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The map label for this gene is hisG

Identifier: 156937547

GI number: 156937547

Start: 677502

End: 678353

Strand: Direct

Name: hisG

Synonym: Igni_0754

Alternate gene names: 156937547

Gene position: 677502-678353 (Clockwise)

Preceding gene: 156937545

Following gene: 156937549

Centisome position: 52.21

GC content: 51.06

Gene sequence:

>852_bases
GTGAGGTTCGTAATACCGAGTAAGGGCAGACTCAAGGACGCTACACTGGAGCTCTTAGAGAGGGCCGGGATCAGGCCGTC
TTACCTCGACTCGCGCGCCTTGATAGTGCCATCTAACAAACCGAATCTGGACCTCGTCTTTGCTAGGCCGGAGGACATAC
CTTGGATAGTCGAGAGCGGCGCGGCTGAGGTGGGGATAACAGGTCACGACTACGTCCTTGAGTCTGGAAGGGACGTCGCA
GAGATCCTTGATCTGAATTACGGTCGCTCGAAGCTCGTCTTGGCGGTTCCCCGAGATTCCGGAATAAAAAGGCCGGAGGA
GCTACCCAAGGGCTTCAGGATAGCTACTAAATTCATCAATATAGCTACTGACTATTTCGAGAAGAAGGGGTTAGACGTGA
AGATCGTGAAGGTCAGCGGCTCGGCTGAGGTGATGCCAGGCATCGGGGCAGCGGACGGGATAATAGACGTAATGTCGACT
GGTACGACGCTTAAGCTGCACGGCTTGACGCCCATAGACGTGATATTGAGTAGCAGCGCCAGATTGATAGTTAGGAAGGA
CTTGCTTGACGACCCTCGCGTGGAAACGATAAAGTTAATGCTTGAGTCAGTTCTACGGGCATCTAAGAAAAAGTTGGTTA
TGATGAACGTACCAGACGAAGCGTTGGACGACGTACTCAAAGTGTTGCCGGCCATGTCGGGTCCTACCATAAGCAAAGTG
AAGAGTGAGAAGCCTATGTGGGAGGTCATTGCGGCTGTAGACGAAGACGAGATAGCTGACATAATAGTAAAGTTGAAGAA
CGCAGGAGCAAAGGACATATTAGTTCTTAATGTTGAGAGACTAATCCCTTAG

Upstream 100 bases:

>100_bases
CAACGCTCCTTCGAGACGCGTTCGTTTAGCGATCTTTTTAGTTTGCCCCACTTTGGTAGTGCTAATTTTCTTGCCCCTTG
GACGCGGACTTCGGAGAGCC

Downstream 100 bases:

>100_bases
CCGGACGATTTTCTGCAAGAGGTCTACAGCTGCCACTAACAAGGGGACACCTAGAATTATGGCTAAGGTTTTATCGTTTA
TCTTTACTATTATATAACTA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MRFVIPSKGRLKDATLELLERAGIRPSYLDSRALIVPSNKPNLDLVFARPEDIPWIVESGAAEVGITGHDYVLESGRDVA
EILDLNYGRSKLVLAVPRDSGIKRPEELPKGFRIATKFINIATDYFEKKGLDVKIVKVSGSAEVMPGIGAADGIIDVMST
GTTLKLHGLTPIDVILSSSARLIVRKDLLDDPRVETIKLMLESVLRASKKKLVMMNVPDEALDDVLKVLPAMSGPTISKV
KSEKPMWEVIAAVDEDEIADIIVKLKNAGAKDILVLNVERLIP

Sequences:

>Translated_283_residues
MRFVIPSKGRLKDATLELLERAGIRPSYLDSRALIVPSNKPNLDLVFARPEDIPWIVESGAAEVGITGHDYVLESGRDVA
EILDLNYGRSKLVLAVPRDSGIKRPEELPKGFRIATKFINIATDYFEKKGLDVKIVKVSGSAEVMPGIGAADGIIDVMST
GTTLKLHGLTPIDVILSSSARLIVRKDLLDDPRVETIKLMLESVLRASKKKLVMMNVPDEALDDVLKVLPAMSGPTISKV
KSEKPMWEVIAAVDEDEIADIIVKLKNAGAKDILVLNVERLIP
>Mature_283_residues
MRFVIPSKGRLKDATLELLERAGIRPSYLDSRALIVPSNKPNLDLVFARPEDIPWIVESGAAEVGITGHDYVLESGRDVA
EILDLNYGRSKLVLAVPRDSGIKRPEELPKGFRIATKFINIATDYFEKKGLDVKIVKVSGSAEVMPGIGAADGIIDVMST
GTTLKLHGLTPIDVILSSSARLIVRKDLLDDPRVETIKLMLESVLRASKKKLVMMNVPDEALDDVLKVLPAMSGPTISKV
KSEKPMWEVIAAVDEDEIADIIVKLKNAGAKDILVLNVERLIP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=32.9931972789116, Blast_Score=144, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320896, Length=287, Percent_Identity=34.8432055749129, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_IGNH4 (A8AAI4)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435343.1
- STRING:   A8AAI4
- GeneID:   5561871
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0754
- eggNOG:   arNOG04876
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   IHOS453591:IGNI_0754-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 30937; Mature: 30937

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVIPSKGRLKDATLELLERAGIRPSYLDSRALIVPSNKPNLDLVFARPEDIPWIVESG
CEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEECC
AAEVGITGHDYVLESGRDVAEILDLNYGRSKLVLAVPRDSGIKRPEELPKGFRIATKFIN
CCEECCCCCHHHHHCCCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCHHHHHHHHHH
IATDYFEKKGLDVKIVKVSGSAEVMPGIGAADGIIDVMSTGTTLKLHGLTPIDVILSSSA
HHHHHHHHCCCEEEEEEECCCCEECCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHCCCC
RLIVRKDLLDDPRVETIKLMLESVLRASKKKLVMMNVPDEALDDVLKVLPAMSGPTISKV
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHH
KSEKPMWEVIAAVDEDEIADIIVKLKNAGAKDILVLNVERLIP
HCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHHHCC
>Mature Secondary Structure
MRFVIPSKGRLKDATLELLERAGIRPSYLDSRALIVPSNKPNLDLVFARPEDIPWIVESG
CEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEECC
AAEVGITGHDYVLESGRDVAEILDLNYGRSKLVLAVPRDSGIKRPEELPKGFRIATKFIN
CCEECCCCCHHHHHCCCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCHHHHHHHHHH
IATDYFEKKGLDVKIVKVSGSAEVMPGIGAADGIIDVMSTGTTLKLHGLTPIDVILSSSA
HHHHHHHHCCCEEEEEEECCCCEECCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHCCCC
RLIVRKDLLDDPRVETIKLMLESVLRASKKKLVMMNVPDEALDDVLKVLPAMSGPTISKV
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHH
KSEKPMWEVIAAVDEDEIADIIVKLKNAGAKDILVLNVERLIP
HCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA