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The map label for this gene is gltP [H]

Identifier: 156976399

GI number: 156976399

Start: 429835

End: 431142

Strand: Direct

Name: gltP [H]

Synonym: VIBHAR_05172

Alternate gene names: 156976399

Gene position: 429835-431142 (Clockwise)

Preceding gene: 156976398

Following gene: 156976404

Centisome position: 19.5

GC content: 48.32

Gene sequence:

>1308_bases
ATGCGTCATTTGCAACTCTCTTTACCTGTCCAACTTCTTATTTCTGCTTTGCTTGCTTGGAGTGGGGCTCAAGCTATCCT
TCTTCTCGTCGAGCATGGTTTTGCAGATAAATCGCTATTGCTGTCGAGTGATTACTACCAAATTTTGATGTTGAGCAAAA
CGGTCTACCTAGGTTTGCTCAAGATGGTAGTGGGCTTGATGGTATTGTTCTCCCTTGTCGAGGGTATTACCAATATCGGC
TCAACCTTACGCCTTAAAGCATTGGGTGGAAGAACGCTGCTTTTCTACAGTTTCACGACTCTAATAGCCATCAGCTTGGG
TCTTGGTGCTTCTTTGGCATTGCCAGCATGGGAACCGCTCAGTCAGACTATTCCTGTTGGCAGTGATGTTCGTTTGATTG
ACGAGCAAGGGGCTGGTGGGGCTGCGATATTGACCAATCTCGTCAAGATGGCCATGGTCAATCCGTTTGCTGCGTTGGCG
AATGGTAACTTACTGGCGATCGTCGTTTTCTCCTTTATGGCAGGCGTTGCGATTTTGCTTTCAGTGCCATCAGGTCACCC
TTTACTGGCGGTGATTTCAGGGTTAAACAAAAGCATCAACACCATGATTCGTGGCATCGTTAAGTTGTCTCCTATTGCTA
TTTTCGCGATCGTGCTTGATATCACGTTGACCTCGAGTGGCAATCTGATTCAGCAACTTGCGTTGTTTGCGCTGCTGGTG
TTTGTGCTTACCATGGTGCATGGGCTAGTCGTGTTACCGACGATTGCTAAGGTTATGACGGGGATTTCGCCGATTACGCT
GTTTAAAGCGATTTCAGCGCCGCTAACTATGGCGTTCGCGACTTCCTCAAGTGCAGCTGCTCTGCCTCTTGCAAAGCAAA
GTGCGGAAGATAATTTAGATGTCTCACCAGAAGTTAGCAGTATGGTGTTGCCACTCGGTTCTGTAATGAACATGGATGGC
ACGGCGCTATTTGAGGGTGTTGCCGCGATTTTCTTGGCGCAACTGTTCGGTGTGGATTTGAGCACGACTGGATTGGTGAT
GATTTTTATCATGGCTATGGTCTCTTCTGTCGGTGCTCCGGGCATGCCTTCTGGCTCTATGTCGGGTATGCAGTTAGTGC
TGTTAGCCGCGGGTATTCCACTGGAAGCGATTGCGATTTTATTGGTGATAGAAAGACCGCTAGATACCTTCCGCACTGCC
GTTAATGTGGAGGGGGATTTAGTCGCGACGCTTGTTATCGACCGTTGGCAAAAGAAGACGACGGTGGATTCACAATCTCT
TGATTCGTCAGAGATGCTAGTGGGCTAA

Upstream 100 bases:

>100_bases
AAGGCTCTTGGTCTTAATCCCAGTCAGTATTATTCGTTTCTGTCTTTTCACTATTATCGAGCGCCCAAATCATAACGATT
TGTGGCGCTAGGTGTTTTTT

Downstream 100 bases:

>100_bases
AAGCAAAACGCACTCTCAATGGAGAGTGCGTTTTTCGTTGTTCTGAACTTAGATGAGCGGAAACGGGCTACGCTTTTTTA
AGCTCGAATAATGCGTCATG

Product: glutamate-aspartate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRHLQLSLPVQLLISALLAWSGAQAILLLVEHGFADKSLLLSSDYYQILMLSKTVYLGLLKMVVGLMVLFSLVEGITNIG
STLRLKALGGRTLLFYSFTTLIAISLGLGASLALPAWEPLSQTIPVGSDVRLIDEQGAGGAAILTNLVKMAMVNPFAALA
NGNLLAIVVFSFMAGVAILLSVPSGHPLLAVISGLNKSINTMIRGIVKLSPIAIFAIVLDITLTSSGNLIQQLALFALLV
FVLTMVHGLVVLPTIAKVMTGISPITLFKAISAPLTMAFATSSSAAALPLAKQSAEDNLDVSPEVSSMVLPLGSVMNMDG
TALFEGVAAIFLAQLFGVDLSTTGLVMIFIMAMVSSVGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLVIERPLDTFRTA
VNVEGDLVATLVIDRWQKKTTVDSQSLDSSEMLVG

Sequences:

>Translated_435_residues
MRHLQLSLPVQLLISALLAWSGAQAILLLVEHGFADKSLLLSSDYYQILMLSKTVYLGLLKMVVGLMVLFSLVEGITNIG
STLRLKALGGRTLLFYSFTTLIAISLGLGASLALPAWEPLSQTIPVGSDVRLIDEQGAGGAAILTNLVKMAMVNPFAALA
NGNLLAIVVFSFMAGVAILLSVPSGHPLLAVISGLNKSINTMIRGIVKLSPIAIFAIVLDITLTSSGNLIQQLALFALLV
FVLTMVHGLVVLPTIAKVMTGISPITLFKAISAPLTMAFATSSSAAALPLAKQSAEDNLDVSPEVSSMVLPLGSVMNMDG
TALFEGVAAIFLAQLFGVDLSTTGLVMIFIMAMVSSVGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLVIERPLDTFRTA
VNVEGDLVATLVIDRWQKKTTVDSQSLDSSEMLVG
>Mature_435_residues
MRHLQLSLPVQLLISALLAWSGAQAILLLVEHGFADKSLLLSSDYYQILMLSKTVYLGLLKMVVGLMVLFSLVEGITNIG
STLRLKALGGRTLLFYSFTTLIAISLGLGASLALPAWEPLSQTIPVGSDVRLIDEQGAGGAAILTNLVKMAMVNPFAALA
NGNLLAIVVFSFMAGVAILLSVPSGHPLLAVISGLNKSINTMIRGIVKLSPIAIFAIVLDITLTSSGNLIQQLALFALLV
FVLTMVHGLVVLPTIAKVMTGISPITLFKAISAPLTMAFATSSSAAALPLAKQSAEDNLDVSPEVSSMVLPLGSVMNMDG
TALFEGVAAIFLAQLFGVDLSTTGLVMIFIMAMVSSVGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLVIERPLDTFRTA
VNVEGDLVATLVIDRWQKKTTVDSQSLDSSEMLVG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468566, Length=265, Percent_Identity=34.7169811320755, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI223468564, Length=265, Percent_Identity=34.7169811320755, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI5032093, Length=265, Percent_Identity=34.7169811320755, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI66773030, Length=258, Percent_Identity=32.9457364341085, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI194239697, Length=266, Percent_Identity=31.9548872180451, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI21314632, Length=271, Percent_Identity=31.7343173431734, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI169790839, Length=255, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4827012, Length=268, Percent_Identity=33.5820895522388, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI40254478, Length=479, Percent_Identity=26.9311064718163, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI301601644, Length=143, Percent_Identity=34.965034965035, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI262359914, Length=190, Percent_Identity=33.1578947368421, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1790514, Length=429, Percent_Identity=30.3030303030303, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789947, Length=384, Percent_Identity=26.5625, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788024, Length=407, Percent_Identity=26.7813267813268, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789473, Length=366, Percent_Identity=25.1366120218579, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71996953, Length=281, Percent_Identity=34.5195729537367, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71983106, Length=427, Percent_Identity=26.9320843091335, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71983099, Length=427, Percent_Identity=26.9320843091335, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17537407, Length=398, Percent_Identity=28.894472361809, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI193206505, Length=436, Percent_Identity=27.5229357798165, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=260, Percent_Identity=31.9230769230769, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=275, Percent_Identity=32.7272727272727, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24583025, Length=281, Percent_Identity=30.2491103202847, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137668, Length=281, Percent_Identity=30.2491103202847, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583023, Length=281, Percent_Identity=30.2491103202847, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281360483, Length=323, Percent_Identity=26.625386996904, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137666, Length=323, Percent_Identity=26.625386996904, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281360481, Length=323, Percent_Identity=26.9349845201238, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45501; Mature: 45501

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHLQLSLPVQLLISALLAWSGAQAILLLVEHGFADKSLLLSSDYYQILMLSKTVYLGLL
CCCEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHH
KMVVGLMVLFSLVEGITNIGSTLRLKALGGRTLLFYSFTTLIAISLGLGASLALPAWEPL
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCH
SQTIPVGSDVRLIDEQGAGGAAILTNLVKMAMVNPFAALANGNLLAIVVFSFMAGVAILL
HHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHH
SVPSGHPLLAVISGLNKSINTMIRGIVKLSPIAIFAIVLDITLTSSGNLIQQLALFALLV
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FVLTMVHGLVVLPTIAKVMTGISPITLFKAISAPLTMAFATSSSAAALPLAKQSAEDNLD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHCCCCCCCC
VSPEVSSMVLPLGSVMNMDGTALFEGVAAIFLAQLFGVDLSTTGLVMIFIMAMVSSVGAP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
GMPSGSMSGMQLVLLAAGIPLEAIAILLVIERPLDTFRTAVNVEGDLVATLVIDRWQKKT
CCCCCCCCHHEEEEHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHC
TVDSQSLDSSEMLVG
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRHLQLSLPVQLLISALLAWSGAQAILLLVEHGFADKSLLLSSDYYQILMLSKTVYLGLL
CCCEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHH
KMVVGLMVLFSLVEGITNIGSTLRLKALGGRTLLFYSFTTLIAISLGLGASLALPAWEPL
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCH
SQTIPVGSDVRLIDEQGAGGAAILTNLVKMAMVNPFAALANGNLLAIVVFSFMAGVAILL
HHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHH
SVPSGHPLLAVISGLNKSINTMIRGIVKLSPIAIFAIVLDITLTSSGNLIQQLALFALLV
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FVLTMVHGLVVLPTIAKVMTGISPITLFKAISAPLTMAFATSSSAAALPLAKQSAEDNLD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHCCCCCCCC
VSPEVSSMVLPLGSVMNMDGTALFEGVAAIFLAQLFGVDLSTTGLVMIFIMAMVSSVGAP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
GMPSGSMSGMQLVLLAAGIPLEAIAILLVIERPLDTFRTAVNVEGDLVATLVIDRWQKKT
CCCCCCCCHHEEEEHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHC
TVDSQSLDSSEMLVG
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]