Click here to switch to the map view.

The map label for this gene is eif2b [H]

Identifier: 156938055

GI number: 156938055

Start: 1129492

End: 1129884

Strand: Direct

Name: eif2b [H]

Synonym: Igni_1268

Alternate gene names: 156938055

Gene position: 1129492-1129884 (Clockwise)

Preceding gene: 156938054

Following gene: 156938059

Centisome position: 87.05

GC content: 56.49

Gene sequence:

>393_bases
TTGGAGAGGGCCTACAGCATGCTCCCGAGCAGGGTGGAGCACAAGGAGAGGTTCCAAGTGCCCAAGCCGAGGGTGCTAAT
AGTCGGAGACAAGACCATAGTACAGAACTTCAAACAAATATGCGACGTACTGAGGAGGGAACCAAAGATAGTGACCAAGT
GGTTCGCCAAAGAGCTCGCCGTGCCAGTCCAAATAGGCGAGAGCGGGGAGATGGTGCTTACCGGGAGGTTCTCGCCCCAA
ATAATAGAGAGGTTGTTGCAGAAGTTCGTGGAGCAGTACGTCATATGCCCTACTTGTGGCGGGCCCGACACCGAGCTCAT
AAGGCTGGACAGGAAGGTGTGGATCCTAAGGTGTCACGTCTGCGGCGCGGAGACCCCCGTGCCGCCCTTGTGA

Upstream 100 bases:

>100_bases
CAAGCTGCTCGAGGAGATGAGCTGAACTTTATAGCATCGCTCCCCTCCCCCCTCGGGGTGTGTAGCCTTTCCGATAAGGG
ACTGGCCGTACGAGAAGCTC

Downstream 100 bases:

>100_bases
GGTGGAGCGTCCATGAAGTATTGCCCCCGCTGCAAGTCACCCATGGAACTCAATATAGAGAAGAGCGTTTCCTCCGACGG
GACGGTGAAGGTCCTCTACT

Product: translation initiation factor 2 subunit beta (aeIF-2b)

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MERAYSMLPSRVEHKERFQVPKPRVLIVGDKTIVQNFKQICDVLRREPKIVTKWFAKELAVPVQIGESGEMVLTGRFSPQ
IIERLLQKFVEQYVICPTCGGPDTELIRLDRKVWILRCHVCGAETPVPPL

Sequences:

>Translated_130_residues
MERAYSMLPSRVEHKERFQVPKPRVLIVGDKTIVQNFKQICDVLRREPKIVTKWFAKELAVPVQIGESGEMVLTGRFSPQ
IIERLLQKFVEQYVICPTCGGPDTELIRLDRKVWILRCHVCGAETPVPPL
>Mature_130_residues
MERAYSMLPSRVEHKERFQVPKPRVLIVGDKTIVQNFKQICDVLRREPKIVTKWFAKELAVPVQIGESGEMVLTGRFSPQ
IIERLLQKFVEQYVICPTCGGPDTELIRLDRKVWILRCHVCGAETPVPPL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family [H]

Homologues:

Organism=Homo sapiens, GI29826335, Length=118, Percent_Identity=33.0508474576271, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508049, Length=123, Percent_Identity=30.8943089430894, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325018, Length=115, Percent_Identity=28.695652173913, Blast_Score=68, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647377, Length=117, Percent_Identity=32.4786324786325, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190 [H]

Pfam domain/function: PF01873 eIF-5_eIF-2B [H]

EC number: NA

Molecular weight: Translated: 14970; Mature: 14970

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAYSMLPSRVEHKERFQVPKPRVLIVGDKTIVQNFKQICDVLRREPKIVTKWFAKELA
CCCHHHHCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
VPVQIGESGEMVLTGRFSPQIIERLLQKFVEQYVICPTCGGPDTELIRLDRKVWILRCHV
CEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCEEEEEEEEE
CGAETPVPPL
CCCCCCCCCC
>Mature Secondary Structure
MERAYSMLPSRVEHKERFQVPKPRVLIVGDKTIVQNFKQICDVLRREPKIVTKWFAKELA
CCCHHHHCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
VPVQIGESGEMVLTGRFSPQIIERLLQKFVEQYVICPTCGGPDTELIRLDRKVWILRCHV
CEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCEEEEEEEEE
CGAETPVPPL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA