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The map label for this gene is atoB [H]

Identifier: 156938188

GI number: 156938188

Start: 1262987

End: 1264177

Strand: Direct

Name: atoB [H]

Synonym: Igni_1401

Alternate gene names: 156938188

Gene position: 1262987-1264177 (Clockwise)

Preceding gene: 156938185

Following gene: 156938189

Centisome position: 97.34

GC content: 55.84

Gene sequence:

>1191_bases
GTGAGCGAAATATACATAATTTCGGCCGTGAGGACGCCGATAGGCAAGTTCCTCGGCTCGCTGAGCGGAATCCCCGCTCC
AGACTTAGCCGCCATAGCCGCTAAAGAGGCAATAAAGAGGGCCGGAATAGAGCCCAAGGACGTAGACTTCTACGCGTTCG
GTAACGTGATAGGGGCGGCTGTAGGTCAAAACCCCGCCCGCAGAACCGCGTTGTTAGCGGGCATCCCATACGAAGTGGAC
GGCCATACGGTAAACTTGGTCTGTTCTTCGGGAATGATGGCAATGATAGACGCTATAAGGGCCTTCAAGGCCGGAGACGC
GAAAATAGCCCTCGTAGGCGGCATGGAAAGTATGAGCAGGGCTCCCCTCTGCCTGCCTCCCGAAGCTAGGAGCGGGATAA
AGCACTTGGTAGGAAGGGAGGCAAAGCTCATAGACACCATGGTACTGGACGGACTAACCGACTCTTGGAACTGGCAGCTA
ATGGGCGTAGAAGCGGACATGACTGCTAAGAAGTACGGAGCGAAGAGGGAAGAACTGGACTGGATCGCTTATCAGAGCCA
CATGAGGGCGGCCAAAGCGACCGACGAAGGAATTTTTGAGAAGGAGATTGTGCCGATAGAGGTTAAGACTAAGAAAGGCG
TCGTAACGATAAAAAGCGACGAGGGGATTAGGAGGGACACCAGCCCAGAGAAGTTAGCCAAGCTTCCCCCGGCCTTCACG
CCCGACGGGGTACACACAGCCGGCAACAGCTCCCAACTGAGCGACGGCGCGGCCGCTCTGATAATGGCTCCAGAAGAAGT
CGTGAACGAGTACGGCCTCAAGCCCGTAGCTAGGGTCCTAGCCTACGACATAGTGGGTTTGAAGCCTGAAGACTTCGTGG
AGGCGCCAGTTCCCGGAATAAAGAGGATATCAGAAAAGGTCGGCGTTAAGCCAGACGACTGGGACCTCTACGAGGTCAAC
GAGGCGTTTGCAATAAGCTTGTGGTTGCCTCACCACCTCTTAGGAATACCTTACGAGCGGATGAACGTACACGGCGGCGC
CATAGCGATAGGCCACCCCTTGGGCGCCTCCGGCGCCAGAATAGTAGTAACCTTGATTAACGCTCTAAAGACCCACAACA
AGAGCCGGGGGGTCGCGACCCTCTGTCACGGAACTGGAGGGGGGAGCACCCTAGCGATCGAAGTGTTTTAA

Upstream 100 bases:

>100_bases
AGGGGGTTTATATAGTATAACTAAAGCTTCTTCAATCACATGTCTAAACATGCATAAGCGATATATGCACTCGGGCGCCC
CGGCTTGGGGTGGGCTTCCA

Downstream 100 bases:

>100_bases
GCCCGGCTCCGACTCGCGACGTCCTTTGTTAAAGGATCATCAATTAGAAGCCTTATTCGACTGAGGATCCCTCACTACTG
GAAATAAAGTATTTAAATAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSEIYIISAVRTPIGKFLGSLSGIPAPDLAAIAAKEAIKRAGIEPKDVDFYAFGNVIGAAVGQNPARRTALLAGIPYEVD
GHTVNLVCSSGMMAMIDAIRAFKAGDAKIALVGGMESMSRAPLCLPPEARSGIKHLVGREAKLIDTMVLDGLTDSWNWQL
MGVEADMTAKKYGAKREELDWIAYQSHMRAAKATDEGIFEKEIVPIEVKTKKGVVTIKSDEGIRRDTSPEKLAKLPPAFT
PDGVHTAGNSSQLSDGAAALIMAPEEVVNEYGLKPVARVLAYDIVGLKPEDFVEAPVPGIKRISEKVGVKPDDWDLYEVN
EAFAISLWLPHHLLGIPYERMNVHGGAIAIGHPLGASGARIVVTLINALKTHNKSRGVATLCHGTGGGSTLAIEVF

Sequences:

>Translated_396_residues
MSEIYIISAVRTPIGKFLGSLSGIPAPDLAAIAAKEAIKRAGIEPKDVDFYAFGNVIGAAVGQNPARRTALLAGIPYEVD
GHTVNLVCSSGMMAMIDAIRAFKAGDAKIALVGGMESMSRAPLCLPPEARSGIKHLVGREAKLIDTMVLDGLTDSWNWQL
MGVEADMTAKKYGAKREELDWIAYQSHMRAAKATDEGIFEKEIVPIEVKTKKGVVTIKSDEGIRRDTSPEKLAKLPPAFT
PDGVHTAGNSSQLSDGAAALIMAPEEVVNEYGLKPVARVLAYDIVGLKPEDFVEAPVPGIKRISEKVGVKPDDWDLYEVN
EAFAISLWLPHHLLGIPYERMNVHGGAIAIGHPLGASGARIVVTLINALKTHNKSRGVATLCHGTGGGSTLAIEVF
>Mature_395_residues
SEIYIISAVRTPIGKFLGSLSGIPAPDLAAIAAKEAIKRAGIEPKDVDFYAFGNVIGAAVGQNPARRTALLAGIPYEVDG
HTVNLVCSSGMMAMIDAIRAFKAGDAKIALVGGMESMSRAPLCLPPEARSGIKHLVGREAKLIDTMVLDGLTDSWNWQLM
GVEADMTAKKYGAKREELDWIAYQSHMRAAKATDEGIFEKEIVPIEVKTKKGVVTIKSDEGIRRDTSPEKLAKLPPAFTP
DGVHTAGNSSQLSDGAAALIMAPEEVVNEYGLKPVARVLAYDIVGLKPEDFVEAPVPGIKRISEKVGVKPDDWDLYEVNE
AFAISLWLPHHLLGIPYERMNVHGGAIAIGHPLGASGARIVVTLINALKTHNKSRGVATLCHGTGGGSTLAIEVF

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=41.2213740458015, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=39.030612244898, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=39.7984886649874, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=35, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=30.5882352941176, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=24.3037974683544, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI19923233, Length=411, Percent_Identity=25.3041362530414, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=43.1472081218274, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=41.1167512690355, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=39.2156862745098, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=38.0597014925373, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=28.8508557457213, Blast_Score=154, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.2820512820513, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=40.0510204081633, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=37.5634517766497, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=34.2639593908629, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=31.25, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=39.1089108910891, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=35.5163727959698, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=41.1167512690355, Blast_Score=304, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=39.1414141414141, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=39.440203562341, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=29.6470588235294, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42217; Mature: 42086

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIYIISAVRTPIGKFLGSLSGIPAPDLAAIAAKEAIKRAGIEPKDVDFYAFGNVIGAA
CCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHH
VGQNPARRTALLAGIPYEVDGHTVNLVCSSGMMAMIDAIRAFKAGDAKIALVGGMESMSR
HCCCHHHHEEEEECCCEEECCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECHHHHCC
APLCLPPEARSGIKHLVGREAKLIDTMVLDGLTDSWNWQLMGVEADMTAKKYGAKREELD
CCEECCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCCHHHHH
WIAYQSHMRAAKATDEGIFEKEIVPIEVKTKKGVVTIKSDEGIRRDTSPEKLAKLPPAFT
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCCCC
PDGVHTAGNSSQLSDGAAALIMAPEEVVNEYGLKPVARVLAYDIVGLKPEDFVEAPVPGI
CCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCCCCHH
KRISEKVGVKPDDWDLYEVNEAFAISLWLPHHLLGIPYERMNVHGGAIAIGHPLGASGAR
HHHHHHHCCCCCCCCEEECCCEEEEEEECCHHHHCCCHHHHCCCCCEEEECCCCCCCCHH
IVVTLINALKTHNKSRGVATLCHGTGGGSTLAIEVF
HHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEC
>Mature Secondary Structure 
SEIYIISAVRTPIGKFLGSLSGIPAPDLAAIAAKEAIKRAGIEPKDVDFYAFGNVIGAA
CCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHH
VGQNPARRTALLAGIPYEVDGHTVNLVCSSGMMAMIDAIRAFKAGDAKIALVGGMESMSR
HCCCHHHHEEEEECCCEEECCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECHHHHCC
APLCLPPEARSGIKHLVGREAKLIDTMVLDGLTDSWNWQLMGVEADMTAKKYGAKREELD
CCEECCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCCHHHHH
WIAYQSHMRAAKATDEGIFEKEIVPIEVKTKKGVVTIKSDEGIRRDTSPEKLAKLPPAFT
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCCCC
PDGVHTAGNSSQLSDGAAALIMAPEEVVNEYGLKPVARVLAYDIVGLKPEDFVEAPVPGI
CCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCCCCHH
KRISEKVGVKPDDWDLYEVNEAFAISLWLPHHLLGIPYERMNVHGGAIAIGHPLGASGAR
HHHHHHHCCCCCCCCEEECCCEEEEEEECCHHHHCCCHHHHCCCCCEEEECCCCCCCCHH
IVVTLINALKTHNKSRGVATLCHGTGGGSTLAIEVF
HHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]