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The map label for this gene is tktA [C]

Identifier: 156938054

GI number: 156938054

Start: 1128577

End: 1129416

Strand: Direct

Name: tktA [C]

Synonym: Igni_1267

Alternate gene names: 156938054

Gene position: 1128577-1129416 (Clockwise)

Preceding gene: 156938053

Following gene: 156938055

Centisome position: 86.98

GC content: 57.38

Gene sequence:

>840_bases
TTGAGGGAAGTGAGCAAGCTAATTGAAGTCACTACGTCAGAAAAGGTAAAAAAGATAGAAGAGGTAGCAAAGCTCATGAG
GAAGTACATAATCGAGATGGCCAGCGTAGAGAAGACCGTCCACCTAGGCTCCAGCATGTCCGTAGTGGAGATCTTGGCGA
CCATCTGGCTGGGCGCGATGGAGCCTAGGAAGTGCGACGAGAGGCCTACGGAGCACGACTGGTTGATCCTCAGTAAGGGC
CACGCCGTACCGGCGTTCTACGCGCTGCTCGCCGCCCTGGAGCTCATACCCCCTCACTGGGTCAAGACCATAAGAGATAT
TTCCAGCCCCCTCCAAGGCCACCCGGACGACACCTTAGCTTGCGTTGACGCCCCCACGGGCAGCCTAGCCCAAGGCTTCA
GCTTCGCCACCGGAGTCGCTAAGGGTCTAAAGATGAAGGGCAGCAAGAAGAGGGTTTACGTGGTCCTAGGCGACGGGGAG
CTGGACGAGGGAGAGGTCTGGGAGGCCGCCTCCACTGCCGCCGCGCACTCCCTCGACAACTTAACGGCCGTAGTGGACTG
GAACGGCTTCCAGCTCGACGGGGAGACATTCAAAGTAAAAAATAAAGGCGACTTAATAGGGAAGTGGAAGGCCTTCGGGT
GGCACGTCATAGTGGTGGACGACGGCCACGACGTGGCGAGCTTGTTGGAGGCCTTGGAAGAGGCTAAAAATGTGAAGGGC
AAACCTACCGTCATATTGGCTAAGACCGTTAGGGGTAAGGGGGTTCCGAGCATAGAGGGGACCAAACAGCAGAGGATAGA
GCCCTCCGAGGCGCGCAAGCTGCTCGAGGAGATGAGCTGA

Upstream 100 bases:

>100_bases
TTAGGTATTCTTATACTTCCTCCCCTTAAGCTCTATGGGGCGCATAAGGCCCTAACAAGCGATATAACCTCCGCCCTCTA
GCCCCACCGGGTTCCCACAC

Downstream 100 bases:

>100_bases
ACTTTATAGCATCGCTCCCCTCCCCCCTCGGGGTGTGTAGCCTTTCCGATAAGGGACTGGCCGTACGAGAAGCTCTTGGA
GAGGGCCTACAGCATGCTCC

Product: transketolase subunit A

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MREVSKLIEVTTSEKVKKIEEVAKLMRKYIIEMASVEKTVHLGSSMSVVEILATIWLGAMEPRKCDERPTEHDWLILSKG
HAVPAFYALLAALELIPPHWVKTIRDISSPLQGHPDDTLACVDAPTGSLAQGFSFATGVAKGLKMKGSKKRVYVVLGDGE
LDEGEVWEAASTAAAHSLDNLTAVVDWNGFQLDGETFKVKNKGDLIGKWKAFGWHVIVVDDGHDVASLLEALEEAKNVKG
KPTVILAKTVRGKGVPSIEGTKQQRIEPSEARKLLEEMS

Sequences:

>Translated_279_residues
MREVSKLIEVTTSEKVKKIEEVAKLMRKYIIEMASVEKTVHLGSSMSVVEILATIWLGAMEPRKCDERPTEHDWLILSKG
HAVPAFYALLAALELIPPHWVKTIRDISSPLQGHPDDTLACVDAPTGSLAQGFSFATGVAKGLKMKGSKKRVYVVLGDGE
LDEGEVWEAASTAAAHSLDNLTAVVDWNGFQLDGETFKVKNKGDLIGKWKAFGWHVIVVDDGHDVASLLEALEEAKNVKG
KPTVILAKTVRGKGVPSIEGTKQQRIEPSEARKLLEEMS
>Mature_279_residues
MREVSKLIEVTTSEKVKKIEEVAKLMRKYIIEMASVEKTVHLGSSMSVVEILATIWLGAMEPRKCDERPTEHDWLILSKG
HAVPAFYALLAALELIPPHWVKTIRDISSPLQGHPDDTLACVDAPTGSLAQGFSFATGVAKGLKMKGSKKRVYVVLGDGE
LDEGEVWEAASTAAAHSLDNLTAVVDWNGFQLDGETFKVKNKGDLIGKWKAFGWHVIVVDDGHDVASLLEALEEAKNVKG
KPTVILAKTVRGKGVPSIEGTKQQRIEPSEARKLLEEMS

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=248, Percent_Identity=37.5, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4507521, Length=248, Percent_Identity=37.5, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI133778974, Length=246, Percent_Identity=36.1788617886179, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI225637459, Length=254, Percent_Identity=28.740157480315, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI225637461, Length=151, Percent_Identity=39.7350993377483, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=151, Percent_Identity=39.7350993377483, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI48994911, Length=261, Percent_Identity=30.6513409961686, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788808, Length=261, Percent_Identity=30.6513409961686, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17539652, Length=260, Percent_Identity=40, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325331, Length=248, Percent_Identity=31.4516129032258, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319593, Length=243, Percent_Identity=28.8065843621399, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666278, Length=259, Percent_Identity=36.6795366795367, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45551847, Length=249, Percent_Identity=36.144578313253, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI45550715, Length=249, Percent_Identity=36.144578313253, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24645119, Length=194, Percent_Identity=41.2371134020619, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30519; Mature: 30519

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVSKLIEVTTSEKVKKIEEVAKLMRKYIIEMASVEKTVHLGSSMSVVEILATIWLGAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
EPRKCDERPTEHDWLILSKGHAVPAFYALLAALELIPPHWVKTIRDISSPLQGHPDDTLA
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEE
CVDAPTGSLAQGFSFATGVAKGLKMKGSKKRVYVVLGDGELDEGEVWEAASTAAAHSLDN
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
LTAVVDWNGFQLDGETFKVKNKGDLIGKWKAFGWHVIVVDDGHDVASLLEALEEAKNVKG
EEEEEECCCEEECCCEEEECCCCCCEEEEEECEEEEEEEECCCCHHHHHHHHHHHHCCCC
KPTVILAKTVRGKGVPSIEGTKQQRIEPSEARKLLEEMS
CCEEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MREVSKLIEVTTSEKVKKIEEVAKLMRKYIIEMASVEKTVHLGSSMSVVEILATIWLGAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
EPRKCDERPTEHDWLILSKGHAVPAFYALLAALELIPPHWVKTIRDISSPLQGHPDDTLA
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEE
CVDAPTGSLAQGFSFATGVAKGLKMKGSKKRVYVVLGDGELDEGEVWEAASTAAAHSLDN
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
LTAVVDWNGFQLDGETFKVKNKGDLIGKWKAFGWHVIVVDDGHDVASLLEALEEAKNVKG
EEEEEECCCEEECCCEEEECCCCCCEEEEEECEEEEEEEECCCCHHHHHHHHHHHHCCCC
KPTVILAKTVRGKGVPSIEGTKQQRIEPSEARKLLEEMS
CCEEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]