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The map label for this gene is flpA [H]

Identifier: 156938204

GI number: 156938204

Start: 1275180

End: 1275899

Strand: Reverse

Name: flpA [H]

Synonym: Igni_1417

Alternate gene names: 156938204

Gene position: 1275899-1275180 (Counterclockwise)

Preceding gene: 156938209

Following gene: 156938193

Centisome position: 98.33

GC content: 55.0

Gene sequence:

>720_bases
ATGCCAATAGAGGTCGTTAACGTTTACGAACACCCTCAATACAAGAATGTGTACGTCGTAGAGCTGGAGGATGGCAGCGT
GCGCTTGGCGACTAAGAACTTGACGCCCGGGCACAGAGTCTACGGCGAGAAGCTCTTCCAGTGGCAAGGCGAGGAGTACC
GCGAGTGGAACGTCCAGCGTTCAAAGTTAGCAGCCGCTTTGGTCAAGGGATTGGAAGAGCTTCCGATAAAGCCCGGCGAC
TCCATACTCTACCTAGGGGCCGCGACCGGAACTACTCCCAGCCACATCTCCGACATTATAGGTGAAGAGGGAAGGCTCTA
CGGCGTAGAGTTCGCTCCTAGAGTTATGAGGGAGTTCGTAAACTTGGCCGAAATAAGGAAGAACATCTTCCCCATACTGG
GCGACGCGAGGAAGCCGCGCGAGTACCGTCACTTGGCGGAGCTGGTCGACGGCCTGTACGCGGACGTGGCCCAGCCCAAC
CAAGCGGAGATAGTCGCCGATAACGCGGACTTCTTCCTAAAGGATGGAGGCTACATGTTAATGGCAATAAAGGCCAGAAG
CGTTGACGTCACCAAGAGCCCGGAGGAGGTGTTCAAGAGGGAGATAGGAGTGCTGAAGTCCAGGGGCTTCGAGATCCTAG
ACATAGTGCACTTAGACCCCTTCGACAAAGACCACGCAATGATATACGCGAGGTTCCATAAGAAGTCGAGCGAAGGGTGA

Upstream 100 bases:

>100_bases
GCCTTGCCGTTCCCCTACGACGCCTATCTCTCGAGCTCCTCTCGAGAGCCCTCGCAGTTTTTATACCATAGAGGGCAGCT
CCGCGGGGGCCAGAAAGGGC

Downstream 100 bases:

>100_bases
ACTTCATAACCCAAAAGGAGGACCTTAACACTTAACCACTTTTAGGAACCCGGCGGCCCTCCTAACCCTCTCCAACGCCT
CCTCCACCGTGGAGCCGGTC

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MPIEVVNVYEHPQYKNVYVVELEDGSVRLATKNLTPGHRVYGEKLFQWQGEEYREWNVQRSKLAAALVKGLEELPIKPGD
SILYLGAATGTTPSHISDIIGEEGRLYGVEFAPRVMREFVNLAEIRKNIFPILGDARKPREYRHLAELVDGLYADVAQPN
QAEIVADNADFFLKDGGYMLMAIKARSVDVTKSPEEVFKREIGVLKSRGFEILDIVHLDPFDKDHAMIYARFHKKSSEG

Sequences:

>Translated_239_residues
MPIEVVNVYEHPQYKNVYVVELEDGSVRLATKNLTPGHRVYGEKLFQWQGEEYREWNVQRSKLAAALVKGLEELPIKPGD
SILYLGAATGTTPSHISDIIGEEGRLYGVEFAPRVMREFVNLAEIRKNIFPILGDARKPREYRHLAELVDGLYADVAQPN
QAEIVADNADFFLKDGGYMLMAIKARSVDVTKSPEEVFKREIGVLKSRGFEILDIVHLDPFDKDHAMIYARFHKKSSEG
>Mature_238_residues
PIEVVNVYEHPQYKNVYVVELEDGSVRLATKNLTPGHRVYGEKLFQWQGEEYREWNVQRSKLAAALVKGLEELPIKPGDS
ILYLGAATGTTPSHISDIIGEEGRLYGVEFAPRVMREFVNLAEIRKNIFPILGDARKPREYRHLAELVDGLYADVAQPNQ
AEIVADNADFFLKDGGYMLMAIKARSVDVTKSPEEVFKREIGVLKSRGFEILDIVHLDPFDKDHAMIYARFHKKSSEG

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=204, Percent_Identity=48.5294117647059, Blast_Score=201, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17563672, Length=208, Percent_Identity=49.0384615384615, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320190, Length=217, Percent_Identity=45.6221198156682, Blast_Score=198, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17647425, Length=204, Percent_Identity=48.0392156862745, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24646406, Length=224, Percent_Identity=30.8035714285714, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 27105; Mature: 26974

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIEVVNVYEHPQYKNVYVVELEDGSVRLATKNLTPGHRVYGEKLFQWQGEEYREWNVQR
CCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHCHHH
SKLAAALVKGLEELPIKPGDSILYLGAATGTTPSHISDIIGEEGRLYGVEFAPRVMREFV
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECHHHHHHHHHH
NLAEIRKNIFPILGDARKPREYRHLAELVDGLYADVAQPNQAEIVADNADFFLKDGGYML
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCEEE
MAIKARSVDVTKSPEEVFKREIGVLKSRGFEILDIVHLDPFDKDHAMIYARFHKKSSEG
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
PIEVVNVYEHPQYKNVYVVELEDGSVRLATKNLTPGHRVYGEKLFQWQGEEYREWNVQR
CEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHCHHH
SKLAAALVKGLEELPIKPGDSILYLGAATGTTPSHISDIIGEEGRLYGVEFAPRVMREFV
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECHHHHHHHHHH
NLAEIRKNIFPILGDARKPREYRHLAELVDGLYADVAQPNQAEIVADNADFFLKDGGYML
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCEEE
MAIKARSVDVTKSPEEVFKREIGVLKSRGFEILDIVHLDPFDKDHAMIYARFHKKSSEG
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA