Click here to switch to the map view.

The map label for this gene is dys

Identifier: 156937424

GI number: 156937424

Start: 567730

End: 568689

Strand: Reverse

Name: dys

Synonym: Igni_0631

Alternate gene names: 156937424

Gene position: 568689-567730 (Counterclockwise)

Preceding gene: 156937426

Following gene: 156937423

Centisome position: 43.83

GC content: 56.77

Gene sequence:

>960_bases
TTGAACAGAGAGGACTTCATAAAAGAGCCTGTTGAGGACATAAGGGTAAGCGAGAGGGACACGGTAGCGGACTTGATAGA
GAAGTACTGCAAGGTCCACGGCTTTACTGCCGCCGACGTCTGTAGGGCGGTCGAGGTGTTGAGCGAGGGGTTGAGGAATA
GCGATTTGAGGTTCTTGTCGTTCACGGCTAACTTGGTCGCCACGGGGCTCAGAGGGCTGTTGGCACAAATGGTGCGCTCC
GGCTACTTCGACGTGGTCGTTACCACTTGCGGCACCCTAGACCACGACGTGGCCAGGTCGTTGGGGCATAAGTACTACAA
AGGCTACTTCGAGGCTGACGACGTCGTGTTGGCGAAGTCCGACATTCACCGTTTGGGAAACGTGTTCATACCCGTTGAGA
ACTACGGACCCCCCGTCGAGAGGTTAGTGAAGGACGTGTTGAGGGAGTTGGGAAAGACTATGGTAGCGCCTTACGAACTG
ATATGGGAGGTAGGAAAGAGGCTCTCGGACGAGAACTCCATACTGAGGGCGGCGTGGGAGCGTAAGGTCCCGGTAATAGT
GCCTGGCATCACCGACGGCGCATTCGGTACGGCAATATTTACGTACTCAGAGGAGCTCAAGCTACAAGGGAAGGACTTCT
GCTTGGACGTCCTCGCGGACGAGAAGCTCCTATCGGACATGGTCTTCAGCAGCAAGAGGTCGGCCGCCCTCGTCGTGGGA
GGGGGAATAAGTAAACACCATGTAATCTGGTGGAACCAGTTTAAGGGGGGCCTGGACTATGCAGTCTACTTGACGACGGC
CCAAGAGTACGACGGGAGCTTGAGCGGCGCGCGCCCCCGAGAGGCCATAACTTGGGGCAAGCTGAAGCCCGAGGGGAGGA
GCGCCACTGTTTACGGGGACGCCACCGTTCTTTTGCCGATAATTTGGGCCGGCGTGTTGGCCAAGGTACAAAAGGCGTAG

Upstream 100 bases:

>100_bases
TAGCAACCTCCAAGACGTTCTCTTCCATAGCCTAACTCCCCTTCGGGTTGTCCGAGGCAGCATAAAAGCGGTCGAAGCGC
GGGGCCTAAAGGGCGGACTC

Downstream 100 bases:

>100_bases
ATTTAAACGACAGTGCGCGAGGCGGACTTGGGTTTTATGACTTGATACCGGTAACTACTATGGTCGTCGGGAGGGGAACG
GTCTCTACGAAGATAAAGGG

Product: deoxyhypusine synthase

Products: NA

Alternate protein names: DHS

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNREDFIKEPVEDIRVSERDTVADLIEKYCKVHGFTAADVCRAVEVLSEGLRNSDLRFLSFTANLVATGLRGLLAQMVRS
GYFDVVVTTCGTLDHDVARSLGHKYYKGYFEADDVVLAKSDIHRLGNVFIPVENYGPPVERLVKDVLRELGKTMVAPYEL
IWEVGKRLSDENSILRAAWERKVPVIVPGITDGAFGTAIFTYSEELKLQGKDFCLDVLADEKLLSDMVFSSKRSAALVVG
GGISKHHVIWWNQFKGGLDYAVYLTTAQEYDGSLSGARPREAITWGKLKPEGRSATVYGDATVLLPIIWAGVLAKVQKA

Sequences:

>Translated_319_residues
MNREDFIKEPVEDIRVSERDTVADLIEKYCKVHGFTAADVCRAVEVLSEGLRNSDLRFLSFTANLVATGLRGLLAQMVRS
GYFDVVVTTCGTLDHDVARSLGHKYYKGYFEADDVVLAKSDIHRLGNVFIPVENYGPPVERLVKDVLRELGKTMVAPYEL
IWEVGKRLSDENSILRAAWERKVPVIVPGITDGAFGTAIFTYSEELKLQGKDFCLDVLADEKLLSDMVFSSKRSAALVVG
GGISKHHVIWWNQFKGGLDYAVYLTTAQEYDGSLSGARPREAITWGKLKPEGRSATVYGDATVLLPIIWAGVLAKVQKA
>Mature_319_residues
MNREDFIKEPVEDIRVSERDTVADLIEKYCKVHGFTAADVCRAVEVLSEGLRNSDLRFLSFTANLVATGLRGLLAQMVRS
GYFDVVVTTCGTLDHDVARSLGHKYYKGYFEADDVVLAKSDIHRLGNVFIPVENYGPPVERLVKDVLRELGKTMVAPYEL
IWEVGKRLSDENSILRAAWERKVPVIVPGITDGAFGTAIFTYSEELKLQGKDFCLDVLADEKLLSDMVFSSKRSAALVVG
GGISKHHVIWWNQFKGGLDYAVYLTTAQEYDGSLSGARPREAITWGKLKPEGRSATVYGDATVLLPIIWAGVLAKVQKA

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family

Homologues:

Organism=Homo sapiens, GI4503325, Length=269, Percent_Identity=33.8289962825279, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI7108338, Length=269, Percent_Identity=27.8810408921933, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI7108340, Length=153, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17536927, Length=266, Percent_Identity=34.9624060150376, Blast_Score=170, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321859, Length=360, Percent_Identity=30, Blast_Score=172, Evalue=7e-44,
Organism=Drosophila melanogaster, GI45550569, Length=263, Percent_Identity=34.2205323193916, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHYS_IGNH4 (A8AA61)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435220.1
- ProteinModelPortal:   A8AA61
- SMR:   A8AA61
- STRING:   A8AA61
- GeneID:   5562987
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0631
- eggNOG:   arNOG05744
- HOGENOM:   HBG716221
- OMA:   YINTGQE
- ProtClustDB:   PRK01221
- BioCyc:   IHOS453591:IGNI_0631-MONOMER
- HAMAP:   MF_00153
- InterPro:   IPR002773
- InterPro:   IPR022899
- Gene3D:   G3DSA:3.40.910.10
- PANTHER:   PTHR11703

Pfam domain/function: PF01916 DS

EC number: =2.5.1.46

Molecular weight: Translated: 35351; Mature: 35351

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: ACT_SITE 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREDFIKEPVEDIRVSERDTVADLIEKYCKVHGFTAADVCRAVEVLSEGLRNSDLRFLS
CCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEH
FTANLVATGLRGLLAQMVRSGYFDVVVTTCGTLDHDVARSLGHKYYKGYFEADDVVLAKS
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHH
DIHRLGNVFIPVENYGPPVERLVKDVLRELGKTMVAPYELIWEVGKRLSDENSILRAAWE
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
RKVPVIVPGITDGAFGTAIFTYSEELKLQGKDFCLDVLADEKLLSDMVFSSKRSAALVVG
CCCCEEECCCCCCCHHHEEEEECHHHEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GGISKHHVIWWNQFKGGLDYAVYLTTAQEYDGSLSGARPREAITWGKLKPEGRSATVYGD
CCCCCCEEEEEECCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
ATVLLPIIWAGVLAKVQKA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNREDFIKEPVEDIRVSERDTVADLIEKYCKVHGFTAADVCRAVEVLSEGLRNSDLRFLS
CCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEH
FTANLVATGLRGLLAQMVRSGYFDVVVTTCGTLDHDVARSLGHKYYKGYFEADDVVLAKS
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHH
DIHRLGNVFIPVENYGPPVERLVKDVLRELGKTMVAPYELIWEVGKRLSDENSILRAAWE
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
RKVPVIVPGITDGAFGTAIFTYSEELKLQGKDFCLDVLADEKLLSDMVFSSKRSAALVVG
CCCCEEECCCCCCCHHHEEEEECHHHEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GGISKHHVIWWNQFKGGLDYAVYLTTAQEYDGSLSGARPREAITWGKLKPEGRSATVYGD
CCCCCCEEEEEECCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
ATVLLPIIWAGVLAKVQKA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA