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The map label for this gene is cobA [H]

Identifier: 156936884

GI number: 156936884

Start: 85094

End: 85840

Strand: Direct

Name: cobA [H]

Synonym: Igni_0089

Alternate gene names: 156936884

Gene position: 85094-85840 (Clockwise)

Preceding gene: 156936883

Following gene: 156936885

Centisome position: 6.56

GC content: 62.38

Gene sequence:

>747_bases
TTGAAGGGTAAGGTTTATCTCGTGGGGGCCGGGCCGGGGGGCGCTTGGCTGGCCCCAGCCGCGGCCTTCGGCTTGCTCCG
GTCAGCCGACGTAGTCTTGTACGATAAGCTCGTGGACAAGTCTCTCTTGTCTTCAGCTTTTAAGGCGGAGAAGGTTTACG
TAGGTAAGGCCCCCGGGGCCCACGCCCTGAGCCAAGAAGAGATCAACGAGCTTTTGATAAAGTATGCCAAAGAAGGGAAG
GTAGTTGTGAGGCTGAAGGGCGGCGACCCCTTCGTGCTCGGAAGGGGGGACGAGGAGTGCGAGGCCCTCCGGGCGGCCGG
GGTGGAGTGCGAGGTGGTCCCCGCCCCCACGTCGGCCACCGCGGTGCCCGCGTGCGCCGGCATCCCGGTAACTAGGAGGA
ACTTAGCCAACACCTTTGCGGTCGCCACGGGGTGGGCGGCGGAGGGGAGCGAGAGGCCGAGGTACGGCGAGATACTAAAG
GTCGTGGACACTCTGGTGGTTCTGATGGGGGTTACGAAGGTTAACGAGATAGTTTCAGACATCCTAAAGGTCAGGGACGT
TCCCGCAGCAGCCGTGACCAACGGGTGTACGGAAGAACAGAAGGTGGTGGTCGCGAGGGCGTCGAAGCTGCCCGAGGTAA
TGGTCCGTAACGGGGTAAAGCCGCCGGCGGTTTTGGTGTTCGGAGAGGTGGTCGAGTGGGCTTGCAAGGCGGGCACGGTA
AGGGACGTGGTAGAGTGCTCACTCTGA

Upstream 100 bases:

>100_bases
GACCATCAGGGCGGAGCTGGAGGAGCTCAAGAAGCGCCTCGAGGGGGGCTGAGCGCGCCGCGGTCAATACCCCCTACTCG
TCAGTCCAAAGGGGAACTCC

Downstream 100 bases:

>100_bases
GCCCCCACGGACCTCCCCCCTTCAAGGACCTCGAAGTGACCAACGTCCCGGCGCTAGAGCTGGTGGACGTCGCGGACGCC
TCCCAAATCAAGGAAGCCAT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKGKVYLVGAGPGGAWLAPAAAFGLLRSADVVLYDKLVDKSLLSSAFKAEKVYVGKAPGAHALSQEEINELLIKYAKEGK
VVVRLKGGDPFVLGRGDEECEALRAAGVECEVVPAPTSATAVPACAGIPVTRRNLANTFAVATGWAAEGSERPRYGEILK
VVDTLVVLMGVTKVNEIVSDILKVRDVPAAAVTNGCTEEQKVVVARASKLPEVMVRNGVKPPAVLVFGEVVEWACKAGTV
RDVVECSL

Sequences:

>Translated_248_residues
MKGKVYLVGAGPGGAWLAPAAAFGLLRSADVVLYDKLVDKSLLSSAFKAEKVYVGKAPGAHALSQEEINELLIKYAKEGK
VVVRLKGGDPFVLGRGDEECEALRAAGVECEVVPAPTSATAVPACAGIPVTRRNLANTFAVATGWAAEGSERPRYGEILK
VVDTLVVLMGVTKVNEIVSDILKVRDVPAAAVTNGCTEEQKVVVARASKLPEVMVRNGVKPPAVLVFGEVVEWACKAGTV
RDVVECSL
>Mature_248_residues
MKGKVYLVGAGPGGAWLAPAAAFGLLRSADVVLYDKLVDKSLLSSAFKAEKVYVGKAPGAHALSQEEINELLIKYAKEGK
VVVRLKGGDPFVLGRGDEECEALRAAGVECEVVPAPTSATAVPACAGIPVTRRNLANTFAVATGWAAEGSERPRYGEILK
VVDTLVVLMGVTKVNEIVSDILKVRDVPAAAVTNGCTEEQKVVVARASKLPEVMVRNGVKPPAVLVFGEVVEWACKAGTV
RDVVECSL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=38.034188034188, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=35.1931330472103, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 26026; Mature: 26026

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKVYLVGAGPGGAWLAPAAAFGLLRSADVVLYDKLVDKSLLSSAFKAEKVYVGKAPGA
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCC
HALSQEEINELLIKYAKEGKVVVRLKGGDPFVLGRGDEECEALRAAGVECEVVPAPTSAT
CCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCC
AVPACAGIPVTRRNLANTFAVATGWAAEGSERPRYGEILKVVDTLVVLMGVTKVNEIVSD
CCCHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKVRDVPAAAVTNGCTEEQKVVVARASKLPEVMVRNGVKPPAVLVFGEVVEWACKAGTV
HHHHCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEHHHHHHHHHHCCCCH
RDVVECSL
HHHHHCCC
>Mature Secondary Structure
MKGKVYLVGAGPGGAWLAPAAAFGLLRSADVVLYDKLVDKSLLSSAFKAEKVYVGKAPGA
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCC
HALSQEEINELLIKYAKEGKVVVRLKGGDPFVLGRGDEECEALRAAGVECEVVPAPTSAT
CCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCC
AVPACAGIPVTRRNLANTFAVATGWAAEGSERPRYGEILKVVDTLVVLMGVTKVNEIVSD
CCCHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKVRDVPAAAVTNGCTEEQKVVVARASKLPEVMVRNGVKPPAVLVFGEVVEWACKAGTV
HHHHCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEHHHHHHHHHHCCCCH
RDVVECSL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]