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The map label for this gene is srp54 [H]

Identifier: 156937833

GI number: 156937833

Start: 930877

End: 932205

Strand: Reverse

Name: srp54 [H]

Synonym: Igni_1044

Alternate gene names: 156937833

Gene position: 932205-930877 (Counterclockwise)

Preceding gene: 156937835

Following gene: 156937831

Centisome position: 71.84

GC content: 56.96

Gene sequence:

>1329_bases
TTGCTCGACGGAGTTAGGGAGGCGGTGAAGAAGTTCCTCCGGTCGTCAGCTGACTACGAGACCTCCGTCAACCTATTTAT
AAAGGAGCTCCAGAAGACCCTAATAAAGTCTGACGTCAACGTTAAGCTGGTGCTACAACTTACCAAGAGGATAAGGGAGA
GGGCCCTCAAGGAGAGGCCTCCCCCGGGCGCCTCCAGGAGGGACTGGTTCGTAAAGATAGTCTACGAAGAGCTGGCCAAC
TTGTTCGGGGGCGACAAGGAGCCCGAGCTGAAGCCCCCTAAGGTGCCGTGGGTCATAATGATGGTCGGCGTCCAAGGAAG
CGGGAAGACCACTACCGCCGGCAAGCTAGCTAGGTTCTACAAGGTCAGGGGTTACCGCGTCGCCTTGGTGGCCGCAGACA
CCTACAGGCCGGGGGCGAAGGACCAGCTCCGCCAGCTCGCCGAGAGGGCGAAGGTTTTGTTTTACACCGAGCCCGGGGAC
GACGCGGTTGGCATAGCGAAGAGGGGGGTGGAGTGGGCCAAGTCCCAAGGCGCTGAAATAATAATAGTTGACACCGCGGG
GAGGCACAAGAACGAGGCGGAACTCCTCAAGGAGATGAAGGAGATGAGCGAGGCAATAAAGCCTGACGAGGTCATGTTGG
TTATAGACGCCAGCATAGGTCAGCAAGCGAAGGCGTTGGCGGAGGCCTTCCACAAGACCACGCCTATAGGGTCCATAGTG
GTAACGAAGCTGGACGGAACGGCGAAGGGCGGGGGCGCGCTCTCCGCGGTCGCGGTCACGGGGGCCACCATAAAGTTCGT
GGGCACCGGAGAGAAGCTGGAGGAGTTGGAACCGTTCAAGCCCAAGAAGTTCGTCGCAAGAATACTGGGGCTGGGCGACC
TGGAGGGGCTGCTGGAGAGGCTCAAGGGCTTGGAAGAGGCCGACAAGCTGGAGGAGATAAGCCAGAAGGTGCTGGAGAAG
GGAGACATAACCTTGAAGGACCTCTACTACCAAATAGTGTCAGTTAAGAAGATGGGGTCTCTCAAGAAGCTGCTCCAGAT
GCTCCCGGGGGTGGGGTTGGCGCTCAACGACAAGGTCCTAGGACAAGTGGACGACAAGGTCCTCGACAAGTGGCTCGCGA
TACTGAACTCCATGACCTTGGAGGAGCTCGAGAAGCCTAACATTATAGACAGGTCCAGGATGAGGAGAATAGCCATAGGC
TCCGGCACGAGCGTTAAGGACGTGGAGGAGCTCCTCAAACACTACCAGATGACTCGGAAGATGATAAGGCAACTAAAGAG
GAAGAGGGGAATGCTGAACAAGTTGATGGAGAAGTTCGAACTTCAGTAA

Upstream 100 bases:

>100_bases
CTTCCCCTCTGAGCATGGCTCCTTTTCGAATATAAAGCTTTCGAACGGTGTGACCCTACTTGAAATACCCCTTGCCCAAT
AAGTTCTGGGGCTAGCAATT

Downstream 100 bases:

>100_bases
CGCCTCCTCTTGTTTAAGAGCTTCCTCTTTACGTACTTCAAGTAGCCCATGGTAGATACGCTCCCCTTCACCACCCTAAC
CCTCCCCTTCAAGATGGCCT

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: SRP54 [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLDGVREAVKKFLRSSADYETSVNLFIKELQKTLIKSDVNVKLVLQLTKRIRERALKERPPPGASRRDWFVKIVYEELAN
LFGGDKEPELKPPKVPWVIMMVGVQGSGKTTTAGKLARFYKVRGYRVALVAADTYRPGAKDQLRQLAERAKVLFYTEPGD
DAVGIAKRGVEWAKSQGAEIIIVDTAGRHKNEAELLKEMKEMSEAIKPDEVMLVIDASIGQQAKALAEAFHKTTPIGSIV
VTKLDGTAKGGGALSAVAVTGATIKFVGTGEKLEELEPFKPKKFVARILGLGDLEGLLERLKGLEEADKLEEISQKVLEK
GDITLKDLYYQIVSVKKMGSLKKLLQMLPGVGLALNDKVLGQVDDKVLDKWLAILNSMTLEELEKPNIIDRSRMRRIAIG
SGTSVKDVEELLKHYQMTRKMIRQLKRKRGMLNKLMEKFELQ

Sequences:

>Translated_442_residues
MLDGVREAVKKFLRSSADYETSVNLFIKELQKTLIKSDVNVKLVLQLTKRIRERALKERPPPGASRRDWFVKIVYEELAN
LFGGDKEPELKPPKVPWVIMMVGVQGSGKTTTAGKLARFYKVRGYRVALVAADTYRPGAKDQLRQLAERAKVLFYTEPGD
DAVGIAKRGVEWAKSQGAEIIIVDTAGRHKNEAELLKEMKEMSEAIKPDEVMLVIDASIGQQAKALAEAFHKTTPIGSIV
VTKLDGTAKGGGALSAVAVTGATIKFVGTGEKLEELEPFKPKKFVARILGLGDLEGLLERLKGLEEADKLEEISQKVLEK
GDITLKDLYYQIVSVKKMGSLKKLLQMLPGVGLALNDKVLGQVDDKVLDKWLAILNSMTLEELEKPNIIDRSRMRRIAIG
SGTSVKDVEELLKHYQMTRKMIRQLKRKRGMLNKLMEKFELQ
>Mature_442_residues
MLDGVREAVKKFLRSSADYETSVNLFIKELQKTLIKSDVNVKLVLQLTKRIRERALKERPPPGASRRDWFVKIVYEELAN
LFGGDKEPELKPPKVPWVIMMVGVQGSGKTTTAGKLARFYKVRGYRVALVAADTYRPGAKDQLRQLAERAKVLFYTEPGD
DAVGIAKRGVEWAKSQGAEIIIVDTAGRHKNEAELLKEMKEMSEAIKPDEVMLVIDASIGQQAKALAEAFHKTTPIGSIV
VTKLDGTAKGGGALSAVAVTGATIKFVGTGEKLEELEPFKPKKFVARILGLGDLEGLLERLKGLEEADKLEEISQKVLEK
GDITLKDLYYQIVSVKKMGSLKKLLQMLPGVGLALNDKVLGQVDDKVLDKWLAILNSMTLEELEKPNIIDRSRMRRIAIG
SGTSVKDVEELLKHYQMTRKMIRQLKRKRGMLNKLMEKFELQ

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=438, Percent_Identity=40.1826484018265, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI226371618, Length=385, Percent_Identity=42.0779220779221, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI89061728, Length=155, Percent_Identity=51.6129032258064, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI23308697, Length=219, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI295424842, Length=219, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=5e-25,
Organism=Escherichia coli, GI1788963, Length=423, Percent_Identity=38.7706855791962, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1789874, Length=243, Percent_Identity=37.8600823045267, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=39.3103448275862, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI193206261, Length=200, Percent_Identity=33.5, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325345, Length=431, Percent_Identity=41.0672853828306, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6320498, Length=224, Percent_Identity=31.25, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17647949, Length=443, Percent_Identity=37.4717832957111, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24641198, Length=219, Percent_Identity=30.1369863013699, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49310; Mature: 49310

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDGVREAVKKFLRSSADYETSVNLFIKELQKTLIKSDVNVKLVLQLTKRIRERALKERP
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PPGASRRDWFVKIVYEELANLFGGDKEPELKPPKVPWVIMMVGVQGSGKTTTAGKLARFY
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHH
KVRGYRVALVAADTYRPGAKDQLRQLAERAKVLFYTEPGDDAVGIAKRGVEWAKSQGAEI
HHCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEE
IIVDTAGRHKNEAELLKEMKEMSEAIKPDEVMLVIDASIGQQAKALAEAFHKTTPIGSIV
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEE
VTKLDGTAKGGGALSAVAVTGATIKFVGTGEKLEELEPFKPKKFVARILGLGDLEGLLER
EEECCCCCCCCCCEEHEEECCCEEEEEECCHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
LKGLEEADKLEEISQKVLEKGDITLKDLYYQIVSVKKMGSLKKLLQMLPGVGLALNDKVL
HHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHH
GQVDDKVLDKWLAILNSMTLEELEKPNIIDRSRMRRIAIGSGTSVKDVEELLKHYQMTRK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHH
MIRQLKRKRGMLNKLMEKFELQ
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDGVREAVKKFLRSSADYETSVNLFIKELQKTLIKSDVNVKLVLQLTKRIRERALKERP
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PPGASRRDWFVKIVYEELANLFGGDKEPELKPPKVPWVIMMVGVQGSGKTTTAGKLARFY
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHH
KVRGYRVALVAADTYRPGAKDQLRQLAERAKVLFYTEPGDDAVGIAKRGVEWAKSQGAEI
HHCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEE
IIVDTAGRHKNEAELLKEMKEMSEAIKPDEVMLVIDASIGQQAKALAEAFHKTTPIGSIV
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEE
VTKLDGTAKGGGALSAVAVTGATIKFVGTGEKLEELEPFKPKKFVARILGLGDLEGLLER
EEECCCCCCCCCCEEHEEECCCEEEEEECCHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
LKGLEEADKLEEISQKVLEKGDITLKDLYYQIVSVKKMGSLKKLLQMLPGVGLALNDKVL
HHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHH
GQVDDKVLDKWLAILNSMTLEELEKPNIIDRSRMRRIAIGSGTSVKDVEELLKHYQMTRK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHH
MIRQLKRKRGMLNKLMEKFELQ
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]