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The map label for this gene is hmgA [H]

Identifier: 156937270

GI number: 156937270

Start: 422877

End: 424103

Strand: Direct

Name: hmgA [H]

Synonym: Igni_0476

Alternate gene names: 156937270

Gene position: 422877-424103 (Clockwise)

Preceding gene: 156937269

Following gene: 156937271

Centisome position: 32.59

GC content: 59.98

Gene sequence:

>1227_bases
TTGGACGAGCTGGAAAAGTACGTAGAGATGTTGGAGAAGGGCGAGCTGAGCTTAAGCAAGCTGGACAAGGTCCTAAACCC
TAACTTGGCCGCCCTGGTCAGGAGGAGGTTCTTAGAAAAGAGGATAGGCAAGCTCCTCCCCGGCATAGCCTCAACCATAC
TCGACTTCGAAGAGCTCGTGGGAAGGAACATAGAGAACCCGATAGGGGCGGTTCAAATTCCCTTGGGCATAGCCGGACCC
ATCAAGGTCAACGGGGACTACGCCAAGGGGGAGTTCTACGTCCCCTTGGCCACCCACGAGGGGGCCCTGGTCGCCTCCGT
CAACAGGGGGATGAAGGCCGTTACCTTGTCCGGCGGCGCAAACGTAAAGGTGTTGAAAGATGGGATGGCTAGAGCCCCGG
TGTTCAGGGTCCCAGACGTGGCGACCGCGCAAGAGCTCGTGGAGTGGGTTAAGGAGCACTTTAACGAGATAAAGGAGGTT
GCTGAAAGCACCACGCGCCACGGGAAGCTGAAGGAAATACAGCCGTTCGTCATGGGGAACAACGTGTGGCTGCGCTTCGT
CTACTTTACCGGCGATGCTATGGGAATGAACATGGCAACGATAGCGACCGAGAAGGCGTGCGAATACATTGAAGAGAACT
TCGGGAGGGCCCAGTGCGTGGCCCTCTCCGGCAACATGTGCGTCGACAAGAAGCCTGCCCACTTGAACGTCCTCTTGGGG
AGAGGGAAGTACGTGGTGGCCGAGGCCTTGATAAAGAAGGAGGTACTGGAGGGGGTGCTTAAGACCGACGCGAGGTCGGT
GCACGAGGTAAACGAGAGGAAGAACTGGGCCGGGAGCGCCTTCGCGGGCTCCTTCTCCTACAACGCCCACTTCGCCAACA
TAATAGCCGCGATATTCTTAGCTACCGGGCAGGACGCCGCGCAAATAGTGGAGTCCTCCATGGGCTTCACTTGGACGGAA
GTGAGGGGCGAGGACTTGTACATCTCCGTCACCCTCCCCAGCTTGGAGGTAGGCACTGTGGGCGGGGGGACTAGGCTGCA
GACCCAGAGGGAGGCCTTGGAGATACTCGGCGTGGCCGGCGGCGGCGACCCCCCTGGCACCAACGCCCTCAAGTTCGCCG
AGATCGTGGGGGCAAGCGTCTTAGCCGGCGAACTAAACCTGCTCGCGGCCCTCGCGGCAAGGCAGCTCGCGAGGGCCCAC
GAGAGGCTCGGGAGGGGGAAGGGTTGA

Upstream 100 bases:

>100_bases
TACAAGCTGCAAGTGTTCTTGGACGAGAGGAAGAAGTAAGCTTTTTCCACTCTCAGACGTTTATGACCTTACTCCCCTCA
CCCCCTCCGGGCAGCCGGCC

Downstream 100 bases:

>100_bases
GGCTCGAGCTGGAGGGCAAGGAGCTGGCCGCGCTCTCGTGGGGCGCGGCGGTGGGGGCCAAGTACGAGGGCGGAGGCTTC
GCGACTTTCTTCGACGAGAA

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MDELEKYVEMLEKGELSLSKLDKVLNPNLAALVRRRFLEKRIGKLLPGIASTILDFEELVGRNIENPIGAVQIPLGIAGP
IKVNGDYAKGEFYVPLATHEGALVASVNRGMKAVTLSGGANVKVLKDGMARAPVFRVPDVATAQELVEWVKEHFNEIKEV
AESTTRHGKLKEIQPFVMGNNVWLRFVYFTGDAMGMNMATIATEKACEYIEENFGRAQCVALSGNMCVDKKPAHLNVLLG
RGKYVVAEALIKKEVLEGVLKTDARSVHEVNERKNWAGSAFAGSFSYNAHFANIIAAIFLATGQDAAQIVESSMGFTWTE
VRGEDLYISVTLPSLEVGTVGGGTRLQTQREALEILGVAGGGDPPGTNALKFAEIVGASVLAGELNLLAALAARQLARAH
ERLGRGKG

Sequences:

>Translated_408_residues
MDELEKYVEMLEKGELSLSKLDKVLNPNLAALVRRRFLEKRIGKLLPGIASTILDFEELVGRNIENPIGAVQIPLGIAGP
IKVNGDYAKGEFYVPLATHEGALVASVNRGMKAVTLSGGANVKVLKDGMARAPVFRVPDVATAQELVEWVKEHFNEIKEV
AESTTRHGKLKEIQPFVMGNNVWLRFVYFTGDAMGMNMATIATEKACEYIEENFGRAQCVALSGNMCVDKKPAHLNVLLG
RGKYVVAEALIKKEVLEGVLKTDARSVHEVNERKNWAGSAFAGSFSYNAHFANIIAAIFLATGQDAAQIVESSMGFTWTE
VRGEDLYISVTLPSLEVGTVGGGTRLQTQREALEILGVAGGGDPPGTNALKFAEIVGASVLAGELNLLAALAARQLARAH
ERLGRGKG
>Mature_408_residues
MDELEKYVEMLEKGELSLSKLDKVLNPNLAALVRRRFLEKRIGKLLPGIASTILDFEELVGRNIENPIGAVQIPLGIAGP
IKVNGDYAKGEFYVPLATHEGALVASVNRGMKAVTLSGGANVKVLKDGMARAPVFRVPDVATAQELVEWVKEHFNEIKEV
AESTTRHGKLKEIQPFVMGNNVWLRFVYFTGDAMGMNMATIATEKACEYIEENFGRAQCVALSGNMCVDKKPAHLNVLLG
RGKYVVAEALIKKEVLEGVLKTDARSVHEVNERKNWAGSAFAGSFSYNAHFANIIAAIFLATGQDAAQIVESSMGFTWTE
VRGEDLYISVTLPSLEVGTVGGGTRLQTQREALEILGVAGGGDPPGTNALKFAEIVGASVLAGELNLLAALAARQLARAH
ERLGRGKG

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=384, Percent_Identity=47.1354166666667, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI196049380, Length=299, Percent_Identity=49.8327759197324, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25144592, Length=405, Percent_Identity=43.2098765432099, Blast_Score=304, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6323565, Length=404, Percent_Identity=44.0594059405941, Blast_Score=286, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6323483, Length=408, Percent_Identity=42.8921568627451, Blast_Score=285, Evalue=9e-78,
Organism=Drosophila melanogaster, GI281362379, Length=420, Percent_Identity=45, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI45553469, Length=420, Percent_Identity=45, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24649399, Length=420, Percent_Identity=45, Blast_Score=292, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 43986; Mature: 43986

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELEKYVEMLEKGELSLSKLDKVLNPNLAALVRRRFLEKRIGKLLPGIASTILDFEELV
CCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRNIENPIGAVQIPLGIAGPIKVNGDYAKGEFYVPLATHEGALVASVNRGMKAVTLSGGA
CCCCCCCCCEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEECCCCCEEEEECCCC
NVKVLKDGMARAPVFRVPDVATAQELVEWVKEHFNEIKEVAESTTRHGKLKEIQPFVMGN
CEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEECC
NVWLRFVYFTGDAMGMNMATIATEKACEYIEENFGRAQCVALSGNMCVDKKPAHLNVLLG
CEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCEEEEEEE
RGKYVVAEALIKKEVLEGVLKTDARSVHEVNERKNWAGSAFAGSFSYNAHFANIIAAIFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHH
ATGQDAAQIVESSMGFTWTEVRGEDLYISVTLPSLEVGTVGGGTRLQTQREALEILGVAG
HCCCHHHHHHHHHCCCEEEEECCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHEEECC
GGDPPGTNALKFAEIVGASVLAGELNLLAALAARQLARAHERLGRGKG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDELEKYVEMLEKGELSLSKLDKVLNPNLAALVRRRFLEKRIGKLLPGIASTILDFEELV
CCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRNIENPIGAVQIPLGIAGPIKVNGDYAKGEFYVPLATHEGALVASVNRGMKAVTLSGGA
CCCCCCCCCEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEECCCCCEEEEECCCC
NVKVLKDGMARAPVFRVPDVATAQELVEWVKEHFNEIKEVAESTTRHGKLKEIQPFVMGN
CEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEECC
NVWLRFVYFTGDAMGMNMATIATEKACEYIEENFGRAQCVALSGNMCVDKKPAHLNVLLG
CEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCEEEEEEE
RGKYVVAEALIKKEVLEGVLKTDARSVHEVNERKNWAGSAFAGSFSYNAHFANIIAAIFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHH
ATGQDAAQIVESSMGFTWTEVRGEDLYISVTLPSLEVGTVGGGTRLQTQREALEILGVAG
HCCCHHHHHHHHHCCCEEEEECCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHEEECC
GGDPPGTNALKFAEIVGASVLAGELNLLAALAARQLARAHERLGRGKG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171410; 10701121; 11427726 [H]