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The map label for this gene is nadC [H]

Identifier: 156938137

GI number: 156938137

Start: 1202321

End: 1203166

Strand: Reverse

Name: nadC [H]

Synonym: Igni_1350

Alternate gene names: 156938137

Gene position: 1203166-1202321 (Counterclockwise)

Preceding gene: 156938139

Following gene: 156938136

Centisome position: 92.73

GC content: 56.62

Gene sequence:

>846_bases
TTGTGCATCCAATACACGCGACGGCTGGCGAGGGACCTCAAGAGGTGGGTTCACGAGGACTCCCCCTTAGGCGACGTCAC
GACTGACGCAGTCTTCTGGTCGAAGGAAGACTCAGAGAAGATTATGGATATACAAGCCCGCAGTCGAGTGTATGTGGTCT
GTCCCTCTTTGATAGAGGGAGCGCTGGGGGCGCTGGGCCTGGAGCCGGAATTCATTGCGCCCGCTGGCTGGACTCAGGGC
GTCGTAGTCAGCGTGAGGGGCCTCACCAAAGAGCTCTTAATGTTCGAGCGGACGTTATTGAACTTCCTCATTCACGTCTT
CTCGATATCGACTGAGGTGAGGAGGGTAAGGGAGCTCTTGGACTCCTCCGGCTTCAAGAACGTCAGGGTAGCCGTAACCC
GGAAGACTGTTCCCGGAATGAGGCTCTGGGCCAAACTCTTCGCTAGGGCCGCGGGGGCCGACACGCACCGGCTGAGCTTG
AGCGACATGATACTAATCAAGGACACACACATCAACGCCTACGGTGACTTGTTAGGGGCGGTGAGGGCCGCCAAGGAGAA
CGCCTCCTTCACCCACAAGATAGAGGTCGAGGTGTCCAGCGAGGAGGAGGCGTTTGAGGTCTTGCCGTATGTCGACGCGA
TAATGCTCGACAACGTGGGTCCGGAGGAGGCTAAAAGGATAGCTTGTAAATTGAAGGAGGCGAAGCCCTCAATTATAGTG
GAGGTAAGCGGGGGAATAAACAGGGAAAACGTCCTTCAGTACGTCAACGAGTGTGTGGACGTGGTGAGTATGGGGTATTT
GACGCTCTCGCCCCCTCTCGTCGACTTGGGTGCGGAGATCAGATGA

Upstream 100 bases:

>100_bases
CTCTCGCCCACGGGCCCACTTACTCCTATAAATTCCTTGTGGCTTGCGAGACGCCGTATTTCTGAACCTCACGCTACCGA
GCGGTGAGCGGAGGAGCGCT

Downstream 100 bases:

>100_bases
GGCTGTGCGTGATAGGTTGCGGGAACGTGGGAAGACTCGTGGCGAAGAACCGCGGGGTTCTGGGCGTTAGTCTCAAGTTC
TTCGATAGACACCCGGAGAG

Product: nicotinate-nucleotide pyrophosphorylase (carboxylating)

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MCIQYTRRLARDLKRWVHEDSPLGDVTTDAVFWSKEDSEKIMDIQARSRVYVVCPSLIEGALGALGLEPEFIAPAGWTQG
VVVSVRGLTKELLMFERTLLNFLIHVFSISTEVRRVRELLDSSGFKNVRVAVTRKTVPGMRLWAKLFARAAGADTHRLSL
SDMILIKDTHINAYGDLLGAVRAAKENASFTHKIEVEVSSEEEAFEVLPYVDAIMLDNVGPEEAKRIACKLKEAKPSIIV
EVSGGINRENVLQYVNECVDVVSMGYLTLSPPLVDLGAEIR

Sequences:

>Translated_281_residues
MCIQYTRRLARDLKRWVHEDSPLGDVTTDAVFWSKEDSEKIMDIQARSRVYVVCPSLIEGALGALGLEPEFIAPAGWTQG
VVVSVRGLTKELLMFERTLLNFLIHVFSISTEVRRVRELLDSSGFKNVRVAVTRKTVPGMRLWAKLFARAAGADTHRLSL
SDMILIKDTHINAYGDLLGAVRAAKENASFTHKIEVEVSSEEEAFEVLPYVDAIMLDNVGPEEAKRIACKLKEAKPSIIV
EVSGGINRENVLQYVNECVDVVSMGYLTLSPPLVDLGAEIR
>Mature_281_residues
MCIQYTRRLARDLKRWVHEDSPLGDVTTDAVFWSKEDSEKIMDIQARSRVYVVCPSLIEGALGALGLEPEFIAPAGWTQG
VVVSVRGLTKELLMFERTLLNFLIHVFSISTEVRRVRELLDSSGFKNVRVAVTRKTVPGMRLWAKLFARAAGADTHRLSL
SDMILIKDTHINAYGDLLGAVRAAKENASFTHKIEVEVSSEEEAFEVLPYVDAIMLDNVGPEEAKRIACKLKEAKPSIIV
EVSGGINRENVLQYVNECVDVVSMGYLTLSPPLVDLGAEIR

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=196, Percent_Identity=40.3061224489796, Blast_Score=128, Evalue=5e-30,
Organism=Escherichia coli, GI1786299, Length=203, Percent_Identity=33.0049261083744, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=33.2142857142857, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31260; Mature: 31260

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIQYTRRLARDLKRWVHEDSPLGDVTTDAVFWSKEDSEKIMDIQARSRVYVVCPSLIEG
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCEEEEECHHHHHH
ALGALGLEPEFIAPAGWTQGVVVSVRGLTKELLMFERTLLNFLIHVFSISTEVRRVRELL
HHHHCCCCCCEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSSGFKNVRVAVTRKTVPGMRLWAKLFARAAGADTHRLSLSDMILIKDTHINAYGDLLGA
HCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCHHHHHHHH
VRAAKENASFTHKIEVEVSSEEEAFEVLPYVDAIMLDNVGPEEAKRIACKLKEAKPSIIV
HHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
EVSGGINRENVLQYVNECVDVVSMGYLTLSPPLVDLGAEIR
EECCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCCCC
>Mature Secondary Structure
MCIQYTRRLARDLKRWVHEDSPLGDVTTDAVFWSKEDSEKIMDIQARSRVYVVCPSLIEG
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCEEEEECHHHHHH
ALGALGLEPEFIAPAGWTQGVVVSVRGLTKELLMFERTLLNFLIHVFSISTEVRRVRELL
HHHHCCCCCCEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSSGFKNVRVAVTRKTVPGMRLWAKLFARAAGADTHRLSLSDMILIKDTHINAYGDLLGA
HCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCHHHHHHHH
VRAAKENASFTHKIEVEVSSEEEAFEVLPYVDAIMLDNVGPEEAKRIACKLKEAKPSIIV
HHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
EVSGGINRENVLQYVNECVDVVSMGYLTLSPPLVDLGAEIR
EECCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]