| Definition | Ignicoccus hospitalis KIN4/I chromosome, complete genome. |
|---|---|
| Accession | NC_009776 |
| Length | 1,297,538 |
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The map label for this gene is rad50 [H]
Identifier: 156938172
GI number: 156938172
Start: 1245159
End: 1247795
Strand: Direct
Name: rad50 [H]
Synonym: Igni_1385
Alternate gene names: 156938172
Gene position: 1245159-1247795 (Clockwise)
Preceding gene: 156938169
Following gene: 156938174
Centisome position: 95.96
GC content: 49.98
Gene sequence:
>2637_bases ATGAAGGCCCAATTATTGAAGCTAGAGTTAAGAAACTTCCTTTCGTACGAGAACTTAGAAGTGCGCATACCGGAAGGCGT GGTAGTCGTAGTGGGTCCCAACGGCGCTGGTAAGAGCAGCTTTGTGGACGCCATAGCCTACGCCCTGACGAGCGCCGCGG TGAGCCGAAAGGTCACCAACAAGGAGCTGATTAATTACGGCGCCAAGAGCGCCGAGGTGGTCCTTACCTTCTCCGCGTCA AATAAGGTATACGAAGTGAAGAGGGCTATAGGAGTTGGAAACTCTGTACAAGCCGTCCTAAAGGAGGGCGGCAAACTATA CGCCTCGGGCTCTCAAGCCGTAAACAAAGCCATAGCTTCCTTATTGGGATTCGGAGACGTCAAAGCGCTGCGTGAAACCG TCTTCGTACCCCAGGGAAAATTGACCGAGTTGGTGGAGTTGAGTCCTTCGGAATTGAAGAACAAGGTTCTAGAGTTGCTG GGAGTTAGAGACAAGGAAGCCGTCGAAGCTTCTCTGAGAGAAATAATAAACTACTATAAGGGCACCGCATCCAACTTGGT GAACGTTCAAAGGACGTATGAAAAGTATAAGAAAGAGTTGAATAGCGAAATGAACAGGATAAAGGAATTACAAGAGAAGC TGCCGTTGCTCAAGGAAGAGCTCCGCATGGTCGAGGACAAACTGAACGACTTAAGGTCTGAACTTAACGAGCTTAAAGAG AAGAAGGCCAAATACCAAAAGGTTAAGGCCCAACTAATGAAAGTCCAAGAGGAGTTGAGGACGCTAATTGGAGAACTTGA AGCTCTTAGCGACCTCGACGAAGCTGAGCTAAACTTGCTGAGGTCCAAGCTAGTTAAGGTTAAGGACCTAAGCCTGATTA AAGAGCGCCTCGAAAACGAACTGAAAGCCATAAAGAGTAAGAAAGAGCTCTTAGCCAAAAGAGAGGCCGTTAAATCCGAG CTGCGCAAGCTCAAGGACTTGGAGAGGAGAAGGGATGAGCTTTCAAAGAAGTTAGACGAAATGTTGGAAAGGCGTCAATT ACTCGTCATGAAGTTGGGAACGCTTGAAAAAGAGGTGGAGGAAATAGAGAAAGAAATCAAAAGGATTGAGAAGAACTATG TCGTGTTGGAGAGGGAGTTGGACGGCCTTACGATCAGCGACCTCGAGCAACGGGTTACAGAGCTCGAAAAGATGTACGAG AACGTCAAGAAAGAGCTAGAGGAGGTCACTAACGAGAGAAGGCTCGTCGAAGTAATGTTGGACGAAAGGCGCCGCGCAAT AGAGATGCTAAGGGGGAGGGACTCCTGCCCGGTCTGCGGGTCCCCACTCCCTCCCGAAAGGCGGGAGTCCCTCATAAGGC GCTACGCCGAGGAAGTCGCGAAGTTTGAAGAAAAGCTGACCGAGTTGAAAGCTAGAGAGAAGAGGTTGGAAACGGAAGCA CGGCTCTTGGAGTCTAGGCTAGAGAAGCTCAAGAGGGCTTTGGACAAGGCGCGCGCCCGATTGGAGAGCCTAGGCTTCGA AGACCTAGACGCATTAGGACTTTATTTAGCTGACTTGAAAAAGAGGTTTAACGAACTGAAAGAACAATTATCGCGAACTA GGGCTTCGGTCGAGCATTACGACAAGCTGGTCAAAGAAGTTAAGGAAGAGCTAAGCGCCGTGACGGCCCAACTAGAGGAG CTAAAAAGGAAGGAGGGGATGCTCAGACAAATAGAACATCAGCTAGAAGAGCTACGAGGAGTAGACGCAAGCAAAGAAGA AGAGGTAGAGAAGCGCTTGAGCGAAATAAAGAAAGAGTTGGAAGTGCTTGGCTCACCAGAAGAGCTCGAAAGGAGAATAG CGGAGCTGGAGAGGTTAGCCTCCAAGAAAAAGGAGCTAAGCGCCGCAGCAGAGCTCAAGAGGAGAGAGGAGGCTGAGCTG AAGAGAGAGTTAGCCTCGCTGGGCTTCGACGAAGCCTCATTAGAACGGCTAGCGCGAGAGGTCGAGGCCTTGGAAAGGAA GAGGGACGCCCTCCTCCGCAACATATCAGAAACGGAGGCAAAAATAATGGAAACTAGGCGGAACGTAGCGAAGCTGAGAG AGGAGCTAAACAGGTACCAGAATGAGATAGAAAAGCTTAGGGCGTACGAACAATACGCCATCTTCCTTGAGGAGTTCAGA AAAACCTTCTCCACCGTCATTATAGACAAACTGACTGAGAGCTTCAGAAAGGCGTGGGAGGAGGAAGCGAACAGAATATT AGATATGTTCGACCTTAACGTAAAGAAGGTGGAGATAAAGGAGATAATTGAAAAGAGGAAGAAGGGGTGGACGATAAGGG CGGTACTAGACGGCGGCGCGAGGGTGACCGTGGACTCCCTCTCCGGAGGCGAGAGGGTCGGGGTCGCCTTGGCTCTGAGG CTCTCGTTAGCGAAGCTCCTCTCTCGCGGGAGGATATCCTTCTTGATAATGGACGAGCCAACAGCCTACTTGGACTCCGA AAGGAGGCAAGCTTTGAAGAAGATAATCTCGTACGCCGTCGGCCCCTCTTTGACCCAAATGATAGTTGTGACTCACGACA GAGAGATGATGGATATTGCCGACTCCGCATGTCACGTTAGAAGGACCCCCAAGGGTTCTACGATTACGTGCGAATGA
Upstream 100 bases:
>100_bases GGGCCGGCCTTGAGAGCCGGTGGGGGAAACCCCGCGCGGGTTCGAATCCCGCCCCCGGCGCCAGAGTCGCACGAACGCGT CGGGCGACTGGTAGATAGTT
Downstream 100 bases:
>100_bases TCCTCTCCCGAGCGAGCGCGAGCAGCTTCCTAAGCGTCTTTTCTCCGACGTTATACCTTTTGCTCACCTCCCTGACGTTC TTCCCGTTGACTACGTAGGC
Product: SMC domain-containing protein
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 878; Mature: 878
Protein sequence:
>878_residues MKAQLLKLELRNFLSYENLEVRIPEGVVVVVGPNGAGKSSFVDAIAYALTSAAVSRKVTNKELINYGAKSAEVVLTFSAS NKVYEVKRAIGVGNSVQAVLKEGGKLYASGSQAVNKAIASLLGFGDVKALRETVFVPQGKLTELVELSPSELKNKVLELL GVRDKEAVEASLREIINYYKGTASNLVNVQRTYEKYKKELNSEMNRIKELQEKLPLLKEELRMVEDKLNDLRSELNELKE KKAKYQKVKAQLMKVQEELRTLIGELEALSDLDEAELNLLRSKLVKVKDLSLIKERLENELKAIKSKKELLAKREAVKSE LRKLKDLERRRDELSKKLDEMLERRQLLVMKLGTLEKEVEEIEKEIKRIEKNYVVLERELDGLTISDLEQRVTELEKMYE NVKKELEEVTNERRLVEVMLDERRRAIEMLRGRDSCPVCGSPLPPERRESLIRRYAEEVAKFEEKLTELKAREKRLETEA RLLESRLEKLKRALDKARARLESLGFEDLDALGLYLADLKKRFNELKEQLSRTRASVEHYDKLVKEVKEELSAVTAQLEE LKRKEGMLRQIEHQLEELRGVDASKEEEVEKRLSEIKKELEVLGSPEELERRIAELERLASKKKELSAAAELKRREEAEL KRELASLGFDEASLERLAREVEALERKRDALLRNISETEAKIMETRRNVAKLREELNRYQNEIEKLRAYEQYAIFLEEFR KTFSTVIIDKLTESFRKAWEEEANRILDMFDLNVKKVEIKEIIEKRKKGWTIRAVLDGGARVTVDSLSGGERVGVALALR LSLAKLLSRGRISFLIMDEPTAYLDSERRQALKKIISYAVGPSLTQMIVVTHDREMMDIADSACHVRRTPKGSTITCE
Sequences:
>Translated_878_residues MKAQLLKLELRNFLSYENLEVRIPEGVVVVVGPNGAGKSSFVDAIAYALTSAAVSRKVTNKELINYGAKSAEVVLTFSAS NKVYEVKRAIGVGNSVQAVLKEGGKLYASGSQAVNKAIASLLGFGDVKALRETVFVPQGKLTELVELSPSELKNKVLELL GVRDKEAVEASLREIINYYKGTASNLVNVQRTYEKYKKELNSEMNRIKELQEKLPLLKEELRMVEDKLNDLRSELNELKE KKAKYQKVKAQLMKVQEELRTLIGELEALSDLDEAELNLLRSKLVKVKDLSLIKERLENELKAIKSKKELLAKREAVKSE LRKLKDLERRRDELSKKLDEMLERRQLLVMKLGTLEKEVEEIEKEIKRIEKNYVVLERELDGLTISDLEQRVTELEKMYE NVKKELEEVTNERRLVEVMLDERRRAIEMLRGRDSCPVCGSPLPPERRESLIRRYAEEVAKFEEKLTELKAREKRLETEA RLLESRLEKLKRALDKARARLESLGFEDLDALGLYLADLKKRFNELKEQLSRTRASVEHYDKLVKEVKEELSAVTAQLEE LKRKEGMLRQIEHQLEELRGVDASKEEEVEKRLSEIKKELEVLGSPEELERRIAELERLASKKKELSAAAELKRREEAEL KRELASLGFDEASLERLAREVEALERKRDALLRNISETEAKIMETRRNVAKLREELNRYQNEIEKLRAYEQYAIFLEEFR KTFSTVIIDKLTESFRKAWEEEANRILDMFDLNVKKVEIKEIIEKRKKGWTIRAVLDGGARVTVDSLSGGERVGVALALR LSLAKLLSRGRISFLIMDEPTAYLDSERRQALKKIISYAVGPSLTQMIVVTHDREMMDIADSACHVRRTPKGSTITCE >Mature_878_residues MKAQLLKLELRNFLSYENLEVRIPEGVVVVVGPNGAGKSSFVDAIAYALTSAAVSRKVTNKELINYGAKSAEVVLTFSAS NKVYEVKRAIGVGNSVQAVLKEGGKLYASGSQAVNKAIASLLGFGDVKALRETVFVPQGKLTELVELSPSELKNKVLELL GVRDKEAVEASLREIINYYKGTASNLVNVQRTYEKYKKELNSEMNRIKELQEKLPLLKEELRMVEDKLNDLRSELNELKE KKAKYQKVKAQLMKVQEELRTLIGELEALSDLDEAELNLLRSKLVKVKDLSLIKERLENELKAIKSKKELLAKREAVKSE LRKLKDLERRRDELSKKLDEMLERRQLLVMKLGTLEKEVEEIEKEIKRIEKNYVVLERELDGLTISDLEQRVTELEKMYE NVKKELEEVTNERRLVEVMLDERRRAIEMLRGRDSCPVCGSPLPPERRESLIRRYAEEVAKFEEKLTELKAREKRLETEA RLLESRLEKLKRALDKARARLESLGFEDLDALGLYLADLKKRFNELKEQLSRTRASVEHYDKLVKEVKEELSAVTAQLEE LKRKEGMLRQIEHQLEELRGVDASKEEEVEKRLSEIKKELEVLGSPEELERRIAELERLASKKKELSAAAELKRREEAEL KRELASLGFDEASLERLAREVEALERKRDALLRNISETEAKIMETRRNVAKLREELNRYQNEIEKLRAYEQYAIFLEEFR KTFSTVIIDKLTESFRKAWEEEANRILDMFDLNVKKVEIKEIIEKRKKGWTIRAVLDGGARVTVDSLSGGERVGVALALR LSLAKLLSRGRISFLIMDEPTAYLDSERRQALKKIISYAVGPSLTQMIVVTHDREMMDIADSACHVRRTPKGSTITCE
Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and
COG id: COG0419
COG function: function code L; ATPase involved in DNA repair
Gene ontology:
Cell location: Cytoplasmic
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Contains 1 zinc-hook domain [H]
Homologues:
Organism=Homo sapiens, GI38045910, Length=463, Percent_Identity=21.5982721382289, Blast_Score=69, Evalue=3e-11, Organism=Caenorhabditis elegans, GI71991183, Length=432, Percent_Identity=19.4444444444444, Blast_Score=67, Evalue=4e-11, Organism=Caenorhabditis elegans, GI71991177, Length=432, Percent_Identity=19.4444444444444, Blast_Score=67, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR022982 - InterPro: IPR007517 - InterPro: IPR003395 - InterPro: IPR013134 [H]
Pfam domain/function: PF04423 Rad50_zn_hook; PF02463 SMC_N [H]
EC number: NA
Molecular weight: Translated: 101077; Mature: 101077
Theoretical pI: Translated: 9.03; Mature: 9.03
Prosite motif: PS51131 ZN_HOOK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKAQLLKLELRNFLSYENLEVRIPEGVVVVVGPNGAGKSSFVDAIAYALTSAAVSRKVTN CCCHHHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH KELINYGAKSAEVVLTFSASNKVYEVKRAIGVGNSVQAVLKEGGKLYASGSQAVNKAIAS HHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCEEECCHHHHHHHHHH LLGFGDVKALRETVFVPQGKLTELVELSPSELKNKVLELLGVRDKEAVEASLREIINYYK HHCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC GTASNLVNVQRTYEKYKKELNSEMNRIKELQEKLPLLKEELRMVEDKLNDLRSELNELKE CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KKAKYQKVKAQLMKVQEELRTLIGELEALSDLDEAELNLLRSKLVKVKDLSLIKERLENE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH LKAIKSKKELLAKREAVKSELRKLKDLERRRDELSKKLDEMLERRQLLVMKLGTLEKEVE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EIEKEIKRIEKNYVVLERELDGLTISDLEQRVTELEKMYENVKKELEEVTNERRLVEVML HHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH DERRRAIEMLRGRDSCPVCGSPLPPERRESLIRRYAEEVAKFEEKLTELKAREKRLETEA HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RLLESRLEKLKRALDKARARLESLGFEDLDALGLYLADLKKRFNELKEQLSRTRASVEHY HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH DKLVKEVKEELSAVTAQLEELKRKEGMLRQIEHQLEELRGVDASKEEEVEKRLSEIKKEL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH EVLGSPEELERRIAELERLASKKKELSAAAELKRREEAELKRELASLGFDEASLERLARE HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH VEALERKRDALLRNISETEAKIMETRRNVAKLREELNRYQNEIEKLRAYEQYAIFLEEFR HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KTFSTVIIDKLTESFRKAWEEEANRILDMFDLNVKKVEIKEIIEKRKKGWTIRAVLDGGA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCC RVTVDSLSGGERVGVALALRLSLAKLLSRGRISFLIMDEPTAYLDSERRQALKKIISYAV EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCHHHHHHHHHHHHHHH GPSLTQMIVVTHDREMMDIADSACHVRRTPKGSTITCE CCHHHHEEEEECCHHHHHHHHHHHHHCCCCCCCCEECC >Mature Secondary Structure MKAQLLKLELRNFLSYENLEVRIPEGVVVVVGPNGAGKSSFVDAIAYALTSAAVSRKVTN CCCHHHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH KELINYGAKSAEVVLTFSASNKVYEVKRAIGVGNSVQAVLKEGGKLYASGSQAVNKAIAS HHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCEEECCHHHHHHHHHH LLGFGDVKALRETVFVPQGKLTELVELSPSELKNKVLELLGVRDKEAVEASLREIINYYK HHCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC GTASNLVNVQRTYEKYKKELNSEMNRIKELQEKLPLLKEELRMVEDKLNDLRSELNELKE CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KKAKYQKVKAQLMKVQEELRTLIGELEALSDLDEAELNLLRSKLVKVKDLSLIKERLENE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH LKAIKSKKELLAKREAVKSELRKLKDLERRRDELSKKLDEMLERRQLLVMKLGTLEKEVE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EIEKEIKRIEKNYVVLERELDGLTISDLEQRVTELEKMYENVKKELEEVTNERRLVEVML HHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH DERRRAIEMLRGRDSCPVCGSPLPPERRESLIRRYAEEVAKFEEKLTELKAREKRLETEA HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RLLESRLEKLKRALDKARARLESLGFEDLDALGLYLADLKKRFNELKEQLSRTRASVEHY HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH DKLVKEVKEELSAVTAQLEELKRKEGMLRQIEHQLEELRGVDASKEEEVEKRLSEIKKEL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH EVLGSPEELERRIAELERLASKKKELSAAAELKRREEAELKRELASLGFDEASLERLARE HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH VEALERKRDALLRNISETEAKIMETRRNVAKLREELNRYQNEIEKLRAYEQYAIFLEEFR HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KTFSTVIIDKLTESFRKAWEEEANRILDMFDLNVKKVEIKEIIEKRKKGWTIRAVLDGGA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCC RVTVDSLSGGERVGVALALRLSLAKLLSRGRISFLIMDEPTAYLDSERRQALKKIISYAV EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCHHHHHHHHHHHHHHH GPSLTQMIVVTHDREMMDIADSACHVRRTPKGSTITCE CCHHHHEEEEECCHHHHHHHHHHHHHCCCCCCCCEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11121031 [H]