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The map label for this gene is arcB

Identifier: 156938174

GI number: 156938174

Start: 1248418

End: 1249353

Strand: Direct

Name: arcB

Synonym: Igni_1387

Alternate gene names: 156938174

Gene position: 1248418-1249353 (Clockwise)

Preceding gene: 156938172

Following gene: 156938177

Centisome position: 96.21

GC content: 57.69

Gene sequence:

>936_bases
TTGCATCTGAAAGGCCGCAGCATGTTGACGTTGCTGGATTTCGCCGAGGACGAAATAAAATTCATCGTAGATACCGCCCT
GCAGATGAAGAGGGAGAACTACGCCGGGAGGCGGTACTGGGGCCTCTTAGAAGGTCGTCACTTGGCCTTGTTGTTCGAAA
AGCCCAGCACGAGGACCAGAGTGGCCTTCGAAGTCGCAGCGAGTCAGCTGGGCATGAGCGTAAGCTACGTAACGAAGTCT
GACAGCCAGCTGTCAAGGGGGGAACCCCTCAAGGACGCCGCGAGGGTCCTAGGAAGGTACGTAGACGCTATAGCGGCCAG
GGTGAAGAGGCACGAAGACCTAGAAACCCTGGTCGAGCACTCGGGCGTCCCAGTCATAAACGCTCTAAGCGATAAGTTCC
ACCCGACCCAAGCGATAGCAGACGTGATGACCATACTGGAAAAGTTGGGCAGAGTCCGCGGGGTAAAGATAGCCTTCGTG
GGAGACGGGGCCGACAACGTGGCCCACAGCCTAGCCCTAGCGGCGACCAGCTTGGGCGCCGACGTAAGAATAGTAACTGC
TCCCGGGTACGAGCCGCTGGACGCGGTGATCGCAGCCGCTGAGGAGAGGGCCCGGAGGAGCGGGGGGAGCTTCGAGCTCG
TGTACGACCCTTGTAAAGGGGTGAAAGGGGCAGACGTCGTGTATACTGACGTGTGGGTGAGCATGGGTCTCGAGGCGGAG
AGGGAGAAGAGGCTTAGGGACTTAAGACCTTACCAAGTCAACTCAGAGCTCTTGAAGTGCGTAGGAAAGGACTACATATT
CATGCACTGTTTACCCGCGCACAGGGGCGAGGAGGTAACCGAAGAGGTCTTGGAGTCCAGCAGAAGCGTCGTGTGGGATC
AAGCTGAAAACAAGCTCCATGCTCAGAGAGCGGTCTTGGCCCTTTTGGTCCCCTAA

Upstream 100 bases:

>100_bases
ATATAGTAATTAACAAGTAGGTACACTCTGTACCGGGAGAGGGTAGCTAGACGAAAGTGTTAAGGCTCTCGCGACGCGGC
GAGGAGCGGGAAGGCGCAGA

Downstream 100 bases:

>100_bases
TCCTTCAAGGTTATCCAACGGGTAAAGGAGTCAGAGAACAAGTGCTTCGGCCTCTTACCACAACACCACAAGAAGGCGCC
CAGCGCTCCGGAGTACTTCC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MHLKGRSMLTLLDFAEDEIKFIVDTALQMKRENYAGRRYWGLLEGRHLALLFEKPSTRTRVAFEVAASQLGMSVSYVTKS
DSQLSRGEPLKDAARVLGRYVDAIAARVKRHEDLETLVEHSGVPVINALSDKFHPTQAIADVMTILEKLGRVRGVKIAFV
GDGADNVAHSLALAATSLGADVRIVTAPGYEPLDAVIAAAEERARRSGGSFELVYDPCKGVKGADVVYTDVWVSMGLEAE
REKRLRDLRPYQVNSELLKCVGKDYIFMHCLPAHRGEEVTEEVLESSRSVVWDQAENKLHAQRAVLALLVP

Sequences:

>Translated_311_residues
MHLKGRSMLTLLDFAEDEIKFIVDTALQMKRENYAGRRYWGLLEGRHLALLFEKPSTRTRVAFEVAASQLGMSVSYVTKS
DSQLSRGEPLKDAARVLGRYVDAIAARVKRHEDLETLVEHSGVPVINALSDKFHPTQAIADVMTILEKLGRVRGVKIAFV
GDGADNVAHSLALAATSLGADVRIVTAPGYEPLDAVIAAAEERARRSGGSFELVYDPCKGVKGADVVYTDVWVSMGLEAE
REKRLRDLRPYQVNSELLKCVGKDYIFMHCLPAHRGEEVTEEVLESSRSVVWDQAENKLHAQRAVLALLVP
>Mature_311_residues
MHLKGRSMLTLLDFAEDEIKFIVDTALQMKRENYAGRRYWGLLEGRHLALLFEKPSTRTRVAFEVAASQLGMSVSYVTKS
DSQLSRGEPLKDAARVLGRYVDAIAARVKRHEDLETLVEHSGVPVINALSDKFHPTQAIADVMTILEKLGRVRGVKIAFV
GDGADNVAHSLALAATSLGADVRIVTAPGYEPLDAVIAAAEERARRSGGSFELVYDPCKGVKGADVVYTDVWVSMGLEAE
REKRLRDLRPYQVNSELLKCVGKDYIFMHCLPAHRGEEVTEEVLESSRSVVWDQAENKLHAQRAVLALLVP

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=310, Percent_Identity=38.7096774193548, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI18105007, Length=318, Percent_Identity=27.6729559748428, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1790703, Length=323, Percent_Identity=40.8668730650155, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1786469, Length=326, Percent_Identity=40.1840490797546, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI48994908, Length=352, Percent_Identity=25, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI2367364, Length=321, Percent_Identity=27.1028037383178, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=326, Percent_Identity=27.9141104294479, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=320, Percent_Identity=35.9375, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322331, Length=315, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642586, Length=324, Percent_Identity=28.3950617283951, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_IGNH4 (A8ACB1)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435970.1
- ProteinModelPortal:   A8ACB1
- SMR:   A8ACB1
- STRING:   A8ACB1
- GeneID:   5562039
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_1387
- eggNOG:   arNOG04256
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- BioCyc:   IHOS453591:IGNI_1387-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34411; Mature: 34411

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 107-107 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLKGRSMLTLLDFAEDEIKFIVDTALQMKRENYAGRRYWGLLEGRHLALLFEKPSTRTR
CCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCHH
VAFEVAASQLGMSVSYVTKSDSQLSRGEPLKDAARVLGRYVDAIAARVKRHEDLETLVEH
HHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGVPVINALSDKFHPTQAIADVMTILEKLGRVRGVKIAFVGDGADNVAHSLALAATSLGA
CCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCC
DVRIVTAPGYEPLDAVIAAAEERARRSGGSFELVYDPCKGVKGADVVYTDVWVSMGLEAE
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEHHHHHCCCCHH
REKRLRDLRPYQVNSELLKCVGKDYIFMHCLPAHRGEEVTEEVLESSRSVVWDQAENKLH
HHHHHHHCCCCCCCHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCEEHHHHHHHHH
AQRAVLALLVP
HHHHHHHEECC
>Mature Secondary Structure
MHLKGRSMLTLLDFAEDEIKFIVDTALQMKRENYAGRRYWGLLEGRHLALLFEKPSTRTR
CCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCHH
VAFEVAASQLGMSVSYVTKSDSQLSRGEPLKDAARVLGRYVDAIAARVKRHEDLETLVEH
HHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGVPVINALSDKFHPTQAIADVMTILEKLGRVRGVKIAFVGDGADNVAHSLALAATSLGA
CCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCC
DVRIVTAPGYEPLDAVIAAAEERARRSGGSFELVYDPCKGVKGADVVYTDVWVSMGLEAE
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEHHHHHCCCCHH
REKRLRDLRPYQVNSELLKCVGKDYIFMHCLPAHRGEEVTEEVLESSRSVVWDQAENKLH
HHHHHHHCCCCCCCHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCEEHHHHHHHHH
AQRAVLALLVP
HHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA