTVLLAQARITDLPLFNLILE
LEKQYPGDIGLFAPLMLNVITLQPGDAMFLDAETPHAYLKGTGLEIMANSDNVLRAGLTPKYMDVKELVACTRFNEKPFD
SLLLAPNEIEDMLEYPIPVDDFKFAIVKQAHQRTLEVQTAEILMPLDTKLVLTHANGETCVIEKGQSVFIPAYAKQVTLD
CEGRVARAYS
>Mature_409_residues
SDLTISDTQTIQTQAAHPMFFLMNNVIQNYAWGSTTSVNQLFGIENPTGEPQAEVWMGAHPNGCSLVMVNGEETKLSSLI
AQDMNAFLSEEVTNRFGELPYLFKVLAAEKALSIQVHPNKQQAELGFALEEKQGIPLTAANRNYKDPNHKPELVYALTEY
QAMNGFRPTSEIISFFSELAIPELQGLVDDLIANQTPTGLATFFSGLLSLEGEQKEMALTVLLAQARITDLPLFNLILEL
EKQYPGDIGLFAPLMLNVITLQPGDAMFLDAETPHAYLKGTGLEIMANSDNVLRAGLTPKYMDVKELVACTRFNEKPFDS
LLLAPNEIEDMLEYPIPVDDFKFAIVKQAHQRTLEVQTAEILMPLDTKLVLTHANGETCVIEKGQSVFIPAYAKQVTLDC
EGRVARAYS

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=417, Percent_Identity=36.9304556354916, Blast_Score=215, Evalue=6e-56,
Organism=Escherichia coli, GI1787899, Length=387, Percent_Identity=47.2868217054264, Blast_Score=349, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI71997620, Length=398, Percent_Identity=33.9195979899498, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17557650, Length=391, Percent_Identity=28.9002557544757, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320839, Length=342, Percent_Identity=33.9181286549708, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21356061, Length=388, Percent_Identity=34.5360824742268, Blast_Score=177, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 45367; Mature: 45235

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLTISDTQTIQTQAAHPMFFLMNNVIQNYAWGSTTSVNQLFGIENPTGEPQAEVWMGA
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCEEEECC
HPNGCSLVMVNGEETKLSSLIAQDMNAFLSEEVTNRFGELPYLFKVLAAEKALSIQVHPN
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCC
KQQAELGFALEEKQGIPLTAANRNYKDPNHKPELVYALTEYQAMNGFRPTSEIISFFSEL
CHHHHHCEEEECCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHHHHHHH
AIPELQGLVDDLIANQTPTGLATFFSGLLSLEGEQKEMALTVLLAQARITDLPLFNLILE
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LEKQYPGDIGLFAPLMLNVITLQPGDAMFLDAETPHAYLKGTGLEIMANSDNVLRAGLTP
HHHHCCCCCCHHHHHHHEEEEECCCCEEEEECCCCCCEEECCCEEEEECCCCEEEECCCC
KYMDVKELVACTRFNEKPFDSLLLAPNEIEDMLEYPIPVDDFKFAIVKQAHQRTLEVQTA
CCCCHHHHHHHHCCCCCCCHHEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEHE
EILMPLDTKLVLTHANGETCVIEKGQSVFIPAYAKQVTLDCEGRVARAYS
EEEEECCCEEEEEECCCCEEEEECCCEEEEEEECEEEEEECCCCEECCCC
>Mature Secondary Structure 
SDLTISDTQTIQTQAAHPMFFLMNNVIQNYAWGSTTSVNQLFGIENPTGEPQAEVWMGA
CCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCEEEECC
HPNGCSLVMVNGEETKLSSLIAQDMNAFLSEEVTNRFGELPYLFKVLAAEKALSIQVHPN
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCC
KQQAELGFALEEKQGIPLTAANRNYKDPNHKPELVYALTEYQAMNGFRPTSEIISFFSEL
CHHHHHCEEEECCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHHHHHHH
AIPELQGLVDDLIANQTPTGLATFFSGLLSLEGEQKEMALTVLLAQARITDLPLFNLILE
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LEKQYPGDIGLFAPLMLNVITLQPGDAMFLDAETPHAYLKGTGLEIMANSDNVLRAGLTP
HHHHCCCCCCHHHHHHHEEEEECCCCEEEEECCCCCCEEECCCEEEEECCCCEEEECCCC
KYMDVKELVACTRFNEKPFDSLLLAPNEIEDMLEYPIPVDDFKFAIVKQAHQRTLEVQTA
CCCCHHHHHHHHCCCCCCCHHEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEHE
EILMPLDTKLVLTHANGETCVIEKGQSVFIPAYAKQVTLDCEGRVARAYS
EEEEECCCEEEEEECCCCEEEEECCCEEEEEEECEEEEEECCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]