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The map label for this gene is thyX [H]

Identifier: 156938209

GI number: 156938209

Start: 1280155

End: 1280961

Strand: Reverse

Name: thyX [H]

Synonym: Igni_1422

Alternate gene names: 156938209

Gene position: 1280961-1280155 (Counterclockwise)

Preceding gene: 156938213

Following gene: 156938204

Centisome position: 98.72

GC content: 50.93

Gene sequence:

>807_bases
ATGGCAAACCGCGTCCGATGTAAGGCCTCTCATTCAGACGAGAGGACTGTTGTGTGTTTGGTCGCTAAGAACTTCGACGA
TCCGAGGAGGCTACCTCTGTTGGCCGTGAAGGTCTCTACGGGGAAGGCTCAAGAGAAGGGTATTGAATACTACCTTAAGA
GCGAGTGGAAAGAGGGTTGGAGCAACTGGCTCAAGGAGGCGAAGGACTCCTTCCCGAGCGTGTTGGAACATTCGGTCTTC
ACGTTTTTCATTGAGGGGTGTTCCAGGGTTTGCTCTCACCAGCTAGTGCGCCACCGGCTGCTGAGCGTGACCCAAGAGAG
CCAGCGCTACTCGGAAGTCAGGATATTGAAAGCCTTCAAAAAAGCTTTCGGAAAAGAGTTGGGGTGGGACGAAATAATTA
AGGTATTAAACGCGAGTTCGCAAGACTTAAGTGAGTTTGAAGAGAGGTTAATTATAAAGGATTTAGAAGAAAGAGGTATA
GGCTGTAAAGAATTGTCTAAAAAGTTAGAGGAGATAGTAGGAGAGCTGTTCGTTATACCGGAGAGCGTAGAGAGGGCGAC
TGCCGTACTCTCAATGATGCACTCCCTCTACTCCTACGCCTTGTGTCGCTCCTCCGCTCCCATGGAGGACTGTCGCTTCT
TGCTCCCTCAAGCTATAAGGACGTCAATGTTGGTTACCGCTAACTTGAGGGAGTGGCTCCACATAATAGAGCTGAGGGAC
CACCCTAAGGCCCAGTGGGAAATAAGGGGCGTCGCTAGGGCGGTGAAGGAGCTGCTAAAGGAAGAGGTCCCCGAGGTCTT
AGCGTAG

Upstream 100 bases:

>100_bases
CTTGGGCGTTGACCCCGTACATCCCGCCGTACGACACTGTGCTCCCCGGCGCCGTGACCCTCAAAAGACTTTATAACAAT
TAGGATGGGGTTCTGAAGCC

Downstream 100 bases:

>100_bases
CGTTAAGGTAAAGCTAACGAAACCCAAGTTGACCGCTGCGAGGTAGACCGATATTAGCAACGATATTGTGGCCAACGGGA
GTACCACTTTCCTGGGATCT

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MANRVRCKASHSDERTVVCLVAKNFDDPRRLPLLAVKVSTGKAQEKGIEYYLKSEWKEGWSNWLKEAKDSFPSVLEHSVF
TFFIEGCSRVCSHQLVRHRLLSVTQESQRYSEVRILKAFKKAFGKELGWDEIIKVLNASSQDLSEFEERLIIKDLEERGI
GCKELSKKLEEIVGELFVIPESVERATAVLSMMHSLYSYALCRSSAPMEDCRFLLPQAIRTSMLVTANLREWLHIIELRD
HPKAQWEIRGVARAVKELLKEEVPEVLA

Sequences:

>Translated_268_residues
MANRVRCKASHSDERTVVCLVAKNFDDPRRLPLLAVKVSTGKAQEKGIEYYLKSEWKEGWSNWLKEAKDSFPSVLEHSVF
TFFIEGCSRVCSHQLVRHRLLSVTQESQRYSEVRILKAFKKAFGKELGWDEIIKVLNASSQDLSEFEERLIIKDLEERGI
GCKELSKKLEEIVGELFVIPESVERATAVLSMMHSLYSYALCRSSAPMEDCRFLLPQAIRTSMLVTANLREWLHIIELRD
HPKAQWEIRGVARAVKELLKEEVPEVLA
>Mature_267_residues
ANRVRCKASHSDERTVVCLVAKNFDDPRRLPLLAVKVSTGKAQEKGIEYYLKSEWKEGWSNWLKEAKDSFPSVLEHSVFT
FFIEGCSRVCSHQLVRHRLLSVTQESQRYSEVRILKAFKKAFGKELGWDEIIKVLNASSQDLSEFEERLIIKDLEERGIG
CKELSKKLEEIVGELFVIPESVERATAVLSMMHSLYSYALCRSSAPMEDCRFLLPQAIRTSMLVTANLREWLHIIELRDH
PKAQWEIRGVARAVKELLKEEVPEVLA

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 30851; Mature: 30720

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRVRCKASHSDERTVVCLVAKNFDDPRRLPLLAVKVSTGKAQEKGIEYYLKSEWKEGW
CCCCCEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
SNWLKEAKDSFPSVLEHSVFTFFIEGCSRVCSHQLVRHRLLSVTQESQRYSEVRILKAFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFGKELGWDEIIKVLNASSQDLSEFEERLIIKDLEERGIGCKELSKKLEEIVGELFVIP
HHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
ESVERATAVLSMMHSLYSYALCRSSAPMEDCRFLLPQAIRTSMLVTANLREWLHIIELRD
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPKAQWEIRGVARAVKELLKEEVPEVLA
CCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANRVRCKASHSDERTVVCLVAKNFDDPRRLPLLAVKVSTGKAQEKGIEYYLKSEWKEGW
CCCCEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
SNWLKEAKDSFPSVLEHSVFTFFIEGCSRVCSHQLVRHRLLSVTQESQRYSEVRILKAFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFGKELGWDEIIKVLNASSQDLSEFEERLIIKDLEERGIGCKELSKKLEEIVGELFVIP
HHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
ESVERATAVLSMMHSLYSYALCRSSAPMEDCRFLLPQAIRTSMLVTANLREWLHIIELRD
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPKAQWEIRGVARAVKELLKEEVPEVLA
CCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]